median sulcus: longitudinally
limiting sulcus: lateral to median sulcus.
medial eminence: between two sulcuses above.
vestibular area: triangular area lateral to limiting sulcus, overlying nucleus of vestibular n.
acoustic tubercle: on lateral angle of vestibular trigone, overlying posterior cochlear nucleus.
hypoglossal trigone: on medial eminence below medullary striae, overlying hypoglossal nucleus (superomedially).
vagal trigone: inferolaterally, overlying dorsal vagal nucleus.
postrema and locus ceruleus
facial colliculus: a round swelling on medial eminence above medullary striae, overlying abducent nucleus.
Ⅳ)The Fourth Ventricle
It lies behind the pons and the upper half of the medulla oblongata, and in front of the cerebellum. The roof is toward the cerebellum, and the floor is rhomboid fossa. This ventricle contains cerebrospinal fluid, which communicates with midbrain aqueduct and central canal.
superior cerebellar peduncles
anterior part
anterior medullary velum
roof posterior medullary velum
posterior part choroids tela of the fourth ventricle
highly vascular tufts of pia matter, producing cerebrospinal fluid.
three apertures median aperture: above tip of inferior angle of rhomboid fossa.
↓
subarachnoid space two lateral apertures: on tip of each lateral recess.
Ⅴ)External Features of Midbrain
It is a short part of brain stem, located between the optid tract of diencephalons above and the upper margin of pons below. Midbrain aqueduct passes through its centre.
1. Ventral surface
cerebral peduncles: formed by descending fibres.
interpeduncular fossa: a deep depression, CN Ⅲ emerging from the medial of it.
2. Dorsal surface
superior colliculus: (visual reflex centre) brachium of superior
Quadrigeminal body: colliculuslateral geniculate body
inferior colliculus: (audiroty reflex centre) brachium of inferior colliculusmedial geniculate body
Ⅱ. Arrangement of Cranial Nerve Nuclei in Brain Stem
The cranial nerve nuclei are located in the dorsal portion of brain stem. They arrange as following from midline to lateral:
Somatic motor nucleivisceral motor nucleivisceral sensory nucleisomatic sensory nuclei.
In the brain stem, the limiting sulcus divides sensory and motor cranial nerve nuclei. The cranial nerve motor nuclei are medial to the limiting sulcus, and the cranial nerve sensory nuclei are lateral to the limiting sulcus.
The functional components of cranial nerve nuclei are:
1. Somatic motor nuclei (general)
oculomotor nucleus
in midbrain
trochlear nucleus
abducent nucleus----in pons
hypoglossal nucleus----in medulla oblongata
2. Special visceral motor nuclei
motor trigeminal nucleus----in pons
facial nucleus----in pons
ambiguous nucleus
in medulla oblongata
accessory nucleus
3. General visceral motor nuclei
parasympathetic mucleus of oculomotor nerve----in midbrain
superior salivatory nucleus----in pons
inferior salivatory nucleus
in medulla oblongata
dorsal vagal nucleus
4. Visceral sensory nuclei (general and special)
Solitary nucleus-in pons and medulla oblongata
5. General somatic sensory nuclei
trigeminal mesencephalic nucleus----in midbrain
trigeminal pontine nucleus----in pons
trigeminal spinal nucleus----in pons and medulla oblongata
6. Special somatid sensory nuclei
vestibular nucleus
in pons and medulla oblongata
cochlear nucleus
Ⅲ. Internal Structure of Medulla Oblongata
The medulla oblongata can be divided into two parts, the upper and lower. The structures of the lower part are almost the same as those in spinal cord, but the strutures in the upper part are changed.
1. Edcussation of pyramids
2. Decussation of medial lemniscus
3. Appearance of inferior olivary nucleus and inferior cerebellar peduncle
4. Enlargement of central canal to form the fourth ventricle floor
Ⅰ)Decussation of Pyramids
corticonuclear tract: hypoglossal nucleus and lower part of facial nucleus receive the fibres only from contralateral corticonuclear tract.
pyramids tract ---------------lateral corticospinal tract
crossed
corticospinal tract ---------------anterior corticospinal tract
uncrossed
Ⅱ)Decussation of Medial Lemniscus
ipsilaterally
Gracile and cuneate fascidulus----------------gracile and cuneate nucleus ( in medulla
sending out fibres
oblongata) --------------------decussation of medial lemniscusmedial lemniscusdorsal thalamus.
Ⅲ)Inferior Olivary Nucleus and Infeior Cerebellar Peduncle
olivocerebellar tract
inferior cerebellar peduncle
posterior spinocerebellar tract
Ⅳ)Nuclei of Cranial Nerves
1. Hypoglossal nucleus
It is located in both sides of the midline, underneath the hypoglossal trigone. The mucleus only receives the contralateral fibres from corticonuclear tract, and innervates the muscle of tongue.
2. Nucleus of accessory neve
medullary partlower end of anbiguous nucleuscranial rootinnervating muscles of larynx and pharynx.
spinal partfrom anterior horn of the upper cervical spinal cordspinal rootinnervating sternocleidomastoid m. and trapezius m.
3. Nuclei of vagal nerve
1) Dorsal vagal nucleus: located underneath vagal trigone, lateral to hypoglossal nucleus; innervating many cervical, thoracic and abdominal viscera.
2) Solitary nucleus: located dorsolateral to dorsal vagal nucleus; trceiving the fibres from all cervical, thoracic and abdominal mucous membrane.
3) Ambiguous nucleus: placed deeply in reticular formation; giving rise to the fibres to pharyngeal and laryngeal muscles.
4) Trigeminal spinal nucleus: lying on medial side of spinal tract; receiving impulse from posterior wall of external acoustic meatus.
4. Nuclei of glossopharyngeal nerve
1) Ambiguous nucleus: giving rise to the fibres to stylopharyngeal m.
2) Solitary nucleus: srceiving impulse from pharynx, auditory tube and posterior 1/3 of tongue (general visceral sense and gustatory sense).
3) Infeiror salivatory nucleus: to parotid gland.
4) Trigeminal spinal nucleus: collecting the fibres from skin of ear.
Ⅳ. Internal Structure of Pons
dorsal portion----pontine tegmentum
two parts
ventral portion----basilar portion
The anterior margin of the trapezoid body is the boundary zone between the ventral and dorsal portion. The muclei of CN Ⅴ, Ⅵ, Ⅶ, Ⅷ are tound in pons.
Ⅰ)Basilar Portion
1. Pyramidal tract
corticospinal tract
corticonuclear tract
2. Corticopontine tract: arising from the cells in frontal, parietal, temporal and occipital regions of cerebral cortex; and terminating in pontine nuclei ispilaterally.
3. Pontine nuclei: comprising all the masses of neurons scattered on this part; the fibres from these nuclei form middle cerebellar peduncle. They relay impulses from the cerebral cortex to the cerebellum.
Ⅱ)Pontien Tegmentum
1. Cochlear nuclei (Dorsal and ventral cochlear nuclei): located on lateral surface of inferior cerebellar peduncle; concerning with hearing.
sending out fibres
Fibres from cochlear n. dorsal and ventral cochlear nuclei------------------------crossing to
turning upward
opposite sidetrapezoid body--------------------lateral lemniscusinferior colliculusmedial geniculate bodycerebral cortex.
2. Vestibular nuclei: four in number (inferior, superior, medial an lateral); underneath vestibular trugone; concerning with equilibrium sense.
sending out fibres vestibulospinal tract
Fibres from vestibular n. vestibular nucleus------------------- medial longitudinal tract
the fibres to cerebellum
3. Nuclei of facila nerve
1) Facial nucleus: lying on dorsolateral to superior olive nucleus; innervating muscles of facial expression.
upper part: receiving fibres from corticonuclear tract of both sides;innervating nucleus muscles above palpebral fissure.
lower part: receiving fibres from corticonuclear tract of opposite side only;innervating muscles below palpebral fissure.
2) Superior salivatory nucleus: in the lateral of reticular formation; controlling the secretion of submandibular gland, sublingual gland, lacrimal gland and glands in mucous membrane of nose and mouth.
3) Solitary nucleus: concerning with the taste in anterior 2/3 of tongue.
4. Abducent nucleus: located underneath facial colliculus; innervating lateral rectus m.
5. Nuclei of trigeminal nerve
1) Motor trigeminal nucleus: located medial to rootlet of trigeminal n. and dorsolateral to reticular formation; innervating m. of mastication.
2) Trigeminal pontine nucleus: lying lateral to motor trigeminal nucleus; conceying impulse of touch sense from skin and mucous membrane of face and forehead.
3) Trigeminal spinal nucleus: a continuation of trigeminal pontine nucleus; conveying the impulse of pain and thermal sense in skin and mucous membrane of face and forehead.
4) Trigeminal mesencephalic nucleus: lying near lateral margin of central grey matter; conveying proprioceptive impulses from teeth, hard palate, m. of mastication, and joint capsules.
Ⅴ. Internal Structure of Midbrain
tectum----superior and inferior colliculus
central grey matter
ascending tract
tegmentum black substance reticular formation
(substantia nigra) red nucleus
cerebral peduncle superior cerebellar peduncle
pyramidal tract
base of cerebral peduncle corticonuclear tract
Ⅰ)Tectum
1. Superior colliculus: consisting of several layers of grey and white matter, a visual reflex centre.
Occipital cortex
superior colliculustectospinal tractmotor nucleus in brain stem,
Retinaoptic tract
anterior horn of spinal cordresulted in movements of head and eyes in response to visual and auditory stimulus.
2. Inferior colliculus: nucleus of inferior colliculus, auditory reflex centre.
Cochlear nucleus
inferior colliculusbrachium of inferior colliculusmedial geniculate
Lateral lemniscus
bodysuperior colliculustectospinal tractmotor nucleus in brain stem and spinal cordreflex in response to auditory stimulus.
Ⅱ)Tegmentum
1. Central grey matter
1) Nuclei of oculomotor nerve
oculomotor nucleus: at the level of superior colliculus; comprising paired lateral and single central nuclei; innervating all xtraocular m., except lateral rectus m. and superior oblique m.
accessory oculomotor muclei (Edinger-Westphal): dorsomedial to oculomotor nucleus; giving rise to preganglionic parasympathetic fibres to ciliary ganglion (synapse); then sending out postganglionic fibres to ciliary m. and sphincter m. of pupil.
2) Trochlear nucleus: dorsal to medial longitudinal fasciculus; their fibres decussating completely in anterior medullary velum; innervating superior oblique m.
2. Red nucleus: ovoid mass in centre of tegmentum and dorsomedial to substantia nigra.
Cerebral and cerebellar cortexred nucleusrubrospinal tractfacilitating flexor motor neurons.
Ⅲ)Substantia Nigra
A lamina of grey matter containing numerous, deeply pigmented nerve cells; lying between tegmentum and base of cerebral peduncle; extending through the whole length of midbrain and subthalamic region; grat development in man.
Ⅳ)Base of Cerebral Peduncle
It is the most ventral part of midbrain.
frontopontine tract (medial 1/5)
corticopontine tract parietopontine
occipitopontine tract (lateral 1/5)
temporopontine
pyramidal tract corticospinal tract
(middle 3/5) corticonuclear tract
Ⅵ. Reticular Formation in Brain Stem
It has long been recognized that scattered among the more conspicuous fibre bundles and nuclei of the brain stem are extensive field of intermingled grey and white matter collectively termed the reticular formation.
Ⅶ. Cerebellum
The cerebellum lies in the posterior cranial fossa, and is connected with the dorsal surface of brain stem by three cerebellar peduncles (superior, middle and inferior). It consists of two cerebellar hemispheres joined by a narrow median strip, the cerebellar vermis.
Ⅰ)Subdivision of Cerebellum
1. Three lobes depending on the groove and fissure on its surface.
flocculi (flocculus)
flocculonodular lobe nodule
(inferior surface) peduncle of flocculi
anterior lobe (prior to primary fissure)
posterior lobe (between primary fissure and posterolateral fissure)
Three parts on its development and connection of afferent fibres.
archicerebllum: viz. flocculonodular lobe, the oldest part; relating to vestibular nerve and nuclei; maintaining equilibrium.
paleocerebellum: including anterior lobe, pyramid of vermis and uvula of vermis in posterior lobe; receiving fibres from anterior and posterior spinocerebllar tracts; regulating muscular tone.
neocerebellum: the newest and largest part; including posterior lobe except pyramid of vermis and uvula of vermis; connecting with cerebral cortex through middle cerebellar peduncle; coordinating skilled movements initiated at cortical level.
Cerebellar tonsils are two elevated masses on both sides of the uvula of vermis, nearby the foramen magnum.
Ⅱ)Internal Structures of Cerebellum
1. Cerebellar cortex: It is a superficial grey matter, which surrounds the white matter called medullary body.
2. Cerebellar nuclei
dentate nucleus: the largest one close to vermis.
emboliform nucleus
medial to dentate nucleus.
globose nucleus
fastigial nucleus: mear midline above roof of the fourth ventricle.
Ⅲ)Fibrous Connection
1. Vestibulocerebellum (Archicerebellum)
inferior cerebellar peduncle
Vestibular nucleus of merves--------------------------------------archicerebellum----------------
efferent fibre brain stem
---------------- inferior vestibular nucleusvestibulospinal tract.
fastigial nucleus----------------------
cerebellar peduncle reticular formationreticulospinal tract.
2. Spinocerebellum (Paleocerebellum)
superior and inferior
Anterior and posterior spinocerebellar tract-----------------------------paleocerebellum------
cerebellar peduncle
inferior cerebellar peduncle vestibular nucleus.
fastigial nucleus--------------------------------
efferent fibres reticular formation.
---------------------- emboliform nucleus superior cerebellar peduncle
------------------------------------------------------
globose nucleus
red nucleusrubrospinal tract.
---------------------
reticular formationreticulospinal tract.
3. Pontocerebellum (Neocerebellum)
middle cerebellar piduncle
Corticopontil tractpontil nucleus---------------------------------neocerebellum-----------------
efferent fibres superior cerebellar peduncle
--------------------dentate nucleus------------------------------------ventrolateral nucleus of dorsal
(decussation)
thalamussomatomotor area.
Ⅷ. Diencephalons
The diencephalons is almost entirely surrounded by the hemispheres of the cerebrum, and consists of five parts, viz. the epithalamus, thalamus (dorsal thalamus), hypothalamus, subthalamus, metathalamus.
Ⅰ)Esternal Features of Diencephalon
1. Dorsal thalamus (Thalamus)
They are two oval grey masses. The third ventricle is a space just between two dorsal thalamus.
anterior tubercle of thalamus: amarrow eminence in anterior end of dorsal surface.
pulvinar: elevation in posterior end.
hypothalamic sulcus: from interventricular foramen to midbrain aqueduct, us a division between thalamus and hypothalamus.
intermediante mass of dosal thalamus: trey matter connecting two thalamus, dorsal to hypothalamic sulcus.
medullary stria and terminal stria
2. Metathalamus
It lies inferolateral to pulvinar.
brachium of inferior colliculus
medial geniculate body-----------------------------------inferior colliculus (auditory sense)
brachium of superior colliculus
lateral geniculae body --------------------------------------superior colliculus (visual sense)
3. Epithalamus
It lies around the roof of the third ventricle.
medullary stria of thalamus: a longitudinal fibrous tract between dorsal and medial surface of thalamus
habenular trigone
habenular commissure: between two habenular trigone.
pineal body: commecting habenular commissure posteriorlly.
posterior commissure: below habenular commissure.
4. Hypothalamus
It is situated below hypothalamic sulcus, and forms the side wall of the lower part of the third ventricle.
anterior optic chiasmoptic tract (terminal lamina)
↓ cinereous tuberinfundibulumhypophysis
posterior mammillary body
5. The third ventricle
It is a median sagittal fissure just between two dorsal thalamus.
anterior: terminal lamina
posterior: passing to midbrain aqueduct
roof: choroids tela, passing to lateral ventricle through interventricular foramen.
floor: mammillary body, cinereous tuber, infundibulum, optic chiasm.
Ⅱ)Internal Structures of Diencephalon
1. Dorsal thalamus and metathalamus
Dorsal thalamus is an ovary grey mass medial to the internal capsule and lateral to the third ventricle.
1) Internal medullary lamina “Y” of thalamus
anterior nuclear group
medial muclear group (dorsomedial nucleus)
dorsolateral nucleus
dorsal layer posterolateral nucleus
pulvinar
lateral ventral anterior nucleus
nuclear group ventral lateral nucleus
ventral layer ventral ventral posterolateral nucleus (VPL)
posterior
nucleus ventral posteromedial nucleus (VPM)
2) Nucleus
median nucleus
interalaminar nucleus
special relay nucleus: ventral layer of lateral nuclear group, medial and lateral geniculate bodies.
association nucleus: medial nuclear group, dorsal layer of lateral nuclear group, anterior nuclear group.
3) Special relay mucleus
①Ventral anterior and ventral lateral nuclei
They connect the xomatic motor area of cerebral cortex with cerebellar cortex.
②Ventral posterior nucleus
medial lemniscus
ventral paosterolateral nucleus: receiving
spinothalamic tract
trigeminal lemniscus
ventral posteromedial nucleus: receiving
gustatory fibres
③Medial and lateral geniculate bodies
They are the relay nuclei of auditory and visual pathways.
2. Enpithalamus habenularnucleus
3. Subthalamus
subthalamic nucleus
red nucleus
substantia nigra
4. Hypothalamus
supraoptic nucleus: dorsal to optic chiasm.
paraventricular nucleus: close to the third ventricle .
nucleus of mammillary body: in mammillary body.
acruate (infundibular) nucleus: near infundibulum.
Ⅸ. Telecephalon
The telecephalon comprises mainly two large cerebral hemispheres, which are almost completely separated by the longitudinal cerebral fissure. At the bottom of this fissure, there is a large bundle of transverse fibres, the corpus callosum, which crosses between the two hemispheres. The transverse cerebral fissure intervenes between the hemispheres and the cerebellum.
cerebral cortex----grey matter
basilar nucleus
medullary centre---white matter
lateral ventricle
gyrus (gyri): upfolds on surface of hemisphere.
fissures (sulcus or sulci): downfolds on surface of hemisphere.
Ⅰ)External Features of Telecephalon
superolateral surface
surfaces medial surface
in ferior (basilar)surface
lateral sulacus
sulci or fissures central sulcus
parieto-occipital sulcus
preoccipital notch
frontal lobe
parietal lobe
lobes occipital lobe
temporal lobe
insula
1. Superolateral surface
1) Frontal lobe
precentral sulcus
parallel
central sulcus
precentral gyrus: between precentral and central sulcus
superior and inferior frontal sulcus: prior to precentral sulcus parallel.
superior, middle and inferior frontal gyrus
2) Parietal lobe
postcentral sulcus: parallel to central sulcus.
postcentral gyrus: between central and postcentral sulcus.
interparietal sulcus: parallel to upper margin of hemisphere.
superior parietal lobule
supramarginal gyrus
inferior parietal lobule angular gyrus
3) Temporal lobe
superior and inferior temporal sulcus
superior, middle, inferior temporal gyrus
transverse temporal gyrus: two short gyri
4) Occipital lobe: irregular sulci and gyri.
5) Insula: There are shorter sulci.
2. Medial and inferior surface
1) Inferior surface of frontal lobe
orbital sulcus
orbital gyrus
olfactory tract
olfactory bulb
olfactory trigone
anterior perforated substance
2) Medial surface of parietal lobe
patacentral lobule: extension of precentral and postcentral gyri.
3) Inferior and medial surface of temporal lobe
occipitotemporal sulcus
inferior medial occipitotemporal gyrus
lateral occipitotemporal gyrus
collateral sulcus
rhinal sulcus
parahippocampal gyrus: medial to collateral sulcus.
medial uncus (unci)
hippocampal sulcus
dentate gyrus
hippocampus
4) Medial surface of occipital lobe
calcarine sulcus: arcuating posteriorly.
cuneus lobe: between calcarine and parieto-occipital sulci.
lingual gyrus: inferior to calcarine sulcus.
5) The other sulci and gyri
sulcus of corpus callosum
cingulate sulcus
cingulate gyrus
Ⅱ)Internal Structures of Telecephalon
1. Lateral ventricle
It lies within the cerebral hemisphere, contains cerebrospinal fluid which passes to the third ventricle by the interventricular foramen.
central part----lying in parietal lobe
four anterior horn----extending into frontal lobe
parts posterior horn----extending into occipital lobe
inferior horn----extending into temporal lobe
Choroid tela of lateral ventricle is within central part and infeior part.
2. Basilar nucleus
The group of nucleus lies near the floor of the cerebral hemisphere, deep in the white matter.
head
caudate nucleus body meostriatum
tail
putamen corpus striatum
lenticular nucleus
pallid globe----paleostriatum
claustrum: between insula cortex and lenticular nucleus.
amyglaloid body: deep to uncus, anterior end of inferior hon of lateral ventricle.
The function of corpus striatum is mainly concerned with the regulation of movement.
3. Cerebral cortex
The cerebral cortex consists of archicortex, paleocortex and niocortex. Brodmann’s map was published in 1909 and consists of approximately 50 areas.
1) Somatic motor area Ⅰ
① Lying precentral gyrus and anterior portion of paracentral lobule.
② Receiving fibres from postcentral gyrus, ventrolateral nucleus, ventral anterior nucleus and ventral posterolateral nucleus.
③ Sending out fibres to form pyramidal tract.
④ Controlling voluntary movements of opposite side of body.
⑤ Characteristics:
precise functional representation.
representation appears inverted, such as head and neck inferiorly, following hand. Arm, trunk and thigh; but head and face are upright.
size of cortical area for a particular part of body is determined by the functional importance and complexity fo the part.
2) Somatic sensory area Ⅰ
① Lying postcentral gyrus and posterior portion fo paracentral lobule.
② Receiving fibres from ventral posterior nucleus of dorsal thalamus for pain, thermal, tactile (touch), pressure, position, movement sense of opposite side of body.
③ Characteristics:
inverted representation, but head and face are upright.
precise functional representation.
size of cortical area depends on functional important and sensitivity of the sense region.
3) Visual area
① Lying medial surface of occipital lobe around calcaren sulcus (adjacent portion of cuneus lobe and lingual gyrus).
② Receibing fibres from lateral geniculate body.
③ The left half of visual field is represented in the visual area of right hemisphere, and vice versa.
4) Auditory area
① Lying transverse temporal gyrus.
② Receiving fibres from medial geniculate body.
③ Representing bilaterally.
5) Language areas (Speech areas)
The hemisphere relating to language function is termed dominant hemisphere, mostly in the left hemisphere because the right handed-persons are much more than the left ones.
① Motor speech area: in posterior portion of inferior frontal gyrus.
② Auditory speech area: in posterior portion of superior temporal gyrus.
③ Writng area: in posterior portion of middle frontal gyrus.
④ Visusl speech area: in angular gyrus.
4. Medullary centre of hemisphere
1) Commissural fibres
They interconnect corresponding area in the opposite hemispheres.
① Corpus callosum
It transverse the floor of cerebral longitudinal fissure and connects the cortex of two cerebral hemisphere. It includes four parts, viz. rostrum, genu, body, splenium, from before backwards.
② Anterior commissrue
It is H-shaped arcuate fibrous bundles anterior to fornix.
③ Fornix and fornix commissure
They are bilateral C-shaped white fibres originating from fimbria of hippocampus to nucleus of mammillary body.
2) Association fibres
They interconnect different cortical area in the came hemisphere.
uncinate fasciculus
superior longitudinal fasciculus
inferior longitudinal fasciculus
3) Projecting fibres
They are referred to ascending and descending fibres connecting cerebral cortex and subcortical structures, such as spinal cord and brain stem.
Internal capsule lies between caudate nucleus, dorsal thalamus medially and lentiform nucleus laterally, and is a “><” shaped layer of white matter. The division and its fibres are as following.
① Anterior limb of internal capsule
It lies between caudate nucleus and lentiform nucleus.
frontopontine tract
containing
anterior thalamic radiation (thalamocortical fibres)
Posterior limb of internal capsule
② Posterior lim of internal capsule
It lies etween thalamus and lentiform mucleus. Its three parts and passing fibres are:
corticospinal tract
corticorubral tract
thalamolenticular part centra thalamic radiation (thalamocortical tract,
such as, trigeminal lemnisus, spinothalamic lemniscus,
medial lemniscus)
optic radiation
retrolenticular part parietopontine tract
occipitopontine tract
auditory radiation
sublenticular part
temporopontine tract
③ Genu of internal capsule
It is an angle area between anterior and posterior limbs, and contains corticonuclear tract.
Ⅲ)Limbic System
Limbic lobe includes septal area, cingulated gyrus, parahippocampal gyrus, hippocampus and dentate gyrus, which circle corpus callosum, almost becoming a ring.
Limbic lobe adds cortical and subcortical structures closely related to it, such as amygdaloid body, septal area, sepptal nucleus, hypothalamus, epithalamus, anterior nucleus of dorsal thalamus, tegmentum of midbrain, then limbic system is formed.
Section 3 The Conduction Pathways of the Brain and Spinal Cord
They are the routes formed by chains of neurons, through which sensory awareness reaches the cerebral cortex and a motor response is initiated. The conduction pathways are commonly classified into ascending (sensory) and descending (motor) ones.
Ascending pathways conduct impulse of various receptors of body to cerebral cortex or other higher centres of brain, and enable the individual to be conscious of his environment. They generally involve three orders of neurons.
deep sense (proprioceptive sensation)----fine touch, pressure, position, movement, sense vibratory sense.
superficial sense----pain, thermal, and simple touch.
Descending pathways bring cerebral cortex and other subcortex into communication with effector tissues (such as muscles and glands), through anterior horn of spinal cord. Thus the body is able to respond to environment change. Two orders of neurons are usually involved.
Ⅰ. The Conscious Deep Sensory Pathway
muscles, tendons, peripheral processes
----------------------------------------------------------
joints, skin. accompanying corresponding spinal nerve
1 2
central processes
-------------------------------------------------------------------<·---------
entering posterior funiculus of spinal
spinal ganglia cord as a garcile and cuneate gracile and cuneate
(first order neuron) fasciculus through dorsal root of nucleus
spinal cord (second order neuron)
3
decussation of medial lemniscus ×
-----------------------------------<·------------------------------------------
ascending as medial lemniscus
ventral posterolateral nucleus of dorsal thalamus (third order neuron)
through posterior limb of internal capsule ①superior, middle part of postcentral gyrus
------------------------------------→ ②posterior part of paracentra lobule
(thalamocortical tract) ③precentral gyrus
Ⅱ)The Deep Sensory Pathway of Head and Face
The exact route of this pathway is still unknown.
Ⅱ. The Unconscious Deep Sensory Pathway
Ⅰ)Posterior Spinocerebellar Tract
1
muscles, tendons, touch, peripheral process
pressure receptors of lower limbs ---------------------------------------------
and lower part of trunk spinal nerve
spinal ganglia
2
central posterior spinocerebellar tract
----------------<·---------------------------------→inferior cerebellar peduncle→
processes ipsilateral lateral funiculus
thoracic nucleus
→cortex of paleocerebellum
Ⅱ)Anterior Spinocerebellar Tract
1
proprioceptive impulse of peripheral process central
lower extremities and -----------------------------------------------------
lower part of trunk spinal nerve processes
spinal ganglia
2
anterior spinocerebellar tract
----<·-------------------------→superior cerebellar peduncle→cortex of paleocerebellum
contralateral lateral funiculus ×
grey layer Ⅴ-Ⅶ of
lumbar enlargement
Ⅲ. The Superficial Sensory Pathway of Trunk and Limbs
1
skin of peripheral processes central processes
trunk and ------------------------------------------------------------------
extremities accompanying entering spinal cord through dorsa roots
corresponding spinal ganglia
spinal nerve
2 3
ascending 1~2 spinal segments, then crossing ×
------<·---------------------------------------------------------<·---------
or cross one segment, spinothalamic tract
cells of posterior ventral posterolateral nucleus
horn (ⅠⅣⅤ) of dorsal thalamus
(thalamocortical tract) superior, middle part of postcentral gyrus
----------------------------→
posterior limb of internal capsule posterior part of paracentral lobule
A hemisection of spinal cord would cause loss of pain and temperature sensation on the opposite side of the body below the section, since the fibres of lateral spinothalamic tract are crossed.
Because the gracile and cuneate fasciculus as well as spinothalamic tract have the same function in touch sense, and because the latter crosses over in spinal cord, the former uncrossed, a hemisection of the spinal cord ont result in complete loss of the sensations of touch.
Ⅳ. The Superficial Sensory Pathway of the Head and Face
1 2
skin, mucous peripheral processes central processes
of head ---------------------------------------------------------<·-----
and face trigeminal nerve entering pons
semilunar ganglion trigeminal pontine nucleus
trigeminal spinal nucleus
3
cross ×
------------------------------<·---------------------------------------------
trigeminal lemniscus posterior limb of internal capsule
ventral posteromedial
nucleus of dorsal thalamus
---------→lower part of postcentral gyrus
Ⅴ. Optic (Visual) Pathway
Visual field is the images of the objects in a visual space scope, which is divided into two part, the nasal half and temporal half. The retina itself also in cludes the nasal half and temporal half.
1 2
rod and peripheral central
----------------- -------------------<·------------optic nerve---
cone cells processes processes
bipolar cells ganglion cells
3
------optic chiasm---------------------------------optic tract---------<·----------
nasal fibres of retina cross
temporal fibres of retina uncross × lateral geniculate body
optic radiation
----------------------------→both sides of calcarine sulcus (suneus lobe and lingual gyrus)
posteror limb of internal capsule
the impulse from upper half retina arrive the dorsal band of calcarine sulcus (cuneus lobe).
The impulse from lower half retina arrive the ventral band of calcarine sulcus (lingual gyrus).
The impulse from macula arrive the posterior portion of calcarine area.
The impulse from peripheral retinal area end in the anterior portion of calcarine area.
Light (Pupillary) Reflex
partial fibres
Cells of retina→optic nerve, optic chiasm, optic tract-----------------------<·------
through brachium
of superior colliculus pretectal area
oculomotor sphincter muscle of pupil
------<·-------------------------<·---------→ (regulating contraction of pupil)
nerve ciliary muscle
parasympathetic ciliary ganglion (regulating convexity of lens)
oculomotor nucleus
(Edinger-Westphal)
Destruction (Inetrruption) analysis
1. Grossing fibres of optic chiasm: would cause blindness of two temporal visual field (bilateral or bitemporal hemianopsia).
2. Laeral (uncrossed) fibres of potic chiasm: would result in blindness of two nasal visual field (bimedial or binasal hemianopsia) .
3. Optic tract, lateral geniculate body, optic radiation, optic cortex on one side would cause blindness in the medial half visual field of one eye (destrcted side) and in the lateral half of the other one (undestructed side).
4. One optic nerve would result in blindness in the corresponding eye with loss of the papillary (light) reflex.
Ⅵ. The Auditory Pathway
1 2
spiral organ peripheral central processes
-----------------·--------------------------------<·-------
(Corti’s organ) processes cochlea nerve
bipolar cells of dorsal and ventral
cochlear spiral ganglion cochlear nuclei
3
trapezoid body brachium of inferior
-------------------------------<·---------------------------------<·-----------
cross lateral lemniscus × colliculus
inferior colliculus medial geniculate body
-------------------------------→transverse temporal gyrus
posterior limb of internl capsule
Ⅶ. Pyramidal System
Two orders of neurons are primarily involved, the upper and lower efferent neurons.
upper efferent hypoglossal nucleus, lower portion
neurons corticonuclear tract of facial nucleus are controlled by
pyramidal tract genu of internal capsule opposite corticonuclear tract; ①
·--------------------- others by bilateral corticonuclear tract.
decussation of pyramid ×
precentral gyrus, anterior part corticospinal tract lateral corticospinal tract ②
of paracentral lobule anterior part of crossing segment by segment
(cortex) posterior limb of in spinal cord ×
Internal capsule anterior corticospinal tract ③
lower efferent neurons exteraocular m.
masticatory m.
-----------<·-----------→ facial m.
① laryngeal m.
motor nucleus of cranial nerve pharyngeal m.
lingual m.
-----------------------<·----------------→
② voluntary m. of trunk and extremities
-----------------------<·----------------→
③
cells of anterior horn of spinal cord
Ⅷ. Extrapyramidal System
Ⅰ)Concept and Composition
It is a common name for all the structures which control voluntary muscle activities, except the pyramidal system. It mainly consists of cerebral cortex, corpus striatum, red nucleus, black substance, cerebellum, reticular formantion, vestibular nucleus.
Ⅱ)Two Simple Descending Pathway
1. cerebral cortex
pons thalamus
cerebellum
red nucleus
spinal cord
2. cerebral cortex
corpus striatum ----→thalamus
subthalamus
black substance
reticular formation
spinal cord
Ⅲ)Two Systems and Four Tracts
1. Neostriatrum----pallid glaobe system
1) Cerebral cortex----corpus striatum----dorsal thalamus----cerebral cortex circle route.
2) Corpus striatum----black substance circle route
3) Pallid globe----subthalamus circle route
2. Corticopontocerebellar system
cortex----pons----cerebellum----dorsal thalamus----cortex circle route
3. Four tracts
Reticulospinal tract
Rubrospinal tract
Tectospinal tract
Vestibulospinal tract
Ⅳ)Function
1. Regulating muscular tone.
2. Maintaining the normal body posture (balance).
3. Coordinating muscular activities (precise motions).
4. Producing habitual and rhythmic movement.
Section 4 The Meninges, Blood Vessels of Brain and Spinal Cord, as well as Cerebrospinal Circulation
Ⅰ. The Meninges of Brain and Spinal Cord
The brain and spinal cord are enclosed by three layers of membrane, the dura mater, arachnoid, pia mater, from external inwards. They protect and support the brain and spinal cord.
Ⅰ)Dura Mater
1. Spinal dura mater
It extends from the foramen magnum to the level of the second sacral vertebra, from which it tapers and forms a covering for the filum terminal of spinal cord.
1) Epidural space
spinal dura mater
lying between periosteum of vertebral canal
containing: loose conjunctive tissue, lymphatic vessels, fat, venous plexus, especially root of spinal nerve.
Being not continuous with cranial cavity upward.
2) Subdural space
spinal dura mater
between
spinal arachnoid
2. Cranial dura matter
1) Double layers: periosteal, meningeal.
2) Loosely contacting with skullcap: closely attached to base of skull.
3) Falx and tentorium formed by meningeal layer.
cerebral falx: extending into cerebral longitudinal fissure.
cerebellar tentorium: between cerebral hemisphere and cerebellum.
tentorial notch: anterior free margin of cerebellar tentorium.
cerebellar falx: extending into two cerebellar hemisphere.
4) Dural venous sinus
Lying between meningeal and peiosteal dura in some place.
Characteristics: novalves, no smooth m., no contractivity.
superior sagitaal sinus: lying in superior convex border of cerebral falx.
inferior sagittal sinus: inferior concave border of cerebral falx.
straight sinus: at the junction between cerebral falx and cerebellar tentorium.
transverse sinus: in transverse sulcus, posterior margin of cerebellar tentorium.
sigmoid sinus: in sigmoid sulcus.
confluent sinus: at confluence of superior sagittal sinus and straight sinus.
cavernous sinus: each side of sella turcica
internal carotid a.
intrasinus
abducent n. (CN Ⅵ)
oculomotor n. (CN Ⅲ)
lateral wall of sinus trochlear n. (CN Ⅳ)
ophthalmic n. (CN Ⅴ1)
maxillary n. (CN Ⅴ2)
superior petrosal sinus: insuperior angle of petrous portion of temporal bone.
inferior perusal sinus: in inferior margin of posterior surface of petrous portion of temporal bone.
The blood draning in dural venous sinus
superior sagittal sinus occipital sinus
inferior sagittal sinusstraight sinusconfluent transverse sigmoid internal jugular v.
cavernous sinussuperior petrosal sinus
inferior petrosal sinus
Ⅱ)Arachnoid
Arachnoid is atranslucent, delicate, avascular membrane between dura and pia mater.
1. Spinal arachnoid
spinal arachnoid
lying between
subarachnoid space: spinal pia mater
containing cerebrospinal fluid
2. Cranial arachnoid
1) Subdural space: between cranial dura mater and cranial arachnoid
2) Subarachnoid space
① Between cranial arachnoid and cranial pia mater
② Enlargement in some area
subarachnoid cisterns
cerebellomedullary cistern
③ Arachnoid granulation: especially in superior sagittal sinus, allowing cerebrospinal fluid to be reabsorbed into dura venous sinus.
Ⅲ)Pia Mater
The pia mater is a delicate vascular membrane, and rich in nerves. It is closely attached to the surface of brain and spinal cord.
1. Spinal pia mater
Denticular ligament: is formed by spinal pia mater, which lies between dorsal and ventral roots of spinal nerve, and is attached to inner surface of spinal dura mater.
2. Cranial pial mater
The cranial pia mater combines its capillaries and ependymal cells to form the choroids tela of the ventricle. Folds of choroids tela form choroids plexuses, which produce cerebrospinal fluid.
Ⅱ. The Blood Vessels of the Brain and Spinal Cord
Ⅰ)The Arteries of Brain
internal carotid a. ----anterior 2/3 of cerebral hemisphere, anterior part
two resource of diencephalon
vertebral a. ----posterior 1/3 of cerebral hemisphere, brain stem, cerebellum, posterior part of diencephalon
1. Internal carotid artery
Arising fom common carotid a. ascending to floor of skullcarotid canalcavernous sinusanterior clinoid process.
1) Posterior communicating a. ----communicating with posterior cerebral a.
2) Anterior choroidal a. ----forming arachnoid plexuses in lateral ventricle, supplying optic tract, internal capsule, base of cerebral peduncle and pallid globe.
3) Anterior cerebral a.
anterior communicating a.----connecting two anterior cerebral a. supplying medial surface of cerebral hemisphere anterior to parietooccipital sulcus, inferior surface of frontal lobe.
central branches----caudate nucleus, lenticular nucleus, internal capsule.
4) Middle cerebral a. ----supplying supralateral surface of hemisphere and insula.
Central branch----caudate nucleus, lenticular nucleus, internal capsule.
2. Vertebral artery
Arising from subcalvian a. transverse foramen of C1-6 vertebraeforamen magnumposterior cranial fossapontomedullary sulcusconfluence of two vertebral a. to form basilar a. basilar sulcussuperior border of pons.
1) Branches of vertebral a.
① Anterior and posterior spinal a. ----spinal cord.
② Posterior inferior cerebellar a. ----inferior surface of cerebellum, medulla oblongata.
2) Branches of basilar a.
① Anterior inferior cerebellar a. ----inferior surface of cerebellum.
② Labyrinthine a. ----inner ear.
③ Pontine a. ----pons.
④ Superior cerebellar a. ----upper part of cerebellum.
⑤ Posterior cerebral a.
supplying base and medial surface of temporal lobe and occipital lobe.
central branches----dorsal thalamus, medial and lateral geniculate body, hypothalamus, subthalamus.
taking part in arachnoid plexuses of lateral and the third ventricles
3. Cerebral arterial circle (Willis circle)
angerior cerebral a.
(beginning prat)
posterior cerebral a.
anterior communicating a.
posterior communicating a.
internal carotid a. (terminal part)
It encircles the optic chiasm, cinereous tuber, mammillary body over sella turcica.
Ⅱ)The Veins of Brain
superficial and deep group
great cerebral v.
Ⅲ)The Vessels of Spinal Cord
anterior spinal a. v.
posterior spinal a. v.
Ⅲ. The Circulation of Cerebrospinal Fluid
1. Cerebrospinal fluid (CSF) is formed by choroids tela the in lateral, the third and fourth ventricles.
2. Circulation
Lateral ventricleinterventricular foramenthe third ventriclemidbrain aqueductthe fourth ventriclemedian and lateral apertures of the fourth ventriclesubarachnoid spacesarachnoid granulationssuperior sagittal sinusinternal jugular v.
PART Ⅵ THE ENDOCRINE SYSTEM
The endocrine system consists of the endocrine glands and endocrine tissues. The endocrine glands have no ducts, therefore they are known as ductless glands, which have a rich supply of blood vessles and pass their secretions derectly into the vascular channels. The secretions are called hormones, which have special effects on the body.
Ⅰ. The Shape and Location of Thyroid Gland
It likes “H” shaped body.
lateral lobesattaching to lateral surface of lower part of larynx and upper part of trachea.
(right and left)
upper end: midpart of thyroid cartilage.
-----→
Lower end: the sixth tracheal cartilage ring.
isthmus: in front of 2~4 tracheal cartilage.
Ⅱ. The Shape and Location of Parathyroid Gland
They are four small yellowish ovoid or lentiform bodies.
upper one pair: at the middle part of posterior border of thyroid gland.
lower one pair: near inferior thyroid a. or at lower 1/3 of posterior part of thyroid gland.
Ⅲ. The Shape and Location of Suprarenal Gland
They are a pair of small yelloweish-brown bodies, lying on medial part of superior end of each kidney, and behind the peritoneum.
right----triangular shape.
left----crescent-like shape or semilunar shape
Ⅳ. The Shape and Location of Hypophysis
It is an ovary gland situated in the hypophyseal fossa of sphenoid body.
adenohypophysis
two parts
neurohpophysis
Ⅴ. The Shape and Location of Pineal Body
It is an ovary body located in the posterosuperior to thalamus, attached the posterior part of the roof of the third ventricle by handle.
Liu Zhiyu
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