Curriculum vitae name: Harumi Jyonouchi, M. D

Department of Pediatrics

Associate Professor

1. 
   Jyonouchi H and Yamaguchi M: A case of neonatal hyperbilirubinemia secondary due to Rh incompatibility. (in Japanese) J Pediatr Practice 40:2008-2011, 1977.
   

2. 
   Jyonouchi H, Yanagisawa N, and Yamaguchi M: Hereditary spherocytosis requiring exchange transfusion during the neonatal period with special reference to the morphological studies of HS erythrocytes. (in Japanese) Acta Paediatr JPN 20:654-658, 1978.
   

3. 
   Jyonouchi H, Yanagisawa N, and Soneda Y: A case of neonatal gastric rupture complicating with congenital diaphragm eventration. (in Japanese) Jap J Pediatr 31:395-398, 1978.
   

4. 
   Yamaguchi M, Shioda S, Jyonouchi H, Yamada K, and Ishikawa A: Infectious mononucleosis in siblings. (in Japanese) Jap J Pediatr 31:2431-2435, 1978.
   

5. 
   Jyonouchi H, Shioda S, Yamaguchi M, Yamada K, Ishikawa A, and Ito M: Clinical studies of infectious mononucleosis. (in Japanese) Jap J Pediatr 31:2436-2442, 1978.
   

6. 
   Yamaguchi M, Jyonouchi H, Sata T, Yokoi K, Yanagisawa N, Yamada K, and Ishikawa A: Clinical and laboratory studies on mycoplasma pneumonia. (in Japanese) Pediatrics of Japan 19:313-319, 1978.
   

7. 
   Jyonouchi H, Yanagisawa N, Ishikawa A, and Ishihara K: One pedigree of hereditary spherocytosis (HS): Scanning electron microscopic studies of HS erythrocytes in vitro. (in Japanese) J Clin Electron Microsc 12:91-105, 1979.
   

8. 
   Jyonouchi H, Kurokawa Y, and Ishidawa A: Studies of RBC 2, 3-DPG in MCLS. (in Japanese) Igaku No Ayumi 109:86-88, 1979.
   

9. 
   Jyonouchi H: Studies of RBC 2, 3-DPG levels in Childhood. 1. Studies on healthy children and low birth weight babies. (in Japanese) J Showa Med Assoc 39:373-379, 1979.
   

10. 
    Jyonouchi H, Yanagisawa N, Ishikawa A, and Ishihara K: Scanning electromicroscopic studies on the erythrocytes of hereditary spherocytosis III. Effect of propranolol-a beta blocking agent on the erythrocyte of hereditary spherocytosis. J Clin Electron Microsc 12:5-6, 1979.
    

11. 
    Yamaguchi J, Isoyama K, Fujita Y, Jyonouchi H, Hanawa H, Yanagisawa N, Yamada K, and Ishikawa A: Clinical studies on the complication of mycoplasma pneumonia. (in Japanese) Jap J Infect Dis 54:173-179, 1980.
    

12. 
    Jyonouchi H, Yokoi K, and Ishikawa A: A congenital bronchobiliary fistula. Acta Paediatr JPN (in Japanese) 84:1270-1277, 1980.
    

13. 
    Yamaguchi M and Jyonouchi H: Two cases of male Turner Syndrome. J Showa Med Assoc 40:76-82, 1980.
    

14. 
    Jyonouchi H and Yoshio T: A case of vascular purpura complicating with remarkable facial edema. (in Japanese) Pediatrics of Japan 21:1981.
    

15. 
    Jyonouchi H, Kincade PW, Good RA, and Fernandes G: Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. J Immunol 127:1232-1235, 1981.
    

16. 
    Jyonouchi H, Kincade PW, and Good RA: Immunosuppression of marrow B lymphocytes by administration of Corynebacterium parvum in mice. J Immunol 127:2502-2507, 1981.
    

17. 
    Jyonouchi H, Cyong JC, Fernandes G, Day NK, and Good RA: Alteration of murine serum lipase activity after allogeneic bone marrow transplantation. J Clin Immunol Immunopathol 22:94-104, 1982.
    

18. 
    Jyonouchi H, Kincade PW, Landreth KS, Lee G, Good RA, and Gershwin ME: Age-dependent deficiency of B lymphocyte lineage precursors in NZB mice. J Exp Med 155:1665-1678, 1982.
    

19. 
    Jyonouchi H and Kincade PW: Changes in B lineage cell populations in liver and spleen of neonatal mice. J Immunol 130:1616-1621, 1983.
    

20. 
    Jyonouchi H, Kincade PW, Good RA, and Gershwin ME: B lymphocyte lineage cells in newborn and very young NZB mice. Evidence for regulatory disorders affecting B cell formation. J Immunol 131:2219-2225, 1983.
    

21. 
    Jyonouchi H, Kincade PW, and Misra HP: Analysis of the effects of erythrocytes on mitogen-dependent clonal proliferation of murine B lymphocytes. Cell Immunol 83:189-198, 1984.
    

22. 
    Jyonouchi H and Kincade PW: Precocious and enhanced functional maturation of B lineage cells in New Zealand Black mice during embryonic development. J Exp Med 159:1277-1282, 1984.
    

23. 
    Jyonouchi H, Kincade PW, and Good RA: Age-dependent changes in B lymphocyte lineage cell populations of autoimmune prone BXSB mice. J Immunol 134:858-864, 1985.
    

24. 
    Jyonouchi H, Kimmel MD, Lee G, Kincade PW, and Good RA: Humoral factors in very young NZB mice that enhance the maturation of normal B cell precursors. Partial Purification and characterization. J Immunol 135:1891-1899, 1985.
    

25. 
    Jyonouchi H, Voss RM, and Good RA: IL-1 like activities present in murine amniotic fluid. A significantly larger amount of IL-1 like activity is present in the amniotic fluid of autoimmune NZB mice. J Immunol 138:3300-3307, 1987.
    

26. 
    Jyonouchi H, Voss RM, and Good RA: The presence of autoantibodies specific for NZB serum factors in adult NZB mice and the establishment of monoclonal antibodies against these humoral factors. Cell Immunol 113:158-174, 1988.
    

27. 
    Jyonouchi H, Voss RM, and Good RA: Up-regulation and down-regulation of cell surface and mRNA expression of CD5 antigen by various humoral factors on murine 70Z/3 pre-B cell leukemia cell line. IL-4 down-regulates CD5 antigen expression. Cell Immunol 130, 66-78, 1990.
    

28. 
    Jyonouchi H, Voss RM, and Good RA: NZB serum factor (NZB-SF): B precursor cell maturation factor identified in murine lupus. I. Identification of 60-kDa glycoprotein as the major component from both spleen cell supernatant and serum. Cell Immunol 132:223-235, 1991.
    

29. 
    Jyonouchi H, Voss RM, and Good RA: NZB serum factor (NZB-SF) - B precursor cell maturation factor: II, In vivo effects of NZB-SF or mAb against NZB SF on B lineage cell population. J Clin Immunol Immunopathol 59:388-397, 1991.
    

30. 
    Jyonouchi H, Voss RM, Krishna S, Urval K, Sjahli H, Welty PB, and Good RA: Soluble Fce R II levels in normal children and patients with immunodeficiency diseases. J Allergy Clin Immunol 87:965-970, 1991.
    

31. 
    Jyonouchi H, Hill RJ, Tomita Y, and Good RA: Studies of immunomodulating actions of carotenoids. I. Effects of b-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system. Nutr Cancer 16:93-105, 1991.
    

32. 
    Jyonouchi H, Voss RM, and Good RA: Zn depletion modifies CD5 expression by 7OZ/3 murine pre-B leukemia cell line. Proc Soci Exp Biol Med 198:818-825, 1991.
    

33. 
    Jyonouchi H, Hill RJ, and Good RA: RNA/nucleotides enhances antibody production in vitro and is moderately mitogenic to murine spleen lymphocytes. Proc Soci Exp Biol Med 200:101-108, 1992.
    

34. 
    Jyonouchi H, Zhang L, and Tomita Y: Studies of Immunomodulating Actions of Carotenoids. II. Astaxanthin enhances in vitro antibody production to T-dependent antigens without facilitating polyclonal B cell activation. Nutr Cancer 19:269-280, 1993.
    

35. 
    Jyonouchi H, Zhang L, and Tomita Y: Studies of immunomodulating actions of RNA/nucleotides. RNA/nucleotides enhance in vitro Ig production by human peripheral blood mononuclear cells in response to T dependent stimuli. Ped Res 33:458-465, 1993.
    

36. 
    Jyonouchi H, Zhang L, Georgieff M, and Tomita Y: Immunomodulating actions of nucleotides. Enhancement of Ig production by human cord blood lymphocytes. Ped Res 34:565-571, 1993
    

37. 
    Jyonouchi H, Hill RJ, Voss RM, and Ishii E: Immunomodulating actions of RNA and nucleotides on murine lymphocytes in vitro. Augmentation of antibody production to T dependent antigens and expansion of T helper cells. J Nutr Immunol 2(2):5-24, 1993.
    

38. 
    Tomita Y, Jyonouchi H, Engelman R, Day NK, and Good RA: Preventive action of carotenoids on the development of autoimmunity in MRL-lpr/lpr mice. J Autoimmunity 16:95-102, 1993.
    

39. 
    Jyonouchi H, Zhang L, and Tomita Y: RNA/nucleotides enhance in vitro antibody and immunoglobulin production to T-dependent antigen but do not facilitate polyclonal B cell activation in both normal and autoimmune-prone NZB strains of mice. J Nutr Immunol 2 (3): 5-22, 1993.
    

40. 
    Jyonouchi H, Zhang L, Gross M, and Tomita Y.: Immunomodulating actions of carotenoid: Enhancement of in vivo and in vitro antibody (Ab) production to T-dependent antigens (TD-Ag). Nutr Cancer 21:47-58, 1994.
    

41. 
    Jyonouchi H: Nucleotide actions on humoral immune responses. J Nutr 124:138S-143S, 1994.
    

42. 
    Loechelt BJ, Egeler M, Filipovich AH, Jyonouchi H, and Shapiro RS: Immunosuppression: an alternative maintenance therapy for familial hemophagocytic lymphohistiocytosis (FEL). Med Ped Oncol 22:325-328, 1994.
    

43. 
    Jyonouchi H, Zhang L, Tomita Y, and Yokoyama H: Nucleotide-free diet impairs T-helper cell functions for antibody production in normal C57Bl/6 mice. J Nutr 124: 475-484, 1994.
    

44. 
    Jyonouchi H, Sun S, and Gross MD: Biological actions of carotenoids: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro Ig production by human peripheral blood mononuclear cells. Nutr Cancer 23:171-183, 1995
    

45. 
    Jyonouchi H, Zhang L, Sun S, and Yokoyama H: Polynucleotides can compensate for impaired T-dependent antibody production induced by a nucleotide-free diet both in vivo and in vitro in C57Bl/6 mice, but mononucleotide/nucleoside mixture (OGVI) is effective only in vivo. J. Nutr. 125:1578-1586, 1995
    

46. 
    Jyonouchi H, Sun S, Tomita Y, and Gross MD: Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses with T-helper clones in response to suboptimal Ag challenges. J. Nutr. 125:2483-2492, 1995.
    

47. 
    Jyonouchi H, Sun S, Goodman D, Yokoyama H, and Sato S: Dietary fatty acid modulates actions of nucleotides on humoral immune responses. Nutrition 11:437-443, 1995.
    

48. 
    Jyonouchi H, Sun S, and Tomita Y: Actions of ß-carotene on T-helper cell functions for antibody production. J. Nutr. Immunol. 3 (4): 21-34, 1995.
    

49. 
    Jyonouchi H and Sun S.: Effects of Orally supplemented mononucleotide mixture on T-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet. J. Nutr. 126:1586-1593, 1996.
    

50. 
    Jyonouchi H, Sun S, and Sato S: A nucleotide-free diet suppresses antigen-driven cytokine production by primed T cells: effects of supplemental nucleotides and dietary fatty acids. Nutrition 12: 608-615, 1996.
    

51. 
    Jyonouchi H, Sun S, Mizokami M, and Gross MD: Effects of Various Carotenoids on Cloned, Effector-stage T-helper Cell Activity. Nutr. Cancer 26:313-324, 1996
    

52. 
    Jyonouchi H and Sun S: The actions of polynucleotides on effector stage cloned T-helper cells differ in each T-helper cell subset and depend on antigen concentration. J. Nutr. 127:411-417, 1997.
    

53. 
    Jyonouchi H, Sun S, Mizokami M, and Ingbar DH: Cell density and antioxidant vitamins determine the effects of hyperoxia on proliferation and death of MDCK epithelial cells. Nutr Cancer 28:115-124, 1997.
    

54. 
    Jyonouchi H, Sun S, Kennedy CA, Kajander, KC, and Rimell FL: IgG antibody levels in the sinus, ear, and airway in a rabbit model of sinusitis with Bacteroides Archives of Otolaryngology-Head and Neck Surgery. 124:767-772, 1998
    

55. 
    Jyonouchi H, Sun S, Chareancholvanich S, and Ingbar DH: The effects of hyperoxic injury and antioxidant vitamins on death and proliferation of human small airway epithelial cells. Am. J. Resp. Cell Mol. Biol. 19:426-436, 1998.
    

56. 
    Jyonouchi H, Sun S, Iijima K., Wong M., and Hecht, SS.: Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. Carcinogenesis. 20: 139-145, 1999.
    

57. 
    Kennedy CA, Jyonouchi H, Kajander KC, Sun S, and Rimell FL: Middle ear changes associated with chronic anaerobic sinusitis in rabbits. Laryngoscope 109: 498-503, 1999.
    

58. 
    Jyonouchi H, Sun S, Kennedy CA, Roche A, Kajander KC, Miller J, Germaine G, , and Rimell FL: The localized sinus inflammation in a rabbit sinusitis model induced by Bacteroides fragilis is accompanied by rigorous immune responses. Otolaryngology-Head and Neck Surgery. 120: 869-875, 1999.
    

59. 
    Iijima K, Sun S, Cyong JC, and Jyonouchi H: Juzen-Taiho-To, a Japanese herbal medicine, modulates type 1 and type 2 T cell responses in old BALB/c mice. Am J Chinese Med 17:191-203, 1999.
    

60. 
    Jyonouchi H. Airway Epithelium and apoptosis. Apoptosis 4:407-417, 1999.
    

60. 
    Jyonouchi H, Sun S, Iijima K, and Gross MD: Anti-tumor activity of astaxanthin and its mode of action. Nutr. Cancer 36: 59-65, 2000.
    

60. 
    Jyonouchi H, Sun S, and Rimell FL: Cytokine production by sinus lavage, bronchial lavage, and blood mononuclear cells in chronic sinusitis with or without atopy. Archives of Otolaryngology-Head and Neck Surgery 126: 522-528, 2000
    

60. 
    Jyonouchi H, Sun S, Kennedy CA, and Rimell FL: Interferon- levels in the sinus, ear, and airway in a rabbit sinusitis model induced by Bacteroides inoculation. Archives of Otolaryngology-Head and Neck Surgery 126: 529-532, 2000
    

60. 
    Jyonouchi H, Sun S, Abiru T, Whinship, T, and Kuchan, MJ: Dietary nucleotides modulate antigen-specific type 1 and type 2 T cell responses in young C57BL/6 mice. Nutrition 16: 442-446, 2000.