University System of Georgia Format for New Program Proposal
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- Journal Articles Published and/or Submitted, (2003 – 2007)
Olypher, A.V., Cymbalyuk, G., Calabrese, R.L. (2006) Hybrid Systems Analysis of the Control of Burst Duration by Low-Voltage-Activated Calcium Current in Leech Heart Interneurons. J Neurophysiol. 96: 2857-2867.Weerasekara, A.B., Matsik, S.G., Cymbalyuk, G.S., and Perera A.G.U. (2006) Grouping behavior of inter-pulse time intervals for triggered pulses in an AlGaAs/InGaAs multilayer structure Physica D: Nonlinear Phenomena 215: 159-165. Shilnikov, A. L., Calabrese R. and Cymbaluyk, G. (2005) Mechanism of bi-stability: tonic spiking and bursting in a neuron model. Phys Review E 71, 056214, 1-9. Cymbaluyk, G. & Shilnikov, A.L. (2005) Coexistence of tonic spiking oscillations in a leech neuron model, J. Computational Neuroscience 18(3):255-263. Shilnikov, A. L. and Cymbaluyk, G. (2005) Transition between tonic-spiking and bursting in a neuron model via the blue-sky catastrophe, Phys Review Letters 94(4):048101, 1-4. Cymbalyuk, G., Calabrese R. and Shilnikov, A. L., (2005) How a neuron model can demonstrate co-existence of tonic spiking and bursting? Neurocomputing 65-66: 869-875. Bondarenko, V.E., Cymbalyuk, G.S., Patel, G., DeWeerth, S.P., Calabrese, R.L. (2004) Bifurcation of a synchronous oscillations into torus in a system of two reciprocally inhibitory silicon neurons: Experimental observation and modeling, Chaos, 14(4): 995-1003. Shilnikov, A. L. and Cymbalyuk, G. (2004) Homoclinic saddle-node orbit bifurcations en a route between tonic spiking and bursting in neuron models, Invited paper, Regular & Chaotic Dynamics, 9(3): 281-297. Sorensen, M., DeWeerth, S., Cymbalyuk, G., Calabrese, R.L. (2004) Using a hybrid neural system to reveal regulation of neuronal network activity by an intrinsic current. J Neurosci. 24(23):5427-5438. Wenning A, Cymbalyuk GS, Calabrese RL. (2004) Heartbeat Control in Leeches: I. Constriction Pattern and Neural Modulation of Blood Pressure in Intact Animals. J Neurophysiol. 91(1): 382-396. Simoni M, Sorensen M, Cymbalyuk G, Calabrese R, DeWeerth S (2004) A multiconductance silicon neuron with biologically matched dynamics IEEE Trans on Biomed Eng 51 (2): 342-354. Bondarenko, V.E., Cymbalyuk, G.S., Patel, G., DeWeerth, S.P., Calabrese, R.L. (2003) A bifurcation of a synchronous oscillations into a torus in a system of two mutually inhibitory aVLSI neurons: experimental observation Neurocomputing 52-4: 691-698. Professional activity; Conferences organized: Local organizing committee of SENN 2006, 2008. Origin and Regulation of Bursting Activity in Neurons April 6-7, 2006 (Organizers: R. Calabrese (Emory), G. Cymbalyuk and A. Shilnikov (GSU)) April 7, 2008 Computational Neuroscience Workshop, GSU (Organizers: G. Cymbalyuk, I. Belykh and A. Shilnikov (GSU)) Focus Session: Artificial Neurons, APS meeting, March 10-14, 2008, New Orleans, Louisiana Name, rank, academic discipline, institutions attended, degrees earned Mukesh Dhamala, Assistant Professor, Physics & Astronomy Education Tribhuvan University, Nepal MS (1994), BS (1990) University of Kansas, Lawrence, Ph. D. (2000), MS (1999) 2. Teaching load: 2 courses/yr Principles of Physics 1112 3. Scholarship and Publications: -M. Dhamala, G. Rangarajan, and M. Ding, ``Analyzing Information Flow in Brain Networks with Nonparametric Granger Causality,'' NeuroImage (in press, 2008). -M. Dhamala, G. Rangarajan, and M. Ding, ``Estimating Granger Causality from Fourier and Wavelet Transforms of Time Series Data,'' Physical Review Letters 100 , 018701 1-4 (2008). - M. Dhamala, C. G. Assisi, V. K. Jirsa, F. L. Steinberg, and J. A. S. Kelso, ``Multisensory integration for timing engages different brain networks,'' NeuroImage 34, 764 - 773 (2007). -M. Dhamala, V. K. Jirsa, and M. Ding, ``Enhancement of neural synchrony by time delay,'' Physical Review Letters 92, 074104 1-4 (2004). -M. Dhamala, V. K. Jirsa, and M. Ding, ``Transitions to synchrony in coupled bursting neurons,'' Physical Review Letters 92 , 028101 1-4 (2004). -M. Dhamala, G. Pagnoni, K. Wiesenfeld, C. F. Zink, M. Martin, and G. S. Berns ``Neural correlates of the complexity of rhythmic finger- tapping,'', NeuroImage 20, 918 - 926 ( 2003). -C. F. Zink, G. Pagnoni, M. Martin, M. Dhamala, and G. S. Berns, ``Human striatal response to salient non-rewarding stimuli," J. Neuroscience 23 , 8092 - 8097 ( 2003). 4. Professional Activity: Physics Colloquium, Flordia Atlantic University, FL, Feb 2008. Physics Colloquim, University of Sydney, Sydney, Feb 2008. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, UF,Gainesville, FL, Feb, 2007. 1. Name, rank, academic discipline, institutions attended, degrees earned Richard Dix, Professor, Biology Education Ph.D. Baylor College of Medicine, 1978 2. Teaching load 2 courses/yr: 3. Scholarship and publication record for past five years; Grant Support:Principal Investigator, NIH-NEI RO1 EY010568, "Pathogenesis of CMV Retinitis" 09/05-08/10 Co-Principal Investigator, NIH-NEI RO1 EY/AI013318, "Immune responses in macular degeneration" 04/05-03/10 Publications: Buckner AE, Dix RD (2006) Nicotine treatment alters NF-kB expression in human cytomegalovirus-infected ARPE-19 cells. Current Eye Research 31: 191-198 Miller DM, Legra J, Dubovy S, Suner I, Sedmak DD, Dix RD, Cousins SW (2004) The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. American Journal of Ophthalmology 138: 323-328 Dix RD, Cousins SW (2004) AIDS-related CMV retinitis: Lessons from the laboratory. Current Eye Research 29: 91-101 Dix RD, Podack, ER, Cousins SW (2003) Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: Interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. Antiviral Research 59: 111-119 Dix RD, Podack ER, Cousins SW (2003) Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. Journal of Virology 77: 3402-3408 4. Professional activity 1. Name, rank, academic discipline, institutions attended, degrees earned Markus Germann, Professor, Chemistry Education B.S. 1982 Technikum Winterthur, Switzerland Chemistry
Chem 4110/6110 Chem 4111 Chem 4160 Chem 4450/6450 Chem 8450 3. Scholarship and Publications
01/01/98-3/31/03 NIH 1RO1AI/GM47459-01 NMR Structure and Activity of Zinc Fingers specific for
NIH 2S06/GM08136-26-5 Charge Transport through DNA (S. Smirnov, P.I. (NMSU, M. Germann Contractor). Annual direct $172,123 (subcontract $30,000). 6/1/01-5/31/04 NIH S06 GM08136-33S1, “Charge Transport through DNA”
“Modulation of DNA Structure and Repair by DNA lesions ” Principal Investigator: Markus W. Germann, Ph.D. Distinguished Cancer Scientist: Georgia Cancer Coalition (2001-2009) “Southeastern Collaboratory for High-Field Biomolecular NMR” (J. Prestegard, P.I. UGA, M. Germann, regional co coordinator) 07/01/02-6/30/07 Funding Internal GSU Research Program Enhancement Grant, "Drug Design and Synthesis" (P.I.: L. Strekowski, M.Germann, Co-investigator). Amount $80,000. 7/1/02-6/30/03 GSU Research Program Enhancement Grant, "Drug Design and Synthesis" (P.I.: L. Strekowski, M.Germann, Co-investigator). Amount $80,000. 7/1/03-6/30/04 GSU Brains and Behavior “Structure-functional Relationship of K+ Channels: De Novo Modeling and Experimentation” (Jiang, Prasad & Germann, Co-investigator, No funds requested for MWG). 1/1/07-12/31/07 GSU Brains and Behavior “Molecular Elucidation of Alarm Cues in Sea Hare Secretions” (Charles Darby & Markus Germann, Co-investigator). Total award: $30,000. 1/1/07-12/31/07. •GSU Brains and Behavior “Search for 5-HT7 Receptor Liglands with potential antidepressant activity” (Lucjan Strekowski & Markus Germann Co-investigator). Total award: $25,832. 1/1/06-12/31/07 Publications last 5 years: Harris, T., Shahidullah, M, Graber, A. R., Germann, M. W. &
Aramini, J. M., Cleaver, S. H., Pon, R. T., Cunningham, R. P. & Germann, M.W. Solution Structure of a DNA Duplex Containing an a- Anomeric Adenosine: Insights into Substrate Recognition by Endonuclease IV. (2004), J. Mol. Biol. (2004), 338, 77-91. Vlassiouk, I., Krasnoslobodtsev, A, Smirnov, S. & Germann, M.W. "Direct" Detection and Separation of DNA Using Nanoporous Alumina Filters. (2004) Langmuir, 20 (23), 9913-9915. Covarrubias, M., Bhattacharji, A., Harris, T., Kaplan, B. and Germann, M. W. "Alcohol and Anesthetic Action at the Gateof a Voltage- Dependent K+ Channel". (2005) ICS 1283 Mechanisms of Anesthesia Conference, MAC-2005. International Congress Series, Elsevier. Salon, J., Chen, G., Portilla, Y., Germann, M.W. & Huang, Z. Synthesis of a 2’-Se-uridine Phosphoramidite and Its Incorporation into Oligonucleotides for Structural Study. Organic Letters (2005), 7, 5645-5648. Fan, F., Germann, M. W. and Gadda, G. "Probing the Chemical Mechanism for Aldehyde Oxidation by Choline Oxidase with Substrate Analogs" Biochemistry (2006), 45, 1979-1986. Yang, H., Johnson, P. M., Ko, K-C., Kamio, M., Germann, M.W., Derby, C. D., & Tai, P. C. "Escapin, a stable and broadly antimicrobial FAD- containing L-amino acid oxidase from ink of the sea hare Aplysia californica, can be functionally expressed in bacteria". Biochemistry (2006), 45, 1979-1986. Covarrubias, M., Bhattacharji, A., Harris, T., Kaplan, B. and Germann, M.W.: "The structural determinants of alcohol-anesthetic action in the activation gate of a voltage-gated K+ channel". Molecular Pharmacology (2006), 70, 1542-1545. Mishra, S. M., Shelley, C. M., Darby, M. K. and Germann, M.W. "Solution structures and characterization of HIV RRE IIB RNA targeting zinc finger proteins". Biopolymers (2006), 83, 352-364. Voehler, M. Collier, G., Young, J.K., Stone, M.P. & Germann, M.W.: "Performance Of Cryogenic Probes As A Function Of Ionic Strength And Sample Tube Geometry". J. Mag. Res. (2006), 183, 102-109. Germann, M.W. Turner, T. & Allison, S.: "Translational Diffusion Constants of the Amino Acids: Measurement by NMR and Their Use in Modeling the Transport of Peptides". Journal of Physical Chemistry (2007), 111, 8, 1452-1455. Kicklighter, C. E., Germann, M. W., Kamio, M. & Derby, C. D: “Molecular Identification of Alarm Cues in the Defensive Secretions if the Sea Hare Aplysis california”. Animal Behavior (2007), 74, 1481-1492. Moskau, D., Kovacs, H., Kümmerle, R., Colson, K., Collier, G. & Germann, M.W.: "New CryoProbe Models for Diverse Analytical Challenges". SpinReport, (2007), 157, 35-43. Di Lullo, G., Reigle, K. L., Turner, K. R. Last, J. A., Birk, D. E., Funderburgh, J. L., Elrod, E., Germann, M.W., Surber, C., Sanderson, R. D. and San Antonio, J. D. "Non-Enzymatic Glycation of Type I Collagen Dimininishes Collagen-Proteoglycan Binding and Weakens Cell Adhesion". Journal of Cellular Biochemistry (2008). 4. Professional activity: 1. Name, rank, academic discipline, institutions attended, degrees earned Kathryn Betty Grant, Associate Professor, Chemistry Education
2. Teaching load 2 courses/yr: CHEM 4210/CHEM 6210: Inorganic Chemistry BIOL 8637/CHEM 8370: Nucleic Acids Structure and Function 3. Scholarship and publication record for past five years: Journal Articles Published and/or Submitted, (2003 – 2007)Wilson, B., Fernández, M.-J., Lorente, A.,* & Grant, K.B.* “Syntheses and DNA Photocleavage by Mono- and Bis-phenothiazinium-piperazinexylene Intercalators.” (2008) Tetrahedron, 64, 3429-3436 [submitted in 2007]. Kassai, M., & Grant, K.B.* “Tuning Zr(IV)-Assisted Peptide Hydrolysis at Near-Neutral pH.” (2008) Inorganic Chemistry Communications, 11, 521-525 [submitted in 2007]. Cepeda, S.S., & Grant, K.B.* “Hydrolysis of Insulin Chain B Using Zirconium(IV) at Neutral pH.” (2008) New Journal of Chemistry, 32, 388 - 391 [submitted in 2007]. Fernández, M.-J., Wilson, B., Palacios, M., Rodrigo, M.M., Grant, K.B.,* & Lorente, A.* “Copper-Activated DNA Photocleavage by a Pyridine-Linked Bis-Acridine Intercalator.” (2007) Bioconjugate Chemistry, 18, 121-129 [submitted in 2006]. Grant, K.B.* & Kassai, M. “Major Advances in the Hydrolysis of Peptides and Proteins by Metal Ions and Complexes.” (2006) Current Organic Chemistry (invited review), 10, 1035-1049 [submitted in 2005]. Gude, L., Fernández, M.-J., Grant, K.B.,* & Lorente, A.* “Syntheses and Copper(II)-Dependent DNA Photocleavage by Acridine and Anthracene 1,10-Phenanthroline Conjugate Systems.” (2005) Organic and Biomolecular Chemistry 3, 1856-1862 [submitted in 2005]. Wilson, B., Gude, L., Fernández, M.-J., Lorente, A.,* & Grant, K.B.* “Tunable DNA Photocleavage by an Imidazole-Acridine Conjugate.” (2005) Inorganic Chemistry, 44, 6159-6173 [submitted in 2004]. Kassai, M., Ravi, R.G., Shealy, S.J., & Grant, K.B.* “Unprecedented Acceleration of Zirconium(IV)-Assisted Peptide Hydrolysis at Neutral pH.” (2004) Inorganic Chemistry 43, 6130-6132 [submitted in 2004]. Espinosa, J.-F., Fernández, M.-J., Grant, K.B.,* Gude, L., Rodrigo, M.-M., & Lorente, A.* “Synthesis, DNA Intercalation and Europium(III)-triggered DNA Photocleavage by a Bis-Proflavine Succinamide Conjugate.” (2004) Tetrahedron Letters 45, 4017-4020 [submitted in 2004]. De Silva, V., Woznichak, M.M., Burns, K.L., Grant, K.B., & May, S.W.* “Selenium Redox Cycling in the Protective Effects of Organoselenides against Oxidant-Induced DNA Damage.” (2004) Journal of the American Chemical Society 126, 2409-2413 [submitted in 2003]. Wilson, B., Lubin, I.M., & Grant, K.B.* “Allele-Specific Polymerase Chain Reaction-Based Genotyping of a Normal Variation in Human Color Vision.” (2003) Journal of Chemical Education 80, 1289-1291 [submitted in 2002]. 4. Professional activity: Research Support, (2003-2007)
NSF Award (9/07-8/10) $390,000 (total costs) Zirconium-Assisted Hydrolysis of Peptides, Proteins, and Lipids, (K.B. Grant P.I.). NSF CAREER Award (2/00-1/06) $349,500 (total costs) CAREER: A Combinatorial Approach to the Discovery of New Metal Complexes for Peptide Cleavage, (K.B. Grant P.I.).
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