An assessment of nucleic acid amplification testing for active mycobacterial infection

Selection criteria

• 
  did not address the research question;
  
• 
  focused on latent TB (as NAAT for latent TB has already been assessed);
  
• 
  did not provide information on the pre-specified target population (i.e. were focused on mycobacteria that cause Hansen’s disease (leprosy);
  
• 
  did not address one of the pre-specified outcomes and/or provided inadequate data on these outcomes;
  
• 
  were in a language other than English and were of a lower level of evidence than the included studies; or
  
• 
  did not have an appropriate study design.
  

Specified a priori patient subgroups of particular interest in the analysis included patients with high and low pre-test probabilities of having TB and patients with HIV.

Search results

The PRISMA flowcharts are shown in Figure 6, Figure 7, Figure 8, Figure 9 and Figure 10. These outline the study selection process and number of papers considered at each stage of the SR (Liberati et al. 2009).

PRISMA flowcharts Source: Liberati et al. (2009)

evidence, accuracy and change in management)" align="bottom" width="545" height="454" border="0">

Figure 6 Summary of the process used to identify and select studies investigating the use of NAAT to diagnose MTB (direct evidence, accuracy and change in management)

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