Received Arnold Prize for Best Design Project in BME Dept

Received Arnold Prize for Best Design Project in BME Dept

Christine Lee Independent Research (BME 240A) summer03

Sanjay Hegde Undergraduate Summer Research (REU) summer03

Tanvir Haque Undergraduate Summer Research (REU) summer03

David Rhee Undergraduate Summer Research (REU) summer03

Ben Lewis Undergraduate Summer Research (REU) summer04

Leighton Ngai Undergraduate Summer Research (REU) summer04

Eric Vick Highschool Student Summer Research summer04

Jon Lee Research Experience for Teachers (RET) summer04

Jan Cathey Research Experience for Teachers (RET) summer04

Tami West Research Experience for Teachers (RET) summer04

Julia Wicke Research Experience for Teachers (RET) summer04

JoAnna Todd Independent Research (BME 240A) fall04/spring 05

Blake Sheridan Undergraduate Summer Research (REU) summer05

Laura Stevens Undergraduate Summer Research (REU) summer05

Sam Cassady Undergraduate Summer Research (REU) summer05

Independent Research fall05/spring06

Chrystina Carter Research Experience for Teachers (RET) summer05

Alanna Patsiokas Undergraduate Summer Research (VUSRP) summer05

Matthew Whitfield Independent Research (BME 240A) fall05/spring06

Aashish Bhapat Independent Research (BME 240A) fall05

Alex Abraham Undergrad Research Assistant (FWS) fall05/spring06

Alex Abraham Independent Research (BME 240A) summer07

Terry Carter Research Experience for Teachers (RET) summer07

Alex Abraham Independent Research (BME 240B) fall07/spring08

Received Arnold Prize for Best Research Project in BME Dept.

Terry Carter Research Experience for Teachers (RET) summer08

Alex Abraham Independent Research summer08

Connor McWade Independent Research spring09

Alex Hannah Senior Design Project (BME 272) fall08/spring09

Jim Frank Senior Design Project (BME 272) fall08/spring09

Clare Osborne Senior Design Project (BME 272) fall08/spring09

Ryan Theuer Senior Design Project (BME 272) fall08/spring09

Melanie Gault Independent Research (BME 240) spring09

Mahnoor Ahmed Independent Research (NSC 292) summer09/fall09

Melanie Gault Undergraduate Summer Research summer09

Melanie Gault Independent Research (BME 240) fall 09/spring10

Connor McWade Independent Research (NSC 292) spring10

Cody Hall Service Learning Project (BME 290) fall09/spring10

Melanie Gault Undergraduate Summer Research (VUSRP) summer 2010

Senior Design Project (BME 272) fall 2010

Greg Wigger Senior Design Project (BME 272) fall 2010


Graduate Student Supervision at Vanderbilt University:

Primary advisor on 10 MS theses and 6 PhD theses. Currently primary advisor for 4 Ph.D. and 2 M.S. students
Molly A. James BME M.S. December 1998

"Monitoring of Holmium:YAG laser induced heat shock protein 70 expression using the bioluminscent luciferase reporter gene"

"Noninvasive monitoring of Hsp70 during Ho:YAG laser irradiation"

"Spectral imaging for brain tumor demarcation"

"Free Electron Laser Ablation of Soft Tissue: The Effects of Chromophore and Pulse Characteristics on Ablation Mechanics"

"Imaging of Optically Active Reporter Genes to Assess Hsp70 Gene Expression Following Thermal Laser Injury"

Ph.D. December 2008

"The Role of Heat Shock Protein 70 in Laser Irradiation and Thermal Preconditioning"

" The Effect of Pulse Structure on Soft Tissue Laser Ablation at Mid-Infrared Wavelengths"

"Vascular Endothelial Growth Factor (VEGF) Expression Trends in Wound Healing and Tumor Growth Visualized Through In Vivo Bioluminescence Imaging of Firefly Luciferase Reporter Gene"

Ph.D. December 2007
Jerry Wilmink BME M.S. December 2004

"Using organotypic raft cultures and bioluminescent imaging to longitudinally study gene expression"

Ph.D. December 2007

"Assessing laser-tissue interactions with optical imaging"

"Optical stimulation of peripheral nerves in vivo"

Ph.D. May 2007
Jack Virostko BME M.S. December 2003

"Determining transplanted pancreatic islet mass using in vivo bioluminescence imaging"

Ph.D. December 2006
Chetan Patil BME M.S. December 2005

"Imaging of Angiogenesis with Doppler Optical Coherence Tomography (OCT)"

Jonathan Cayce BME M.S. May 2009

Ph.D. Expected: May 2010

"Optical stimulation of the Central Nervous System"
Jonathan Malphrus BME Ph.D. Expected: May 2011

"Nanoparticle-assisted optical stimulation of neurons"

"Modulation of the heatshock response to enhance wound healing in diabetic patients"

"Combined optical and electrical stimulation of neural tissue in vivo"

Ph.D. Expected May 2011


Graduate Student Thesis Committees:

Karthik Mariappan BME M.S. August 2000 (2^nd reader)

Todd Monroe BME Ph.D. July 2001 (dissertation committee)

Mark Mackanos BME M.S. August 2001 (2^nd reader)

Ph.D. December 2004

Chad Lieber BME Ph.D. May 2004

Stephen Uhlhorn BME Ph.D. August 2002

Steven Gebhart BME M.S. May 2002 (2^nd reader)

Ph.D. December 2006

Shannon Faley BME M.S. December 2002

Ph.D. December 2007

Josh Beckham BME M.S. December 2002

Ph.D. December 2008

David Roth BME M.S. May 2005 (2^nd reader)

Jack Virostko BME M.S. December 2003

Ph.D. December 2006

Jerry Wilmink BME M.S. December 2004

Ph.D. December 2007

Chetan Patil BME M.S. December 2005

Ph.D December 2009

Adam Smith BME Ph.D. May 2006

Greg Stone BME Ph.D. December 2005

Gilma Adunas-Rivas Physics Ph.D. DNF

Shelby Wyatt BME Ph.D. May 2007

Richard Chen BME Ph.D. December 2006

Jonathan Cayce BME M.S. May 2008

Ph.D. Expected: 2010

Nicole Dygert Physics Ph.D. December 2008

Elizabeth Kanter BME Ph.D. May 2009

Jonathan Malphrus BME M.S. Expected: December 2009

Austin Duke BME M.S. May 2009

Ph.D. Expected: 2011

Matt Keller BME Ph.D. December 2009

Elizabeth Vargis BME Ph.D. Expected: December 2010

Aroshan Jayasinghe Physics Ph.D. Expected: 2013


Director of Graduate Studies – August 2009 - current.
Graduate Student Committees Elsewhere:

The University of Texas at Austin

Kin Foong Chan secondary thesis reader EE MS Awarded: December 1997

Kin Foong Chan dissertation committee EE Ph.D. Awarded: August 2000

Agnella Izzo dissertation committee BME PhD Awarded: 2006

1997-99 Dr. Hans Pratisto – Project: Interaction of Free Electron Laser pulses with biological tissue

1997-00 Dr. Wei-Chiang Lin – Project: Spectroscopic-guided FEL ablation of tissue using hollow wave guides

1997-99 Dr. Jin-hui Shen (15%) – Project: Free Electron Laser beam delivery for applications in Opthalmology

1999-00 Dr. Brain Keay – Project: Interaction of Free Electron Laser pulses with biological tissue

2005 Dr. Mark Mackanos – Project: Development & Characterization of alternatives to FEL

2005-2007 Dr. Gajendiran Mahadevan – Project: Optical stimulation of neural tissue

2010-current Dr. Mykyta Chernov – Project: Optical stimulation of the cerebellum

Following is a summary of grants awarded. A complete list of grants awarded, pending and rejected, including a brief summary of the projects and my role can be found in the Sponsored Research document

PI: Wei-Chiang Lin (E.Duco Jansen, Michael Copeland, Massoud Motamedi – mentors)

Office of Naval Research (ONR) – FEL Laser Fellowship

Period: 10/97 – 10/98

Project Budget: $ 45,000
‘Interaction of Free Electron Laser pulses with biological tissue’

PI: Hans S. Pratisto (E.Duco Jansen – mentor)

Swiss National Science Foundation

Period: 9/97 – 8/98

Project Budget: Fellowship $ 22,000
‘Medical Free Electron Laser beam delivery for human care’

PI: E.Duco Jansen

Subcontract to ‘Medical & Materials Research with Free Electron Laser’ PI: Glenn Edwards, Office of Naval Research (ONR) Contract #N00014-94-1-1023

Period: 1/97 – 4/99

Project Budget: $ 628,842
‘Multispectral in vivo monitoring of laser-induced injury to biological tissue’

PI: E.Duco Jansen

Whitaker Foundation Research Award

Period: 9/98 – 8/01

Project Budget: $ 210,000
‘Bioluminescent reporter genes as a method for monitoring laser-induced injury’

PI: E.Duco Jansen

University Research Council

Period: 7/98 – 6/99

Project Budget: $ 9,939
‘Spectroscopic-guided FEL ablation of tissue using hollow waveguides’

PI: Wei-Chiang Lin (E.Duco Jansen, Massoud Motamedi, Anita Mahadevan-Jansen, Peter Konrad – mentors)

Office of Naval Research (ONR) – FEL Laser Fellowship (renewal)

Period: 10/98 – 9/99

Project Budget: $ 45,000
‘Acquistion of an Optical Coherence Tomography System’

PI: E.Duco Jansen

ONR/FEL Supplemental Applications

Period: 9/98 – 4/99

Project Budget: $ 49,353
‘Repair of Peripheral Nerves using the FEL’

PI: Peter Konrad, coPI: E.Duco Jansen

ONR/FEL Supplemental Applications

Period: 8/98 – 4/99

Project Budget: $ 23,868
‘Research Experiences for Undergraduates‘

PI: Robert L. Galloway, coPI's: Benoit Dawant, Michael Fitzpatrick, Cynthia Paschal, E. Duco Jansen

National Science Foundation (NSF) EEC-9820566

Period: 5/99 - 4/04

Project Budget: $ 312,500
‘Laser-Tissue Interaction Studies and MFEL Beam Delivery for Human Care’

PI: E.Duco Jansen

Subcontract to ‘Center for Medical & Materials Research with Free-Electron Lasers’ PI: Glenn Edwards Office of Naval Research (ONR) Contract #N00014-99-1-10779

Period: 5/1/99 – 5/30/00

Project Budget: $ 154,735
‘Spectroscopic-guided FEL ablation of tissue using hollow waveguides - extension’

PI: Wei-Chiang Lin (E. Duco Jansen, Massoud Motamedi, Anita Mahadevan-Jansen, Steven Toms - mentors)

ONR/FEL Laser Fellowship (extension)

Period: 10/99 – 4/00

Project Budget: $ 20,000
‘Vanderbilt-Northwestern-Texas-Harvard-MIT (VaNTH) Engineering Research Center for Bioengineering Education Technology’

PI: Thomas R. Harris

National Science Foundation(NSF) EEC-9876363

Period: 9/1/99 – 8/31/07

Project Budget: $ 9,996,191
‘Laser-tissue interaction studies and MFEL beam delivery for human care’

PI: E. Duco Jansen

Subcontract to ‘Vanderbilt Free Electron Laser Center’, PI: David W. Piston

Air Force Office of Scientific Research (AFOSR F49620-01-1-0429)

Period: 06/01– 9/03

Project: $180,011 (project); $2,500,000 (entire grant)

PI: David Piston

NIH (P20 CA86283-01)

Period: 6/00 - 5/03

Project Budget: $ 1,350,000
‘Microvasculature characterization with optical coherence tomography’

PI: E.Duco Jansen

University Central Intramural Discovery Grant Program IDGP-4509999016

Period: 1/01 - 6/03

Project Budget: $ 50,000
‘In vivo assessment of transplanted islets’

PI: Alvin C. Powers

Supplement Pilot & Feasibility Study, part of ‘Diabetes Research & Training Center’, PI: Daryl K. Granner

NIH/NIDDK: P60 DK20593-24

Period: 10/01 - 9/02

Project Budget: $189,218 (Pilot & Feasibility Study)

‘In Vivo System for Screening Anti-inflammatory Compounds’

PI: Timothy S. Blackwell

NIH (STTR): R41 AI049692-01 (Blackwell, Timothy S.)

Period: 7/01-6/02

Project Budget: $100,000
‘In vivo optical imaging of transplanted pancreatic islets’

PI: E. Duco Jansen

Supplement Pilot & Feasibility Study, part of ‘Diabetes Research & Training Center’, PI: Daryl K. Granner

NIH/NIDDK: P60 DK20593

Period: 4/02-3/04

Project Budget: $100,000

PI: E. Duco Jansen

Supplement (PER) to VaNTH ERC

NSF (PER): EEC-0121976

Period: 12/01/02-11/31/07

Project Budget: $ 300,000

PI: Alvin C. Powers

Juvenile Diabetes Foundation (JDF)

Period: 2/03-1/06

Project Budget: $ 691,828
‘In vivo optical imaging of vascular endothelial growth factor (VEGF) expression during tumor angiogenesis’

PI: E. Duco Jansen

Am Cancer Society (ACS: IRG #58-009-45)

Period: 1/02-12/02

Project Budget: $ 20,000
‘Acquisition of a tunable, 10-fs and 100-fs laser spectroscopy system for chemistry, biomedical engineering, materials science and physics’

PI: Norman H. Tolk, co-PI: Sandy Rosenthal, Richard Haglund, E. Duco Jansen

NSF (0321171) MURI

Period: 09/01/03-08/31/04

Project Budget: $ 400,000
‘Low cost confocal corneal pachymeter’

PI: Jin Shen

NIH (5R21EB002382)

Period: 10/01/03-9/30/05

Project Budget: $ 361,139

‘Assessment of wound healing using optically active reporter genes in organotypic (Raft) cultures’

PI: E. Duco Jansen

NIH NIAMS (pilot & feasibility project in 2P30AR041943 - Skin Disease Research Core Centers, George Stricklin, PI)

Period: 10/01/03-9/30/06

Project Budget: $ 60,000

PI: John C. Gore

NIH 5T32EB001628

Period: 09/30/03 - 08/30/08

Project Budget: $ 1,743,435
‘Predoctoral program in biomedical imaging’

PI: John C. Gore

NIH 1T32EB003817

Period: 09/01/04-08/30/09

Budget: $ 2,822,543
‘Vanderbilt University Biomedical Engineering RET side project’

PI: Stacy Klein; co-PI: Todd Giorgio, E. Duco Jansen, Cynthia Paschal

NSF Research Experience for Teachers (RET) program (EEC 0338092)

Period: 5/1/04 – 4/30/07

Project Budget: $ 449,996
‘Prevention & metastasis: final frontiers in colon cancer’

PI: Robert J. Coffey

NIH (2U01CA084239) Mouse Models for Human Cancer Consortium

Period: 5/1/04 – 4/30/09

Project Budget: $ 5,144,311
‘Vanderbilt Free-Electron Laser Center for Research in Surgery, Medicine, Photobiology and Materials Science’

PI: E. Duco Jansen (project); David Piston (overall)

DOD, AFOSR (BAA 2003-4)

Period: 11/01/03-12/31/07

Project Budget: $ 531,018; overall grant budget: $ 10,255,356
‘Bioluminescence imaging system’

PI: E. Duco Jansen

NIH (NCRR) 1S10 RR019185

Period: 4/01/04-03/31/05

Project Budget: $ 145,242
‘Correlations between single-cell signaling dynamics and protein expression profiles’

PI: John Wikswo

DOD / DARPA

Period: 9/01/04 – 06/31/06

Project Budget: $ 199,842
‘Development of a high resolution, high throughput optical nerve/brain stimulator’

PI: Mark Bendett / E. Duco Jansen

NIH (NINDS) 1 R43 NS051926-01

Period: 06/01/05 - 05/31/06

Project Budget: $ 202,284
‘Optical stimulation of neural tissue’

PI: E. Duco Jansen

NIH (NINDS/NIBIB) R01-NS052407-01

Period: 7/15/05-6/30/10

Project Budget: $ 1,748,851
‘Neural precursor cell therapy for disseminated glioma’

PI: Moneeb Ethesham

NIH/NINDS (R01 NS51557-01A1)

Period: 10/01/05-9/30/09

Budget: $ 1,338,750
‘TGF-b and IGF in mesenchymal stem cell chondrogenesis’

PI: Anna Spagnoli

Funding Source: NIH R01 DK70929-01A1

Period: 4/5/06-3/31/10

Project Budget: $ 1,134,282
‘Development of an optical nerve/brain stimulator’

PI: Mark Bendett / E. Duco Jansen

NIH (NINDS) R44 NS051926-02

Period: 11/01/06-5/30/09

Project Budget: $ 930,932
‘Induction of thermotolerance in laser-irradiated tissue’

PI: E. Duco Jansen

Funding Source: Am Soc for Laser Surgery and Medicine

Period: 07/01/07-12/31/08

Project Budget: $ 69,835
‘Infrared light for neural stimulation’

PI: E. Duco Jansen and Maarten A. Frens

Funding Source: Human Frontiers Science Program (HFSP)

Period: 9/1/08-8/31/11

Project Budget: $ 750,000
‘Neurophotonic Research Center: A Focused Collaboration Developing a Complete Neurophotonic Interface’

PI: Mark Christensen; Vanderbilt PI: E. Duco Jansen

Funding Source: DOD/DARPA Center for Integrated Photonics Engineering Research (CIPhER)

Period: 8/12/10-9/30/12

Project Budget: $ 5,764,725
‘Optical Neural Techniques for Combat/Post-Trauma Healthcare’

PI: E. Duco Jansen

Funding Source: DOD/TATRC

Period 7/15/10-7/14/11

Project Budget: $ 64,050

Publications

1. 
   Methods and device for optical stimulation of neural tissues – Mahadevan-Jansen A, Wells JD, Konrad P, Kao C, Jansen ED (US patent # 6921413).
   
2. 
   Identification of human tissue using optical spectroscopy - Lin WC, Mahadevan-Jansen A, Toms SA, Jansen ED (US patent #6377841).
   
3. 
   Guided skin disorder treatment using optical spectroscopy - Lin WC, Ellis DL, Jansen ED (invention disclosure filed)
   
4. 
   Reduction of blood contamination effect on optical spectra - Lin WC, Mahadevan-Jansen A, Jansen ED (invention disclosure filed).
   
5. 
   Device for tissue ablation using 6.45 µm Sr vapor laser – Haglund RF, Ivanov BL, Jansen ED, Kostadinov I, Piston DW, Soldatov AN (invention disclosure filed).
   
6. 
   Apparatus and Methods for optical stimulation – US Provisional Patent – Docket No. 14506-57727
   
7. 
   Optical Stimulation Devices for Experimental and Human Use (VU04123) - Mahadevan-Jansen A, Konrad PE, Jansen ED, Wells JD, Kao CC – US PATENT UNDER PROSECUTION; 3 method claims; published US 2005-0216072
   
8. 
   Optical Stimulation of the Auditory Nerve VU0607) - Jansen ED, Walsh JT, Izzo AD, Richter CP – US PATENT PROSECUTION ACTIVE; published US 2006-0161227 A1; NORTHWESTERN PROSECUTING
   
9. 
   Exogenous Chromophores and/or Optical Agents to Facilitate or Enhance Pulsed Laser Neural Stimulation Including Both the Peripheral and Central Nervous System (VU0709) - Mahadevan-Jansen A, Jansen ED, Wells JD – US NPA filed 11-27-07; Published US 2009-0069871 A1; Response to OA filed 9-8-09
   
10. 
    Combined Optical and Electrical Stimulation of Excitable Tissue – Duke AR, Jansen ED, Mahadevan-Jansen A, Konrad PE – Invention Disclosure filed.
    

1. 
   Verdaasdonk RM, Holstege FC, Jansen ED, Borst C - In vitro comparison of a radiofrequency heated and laser heated metal probe for angioplasty - Invest Radiol 25(6), 686-691 (1990).
   
2. 
   Welch AJ, Motamedi M, Rastegar S, LeCarpentier GL, Jansen ED - Laser thermal ablation - Photochem Photobiol 53(6): 815-823 (1991).
   
3. 
   Verdaasdonk RM Holstege FC, Jansen ED, Borst C -Temperature along the surface of modified fiber tips for Nd:YAG laser angioplasty - Lasers Surg Med 11: 213-222 (1991).
   
4. 
   Verdaasdonk RM, Jansen ED, Holstege FC, Borst C - Mechanism of CW Nd:YAG recanalization with modified fiber tips: influence of temperature and axial force on tissue penetration in vitro - Lasers Surg Med 11: 204-212 (1991).
   
5. 
   Rienks R, Smits PC, Verdaasdonk RM, Jansen ED, Velema E, Borst C - Coronary delivery of continuous wave Neodynium:YAG laser irradiation in the dog by transparent contact probe catheter - Lasers Life Sci 5(1): 25-35 (1992).
   
6. 
   
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