University System of Georgia Format for New Program Proposal

B.A., Physics, Cambridge University, Cambridge, England, 1974

M.A., Physics, Cambridge University, Cambridge, England, 1978

D. Phil., Molecular Biophysics, Oxford University, Oxford, England, 1978

2. Teaching load 2 courses/yr:

Course Bio/Che/CSc 8630, Bioinformatics.

Course Bio/Che/CSc 6640, Fundamentals of Bioinformatics.

Bio 8800, Biology Research.

Bio 9999, Dissertation Research.

Bio. 6900, Directed Lab Study

Bio 9991, Doctoral Research Proposal

3. Scholarship and publication record for past five years;

NIH

Main Goal: To elucidate the molecular basis for the activities of inhibitor resistant variants of HIV-1 protease by analyzing the structures and activities of variants of HIV-1 protease and evaluating new inhibitors.

Role: PI
P20 GM065762 6/1/03-5/31/08

NIH

Main goal: To plan for a biomedical center of excellence in research and education at Georgia State University.

Role: Co-Investigator
Distinguished Cancer Scientist Award 8/1/02-6/30/08

Georgia Cancer Coalition

Structural studies of cancer-related proteins

Main goal: Structural analysis of proteins involved in development or treatment of cancer.

Role: PI
1 R03 TW 01001 7/1/99-6/30/06

NIH/Fogarty International Center

Specificity Studies of HIV and HTLV Proteases

Main Goal: Studying the specificity of HIV and HTLV proteases as an extension of GM62920.

Role: PI
Publications
Mahalingam, B., Boross, P., Wang, Y.F., Louis, J.M., Fischer, C., Tozser, J., Harrison, R.W., Weber, I.T. Combining mutations in HIV-1 protease to understand mechanisms of resistance. (2002) Proteins 48, 107-116.

Koh, Y., Nakata, H., Maeda, K., Ogata, H., Bilcer, G., Devasamundam, T., Kincaid, J.F., Boross, P., Wang, Y.-F., Tie, Y., Volarath, P., Gaddis, L., Harrison, R.W., Weber, I.T., Ghosh, A.K., Mitsuya, H. A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) potent against multi-PI-resistant HIV in vitro. (2003) Antimicrob. Agent Chemother. 47, 3123-3129.

Petock, J.M., Torshin, I.Y., Weber, I.T., Harrison, R.W. Analysis of Protein Structures Reveals Regions of Rare Backbone Conformation at Functional Sites. (2003) Proteins 53, 872-879.

Tie, Y., Boross, P.I., Wang, Y.-F., Gaddis, L., Hussain, A.K., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T. High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active against Multi-Drug Resistant Clinical Strains. (2004) J. Mol. Biol. 338, 341-352.

Mahalingam, B., Wang, Y.-F., Boross, P.I., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T. Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. (2004) Eur. J. Biochem. 271, 1516-1524.

Bagossi, P., Kádas, J., Miklóssy, G., Boross, P., Weber, I.T., Tözsér, J. Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases. (2004) J. Virol. Methods 119, 87-93.

Daniel R, Myers CB, Kulkosky J, Taganov K, Greger JG, Merkel G, Weber IT, Harrison RW, Skalka AM. Characterization of a naphthalene derivative inhibitor of retroviral integrases. AIDS Res Hum Retroviruses. (2004) 20, 135-44.

Kádas, J., Weber, I.T., Bagossi, P., Miklóssy, G., Boross, P., Oroszlan, S., Tözsér, J. Narrow substrate specificity and sensitivity towards ligand binding site mutations of human T-cell leukemia virus type-1 protease. (2004) J. Biol. Chem. 279, 27148-27157.

Liu, P., Wang, Y.-F., Ewis, H., Abdelal, A., Lu, C.D., Harrison, R.W., Weber, I.T. Covalent Reaction Intermediate Revealed in Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est30. (2004) J. Mol. Biol. 342, 551-556.

Chen, X., Weber, I.T., Harrison, R.W. Molecular Dynamics Simulations of 14 HIV Protease Mutants in Complexes with Indinavir. (2004) J. Mol. Model. 10, 373-381.

Tie, Y., Boross, P.I., Wang, Y.-F., Gaddis, L., Liu, F., Chen, X., Tozser, J., Harrison, R.W., Weber, I.T. Molecular basis for substrate recognition and drug resistance from 1.1-1.6 Å resolution crystal structures of HIV-1 protease mutants with substrate analogs. (2005) FEBS J. 272, 5265-5277.

Vana, M.L., Boross, P., Weber, I., Colman, D., Barklis, E., Leis, J. Mutations affecting cleavage at the p10-Capsid protease cleavage site block Rous sarcoma virus replication. (2005) Retrovirology 2, 58.

Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T. Distinct structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S. (2005) J. Mol. Biol. 354, 789-800.

Chen, A., Weber, I.T., Harrison, R.W., Leis, J. Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends. (2006) J. Biol. Chem. 281, 4173-4182.

Kovalevsky, A.Y., Tie, Y., Liu, F., Boross, P.I., Wang, Y.-W., Leshchenko, S., Ghosh, A.K., Harrison, R.W., Weber, I.T. Effectiveness of Nonpeptide Clinical Inhibitor TMC114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V and L90M. (2006) J. Med. Chem. 49, 1379-1387.

Feher, A., Boross, P., Sperka, T., Miklossy, G., Kadas, J., Bagossi, P., Oroszlan, S., Weber, I.T., Tozser, J. Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus protease. (2006) J. Gen. Virol. 87, 1321-1330.

Liu, F., Kovalevsky, A.Y., Louis, J.M., Boross, P.I., Wang, Y.-F., Harrison, R.W., Weber, I.T. Mechanism of Drug Resistance Revealed by the Crystal Structure of the Unliganded HIV-1 Protease with F53L Mutation. (2006) J. Mol. Biol. 358, 1191-1199.

Ghosh, A.K., Sridhar, P.R., Kumaragurubaran, N., Koh, Y., Weber, I.T., Mitsuya, H. Bis-Tetrahydrofuran: A Privileged Ligand for a New Generation of HIV-Protease Inhibitors That Combat Drug-Resistance. (2006) ChemMedChem, (review) 1, 939-950.

Ghosh, A.K., Sridhar, P.R., Leshchenko, S., Hussain, A.K., Li, J., Kovalevsky, A.Y., Walters, D.E., Wedekind, J.E., Tokars, V.L., Das, D., Koh, Y., Maeda, K., Gatanaga, H., Weber, I.T., Mitsuya, H. Structure-Based Design of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance. (2006) J. Med. Chem. 49, 5252-5261.

Kovalevsky, A.Y., Liu, F., Leshchenko, S., Ghosh, A.K., Louis, J.M., Harrison, R.W., Weber, I.T. Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. (2006) J. Mol. Biol. 363, 161-173.

Volarath, P., Weber, I.T., Harrison, R.W. Structure Based Drug Design for HIV Protease: From Molecular Modeling to Cheminformatics. (2006) Current Topics in Medicinal Chemistry, (review) in press.

Fang, B., Boross, P.I., Tozser, J., Weber, I.T. Structural Insight into Caspase-3 Selectivity for Substrate Positions P2, P3, and P5 (2006) J. Mol. Biol. 360, 654-666.

Guo, X., Chen, X., Weber, I.T., Harrison, R.W., Tai, P.C. Molecular Basis for Differential Nucleotide Binding of ABC-transporter CvaB. (2006) Biochemistry, 45, 14473-80.

Tie, Y., Kovalevsky, A.Y., Boross, P.I., Wang, Y.-F., Ghosh, A.K., Tozser, J., Harrison, R.W., Weber, I.T. Atomic Resolution Crystal Structures of HIV-1 Protease and Mutants V82A and I84V with Saquinavir. (2007) Proteins, 67, 232-242.

Liu, P., Ewis, H., Lu, C.D., Tai, P.C., Weber, I.T. Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11. (2007) J. Mol. Biol. 367, 212-23.

Louis, J.M., Ishima, R., Torchia, D.A., Weber, I.T. HIV-1 Protease: Structure, Dynamics and Inhibition. In: Advances in Pharmacology, HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms, 2^nd edition. ed. Jeang, H.-T., Academic Press, San Diego, CA. (review) (2007), 55, 261-98.

Amano, M., Koh, Y., Das, D., Wang, Y.-F., Boross, P.I., Li, J., Leschenko, S., Weber, I.T., Ghosh, A.K., Mitsuya, H. A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) GRL-98065 Potent Against Multi-Pi-Resistant HIV In Vitro. (2007) Antimicrob. Agents Chemother. 51, 2143-2155.

Volarath, P., Weber, I.T., Harrison, R.W. Structure Based Drug Design for HIV Protease: From Molecular Modeling to Cheminformatics. (2007) Current Topics in Medicinal Chemistry, 7, 1041-9.

Weber, I.T., Kovalevsky, A.Y., Harrison, R.W. Structures of HIV Protease Guide Inhibitor Design to Overcome Drug Resistance. Frontiers in Drug Design & Discovery, eds., G.W. Caldwell, M.R. D’Andrea, Atta-ur-Rahman, M.I. Choudhary, Bentham Science Publishers, (2007) 3, 45-62.

Tozser, J., Weber, I.T. The protease of human T-cell leukemia virus type-1 is a potential therapeutic target. (2007) Current Pharmaceutical Design, 13, 1285-1294.

Sperka, T., Miklóssy, G., Tie, Y., Bagossi, P., Zahuczky, G., Boross, P., Matúz, K., Harrison, R.W., Weber, I.T., Tözsér^, J. Bovine Leukemia Virus Protease: Comparison with Human T-cell Leukemia Virus and Human Immunodeficiency Virus Proteases. (2007) J. Gen. Virol. 88, 2052-2063.

Wang, Y.-F., Tie, Y., Boross, P.I., Tozser, J., Ghosh, A.K., Harrison, R.W., Weber, I.T. Potent Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease. (2007) J. Med. Chem. 50, 4509-4515.

Liu, P., Ewis, H.E., Huang, Y.-J., Lu, C.-D., Tai, P.C., Weber, I.T. Crystal Structure of the Bacillus subtilis Superoxide Dismutase. (2007) Acta Crystallog. F, 63, 1003-7.

Agniswamy, J., Fang, B., Weber, I.T. Plasticity of S2-S4 Specificity Pockets of Executioner Caspase-7 Revealed by Structural and Kinetic Analysis. (2007) FEBS J. 274, 4752-4765.

Kovalevsky, A.Y., Chumanevich, A.A., Liu, F., Weber, I.T. Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate. (2007) Biochemistry, 46, 14854-14864.

Ghosh, A.K., Chapsla, B.D., Weber, I.T., Mitsuya, H. The design of protease inhibitors targeting protein backbone: an effective strategy for combating drug-resistance. (2008) Acc. Chem. Res., 41, 78-86.

Weber, I.T., Fang, B., Agniswamy, J. Caspases: Structure-Guided Design of Drugs to Control Cell Death. (2007) Mini Rev. Med. Chem., in press.

Sayer, J.M., Liu, F., Ishima, R., Weber, I.T., Louis, J.M. Effect of the Active-Site D25N Mutation on the Structure, Stability and Ligand Binding of the Mature HIV-1 Protease. J. Biol. Chem. (2008) in press.

2002 Distinguished Cancer Scientist Award, Georgia Cancer Coalition.

1. Name, rank, academic discipline, institutions attended, degrees earned;

B.S. 1982 Xiangtan University

M.S. 1985 Xiangtan University

Ph.D. 1992 Florida State University

Postdoc Oxford UK

Research Fellow Yale

Protein structure and function

BioNMR

Advanced Biochemistry Methods

Design of Protein-Based MRI Contrast Agents with High Relaxivity, National Institutes of Health/NIBIB 1R01EB007268-0108/06/07- 4/30/11. PI: Dr. Jenny J. Yang, Co-PI: Dr. Zhi-ren Liu, $1,380,500

Structural Biology of receptor-mediated extracellular calcium signaling, NIH/GM 1R01GM081749-01. PI: Dr. Jenny J. Yang, Co-PI: Dr. Ed. Brown 09/01/07 - 08/31/11, $1,129,044

Rational Design and Analysis of Calcium Binding Proteins, National Institute of Health/GM 1RO1GM62999-01, PI: Dr. Jenny J. Yang, 07/01/01 – 06/30/08, $1,272,500

Identification of Calcium-Binding Sites in Calcium-sensing Receptors, American Heart Association, PI: Dr. Jenny J. Yang, 07/01/06 - 06/30/08, $154,000

Molecular Imaging of Cancers, ELSA U Pardee Foundation, 06/01/06– 05/31/08. PI: Dr. Jenny J Yang, $75,000

Regulation of Lens Gap Junctions, National Institute of Health/Eye Institute 5R01AI021389. PI: Dr. Charles Louis, Co-PI: Dr. Jenny J. Yang. 09/01/04- 08/31/08, $1,250,000

Molecular Biology of Rubella Virus, NIH/NIAID 5R01AI021389, PI: Dr. Teryl K. Frey Co-PI: Dr. Jenny J. Yang. Period: 04/01/03 - 03/31/09, $1,150,000

Functional role of p68 tyrosine phosphorylation in cancer metastasis, National Institutes of Health/NCI, PI: Dr. Zhi-ren Liu, Co-PI: Dr. Jenny J. Yang. 07/01/07- 06/30/12, $1,000,000

Molecular MR Imaging by Targeting Cancer Biomarkers National Institutes of Health/NCI 1R21CA120181-01A1. PI: Dr. Zhi-ren Liu, Co-PI: Dr. Jenny J. Yang.. 05/01/07- 04/30/09, $275,000.

Supplemental Award for Minority Undergraduate Student Research, National Institute of Health/GM, PI: Dr. Jenny J. Yang. 03/01/04 – 06/30/08, $114,385.

Instrument for Design of Protein-Based MRI Contrast Agents with High Relaxivity, National Institutes of Health/NIBIB 1R01EB007268-01 S1, PI: Dr. Jenny J. Yang, Co-PI: Dr. Zhi-ren Liu, 08/06/07- 4/30/11, $80,000

Analysis of Neuro-Muscular Control of Locomotion of the Nematode Caenorhabditis Elegans, GSU Brain and Behavior Research Program , PI: Dr. Gennady Cymbalyuk, Co-PIs: Drs. Walter Bill Walthall and Jenny J. Yang. 01/01/07– 12/31/07, $29, 743.

Monitoring Calcium Signaling in Brains and Neurons, GSU Research Program, PI: Dr. Jenny J Yang, Co-PI: Vincent Rehder. 07/01/05– 12/31/07 , $20,000

Brains and Behavior Pre-doctoral Fellowship, Awardee: Ms. Nancy Yun Huang, 1/1/07-2/30/2010, Stipend: $22,500/yr

Molecular Bases of Diseases Pre-doctoral Fellowship, Awardee: Mr. Ning Chen (Pre-doctoral Fellowship), 5/1/07-4/30/10, Stipend: $22,500/yr

Molecular Bases of Diseases Pre-doctoral Fellowship, Awardee: Mr. Yubin Zhou, 151/06-4/30/08, Stipend: $22,500/yr

(51). Jenny J. Yang, Jianhua Yang, Lixia Wei, Wei Yang, Omar Zurkiya, Hui Mao, Fuqian Zhao, Russell Malchow, Shunyi Li, Anna L. Wilkins Mannicia, Shumin Zhao, Jin Zou, Julian Johnson, Xiaoping Hu, Eirk Krogstad, and Zhi-Ren Liu, Rational Design Protein Based MRI Contrast Agents with High Relaxivity Journal of the American Chemical Society (2008), Accepted.

(50) Lisa Jones, Wei Yang, Anna L. Wilkins Mannicia, Alice Kearney, Anton P. van der Merwe, and Jenny J. Yang. Rational Design of a novel calcium binding site adjacent to the ligand binding site on CD2 increases its adhesion function. Protein Science (2008). 17: 1-11.

(49) Yubin Zhou, Wei Yang, Yiming Ye, Yun Huang , Hsiau-Wei Lee, Monica M. Lurtz, Charles F. Louis, and Jenny J. Yang. Identification of the Calmodulin-Binding Domain of Connexin43. Journal of Biological Chemistry (2007). Sep 27; [Epub ahead of print] 282(48):35005-17.

(48) Yubin Zhou, Wei Yang, Hsiau-Wei Lee, Yiming Ye, Yumei Zhou, Suganthi Suppiah, Teryl K. Frey and Jenny J. Yang. Probing the Ca²⁺-Binding Properties of the Rubella Virus Nonstructural Protease. Journal of Virology (2007) Epub 2007 May 2. Jul;81(14):7517-28.

(47). Yun Huang, Yubin Zhou, Wei Yang, Robert Butters, Hsiau-wei Lee, Shunyi Li, Andriana Castiblanco, Edward Brown, and Jenny J. Yang. Identification and dissection of Ca2+-binding sites in the extracellular domain of Ca²⁺-sensing receptor. Journal of Biological Chemistry (2007). May 3; [Epub ahead of print]. 282(26):19000-10.

(45) Jin Zou, Aldebaran M. Hofer, Monica Lurtz, Giovanni Gadda, April L. Ellis, Ning Chen, Yun Huang, Angela Holder, Yiming Ye, Charles Louis, Kristy Welshhans, Vincent Rehder, and Jenny J. Yang^. Developing Sensors for Real Time Imaging of High Calcium Concentrations. Biochemistry 2007 Oct 9; [Epub ahead of print]. Oct 30;46(43):12275-88.

(44). Jenny J. Yang, Roland Pochet, and Arthur S. Nolen. Calcium, diversity and evolution, Meeting report of calcium binding proteins in normal and transformed cells and Diseases, Calcium Binding Protein (2006) 1(3), 170-174.

(43). Yuan Liu, Qiao Tong, Yubin Zhou, Hsiau-Wei Lee, Jenny J. Yang, Hans-Jörg Bühring, Yi-Tien Chen, Binh Ha, Celia X.-J. Chen and Ke Zen. Functional Elements on SIRPα IgV Domain Mediate Cell Surface Binding to CD47 Journal of Molecular Biology (2006) 365(3):680-93. Epub 2006 Oct 3.

(42) Jenny J. Yang. Calmodulin, the Surprises Continue. Calcium Binding Protein (2006), 1 (2), 65-66.

(41). Yubin Zhou, Michael Kirberger, Hsiau-Wei Lee, Gayatri Ayalasomayajula, Wei Yang, and Jenny J.Yang. Prediction of EF-hand calcium binding proteins and Analysis of Bacterial EF-Hand Proteins. Proteins: Structure, Function, and Bioinformatics (2006), 65(3):643-55.

(39) Hai Deng, GT Chen, Wei Yang and Jenny J. Yang. Identifying and Predicting Calcium Binding Sites in Proteins using Graph and Geometry Algorithms. Proteins (2006), 64(1):34-42.Apr 14; [Epub ahead of print].

(38). Chunru Lin, Liuqing Yang, Jenny J. Yang, Youliang Huang, and Zhi-Ren Liu, ATPase/Helicase Activities of p68 RNA Helicase are Required for Pre-mRNA Splicing but not for Assembly of the Spliceosome. Molecular and Cellular Biology (2005). 25 (17) 7484-7493.

(37) Wei Yang, Anna Wilkins, Shunyi Li, Yiming Ye, and Jenny J Yang. The Effects of Ca²⁺ Binding on the Dynamic Properties of a Designed Ca²⁺-binding Protein. Biochemistry (2005), 44, 8267-8273.

(36) Jin Zou, Yiming Ye, Kristy Welshhans, Monica Lurtz, April Ellis, Charles Louis, Vincent Rehder and Jenny J. Yang. Expression and Optical Properties of Green Fluorescent Protein Expressed in Different Cellular Environments. Journal of Biotechnology (2005). 119(4):368-78.

(35) Yiming Ye, Hsiau-Wei Lee, Wei Yang, and Jenny J. Yang. Calcium and Lanthanide Affinity of the EF-loops from the C-terminal of Calmodulin. Journal of Inorganic Biochemistry (2005), 99, 1376-1383.

(34) Amy R. Carroll, Wei Yang, Yiming Ye, and Jenny Jie Yang. Amyloid Fibril Formation in a Domain of Rat Cell Adhesion Molecule. Cell Biochemistry and Biophysics (2006), 44(2):241-50.

(33) Yiming Ye, Hsiau-Wei Lee, Wei Yang, Sarah Shealy, and Jenny J. Yang. Probing site-specific metal binding affinity of EF-hand Proteins by Grafting. Journal of the American Chemical Society (2005), 127 (11), 3743-50.

(32) Wei Yang, Anna Wilkins, Yiming Ye, Zhi-ren Liu, Shunyi Li, Jeffrey L. Urbauer, Homme W. Hellinga, Alice Kearney, Anton P. van der Merwe and Jenny J. Yang. Design of a Calcium-Binding Protein with Desired Structure in a Cell Adhesion Molecule. Journal of the American Chemical Society (2005), 127 (7), 2085-2093.

(31) Liuqing Yang, Jenny Yang, Youliang Huang, and Zhi-Ren Liu, Phosphorylation of p68 RNA helicase regulates RNA binding by the C-terminal domain of the protein. BBRC (2004), 314(2), 622-630.

(30) Wei Yang, Lisa Jones, Leanne Isley, Yiming Ye, Hsiau-Wei Lee, Anna Wilkins, Zhi-ren Liu, Homme W. Hellinga, Russell Malchow, Mohammed Ghazi and Jenny J. Yang. Rational Design of a Calcium Binding Protein. Journal of the American Chemical Society, (2003), 125(20), 6165-71.

(29) Anna Wilkins, Wei Yang, and Jenny J. Yang, Structural Biology of the Cell Adhesion Protein CD2: From Molecular Recognition to Protein Folding and Design. Current Protein and Peptide Science (2003), 4, 367-73.

(28) Jenny J. Yang and Wei Yang, Calcium Binding Proteins Encyclopedia of Inorganic Chemistry, Bruce King (Eds.) 2nd Edition, John Wiley & Sons, Ltd (2005).

(27) Yiming Ye, Sarah J. Shealy, Hsiau-Wei Lee, Ivan Torshin, Robert Harrison, and Jenny J. Yang “A Grafting Approach for Site-Specific Metal Binding Affinity of EF-hand Proteins.” Protein Engineering (2003), 16(6), 429-34.

(26) Jenny J. Yang, Amy Gawthrop, and Yiming Ye “Obtaining Site-specific Calcium –binding Affinities of Calmodulin” Protein and Peptide Letter (2003), 10 (4), 331-345.

4. Professional activity; (honors, etc)

2005-present Editorial Board Member of Journal of Protein & Peptide Letters (PPL)

2004-present Associate Editor of Journal of Calcium Binding Protein

2007-present Panel Grant Reviewer of the Study Session of Biochemistry and Biophysics of Membranes Study Section, National Institute of Health

2005-2007 National Institute of Health/ National Cancer Institute (Study Session of STTR/SBIR)

2005-06 National Institute of Health (Study Session of Biophysics-Postdoctoral Fellowship)

2002-2007 National Institute of Health (Study Session for Predoctoral Fellowship)

2001-2004 National Science Foundation (Panel of MCB)

2004-2005 Medical Research Award from NIH, Southeast Research Center for Emerging Diseases and Biodefense (SERCEB)

2005-present Panel Grant Reviewer of the Study Session of SBMI Medical Imaging Technologies, National Institute of Health (National Cancer Institute)

2005-2006 Panel Grant Reviewer of the Study Session of National Institute of Health for postdoctoral Fellowship of Biophysics and Biochemistry

2004 Speaker at the Gordon Conference of Biomineralization

2001-2004 Panel Grant Reviewer of National Science Foundation (NSF-MCB)

2004 Panel Grant Reviewer of the Study Session of National Institute of Health (SBDD)

2003 Honor from McNair Program for outstanding achievement in training minority undergraduate researchers

2002-2005 Panel Grant Reviewer of the Study Session of National Institute of Health for Predoctoral Fellowship (F31)

2003 Outstanding Faculty Achievement Award, Georgia State University

2003 Featuring Recognition for Outstanding Contribution to McNair Minority Undergraduate Research Program

1. Name, rank, academic discipline, institutions attended, degrees earned

B.S. Computer Science, Tianjin University, July 1983

M.S. Computer Science, Tianjin University, June 1986

Ph.D. Computer Science, University of South Florida, August 1997

CSc 4810/6810 Artificial Intelligence,

CSc 8810 Computational Intelligence

CSc 8320 Advanced Operating Systems

T.Y. Lin, L. A. Zadeh and Y.-Q. Zhang (eds.), Granular Computing, World Scientific, 2008.

Y.-Q. Zhang and Jagath C Rajapakse (eds.), Machine Learning in Bioinformatics, Wiley Book Series on Bioinformatics: Computational Techniques and Engineering, John Wiley & Sons, 2008.

J. Y. Yang, M. Q. Yang, M. M. Zhu, Y.-Q. Zhang, H. R. Arabnia, Y.P. Deng and N. Bourbakis, Proceedings of IEEE 7th International Conference on BioInformatics and BioEngineering, ISBN 1-4244-1509-8, IEEE, 2007.

W.-R. Zhang, Y.-Q. Zhang and X.H. T. Hu (eds.), Proceedings of the 2005 IEEE ICDM Multiagent Data Warehousing and Multiagent Data Mining Workshop, ISBN 0-9738918-0-7, 2005.

H.B. Wang, F. Smarandache, Y.-Q. Zhang and R. Sunderraman, Interval Neutrosophic Sets and Logic: Theory and Applications in Computing, Neutrosophic Book Series, no. 5, HEXIS, 2005.

Y.-Q. Zhang, A. Kandel, T.Y. Lin and Y.Y. Yao (eds.), Computational Web Intelligence: Intelligent Technology for Web Application, Series in Machine Perception and Artificial Intelligence, volume 58, World Scientific, 2004.

Y.-Q. Zhang and A. Kandel, Compensatory Genetic Fuzzy Neural Networks and Their Applications, Series in Machine Perception Artificial Intelligence, volume 30, World Scientific, 1998.

Y.C. Tang, Y.-Q. Zhang, Z. Huang, X.H. T. Hu, and Y. Zhao, “Recursive Fuzzy Granulation for Gene Subsets Extraction and Cancer Classification,” IEEE Transactions on Information Technology in Biomedicine, 2008.

Y.-Q. Zhang, B. Jin and Y.C. Tang, “Granular Neural Networks with Evolutionary Interval Learning,” IEEE Transactions on Fuzzy Systems, 2008.

M. Atlas and Y.-Q. Zhang, “Fuzzy Neural Web Agents for Efficient NBA Scouting,” Web Intelligence and Agent Systems: An International Journal, 2008.

Minyong Li, Nanting Ni, Binghe Wang and Y.-Q. Zhang, “Modeling the Excitation Wavelengths (λ_ex) of Boronic Acids,” Journal of Molecular Modeling, 2008.

W.R. Zhang, J. Zhan, P.P. Wang and Y.-Q. Zhang, “On Truth, Uncertainty, Equilibrium and Harmony – a Taxonomy for YinYang Scientific Compiting,” New Mathematics and Natural Computation, 2008.

X.J. Chen, Y. Li, R. Harrison and Y.-Q. Zhang, “Interval Type-2 Fuzzy Classifier Fusion for Support Vector Machines,” Applied Soft Computing, 2008

Y. Qiu, H. Yang, Y.-Q. Zhang and Y.C. Zhao, “Polynomial Regression Interval-valued Fuzzy Systems,” Soft Computing - A Fusion of Foundations, Methodologies and Applications, vol. 12, no. 2, pp. 137-145, Jan. 2008.

F. Tan, X.Z. Fu, Y.-Q. Zhang and A. Bourgeois, “A Genetic Algorithm-based Feature Subset Selection,” Soft Computing - A Fusion of Foundations, Methodologies and Applications, vol. 12, no. 2, pp. 111-120, Jan. 2008.

X.J. Chen, R. Harrison and Y.-Q. Zhang, “Genetic Fuzzy Classification Fusion of Multiple SVMs for Biomedical Data,” Special Issue on Evolutionary Computing in Bioinformatics, Journal of Intelligent and Fuzzy Systems, vol. 18, no. 6, pp. 527-541, 2007.

Y.C. Tang, Y.-Q. Zhang and Z. Huang, “Development of Two-Stage SVM-RFE Gene Selection Strategy for Microarray Expression Data Analysis,” IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 4, no. 3, pp. 365-381, July-September 2007.

B. Jin, Y.-Q. Zhang and B.H. Wang, “Granular Kernel Trees with Parallel Genetic Algorithms for Drug Activity Comparisons,” International Journal of Data Mining and Bioinformatics, vol. 1, no. 3, pp. 270-285, 2007.

Y.-Q. Zhang and X.H. Wan, “Statistical Fuzzy Interval Neural Networks for Currency Exchange Rate Time Series Prediction,” Special Issue on Soft Computing for Time Series Prediction, Applied Soft Computing, vol. 7, no. 4, pp. 1145-1234, August 2007.

L. Gu and Y.-Q. Zhang, “Web Shopping Expert Systems Using New Interval Type 2 Fuzzy Reasoning,” Special Issue on Web Intelligence and Chance Discovery, Soft Computing - A Fusion of Foundations, Methodologies and Applications, vol. 11, no. 8, pp. 741-751, June 2007.

B. Jin, Y.C. Tang and Y.-Q. Zhang, “Support Vector Machines with Genetic Fuzzy Feature Transformation for Biomedical Data Classification,” Special Issue on Advances in Fuzzy Logic, Information Sciences, vol. 177, no. 2, pp. 476-489, 2007.

Y.C. He, Y.C. Tang, Y.-Q. Zhang and R. Sunderraman, “Adaptive Fuzzy Association Rule Mining for Effective Decision Support in Biomedical Applications,” International Journal of Data Mining and Bioinformatics, vol. 1, no. 1, pp. 3-18, 2006.

H.B. Wang, F. Smarandache, Y.-Q. Zhang and R. Sunderraman, “Interval Neutrosophic Logic,” Advances in Fuzzy Sets and Systems, vol. 1, no. 3, pp. 187-218, Oct. 2006.

B. Jin and Y.-Q. Zhang, “Evolutionary Construction of Granular Kernel Trees for Cyclooxygenase-2 Inhibitor Activity Comparison,” LNCS Transactions on Computational Systems Biology, vol. V, pp. 25-35, 2006.

H.B. Wang, Y.-Q. Zhang and R. Sunderraman, “Soft Semantic Web Services Agent,” Soft Computing - A Fusion of Foundations, Methodologies and Applications, vol. 10, no. 11, pp. 1021-1029, Sept. 2006.

T. Surdilovic and Y.-Q. Zhang, “Convenient intelligent cursor control web systems for Internet users with severe motor-impairments,” Special Issue on Health and the Internet for All, International Journal of Medical Informatics, vol. 75, Issue 1, pp. 86-100, Jan. 2006.

Y.-Q. Zhang, “Constructive Granular Systems with Universal Approximation and Fast Knowledge Discovery,” IEEE Transactions on Fuzzy Systems, vol. 13, no. 1, pp. 48-57, Feb. 2005.

L.X. Yu and Y.-Q. Zhang, “Evolutionary Fuzzy Neural Networks for Hybrid Financial Prediction,” Special Issue on Knowledge Extraction and Incorporation in Evolutionary Computation, IEEE Transactions on Systems, Man, And Cybernetics (Part C: Applications and Reviews, vol. 35, no. 2, pp. 244-249, May 2005.

Y.C. Tang, B. Jin and Y.-Q. Zhang, “Granular Support Vector Machines with Association Rules Mining for Protein Homology Prediction,” Artificial Intelligence in Medicine, Special Issue on Computational Intelligence Techniques in Bioinformatics, vol. 35, no. 1-2, pp. 121-134, Sept.-Oct. 2005.

X.J. Chen, R. Harrison and Y.-Q. Zhang, “Multi-SVM Fuzzy Classification and Fusion Method and Applications in Bioinformatics,” Special Issue on Computational Intelligence for and Bioinformatics, the Journal of Theoretical and Computational Nanoscience, vol. 2, no. 4, pp. 514–52, Dec. 2005.

H.B. Wang, P. Madiraju, Y.-Q. Zhang and R. Sunderraman, “Interval Neutrosophic Sets,” International Journal of Applied Mathematics & Statistics, vol. 3, no. M05, pp. 1-18, March 2005.

T.M. Dave, Y.-Q. Zhang, G. Scott Owen and Raj Sunderraman, “Intelligent Web Agents for a 3D Virtual Community,” International Journal for Infonomics, Issue 1, pp. 38-49, Jan. 2005.

F.Y. Liu, H.L. Geng and Y.-Q. Zhang, “Interactive Fuzzy Interval Reasoning for Smart Web Shopping,” Applied Soft Computing, vol. 5, no. 4, pp. 433-439, July 2005.
C. Publications – Book Chapters
Y.-Q. Zhang, “Granular Neural Networks,” Encyclopedia of Complexity & System Science, Robert Meyers (Ed.), Springer, 2008.

Z.J. Ding and Y.-Q. Zhang, “Fuzzy Logic,” The Handbook of Technology Management, H. Bidgoli (Ed.), John Wiley & Sons, 2008.

Y. Chen and Y.-Q. Zhang, “A Personalized Semantic Web Search Agents Based on Fuzzy Semantic Trees and Neural Networks,” book chapter, T.J. Yao eds., Novel Developments in Granular Computing: Applications for Advanced Human Reasoning and Soft Computation, IGI Global, 2008.

B. Jin and Y.-Q. Zhang, “Evolutionary Kernel Machines for Biomedical Data Multi-classification,” Machine Learning in Bioinformatics, Y.-Q. Zhang and Jagath C Rajapakse (eds.), John Wiley & Sons, 2007.

Y.C. He, Y.C. Tang, Y.-Q. Zhang and R. Sunderraman, “Fuzzy-Granular Gene Selection from Microarray Expression Data,” Computational Intelligence for Bioinformatics, Gary B. Fogel, David Corne, and Yi Pan (eds.), IEEE Press, 2007.

B. Jin and Y.-Q. Zhang, “Voting Scheme Based Evolutionary Kernel Machines for Drug Activity Comparisons,” Knowledge Discovery in Bioinformatics: Techniques, Methods and Applications, Yi Pan and Xiaohua Hu (eds.), John Wiley & Sons, 2007.

Y. Tang and Y.-Q. Zhang, “Soft Statistical Decision Fusion for Distributed Medical Data on Grids,” Artificial Intelligence and Integrated Intelligent Information Systems: Emerging Technologies and Applications, X.F. Zha (ed.), IRM Press, Oct. 2006.

Y.C. Tang and Y.-Q. Zhang, “Intelligent Type-2 Fuzzy Inference for Web Information Search Task,” Soft Computing for Information Processing and Analysis, Series in Fuzziness and SoftComputing, vol. 164, M. Nikravesh,L.A. Zadeh and J. Kacprzyk (eds.), Physica-Verlag, Springer, 2005.

Y.-Q. Zhang, A. Kandel, T.Y. Lin and Y.Y. Yao, “Introduction to Computational Web Intelligence and Hybrid Web Intelligence,” Computational Web Intelligence: Intelligent Technology for Web Applications, Y.-Q. Zhang, A. Kandel, T.Y. Lin and Y.Y. Yao (eds.), World Scientific, 2004.

Y. Tang, Y.-Q. Zhang, A. Kandel, T.Y. Lin and Y.Y. Yao, “Personalized Web Search Agents Using Data Mining and Granular Fuzzy Techniques,” Enhancing the power of the Internet, M. Nikravesh, B. Azvine, R. Yagar, and L.A. Zadeh (eds.), pp. 207-224, Physica-Verlag, Springer, 2004.

Y.C. Tang and Y.-Q. Zhang, “Smart Homepage-Finder — A TSK-Based Genetic Fuzzy Information Filtering Agent for Searching Homepages Intelligently,” Enhancing the power of the Internet, M. Nikravesh, B. Azvine, R. Yagar, and L.A. Zadeh (eds.), pp. 379-402, Physica-Verlag, Springer, 2004.

Y.F. Wang and Y.-Q. Zhang, “Fuzzy Web Information Classification Agents,” Fuzzy Logic and the Internet, V. Loia, M. Nikravesh and L.A. Zadeh (eds.), pp. 309-325, Physica-Verlag, Springer, 2004.

Organizing Co-Chair: 2008 International Symposium on Bioinformatics Research and Applications (ISBRA2008), Atlanta, May 6-8, 2008.

Program Co-Chair and Bioinformatics Track Chair: IEEE 7th International Conference on Bioinformatics & Bioengineering (BIBE07), Cambridge - Boston, Massachusetts, USA, October 15-17, 2007.             

Publicity Co-Chair: 2007 International Workshop on Pattern Recognition in Bioinformatics (PRIB 2007), Singapore, Oct. 1-2, 2007.

Vice Chair: The 2007 International Conference on Bioinformatics & Computational Biology (BIOCOMP'07), Las Vegas, June 25-28, 2007.

Vice Chair: The 2007 International Conference on Artificial Intelligence, Las Vegas, June 25-28, 2007.

Vice Chair: The 2007 International Conference on Genetic and Evolutionary Methods (GEM'07), Las Vegas, June 25-28, 2007.

Vice Chair: The 2007 International Conference on Image Processing, Computer Vision, and Pattern Recognition (IPCV'07), Las Vegas, June 25-28, 2007.

Organizing Co-Chair: 2007 International Symposium on Bioinformatics Research and Applications (ISBRA2007), Atlanta, May 7-10, 2007.

Chair of the Session on Kernel Methods at ISNN2006, Chengdu, May 28-31, 2006.

Program Committee Co-Chair (with W. Pedrycz and M.-C. Shan): 2006 IEEE International Conference on Granular Computing (IEEE-GrC2006), Atlanta, May 10-12, 2006.

Panel Moderator of Panel on Granular Computing: Theory and Applications at IEEEGrC2006, May 12, 2006.

 Program Committee Co-Chair (with W.R. Zhang and X.H. T. Hu): 2005 IEEE-ICDM Workshop on MultiAgent Data Warehousing and MultiAgent Data Mining, Houston, November 27, 2005.

 Co-Chair (with Zhang Y.): the Special Session on Ying-Yang Computation for Brain, Behavior and Machine Learning at the Second International Conference on Neural Networks and Brain (ICNN&B2005, http://cnnc.org.cn/), Beijing, October 13-15, 2005.

 Chair: Workshop on Ying-Yang Computation for Brain, Behavior and Machine Learning (http://www.cs.gsu.edu/~cscyqz/conf/GSU-YYC-BBML-Workshop.htm) at GSU, Atlanta, Aug. 30, 2005.

Publication Chair of the Second Annual Fall Workshop on Bio-Computing (SECAB 2005), Atlanta, October 27, 2005.

Chair of the Best Paper award committee of IEEE-GrC2005.

Chair of the Session on Machine Learning, Data Mining, Theory and the Session on Granular Computing at IEEE-GrC2005.

Chair of the Session on Data Mining and Related Topics of SPIE’s Defense&Security 2004: Conference on Data Mining and Knowledge Discovery: Theory, Tools, and Technology.

Chair of the Stream on Computational Web Intelligence of the Third International Workshop on Intelligent Systems Design and Applications 2003.

Chair of the Special Sessions of the Third International Workshop on Intelligent Systems Design and Applications 2003.

Chair of the Session on Intelligent Web Computing of the Third International Workshop on Intelligent Systems Design and Applications 2003.

Chair of the Session on Web and E-Commerce Applications of SPIE’s AeroSense 2003: Conference on Data Mining and Knowledge Discovery: Theory, Tools, and Technology.

Chair of the Session on Information Fusion and Knowledge Discovery of SPIE’s AeroSense 2003: Conference on Data Mining and Knowledge Discovery: Theory, Tools, and Technology.

Chair of 2002 IEEE International Conference on Fuzzy Systems of World Congress of Computational Intelligence 2002: Special Session on Computational Web Intelligence.

Chair of the Second International Workshop on Intelligent Systems Design and Applications 2002: Session on Knowledge Discovery and Data Mining.

Chair of the Session on Image and Web Mining of SPIE’s AeroSense 2001: Conference on Data Mining and Knowledge Discovery: Theory, Tools, and Technology.

Chair of the Session on Soft Computing, Rough Sets and Fuzzy Logic of SPIE’s AeroSense 2001: Conference on Data Mining and Knowledge Discovery: Theory, Tools, and Technology.

Chair of SCI/ISAS1999 Invited Session on Intelligent Data Mining and Knowledge Discovery.

Associate Editor of Journal of Computational Intelligence in Bioinformatics and Systems Biology.

Editorial Board member of International Journal of Data Mining and Bioinformatics.

Guest Editor (with J. C. Rajapakse and G. B. Fogel): Special Section on Computational Intelligence Approaches in Computational Biology and Bioinformatics, IEEE/ACM Transactions on Computational Biology and Bioinformatics, April-June, 2007.

Jagath C. Rajapakse, Yan-Qing Zhang, Gary B. Fogel: Guest Editors' Introduction to the Special Section: Computational Intelligence Approaches in Computational Biology and Bioinformatics. IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 4, no. 2, pp. 161-162, April-June, 2007.

1. Name, rank, academic discipline, institutions attended, degrees earned;

B. S. in Mathematics, Peking University, 1987.

M. S. in Applied Mathematics, Peking University, 1991.

M. S. in Stochastics and Operations Research, Univ. Utrecht, Netherlands, 1997

M. S. in Statistics, Florida State University, 1999, GPA 4.0.

Ph.D in Statistics, Florida State University, 2002, GPA 4.0.

Survival Analysis

Monte Carlo Methods

Introduction to Statistical Methods

Regression Analysis

Elementary Statistics

Biostatistics
3. Scholarship and publication record for past five years;

Recent and current grant support

Funding for Professional Development Stipends, Pilot Mentor Program, Georgia State University, 2008, $2400.

NSF-Sponsored Young Investigator Grant to Current and Future Trends in Nonparametrics, Columbia, SC, October 11—12, 2007, $500.

Travel Support to SAMSI Summer Program on Challenges in Dynamic Treatment Regimes and Multistage Decision-Making, SAMSI, Research Triangle Park, NC, June 18—29, 2007, $500.

Funding for Professional Development Stipends, Pilot Mentor Program, Georgia State University, Atlanta, GA, 2007, $800.

Faculty Mentoring Grant, Georgia State University, Atlanta, GA, 2006—2007 (Mentor: G. Chen), $9,304.

National Security Agency, Empirical Likelihood Inference in Survival Analysis, 2006---2008, $27,983, single PI.

NSF Travel Support to attend International Biometric Conference, July 2006, McGill University, Canada, $1,428.

Funding for Professional Development Stipends, Pilot Mentor Program, Georgia State University, 2006, $800.

NCI Full Support for ENAR workshop for young researchers, Tampa, 2006, $800.

Graduate Student Fellowship Grant, Brain and Behaviors Program, Georgia State University, PI (with A. Petrulis) (supports Min Lu), 2005—2006. $1,1000.

New Researcher Travel Award to UF Winter Workshop: Longitudinal Data Analysis, University of Florida, January, 2005, $338.20.

NSF Travel Support to UFL Winter Workshop: Data Mining, Statistical Learning, and Bioinformatics, University of Florida, January, 2004, $400.

NSF Travel Support to the AMS-IMS-SIAM Summer Research Conference: Machine Learning Statistics and Discovery, Utah, 2003, $845.

NSF Travel Support to the International Conference on Reliability and Survival Analysis, University of South Carolina, 2003, $295.

[3] Z. Xu and Y. Zhao, 2004. Statistical analysis of general additive--multiplicative hazard model and mixed discrete--continuous Cox regression model via empirical likelihood, Proceedings of the American Statistical Association, Biopharmaceutical Section, 938--942.

[4] Y. Zhao and Y.S. Hsu, 2004. Statistical inference of semiparametric additive risk model, Proceedings of the American Statistical Association, Biometrics Section, 566—570.

[5] Y. Zhao and Y.S. Hsu, 2005, Semiparametric analysis for additive risk model via empirical likelihood, Communications is Statistics--Simulation and Computation, 34, 135—143.

[6] Y. Zhao, 2005. Regression analysis for long-term survival rate via empirical likelihood, Journal of Nonparametric Statistics, 17, 995--1007

[7] Y. Qiu, Y. Q. Zhang, and Y. Zhao, 2005. Statistical interval-valued fuzzy systems via linear regression, Proc. of IEEE-GrC 2005, pp. 229-232, Beijing, July 25-27.

[8] Y. Zhao and Z. Xu, 2005. Inference for the mixed discrete and continuous Cox regression model via empirical likelihood, Advances and Applications in Statistics, 5, 145—157.

[9] Y. Zhao and Z. Xu, 2005. Empirical likelihood Inference for the additive-multiplicative hazard model, Far East Journal of Theoretical Statistics, 16, 105—112.

[10] I.W. McKeague and Y. Zhao, 2005. Comparing distribution functions via empirical likelihood, International Journal of Biostatistics, Vol.1, Issue 1, article 5.

[11] Y. Zhao and F. Chen, 2005. Empirical likelihood estimation for median regression model via MIP, Proceedings of the American Statistical Association, Nonparametric Statistics Section, 1690--1694.

[12] Y. Zhao and G. Qin, 2006. Inference for the mean residual life function via empirical likelihood, Communications in Statistics—Theory and Methods, 35, 1025--1036.

[13] I. W. McKeague and Y. Zhao, 2006. Width-scaled confidence bands for survival functions. Statistics and Probability Letters, 76, 327—339.

[14] Y. Zhao and M. Lu. 2006. Empirical likelihood analysis of the calibration regression model, Proceedings of the American Statistical Association, Biometrics Section, CD-ROM.

[15] Y. Zhao and Y. Zhou. 2006. Statistical analysis of high dimensional gene data, Proceedings of IEEE-Granular Computing 2006, Atlanta, 502—505.

[16] Y. Zhao and G. Qin. 2007. Inference for a functional of cumulative hazard functions via empirical likelihood, Communications in Statistics---Theory and Methods, 36, 313—327.

[17] G. Qin and Y. Zhao. 2007. Empirical likelihood inference for the mean residual life under random censorship, Statistics and Probability Letters, 77, 549—557.

[18] N. Glenn and Y. Zhao. 2007. Weighted empirical likelihood estimates and their robustness properties, Computational Statistics and Data Analysis, 51, 5130—5141.

[19] Y.C. Tang, Y.-Q. Zhang, Z. Huang, X. Tony Hu, Y. Zhao, 2007. Granular SVM-RFE feature selection algorithm for reliable cancer-related gene subsets extraction on microarray gene expression data, Special Issue on Bioinformatics, Pattern Recognition, accepted.

[20] Y. Zhao and W. Jian. 2007. Analysis of longitudinal data in the case-control studies via empirical likelihood, to appear in Communications in Statistics—Simulation and Computation, 36, 565—578.

[21] Y. Zhao and Y. Huang. 2007. Test-based interval estimation under the accelerated failure time model , to appear in Communications in Statistics—Simulation and Computation, 36, 593—605.

[22] Y. Zhao and S. Yang. 2007. Empirical likelihood inference for censored median regression with weighted empirical hazard functions, to appear in Annals of Institute of Statistical Mathematics.

[23] Y. Qiu, Y.-Q. Zhang, Y. Zhao. 2007. Statistical genetic interval-valued fuzzy systems with prediction in clinical trials, Proceedings of IEEE-Granular Computing, Silicon Valley, CA, November, 2—4, pp. 129—132.

[24] Y. Qiu, H. Yang, Y.Q. Zhang and Y. Zhao. 2008. Polynomial regression interval-valued fuzzy systems, Soft Computing --A Fusion of Foundations, Methodologies and Applications, 12, 137—145.

[25] S. Yang and Y. Zhao. 2007. Testing treatment effect via empirical likelihood using weighted log rank tests, Statistics and Probability Letters, 77, 1385—1393.

[26] X. Chen, Y. Zhao, Y.-Q. Zhang and R. Harrison. 2008. Combining SVM classifiers using genetic fuzzy systems based on AUC for gene expression data analysis. Proceedings of International Symposium on Bioinformatics Research and Applications, the Springer Verlag Lecture Notes in Bioinformatics Series, Vol. 4463, 496—505.

[27] E. Bishop and Y. Zhao. 2008. Empirical likelihood based rank regression inference, Communications in Statistics, in press, 37, issue 4.

[28] Y. Zhao and F. Chen. 2008. Empirical likelihood inference for median regression model via nonparametric kernel estimation, Journal of Multivariate Analysis, 99, 215—231.

[29] Y.C. Tang, Y.-Q. Zhang, Z. Huang, X. Tony Hu and Y. Zhao. 2008. Recursive fuzzy granulation for gene subsets extraction and cancer classification, to appear in IEEE Transactions on Information Technology in Biomedicine.

4. Professional activity;

Awards and honors

NSF Funded Full Support to the Seventh North American New Researchers Conference, Toronto, 2004

NSF Funded Travel Partial Support for the Second Erich L. Lehmann Symposium, Rice University, 2004

Academic Keys Who's Who in Sciences Higher Education (WWSHE), 2004

Laha Travel Award at the IMS Annual Meeting in San Francisco, CA, 2003

Ralph A. Bradley Award, Department of Statistics, Florida State University, 2002

R.L. Anderson Award, Summer research Conference in Statistics, SRCOS/ASA, 2002

Student Research Paper Award and Travel Fellowship in International Chinese Statistical Association Applied Statistics Symposium, 2002

Travel Award to UFL Workshop: An IMS Mini-Meeting on Imaging, Classification and Clustering, University of Florida, 2002

Student Research Paper Award and Travel Fellowship in International Chinese Statistical Association Applied Statistics Symposium, 2001

Student Research Paper Award in Florida Chapter of ASA, 2001

Travel Award to UFL Winter Workshop: Monte Carlo in the New Millennium, University of Florida, 2001

Travel Award to Symposium on Inference for Stochastic Process in University of Georgia, 2000

Member of the Honor Society of Phi Kappa Phi, Florida State University, 1999

Best First Year Student of Theoretical Statistics, Department of Statistics, Florida State University, 1998

Full Fellowship from NUFFIC (the Netherlands Organization for International Cooperation in Higher Education), Mathematical Research Institute, University of Utrecht, 1996—1997

1. Name, rank, academic discipline, institutions attended, degrees earned;

Ying Zhu, Assistant Professor, Computer Science
Education

B.Eng. Computer Science, Southwest Jiaotong University, China, 1991

M.Eng. Computer Science, Univ. Electronic Science & Technology, China, 1994

Ph.D. Computer Science, George Mason University, Fairfax, Virginia, USA, 2000

Computer Graphics Imaging

Advanced Graphics Algorithms

Scientific Visualization

Computer Graphics Algorithms

Scholarship and publications in the past five years:

Research Support

National Institute of Health (1R21MH076753 – 01)

Georgia State University Brains & Behavior Program Seed Grant

Georgia State University Faculty Mentoring Grant

Georgia State University Brains & Behavior Program Seed Grant

Georgia State University Biomedical Computing Center Seed Grant

Georgia State University Research Initiation Grant

Georgia State University Biomedical Computing Center Seed Grant

J. W. Chastine, K. Nagel, Y. Zhu, and M. Hudachek-Buswell, “The Cost of Supporting References in Collaborative Augmented Reality,” accepted by the 34th Graphics Interface Conference (GI), 2008.

J. W. Chastine, K. Nagel, Y. Zhu, and M. Hudachek-Buswell, “Studies on the Effectiveness of Virtual Pointers in Collaborative Augmented Reality,” accepted by the 3rd IEEE Symposium on 3D User Interfaces (3DUI), IEEE, 2008.

Y. Zhu, “Visualizing Menisci-Femur Contact Using Deformable Knee Models,” to appear in International Journal of Functional Informatics and Personal Medicine.

X. Suo, Y. Zhu, and G. S. Owen, “Measuring the Complexity of Visualization Design,” accepted by the 2007 Workshop on Visualization for Computer Security (VizSEC), Springer, 2007.

Y. Zhu, “High Level Task Analysis for Computer Security Visualization” (invited paper), in Proceedings of the 2007 Symposium on Information, Electronics, and Control Technologies (IECT), Chengdu, China, 2007.

Y. Zhu, X. Suo, and G. S. Owen, "Complexity Analysis for Information Visualization Design and Evaluation," Advances in Visual Computing, Lecture Notes in Computer Science (LNCS), G. Bebis et al. (Eds.), Vol. 4841, pp. 576-585, Springer-Verlag, 2007.

Y. Zhu, “Measuring Effective Data Visualization,” Advances in Visual Computing, Lecture Notes in Computer Science (LNCS), G. Bebis et al. (Eds.), Vol. 4842, pp. 652-661, Springer-Verlag, 2007.

Y. Zhu, “Simulation and Visualization of Menisci-Femur Contact Using Patient-Specific Deformable Models,” in Proceedings of IEEE 7^th International Symposium on BioInformatics and BioEngineering (BIBE), Boston, MA, IEEE, 2007.

J. W. Chastine, K. Nagel, Y. Zhu, and L. Yearsovich, “Understanding the Design Space of Referencing in Collaborative Augmented Reality Environments," in the Proceedings of the 33rd Graphics Interface Conference (GI), ACM, 2007.

R. Calin-Jageman,  Y. Chen,  A. Dhawan,  C. Frederick,  N. Hiremath,  W. Ma,  X. Shen,  H. Yang,  S. Prasad, R. Sunderraman, Y. Zhu, and P. Katz, “Development of NeuronBank: A Federation of Customizable Knowledge Bases of Neural Circuitry,” IEEE International Workshop on Service Oriented Technologies for Biological Databases and Tools (SOBDAT), in Proceedings of IEEE Congress on Services (SERVICES 2007), IEEE, 2007.

J. W. Chastine, Y. Zhu, and J. A. Preston, “A Framework for Inter-referential Awareness in Collaborative Systems,” in the Proceeding of the 2^nd IEEE International Conference on Collaborative Computing (CollaborateCom), Atlanta, GA, IEEE, 2006.

A. S. Aquilio, J. C. Brooks, Y. Zhu, and G. S. Owen, “Real-time GPU-based Simulation of Dynamic Terrain,” in Advances in Visual Computing, Lecture Notes in Computer Science (LNCS), G. Bebis et al. (Eds.), Vol. 4291, pp. 891-900, Springer-Verlag, 2006.

X. Suo, Y. Zhu, and G. S. Owen, “Analysis and Design of Graphical Password,” in Advances in Visual Computing, Lecture Notes in Computer Science (LNCS), G. Bebis et al. (Eds.), Vol. 4292, pp. 741-749, Springer-Verlag, 2006.

X. Suo, Y. Zhu, and G. S. Owen, “A Survey of Graphical Passwords,” IAnewsletter, Vol. 9, No. 2, 2006, pp. 24-28.

H. Tian, R. Sunderraman, R. Calin-Jageman, H. Yang, Y. Zhu, and P. S. Katz, “NeuroQL: A Domain-Specific Query Language for Neuroscience Data,” in Current Trends in Database Technology, Lecture Notes in Computer Science (LNCS), T. Grust et al. (Eds.), Vol. 4254, pp. 613-624, Springer-Verlag, 2006.

P. Madiraju, Y. Zhang, G. S. Owen, and Y. Zhu, "Graphical Web Mining Agent for Class Teaching Enhancement," International Journal for Infonomics, 2006.

H. Tian, Y. Wang, H. Yang, R. Sunderraman, P. Katz, and Y. Zhu, “A Novel Neuron Data Model with Domain Specific Language,” in Proceedings of 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Shanghai, China, IEEE, 2005.

J. W. Chastine, J. C. Brooks, Y. Zhu, G. S. Owen, R. W. Harrison, and I. T. Weber, “AMMP-Vis: A Collaborative Virtual Environment for Molecular Modeling”, in Proceedings of ACM Symposium on Virtual Reality Software and Technology (VRST), Monterey, CA, ACM, 2005.

X. Suo, Y. Zhu, and G. S. Owen, “Graphical Password: A Survey”, in Proceedings of 21^st Annual Computer Security Applications Conference (ACSAC), Tucson, AZ, IEEE, 2005.

J. W. Chastine, Y. Zhu, J. C. Brooks, G. S. Owen, R. W. Harrison, and I. T. Weber, "A Collaborative Multi-View Virtual Environment for Molecular Visualization and Modeling," in Proceedings of the 3rd IEEE International Conference on Coordinated & Multiple Views in Exploratory Visualization (CMV). London, UK, IEEE, 2005.

F. Liu, G. S. Owen, Y. Zhu, R. W. Harrison, and I. T. Weber, "Web Based Molecular Visualization using Procedural Shaders in X3D," in Proceedings of ACM SIGGRAPH Conference Web Program. Los Angeles, CA, ACM, 2005.

G. S. Owen, Y. Zhu, J. W. Chastine, and B. R. Payne. "Teaching Programmable Shaders: Lightweight versus Heavyweight Approach," in ACM SIGGRAPH Conference Educators Program. Los Angeles, CA, ACM, 2005.

J. A. Pamplin, Y. Zhu, P. S. Katz, and R. Sunderraman, "A 3D User Interface for Visualizing Neuron Location in Invertebrate Ganglia," in Computational Science - ICCS 2005, Lecture Notes in Computer Science (LNCS), V. S. Sunderam et al. (Eds.), Volume 3515, pp. 347-350, Springer-Verlag, 2005.

R. Payne, S. O. Belkasim, G. S. Owen, M. C. Weeks, and Y. Zhu, “Accelerated 2D Image Processing on GPUs”, in Computational Science - ICCS 2005, Lecture Notes in Computer Science (LNCS), V. S. Sunderam et al. (Eds.), Volume 3515, pp. 256-264, Springer-Verlag, 2005.

Y. Zhu and S. O. Belkasim, "A 3D Reconstruction Algorithm Based on 3D Deformable Atlas," in Proceedings of IEEE International Conference on Information Technology and Applications (ICITA). Sydney, Australia, IEEE, 2005.

G. Bays and Y. Zhu, "ScoreSVG: A Three-Tiered Software Architecture for Creating Music Scores in SVG," in Proceedings of the 4th Annual Conference on Scalable Vector Graphics (SVG Open). Enschede, The Netherlands, 2005.

Y. Zhu and J. X. Chen, “Simulation and Visualization of Knee Joint Contact using Deformable Model”, in Proceedings of the 4^th IEEE International Conference on Computer and Information Technology (CIT), Wuhan, China, IEEE, 2004.

Y. Zhu and G. S. Owen, “Integrating Modeling and Animation Tools into an Introductory Computer Science Graphics Course,” ACM SIGGRAPH Conference Educators Program, Los Angeles, CA, ACM, 2004.

Y. Zhu, G. S. Owen, F. Liu, and A. Aquilio, “GPU-Based Volumetric Lighting Simulation,” in Proceedings of the 7^th IASTED International Conference on Computer Graphics and Imaging (CGIM), Kauai, HI, 2004.

Y. Zhu, "A Multi-thread Based Terrain Visualization Algorithm," in Proceedings of the 7th IASTED International Conference on Computer Graphics and Imaging (CGIM). Kauai, HI, 2004.

J. A. Pamplin and Y. Zhu, "Design and Implementation of a Workflow Rendering Engine," in Proceedings of the International Conference on Modeling, Simulation and Visualization Methods, Las Vegas, Nevada, 2004.

APPENDIX V

Comparison of Library Resources at Peer Institutions