E. Duco Jansen Department of Biomedical Engineering Vanderbilt University Box 351631, Station b nashville, tn 37235



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Jansen ED, Wells JD, Kao C, Konrad PE, Mahadevan-Jansen A - Optical Stimulation of
Neural Tissue In Vivo – in: Optical Interactions with Tissue and Cells XVI, SPIE, San Jose, CA (2005).

  • *Mackanos MA, Jansen ED, Schwettman HA, Simanovskii D – Comparison of a ZGP-OPO with a Mark-III FEL as potential replacement for mid-infrared soft tissue applications, 27th international FEL conference, Stanford Univ, Palo Alto, CA (2005).

  • Richter CP, Izzo AD, Walsh JT, Jansen ED - Optically-evoked acoustic nerve activity – 2005 Mid-Winter Meeting for the Association for Research in Otolaryngology (ARO).  New Orleans, LA, (2005).

  • Izzo AD, Richter CP, Walsh JT, Jansen ED - Safe ranges for optical cochlear neuron stimulation – 2005 Mid-Winter Meeting for the Association for Research in Otolaryngology (ARO).  New Orleans, LA (2005).

  • Wilmink JJ, Beckham JT, Opalenik S, Viehoever A, Jansen ED – Using bioluminescent reporter genes in a novel skin model to temporally and noninvasively monitor gene expression – Annual meeting Am Soc Lasers Med Surg, Orlando, FL (2005)

  • Izzo A, Walsh JT, Richter CP, Jansen ED – Optical Stimulation of the Gerbil Cochlea: Characterization of Sensory Nervous System Stimulation in an in vivo Animal Model – Annual meeting Am Soc Lasers Med Surg, Orlando, FL (2005)

  • Wells JD, Kao C, Konrad PE, Mahadevan-Jansen A, Jansen ED – Photobiological mechanisms in optical stimulation of neural tissue – Annual meeting Am Soc Lasers Med Surg, Orlando, FL (2005).

  • Joos KM, Mawn LA, Shen JH, Jansen ED, Robinson RD, Mackanos MA, Mavity-Hudson J, Casagrande VA - Human optic nerve sheath fenestration with the free electron laser (FEL) - Annual meeting Am Soc Lasers Med Surg, Orlando, FL (2005).

  • Wells JD, Konrad PE, Mahadevan-Jansen A, Jansen ED - Biophysical mechanisms of optical stimulation of neural tissue – NIH symposium on Neural Interfaces – Bethesda, MD (2005).

  • Richter CP, Izzo A, Walsh JT, Jansen ED – Optical stimulation of the auditory system – NIH symposium on Neural Interfaces – Bethesda, MD (2005).

  • Richter CP, Izzo A, Jansen ED, Walsh JT – Spatial cochlear tuning obtained with optical stimuli - Conference of Implantable Auditory Prostheses, Pacific Grove, CA (July 2005)

  • Moulton K, Williams E, Lovell F, Ryan P, Lay D, Jansen ED, Willard A - A Comparison of Optical Clearing Agents to Enhance Photonic Detection of Salmonella through Pig Skin - Am Soc for Cell Biology 45th Annual Meeting San Francisco, CA (2005).

  • *Izzo AD, Pathria J, Suh E, Walsh JT, Jansen ED, Richter CP - Selectivity of optical stimulation in the auditory system – in: Advanced technology and instrumentation in otolaryngology: lasers, optics, radio frequency, and related technology – SPIE, San Jose, CA (2006).

  • *Wells JD, Jansen ED, Mahadevan-Jansen A, Konrad PE, Kao C - Biophysical mechanisms responsible for pulsed low-level laser excitation of neural tissue – in: Optical interactions with cells and tissues XVII – SPIE, San Jose, CA (2006).

  • Jansen ED, Wells JD, Kao C, Konrad PE, Mahadevan-Jansen A, Ralph HA, Webb J, Bendett MP - Development and validation of an optical nerve stimulator, in: Optical interactions with cells and tissues XVII – SPIE, San Jose, CA (2006).

  • *Virostko JM, Jansen ED - Assessment of Luminescent Source Reconstruction Using Single-View Bioluminescence Tomography – OSA topical meeting on Biophotonics, Ft. Lauderdale, Fl (2006).

  • *Patil CA, Jansen ED - Doppler optical coherence tomography velocimetry of blood flow in angiogenic tumor vasculature – OSA topical meeting on Biophotonics, Ft. Lauderdale, Fl (2006).

  • Cassady SR, Abrahan AA, Faley SL, Stevenson C, Jansen ED – Intraoperative discrimination of glioma cells using quantum dots – Ann mtg Am Soc for Laser Surg Med, Boston, MA (2006).

  • Chen Z, Virostko JM, Poffenberger G, Aramandla R, Jansen ED, Powers AC – Transplanted islets have reduced survival at intra-hepatic site (1922P) – Annual mtg of the Am Diabetes Assoc, Chicago, IL (2006).

  • Aramandla R, Poffenberger G, Virostko JM, Chen Z, Brissova M, Magnuson MA, Jansen ED, Powers AC – Non-invasive monitoring of islets within the pancreas and following transplantation using in vivo bioluminescence imaging (339OR) – Annual mtg of the Am Diabetes Assoc, Chicago IL (2006).

  • Landis B, Shimer K, Furmanski T, O’Rear L, Granero-Molto F, Jansen ED, Spagnoli A – Bone marrow derived mesenchymal stem cells in fracture healing: evidence of tropism without effect on biomechanical properties – Vanderbilt University Spring Emphasis Forum (2006).

  • Littlefield P, Izzo AD, Walsh JT, Jansen ED, Webb J, Ralph H, Richter CP - Laser stimulation of the auditory nerve is possible at high repetition rates – NIH Neural Interfaces workshop, Bethesda, MD (2006)

  • Gajendiran M, Wells JD, Kao C, Konrad PE, Mahadevan-Jansen A, Jansen ED – Laser pulse induced ventral and dorsal root potential of mammalian spinal cord: an in vivo study - NIH Neural Interfaces Workshop, Bethesda, MD (2006).

  • Gajendiran M, Wells JD, Kao C, Konrad P, Mahadevan-Jansen A, Jansen ED - Laser Stimulation-induced Ventral and Dorsal Root Potentials of Mammalian Spinal Cord In Vivo – Soc for Neuroscience, annual meeting, Atlanta, GA (2006).

  • Izzo AD, Walsh JT, Jansen ED, Richter CP - Laser Stimulation of Auditory Nerves: The Effect of Optical Parameters – BMES meeting, Chicago, IL (2006).

  • *Izzo AD, Littlefield P, Walsh JT, Jansen ED, Richter CP - Laser stimulation of auditory neurons at high repetition rate – in: Optical interactions with cells and tissues XVIII – SPIE, San Jose, CA (2007).

  • * Wilmink J, Beckham JT, Mackanos MA, Contag CH, Davidson J, Jansen ED – Wavelength-dependent dynamics of heat shock protein 70 expression in free electron laser wounds – in: Thermal Treatment of Tissue: Energy Delivery and Assessment IV – SPIE, San Jose, CA (2007).

  • Wilmink J, Opalenik S, Mackanos MA, Contag C, Davidson J, Jansen ED – Heat shock protein 70 expression in free electron laser wounds – Ann mtg Am Soc for Laser Surg Med, Grapevine, TX (2007).

  • Beckham JT, Jansen ED – Hsp70 deficient cells display an altered Arrhenius response to thermotolerance – Ann mtg Am Soc for Laser Surg Med, Grapevine, TX (2007).

  • Jansen ED – Talking to neurons using light (invited talk), CLEO Pacific Rim Conference, Seoul, South Korea (2007).

  • *Wilmink GJ, Beckham JT, Mackanos M, Contag CH, Davidson JM, Jansen ED – Use of optical reporter genes to assess sub-lethal cellular damage following skin ablation – in: Optical interactions with cells and tissues XIX – SPIE, San Jose, CA (2008).

  • *Wilmink GJ, Beckham JT, Carter T, Davidson JM, Jansen ED – Laser Preconditioning Enhances Dermal Wound Repair – in: Photonics in Dermatology and Plastic Surgery – SPIE, San Jose, CA (2008).

  • *Wells JD, Bendett MP, Webb J, Ralph HA, Richter CP, Izzo AD, Jansen ED, Mahadevan-Jansen A – Frontiers in optical stimulation of neural tissues: past, present, and future (invited paper) – in: Optical interactions with cells and tissues XIX – SPIE, San Jose, CA (2008).

  • *Littlefield P, Izzo AD, Mundi J, Walsh JT, Jansen ED, Bendett MP, Webb J, Ralph HA, Richter CP – Characterization of single auditory nerve fibers in response to laser stimulation – in: Optical interactions with cells and tissues XIX – SPIE, San Jose, CA (2008).

  • *Cayce J, Kao CC, Mahadevan G, Malphrus J, Konrad PE, Mahadevan-Jansen A, Jansen ED – Optical Stimulation of Rat Thalamocortical Brain Slices – in: Optical interactions with cells and tissues XIX – SPIE, San Jose, CA (2008).

  • *Malphrus J, Cayce J, Konrad P, Jeon NL, Mahadevan-Jansen A, Jansen ED – A Microfluidic Approach to Optical Nerve Stimulation, in: Optical interactions with cells and tissues XIX – SPIE, San Jose, CA (2008).

  • Virostko JM, Powers AC, Jansen ED – Validation of luminescent source reconstruction using spectrally resolved bioluminescent images – in: Clinical technologies and systems – SPIE, San Jose, CA (2008).

  • Beckham JT, Jansen ED – Hsp70 in thermal pretreatment of murine cell culture – SPIE Symposium on Laser-Tissue Interaction in honor of AJ Welch – Austin, TX (Feb 2008).

  • Wilmink GJ, Davidson JM, Jansen ED – Optimization of a laser preconditioning protocol to enhance cutaneous wound repair – SPIE Symposium on Laser-Tissue Interaction in honor of AJ Welch – Austin, TX (Feb 2008).

  • *Cayce JM, Kao CC, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A – Optical Stimulation of the Central Nervous System in vitro – OSA Topical meeting Biomed, St. Petersburg, FL (March 2008)

  • Beckham JT, Jansen ED – Microarray analysis of genes responsible for thermotolerance in hsp70 deficient cells – Ann mtg Am Soc for Laser Surg Med, Orlando, FL (2008).

  • Abraham AA, Wilmink GJ, Beckhman JT, Davidson JM, Jansen ED – Laser preconditioning augments cutaneous wound repair in a diabetic murine model – Ann mtg Am Soc for Laser Surg Med, Orlando, FL (2008).

  • Jansen ED, Wilmink GJ, Beckham JT, Davidson JM – Induction of thermotolerance in laser irradiated tissue – Ann mtg Am Soc for Laser Surg Med, Orlando, FL (2008).

  • Wilmink GJ, Opalenik SR, Nanney LB, Mahadevan-Jansen A, Davidson JM, Jansen ED – Molecular imaging-assisted optimization of laser preconditioning for wound repair enhancement. Annual mtg Wound Healing Society. San Diego, CA (2008).

  • Cayce JM, Kao C, Friedman R, Malphrus J, Konrad PE, Jansen ED, Mahadevan-Jansen A. – Optical stimulation of the brain. (invited as a platform presentation) – Neural Interfaces Conference, Cleveland, OH, June 18, (2008).

  • Duke A, Cayce JM, van Gessel I, Jansen ED – Optical stimulation of the vagus nerve in vivo – Neural Interfaces Conference, Cleveland, OH, June 18, (2008).

  • Mahadevan G, Kao C, Konrad PE, Mahadevan-Jansen A, Jansen ED – Infrared laser pulse-Induced dorsal, ventral, and the spinal monosynaptic reflex potentials of mammalian spinal cord: an in vivo Study – Neural Interfaces Conference, Cleveland, OH, June 18, (2008).

  • Mahadevan G, Kao CC, Konrad PE, Mahadevan-Jansen A, Jansen ED – Infrared pulse-induced spinal cord potentials of mammalian spinal cord (887.10) – Society for neuroscience Annual meeting, Washington DC, November (2008)

  • Cayce JM, Friedman RM, Remple M, Konrad PE, Jansen ED, Mahadevan-Jansen A, Roe AW– Infrared neural stimulation of the somatosensory cortex of the rat (887.9) – Society for neuroscience Annual meeting, Washington DC, November (2008)

  • Feng H, Kao CC, Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, McDonald RL – Alteration of GABA-ergic neurotransmission by pulsed infrared laser stimulation (887.8) – Society for neuroscience Annual meeting, Washington DC, November (2008)

  • Kao CC, Cayce JM, Jansen ED, Mahadevan-Jansen A, Konrad PE – Optical evoked high-frequency following action potentials in rat thalamocortical slices (136.1) - Society for neuroscience Annual meeting, Washington DC, November (2008)

  • Frens MA, Cayce JM, Louw S, Spoor M, Jansen ED - Infrared light for neural stimulation – annual meeting of the Human Frontier Science Program (HFSP) – Tokyo, Japan (June 2009).

  • Eckert J, Gault M, Duke A, Jenkins M, Lu H, Jansen ED, Rollins A, Chiel H - Investigating Optical Methods for Stimulating Neurons – Annual meeting of the Biomedical Engineering Society (BMES), Pittsburgh, PA (2009).

  • *Cayce JM, Friedman RM, Roe AW, Jansen ED, Konrad PE, Mahadevan-Jansen A - Infrared neural stimulation and optical recording of somatosensory cortex. - SPIE Photonics West San Jose, CA (2009).

  • Jansen ED, Duke AR, Malphrus JD, Cayce JM, Mahadevan-Jansen A - Combined electrical and optical stimulation in the sciatic nerve. SPIE Photonics West San Jose, CA (2009).

  • Duke AR, Cayce JM, van Gessel I, Jansen ED - Optical stimulation of the efferent vagus nerve in vivo.- SPIE Photonics West. San Jose, CA (2009).

  • Cayce JM, Wells JD, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A – A pilot study on the safety and efficacy of infrared neural stimulation in humans – Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside, NIH01-76, NIH Bethesda, MD. (2009)

  • Duke AR, Malphrus JD, Cayce JM, Jansen ED – Combined optical and electrical stimulation of neural tissue in vivo – Annual mtg of the Society for Neuroscience, Chicago IL, 485.12/GG126 (2009).

  • Kao CC, Feng HF, Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, Macdonald RL –Stimulation of GABAergic neurotransmission using pulsed infrared laser light – Annual Mtg of the Society for Neuroscience, Chicago, IL, 485.4/GG118 (2009).

  • Feng HF, Kao CC, Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, Macdonald RL – Pulsed infrared laser light: a potential new tool to stimulate GABAergic neurotransmission – Abcam Conference (Synaptic Inhibition in Health and Disease conference), Chicago, IL (2009).

  • Cayce JM, Friedman R, Jansen ED, Mahadevan-Jansen A, Konrad PE – A comparison between infrared neural and electrical stimulation in the rat brain. – SPIE Photonics West, San Francisco CA (2010).

  • Duke AR, Gault MA, Eckert J, Lu H, Jenkins MW, Chiel HJ, Jansen ED – Investigating the effects of infrared neural stimulation in the Aplysia californica – SPIE Photonics West, San Francisco CA (2010).

  • Duke AR, Cayce JM, Malphrus JD, Konrad P, Mahadevan-Jansen A, Jansen ED – Combined optical and electrical stimulation of neural tissue – SPIE Photonics West, San Francisco CA (2010).

  • Makowski AJ, Davidson JM, Mahadevan-Jansen A, Jansen ED – Laser preconditioning for wound healing: a Raman spectroscopy analysis – Am Soc Laser Surg Med, annual mtg, Phoenix, AZ (accepted)

  • Jenkins MW, Duke AR, Gu S, Chiel HJ, Watanabe M, Jansen ED, Rollins AM – Optical pacing - Optical pacing of the embryonic quail heart – Optical Society of America (OSA) – Biomedical Optics (BIOMED) topical meeting – Miami, FL (accepted).

  • Eckert J, Gault MA, Duke AJ, Jenkins MW, Lu H, Jansen ED, Rollins AM, Chiel HJ – Investigating optical methods for imaging and stimulating neurons – ShowCASE, Case Western University Symposium, Cleveland, OH (submitted).


    Invited talks:


    1. Jansen ED - Pulsed ablation of biological tissue (invited) - Bioengineering Seminar, Texas A&M University, College Station, TX (1994)

    2. Jansen ED - Laser-tissue interaction during TMLR (invited) - Research Colloquim, Heart-Lung Institute, University Hospital Utrecht, Utrecht, The Netherlands (1995)

    3. Jansen ED - Laser-tissue Interaction during TMLR (invited) - 1996 Symposium on TMLR, San Diego (1996).

    4. Jansen ED - TMLR: Relative merits and limitations of CO2, holmium and excimer laser (invited)- Gordon Conference on "Lasers in medicine and biology", Meriden, NH (1996).

    5. Jansen ED – Comparison of 2 micron, 10.6 micron and ultraviolet lasers in transmyocardial laser vascularization (invited) – Lasers and Electro-Optics Society (IEEE-LEOS), special symposium on "Lasers in Medicine and Biology", San Francisco, CA, (1997).

    6. Jansen ED – Shock wave and cavitation bubble measurements of ultrashort pulse laser-induced breakdown in water (invited) – Seminar in Applied Physics, Vanderbilt University, Nashville, TN (1997).

    7. Jansen ED – An overview of Biomedical Optics research at Vanderbilt University (invited) – Lawrence Livermore National Labs, (1998).

    8. Jansen ED, Pratisto HS, Uhlhorn SR, Lin WC, Joos K, Shen JH, Cram G, Copeland M, Peavey G, Edwards GS – Clinical beam delivery and emerging medical applications of the Vanderbilt FEL (invited) – 20th International FEL98 Conference (Users Workshop) – Williamsburg, VA (1998).

    9. Jansen ED – Spectral imaging and in vivo bioluminescence monitoring: Novel optical technologies and their use in biomedicine (invited) – Seminar in Department of Dermatology (invited), Vanderbilt University Medical Center, Nashville, TN (1998).

    10. Lin WC, Toms SA, Motamedi M, Jansen ED, Mahadevan-Jansen A – Optical spectroscopy in brain tumor margin detection (invited) – Second Tennessee Meeting on Biomedical Engineering, "Improving Health Care through Technology", Nashville, TN (1999).

    11. Lin WC, Toms SA, Motamedi M, Jansen ED, Mahadevan-Jansen A – Fluorescence and reflectance spectroscopy in brain tumor margin detection (invited) – Laser Medicine and Biophysics 99, La Jolla, CA (1999).

    12. Jansen ED – Medical applications of lasers and light (invited) – guest lecture, Retirement Learning Series, Vanderbilt University (1999).

    13. Copeland M, Cram GP, Edwards GS, Ernst D, Gabella W, Jansen ED - First Human Surgery with a Free Electron Laser (invited) - in: Plenary Session, SPIE, San Jose, CA, 2000

    14. Jansen ED – Use of lasers in medicine: Science or fiction? (invited) - National Society of Black Engineers (NSBE) – Nashville, TN (2000).

    15. Jansen ED – Novel approaches in optical imaging of biological processes (invited) – Center for Vascular Biology, Vanderbilt Ingram Cancer Center (2000).

    16. Jansen ED – Optimized laser surgery: from free electron laser beam delivery to biological response – (invited) Northwestern University, Dept of Biomedical Engineering (2000).

    17. Copeland ML, Cram G, Gabella W, Jansen ED, Mongin JD, Pratisto HS, Uhlhorn SR, Edwards GS – First human application of a free electron laser – (invited) 22nd International Free Electron Laser Conference Users Workshop, Durham, NC (2000).

    18. Jansen ED – Research capabilities and opportunities for in vivo imaging – (invited) Vanderbilt-Ingram Cancer Center seminar series 'On the Horizon', Vanderbilt University (2000).

    19. Jansen ED, Baran JA, Beckham JT - Bioluminescence imaging of gene expression following laser irradiation of biological samples (invited) - Research Seminar, Stanford University School of Medicine and Free Electron Laser Center, (Jan 2001).

    20. Jansen ED - Use of photoactive reporter genes in imaging gene expression in vivo - Research Colloqium, Heart Lung Institute and Department of Experimental Cardiology, University Hospital Utrecht, Utrecht, The Netherlands, (2001).

    21. Jansen ED - Technology supported learning (invited) – ‘Biomedical Engineering Education in Europe’ symposium - Eindhoven, The Netherlands (Oct 2001)

    22. Jansen ED - In vivo optical imaging of gene expression using photoactive reporter genes (invited) - seminar Laser Center, Amsterdam Medical Center (Oct 2001).

    23. Jansen ED - Novel approaches in optical imaging of biological processes - Vanderbilt In Vivo Imaging Center (Dec 2001).

    24. Jansen ED - In vivo optical imaging of gene expression using photoactive reporter genes (invited) - Symposium on In vivo imaging, Day of Biophysics and Biomedical Engineering, Eindhoven, The Netherlands (Nov 2001).

    25. Jansen ED, Faley S, Crooke C, Takahashi K, Takahashi T – Monitoring angiogenesis in vivo using transgenic mouse model – Vanderbilt In Vivo Imaging Center (Oct 2002)

    26. Jansen ED – Snapshots from the Vanderbilt classroom: Technology supported learning (invited) – New Faculty Orientation, Center for Teaching (Aug 2002).

    27. Jansen ED, Norris P - VSAS (VaNTH Student Assessment System) a.k.a. computer-based PRS (invited) – Campus Technology Forum (CTF) (Nov 2002).

    28. Jansen ED – VSAS (VaNTH Student Assessment System) (invited) – Vanderbilt University School of Engineering faculty meeting (Nov 2002).

    29. Jansen ED, Faley S, Crooke C, Takahashi K, Takahashi T – In vivo bioluminescence imaging of VEGF expression during tumor angiogenesis (invited) - Host-tumor interactions program seminar Vanderbilt Ingram Cancer Center (Jan 2003)

    30. Jansen ED – In vivo bioluminescence imaging of Vascular Endothelial Growth Factor expression during tumor angiogenesis (invited) – Annual Meeting TN chapter of Am Cancer Soc (ACS) (March 2003)

    31. Jansen ED, Faley S, Crooke C, Takahashi K, Takahashi T – In vivo Bioluminescence imaging of vascular endothelial growth factor (VEGF) expression during tumor angiogenesis (invited) – Tissue Optics Symposium of the Dutch Society for Biophysics and Biomedical Technology, Enschede, The Netherlands (2003)

    32. Powers AC, Fowler MJ, Virostko J, Nicholson W, Shiota M, Brissova M, Hirshberg B, Harlan D, Jansen ED – Using Bioluminescence to non-invasively image and assess transplanted islet mass (invited) – NIH (NIBIB/NIDDK) and JDRFI sponsored workshop “Imaging the pancreatic beta cell”, Bethesda, MD (2003)

    33. Mahadevan-Jansen A, Mariappan K, Albea J, Konrad PE, Jansen ED - Optical Stimulation of Neural Tissue (invited) – LEOS annual meeting, Tucson AZ (October 2003)

    34. Jansen ED – In vivo optical imaging of gene expression, tissue transplants and sub-lethal thermal tissue injury (invited) – Univ of Arizona / Arizona Cancer Center, Tucson, AZ (October 2003).

    35. Jansen ED – In vivo imaging of tumor associated VEGF expression (invited) – Breast cancer seminar Vanderbilt Ingram Cancer Center (Nov 2003).

    36. Piston D, Jansen ED - Overview of optical techniques in molecular imaging: concepts, methods, sensitivity and resolution – Molecular Imaging workgroup, Vanderbilt University Small Animal Imaging Center (Feb 2004).

    37. Mackanos M, Jansen ED – The Effect of Pulse Structure on Soft Tissue Laser Ablation at Mid-Infrared Wavelengths" – Seminar FEL IR ablation workgroup (Oct 2004))

    38. Jansen ED – Optical imaging of gene expression during wound healing in engineered skin (invited) – Research meeting of the Skin Disease Research Core Center, Vanderbilt University (Oct 2004).

    39. Wells JD, Kao CC, Konrad PE, Mahadevan-Jansen A, Piston D, Jansen ED – Optical Stimulation of Peripheral Nerves – MFEL conference, Boston, MA (Dec 2004)

    40. Mackanos MA, Jansen ED – Effects of micropulse and macro pulse duration on infrared ablation with the FEL – FEL seminar series (Feb 2005).

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