Kozar ra curriculum vitae



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Pati S, Matijevic N, Doursout MF, Ko T, Cao Y, Deng X, Kozar RA, Hartwell E, Conyers J, Holcomb JB. Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. 2010 Jul;69 Suppl 1:S55-63


  • Ban K, Santora R, Kozar RA. Enteral arginine modulates inhibition of AP-1/c-Jun by SP600125 in the postischemic gut. Mol Cell Biochem. 2011 347:191-9.2010 Oct 29. [Epub ahead of print]

  • Ban K, Kozar RA. Glutamine protects against apoptosis via down-regulation of Sp3 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010 299:1344-53.2010 Sep 30. [Epub ahead of print]

  • Kozar RA, McNutt MK. Management of adult blunt hepatic trauma. Curr Opin Crit Care. 2010 Dec;16(6):596-601.

  • Hatch QM, Osterhout LM, Podbielski J, Kozar RA, Wade CE, Holcomb JB, Cotton BA. Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy. J Trauma. 2011 Dec;71(6):1503-11. PMID: 22182860

  • Ban K, Peng Z, Lin W, Kozar RA. Arginine decreases peroxisome proliferator-activated receptor-γ activity via c-Jun. Mol Cell Biochem. 2011 Oct 26. [Epub ahead of print] PMID: 22038625

  • Pati S, Gerber MH, Menge TD, Wataha KA, Zhao Y, Baumgartner JA, Zhao J, Letourneau PA, Huby MP, Baer LA, Salsbury JR, Kozar RA, Wade CE, Walker PA, Dash PK, Cox CS Jr, Doursout MF, Holcomb JB. Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock. PLoS One. 2011;6(9):e25171. Epub 2011 Sep 28. PMCID: PMC3182198.

  • Wade CE, del Junco DJ, Holcomb JB; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigman J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion. J Trauma. 2011 Aug;71(2 Suppl 3):S389-93. PMID: [PubMed - in process]

  • Rowell SE, Barbosa RR, Diggs BS, Schreiber MA; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper J, Marin B. Specific abbreviated injury scale values are responsible for the underestimation of mortality in penetrating trauma patients by the injury severity score. J Trauma. 2011 Aug;71(2 Suppl 3):S384-8. PMID: 21814109 [PubMed - in process]

  • Rowell SE, Barbosa RR, Allison CE, Van PY, Schreiber MA; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Pomper P, Pomper GJ, Marin B. Gender-based differences in mortality in response to high product ratio massive transfusion. J Trauma. 2011 Aug;71(2 Suppl 3):S375-9. PMID: 21814107 [PubMed - in process

  • Barbosa RR, Rowell SE, Sambasivan CN, Diggs BS, Spinella PC, Schreiber MA; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Pomper GJ, Marin B. A predictive model for mortality in massively transfused trauma patients. J Trauma. 2011 Aug;71(2 Suppl 3):S370-4. PMID: 21814106 [PubMed - in process].

  • Barbosa RR, Rowell SE, Diggs BS, Schreiber MA; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. Profoundly abnormal initial physiologic and biochemical data cannot be used to determine futility in massively transfused trauma patients. J Trauma. 2011 Aug;71(2 Suppl 3):S364-9. PMID: 21814105 [PubMed - in process]

  • Brown LM, Aro SO, Cohen MJ; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. A high fresh frozen plasma: packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio. J Trauma. 2011 Aug;71(2 Suppl 3):S358-63. PMID: 21814104 [PubMed - in process]

  • Rowell SE, Barbosa RR, Diggs BS, Schreiber MA; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. Effect of high product ratio massive transfusion on mortality in blunt and penetrating trauma patients. J Trauma. 2011 Aug;71(2 Suppl 3):S353-7. PMID: 21814103 [PubMed - in process]

  • Brasel KJ, Vercruysse G, Spinella PC, Wade CE, Blackbourne LH, Borgman MA, Zarzabal LA, Du F, Perkins JG, Maegele M, Schreiber M, Hess JR, Jastrow KM 3rd, Gonzalez EA, Holcomb JB, Kozar R; Trauma Outcomes Group, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Cryer HM, Pittet JF, Knudson P, De Moya MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injury. J Trauma. 2011 Aug;71(2 Suppl 3):S343-52. PMID: 21814102 [PubMed - in process]

  • Brown LM, Call MS, Margaret Knudson M, Cohen MJ; Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Pittet JF, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Brunsvold M, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma. 2011 Aug;71(2 Suppl 3):S337-42. PMID: 21814101 [PubMed - in process]

  • Sambasivan CN, Kunio NR, Nair PV, Zink KA, Michalek JE, Holcomb JB, Schreiber MA; Trauma Outcomes Group, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. J Trauma. 2011 Aug;71(2 Suppl 3):S329-36. PMID: 21814100 [PubMed - in process]

  • Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE; Trauma Outcomes Group. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma. 2011 Aug;71(2 Suppl 3):S318-28. PMID: 21814099 [PubMed - in process]

  • Holcomb JB, Wade CE; Trauma Outcomes Group, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. Defining present blood component transfusion practices in trauma patients: papers from the Trauma Outcomes Group. J Trauma. 2011 Aug;71(2 Suppl 3):S315-7. PMID: 21814098 [PubMed - in process]

  • Cotton BA, Reddy N, Hatch QM, Lefebvre E, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Holcomb JB. Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients. Ann Surg. 2011 Oct;254(4):598-605. PMID: 21918426 [PubMed - in process]

  • Haywood-Watson RJ, Holcomb JB, Gonzalez EA, Peng Z, Pati S, Park PW, Wang WW, Zaske AM, Menge T, Kozar RA. Modulation of Syndecan-1 shedding after hemorrhagic shock and resuscitation. PLoS ONE 2011;6(8):e23530. Epub 2011 Aug 19. PMCID: PMC3158765

  • Cotton BA, Faz G, Hatch QM, Radwan ZA, Podbielski J, Wade C, Kozar RA, Holcomb JB. Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. J Trauma. 2011 Aug;71(2):407-17. PMID: 21825945 [PubMed - in process]

  • Cotton BA, Kao LS, Kozar R, Holcomb JB. Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis. J Trauma. 2011 Aug;71(2):375-9. PMID: 21825941 [PubMed - in process]

  • Kozar RA, Feliciano DV, Moore EE, Moore FA, Cocanour CS, West MA, Davis JW, McIntyre RC Jr. Western Trauma Association/Critical Decisions in Trauma: Operative Management of Adult Blunt Hepatic Trauma. J Trauma. 2011 Jul;71(1):1-5PMID: 21818009 [PubMed - as supplied by publisher]

  • Feliciano DV, Moore FA, Moore EE, West MA, Davis JW, Cocanour CS, Kozar RA, McIntyre RC Jr. Evaluation and Management of Peripheral Vascular Injury. Part 1. Western Trauma Association/Critical Decisions in Trauma. J Trauma. 2011 Jun;70(6):1551-1556. PMID: 21817992 [PubMed - as supplied by publisher]

  • Hatch QM, Osterhout LM, Ashraf A, Podbielski J, Kozar RA, Wade CE, Holcomb JB, Cotton BA. Current use of damage-control laparotomy, closure rates, and predictors of early fascial closure at the first take-back. J Trauma. 2011 Jun;70(6):1429-36. PMID: 21817992 [PubMed - as supplied by publisher]

  • Ban K, Sprunt JM, Martin S, Yang P, Kozar RA. Glutamine activates perxisome proliferator-activated receptor gamma in intestinal epithelial cells via 15-S-HETE and 13-OXO-ODE: A novel mechanism. Am J Physiol Gastrointest Liver Physiol. 2011 Jul 7. [Epub ahead of print]. PMID: 21737777 [PubMed - as supplied by publisher]

  • Zarzaur BL, Kozar RA, Fabian TC, Coimbra R. A survey of American Association for the Surgery of Trauma member practices in the management of blunt splenic injury. J Trauma. 2011 May;70(5):1026-31. PMID: 21610420 [PubMed - indexed for MEDLINE]

  • Duan C, Cao Y, Deng X, Wang W, Yang W, Liu X, Chen Z, Pati S, Kozar RA, Gonzalez EA, Wade CE, Holcomb JB, Ko TC. Increased TGF-β Contributes to Deterioration of Refrigerated Fresh Frozen Plasma's Effects in Vitro on Endothelial Cells. Shock 2011 36(1):54-59, Feb 15. [Epub ahead of print]

  • Kozar RA, Santora RJ, Poindexter BJ, Milner SM, Bick RJ. Alterations in content and localization of defensins in rat ileum and jejunum following ischemia-reperfusion. Specific peptides, in specific places, for specific jobs? ePlasty 2011 Feb 23;11:e8

  • Kozar RA, Peng Z, Zhang R, Holcomb JB, Pati S, Park P, Ko TC, Paredes A. Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg. 2011 112:1289-1295.

  • Adams SD, Cotton BA, McGuire MF, Dipasupil E, Podbielski J, Zaharia A, Jastrow K, Ware DN, Gill BS, Albarado R, Kozar RA, Gonzalez EA, Duke JR, Adams PR, Dyer CB, Holcomb JB. The unique pattern of complications in elderly trauma patients at a Level 1 trauma center. J Trauma 2011 72(1):112-8.

  • Matijevic N, Kostousov V, Wang YW, Wade CE, Wang W, Letourneau P, Hartwell E, Kozar R, Ko T, Holcomb JB. Multiple levels of degradation diminish hemostatic potential of thawed plasma. J Trauma. 2011 Jan;70(1):71-9; discussion 79-80.

  • Menge T, Zhao Y, Zhao J, Wataha K, Geber M, Zhang J, Letourneau P, Redell J, Shen K, Wang J, Peng Z, Xue H, Kozar R, Cox C, Khakoo AY, Holcomb H, Dash P, Pati S. Mesenchymal stem cells regulate blood brain barrier integrity in traumatic brain injury through production of the soluble factor TIMP3. Science Translational Medicine 2012, 21(4):161):161ra150.

  • Kwiatt ME, Patel MS, Ross SE, Lachant MT, Macnew HG, Ochsner MG, Norwood SH, Speier L, Kozar R, Gerber JA, Rowell S, Krishnakumar S, Livingston DH, Manis G, Haan JM. Is low-molecular-weight heparin safe for venous thromboembolism prophylaxis in patients with traumatic brain injury? A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2012 Sep;73(3):625-628. PMID: 22929493

  • Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Khan S, Adams PR, McCarthy JJ, Cotton BA. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012 Sep;256(3):476-86. PMID: 2286837

  • Ban K, Kozar RA. Protective Role of p70S6K in Intestinal Ischemia/Reperfusion Injury in Mice. PLoS One 2012;7(7):e41584. Epub 2012 Jul 27. PMID: 22848534

  • Peng Z, Ban K, Sen A, Grill R, Park PY, Costantini TW, Lin W, Kozar RA. Syndecan-1 plays a novel role in enteral glutamine’s gut protective effects of the post ischemic gut. Shock 2012 Jul 38(1):57-62. Epub May 2011 PMID: 22575998

  • Cotton BA, Minei KM, Radwan ZA, Matijevic N, Pivalizza E, Podbielski J, Wade CE, Kozar RA, Holcomb JB. Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients. J Trauma Acute Care Surg. 2012 Jun;72(6):1470-5; discussion 1475-7. PMID: 22695409

  • Michetti CP, Fakhry SM, Ferguson PL, Cook A, Moore FO, Gross R; AAST Ventilator-Associated Pneumonia Investigators. Ventilator-associated pneumonia rates at major trauma centers compared with a national benchmark: a multi-institutional study of the AAST. J Trauma Acute Care Surg. 2012 May;72(5):1165-73. PMID: 22673241

  • Podoll AS, Kozar R, Holcomb JB, Finkel KW. Incidence and outcome of early acute kidney injury in critically-ill trauma patients PLoS One 2013, 2013 Oct 17;8(10):e77376.

  • Ban K, Peng Z, Kozar RA. Inhibition of ERK ½ worsens intestinal ischemia/reperfusion injury. PLoS One 2013, Sep 20;8(9):e76790.

  • Moisey LL, Mourtzakis M, Cotton BA, Premji T, Heyland DK, Wade CE, Bulger E, Kozar RA. Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Critical Care 2013, Sep 19;17(5):R206. [Epub ahead of print]

  • Tilquist M, Leung R, Kutsogiannis J, Wischmeyer, P, Karvellas D, Preiser JC, Bird N, Kozar R, Heyland DK. Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness in the critically ill. JPEN J Parenter Enteral Nutr 2013, Oct;258(4):527-33.

  • McClave SA, Kozar R, Martindale RG, Heyland DK, Braga M, Carli F, Drover JW, Flum D, Gramlich L, et al. Summary points and consensus recommendations from the North American Surgical Nutrition Summit. JPEN 2013, Sept;37(5 Suppl):99S-105S.

  • Pierre JF, Heneghan AF, Lawson SM, Wischmeyer PE, Kozar RA, Kudsk KA. Pharmaconutrition review: physiological mechanisms. JPEN 2013, Sept;37(5 Suppl):51S-65S.

  • Finnerty C Mabvuure N, Ali A, Kozar RA, Herdon D. Nutritional Supplementation of the surgically-induced stress response. JPEN 2013, Sept;37(5 Suppl):21S-9S.


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