|
SENTINEL SYMPTOMS PRESENT OR UNCERTAIN
|
Cases
|
Controls
|
Unadjusted
|
Adjusted Estimates1
|
|
(n=154)
|
(n=301)
|
Matched
OR
|
Matched
OR |
LCL2
|
p-value
|
|
No.
|
%
|
No.
|
%
|
No use3
|
145
|
94.2%
|
288
|
95.7%
|
--
|
--
|
--
|
--
|
Any PPA
|
7
|
4.6%
|
7
|
2.3%
|
2.13 (p=.141)
|
2.19
|
0.80
|
.099
|
Cough/cold remedy
|
5
|
3.2%
|
7
|
2.3%
|
1.48 (p=.365)
|
1.71
|
0.58
|
.206
|
Appetite suppressant
|
2
|
1.3%
|
0
|
0.0%
|
4.83 (p=.111)
|
--
|
--
|
--
|
1Matched odds ratio adjusted for smoking, hypertension, race and education.
2Lower limit of one-sided 95% confidence interval.
3No PPA use in 2-week period before focal time.
4One case used PPA in both a cough/cold remedy and an appetite suppressant in 3-day window.
Appendix E, continued
Analyses Stratified by Sentinel Symptoms: Recency of PPA Exposure
and Risk of Hemorrhagic Stroke
NO SENTINEL SYMPTOMS
|
Cases
|
Controls
|
Unadjusted
|
Adjusted Estimates1
|
|
(n=548)
|
(n=1075)
|
Matched
OR
|
Matched
OR |
LCL2
|
p-value
|
|
No.
|
%
|
No.
|
%
|
No use3
|
519
|
94.7%
|
1022
|
95.1%
|
|
|
|
|
Current use4
|
17
|
3.1%
|
18
|
1.7%
| 1.85 (p=.054) | 1.42 |
0.78
|
.169
|
First use5
|
6
|
1.1%
|
4
|
0.4%
|
3.00 (p=.077)
|
3.34
|
1.08
|
.040
|
Not-first use
|
11
|
2.1%
|
14
|
1.3%
|
1.55 (p=.196)
|
1.02
|
0.50
|
.479
|
|
|
|
|
|
|
|
|
|
Prior use6
|
3
|
0.6%
|
8
|
0.7%
| |
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