A review of ssri-induced indifference



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Ven draft 11 july

Corrubleet al.8 2013

Efficacy of agomelatine and escitalopram on depression, sleep and emotional experience



24-week RCT comparing patients started on agomelatine versus escitalopram

Agomelatine n=25, escitalopram n=20


Agomelatine versus Escitalopram

Oxford Questionnaire on emotional side-effects, 28% of agomelatine versus 60% on escitalopram felt emotions lacked intensity,

Poor quality

Small population

Randomization and blinding not described, no intention to treat analysis

Sponsored by Servier (producers of agomelatine)

Outcome measures cherry picked from questionnaire and week intervals



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