An assessment of nucleic acid amplification testing for active mycobacterial infection



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Incidence of TB based on WHO estimates from 2012: high incidence = > 100 cases per 100,000 people. The combined values are for all studies in both Figures 43 and 44.

AFB = acid-fast bacilli; NAAT = nucleic acid amplification test; TB = tuberculosis



Forest plot of the sensitivity and specificity of NAAT compared with culture <a href=in AFB-positive specimens, grouped according to type of NAAT and incidence of TB" align="bottom" width="829" height="533" border="0">

Figure 45 Forest plot of the sensitivity and specificity of NAAT compared with culture in AFB-positive specimens, grouped according to type of NAAT and incidence of TB

Incidence of TB based on WHO estimates from 2012: low incidence = ≤ 10 cases per 100,000 people; medium incidence = 10–100 cases per 100,000 people; high incidence = > 100 cases per 100,000 people

AFB = acid-fast bacilli; NAAT = nucleic acid amplification test; TB = tuberculosis



Forest plot of the sensitivity and specificity of NAAT compared with culture <a href=in AFB-negative specimens, grouped according to use of in-house or commercial NAAT and incidence of TB" align="bottom" width="773" height="518" border="0">

Figure 46 Forest plot of the sensitivity and specificity of NAAT compared with culture in AFB-negative specimens, grouped according to use of in-house or commercial NAAT and incidence of TB



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