An assessment of nucleic acid amplification testing for active mycobacterial infection
Download 12.08 Mb.
|
|
AFB = acid-fast bacilli; High TB incidence = > 100 cases per 100,000 people based on WHO estimates from 2012; HIV = human immunodeficiency virus; K = the number of studies; NAAT = nucleic acid amplification testing; TB = tuberculosis HIV-positive patients with pulmonary TB commonly produce AFB-negative sputum specimens (de Albuquerque et al. 2014; Scherer et al. 2011). Thus, the difficulty associated with diagnosis of TB in HIV-positive patients is related to the reduced sensitivity of NAAT compared with culture in AFB-negative specimens. Figure 27 shows that 33% (1 – sensitivity) of AFB-negative sputum specimens will have a false-negative NAAT result when compared with culture; in contrast, only 3% of AFB-positive specimens will have a false-negative result. The difference in the pooled sensitivity for non-sputum specimens is more modest (14% and 0%, respectively) but still sufficient to be of some concern to clinicians. 
Figure 27 Forest plot comparing the pooled sensitivity and specificity values for NAAT versus culture according to AFB result and specimen type in HIV-positive specimens AFB = acid-fast bacilli; K = the number of studies
Directory: internet internet -> Applications and limitations internet -> L. and Gossypium barbadense internet -> Natural Resources Conservation Service Conservation Practice Standard internet -> Practice Exercise Created By Stavros Charalambous The Internet internet -> It’s a good Topic internet -> National Preventative Health Strategy – the roadmap for action internet -> Downloading gps gr-3 Surveys Summary of Procedure internet -> 3G300m-how to setup the 3g router Mode? Product line: 3g question categories: Function configurations Note internet -> Installation Work has never been simpler or easier Download 12.08 Mb. Share with your friends:
|