Supporting Information (SI) Diet-induced over-expression of flightless-i protein and its relation to flightlessness in Mediterranean fruit fly



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Supporting Information (SI)
Diet-induced over-expression of flightless-I protein and its relation to flightlessness in Mediterranean fruit fly, Ceratitis capitata
Il Kyu Cho1, Chiou Ling Chang2 and Qing X. Li1*
1 Department of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, Hawaii, USA.

2 U.S. Pacific Basin Agricultural Research Center, Hilo, Hawaii, USA.
Table S4 A list of 233 under-expressed proteins in pupae B whose adult flies showed a low flight rate. The LC-MS/MS data were matched with Drosophila melanogaster database via MASCOT for the sequence alignments.

No.

Protein names

No. of matched peptides

Mascot Scores (p=0.05)

Accession numbers

Biological functions

1

Bifunctional arginine demethylase and lysyl-hydroxylase PSR

5

70 (33)

Q9VD28

Dioxygenase

2

Neuropathy target esterase sws

5

62 (33)

B3NY03

Neurogenesis/Endoplasmic reticulum

3

Interference hedgehog

5

61 (33)

B4GKZ8

Smoothened signaling pathway

4

Protein split ends

9

63 (26)

Q8SX83

Wnt receptor signaling pathway

5

Serine/threonine-protein kinase PLK4

4

57 (33)

O97143

Centriole replication

6

Histone H1

8

54 (33)

P02255

Nucleosome assembly

7

Protein KIAA0664

4

53 (33)

B4GAM1

KIAA0664/TIF31 family.c

8

G protein-coupled receptor kinase 1

4

35 (29)

P32865

Specifically phosphorylates the activated forms of G protein-coupled receptors

9

Protein cubitus interruptus

4

51 (33)

P19538

Cuticle pattern formation

10

Protein lin-54

5

49 (33)

A1Z9E2

Adult lifespan

11

Protein daughter of sevenless

3

47 (33)

Q9VZZ9

signaling from various receptor tyrosine kinases such as Sevenless

12

Protein disks lost

2

46 (33)

Q8T626

Cellular process

13

RNA-binding protein orb2

3

46 (33)

Q9VSR3

Long-term memory

14

Axin

5

46 (33)

Q9V407

Wnt signaling pathway

15

Eukaryotic translation initiation factor 3 subunit B

3

54 (33)

B4J6D5

Protein biosynthesis

16

Eukaryotic translation initiation factor 3 subunit D-2

5

44 (33)

B4QT07

Protein biosynthesis

17

Origin recognition complex subunit 2

4

44 (33)

Q24168

DNA replication/nucleus

18

Tyrosine-protein phosphatase corkscrew

3

44 (33)

Q24708

Protein amino acid dephosphorylation

19

Myosin heavy chain, non-muscle

6

43 (33)

Q99323

Malpighian tubule morphogenesis

20

Negative elongation factor E

2

43 (33)

Q95ZE9

Transcription regulation/Nucleus

21

DNA polymerase subunit gamma-1

4

42 (33)

Q27607

DNA replication

22

Histone-lysine N-methyltransferase, H3 lysine-79 specific

5

54 (33)

Q8INR6

Chromatin silencing at telomere

23

Cell division cycle 2-like protein kinase CG7597

4

41 (33)

Q9VP22

Protein amino acid phosphorylation

24

Diacylglycerol kinase 1

5

41 (33)

Q01583

Activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

25

Nucleolar protein 14

3

40 (33)

Q9VEJ2

Ribosome biogenesis/rRNA processing

26

Protein sickie

8

73 (33)

Q9VIQ9

Immune response/Innate immunity

27

Histone-lysine N-methyltransferase Mes-4

4

39 (33)

Q8MT36

Histone methyltransferase

28

Inhibitor of nuclear factor kappa-B kinase

2

39 (33)

Q9VEZ5

Immune response/Innate immunity

29

Tyrosine-protein phosphatase corkscrew

3

39 (33)

P29349

Epidermal growth factor receptor signaling pathway

30

La-related protein CG11505

5

39 (33)

Q9I7T7

RNA binding

31

Conserved oligomeric Golgi complex

3

38 (33)

Q9VJD3

Differentiation

32

Dual specificity mitogen-activated protein kinase kinase hemipterous

2

38 (33)

Q23977

JNK (c-Jun N-terminal kinase) cascade

33

Centaurin-gamma-1A

12

37 (33)

Q9NGC3

Regulation of ARF GTPase activity

34

Protein aurora borealis

2

37 (33)

Q9VVR2

Cell cycle

35

Glutamate dehydrogenase

2

37 (33)

P54385

NADH oxidation

36

Circadian locomoter output cycles protein kaput

2

36 (33)

O61735

Behavioral response to cocaine

37

Homeotic protein female sterile

4

36 (33)

P13709

Multicellular organismal development

38

Kinesin heavy chain

2

36 (33)

P17210

Axon cargo transport/microtubule

39

Eukaryotic translation initiation factor 3

5

35 (33)

B3LZN3

Protein biosynthesis

40

Protein spire

3

35 (33)

Q29KT5

Multicellular organismal development

41

Polycomb protein Su(z)12

4

40 (33)

Q9NJG9

Dendrite morphogenesis

42

RRP12-like protein

4

38 (33)

Q9VYA7

Phosphoprotein

43

Cyclic AMP response element-binding protein A

2

34 (33)

P29747

Chitin-based larval cuticle pattern formation

44

Transcription-associated protein 1

5

42 (33)

Q8I8U7

Transcription regulation

45

Host cell factor

2

34 (33)

Q9V4C8

Cell cycle

46

Serrate RNA effector molecule

3

34 (33)

Q9V9K7

RNA-mediated gene silencing

47

Histone-lysine N-methyltransferase ash1

7

70 (33)

Q9VW15

Chromatin-mediated maintenance of transcription

48

Exocyst complex component 6

5

67 (33)

Q9VDE6

Exocytosis/cytoplasmic vesicle

49

Protein three rows

5

61 (33)

P42286

Cell cycle

50

Integrin alpha-PS4

7

56 (33)

Q9V7A4

Cell adhesion

51

Exostosin-1 (Protein tout-velu)

9

54 (33)

Q9V730

Wnt signaling pathway

52

Cell cycle regulator Mat89Bb

4

52 (33)

B4QX59

Cell cycle/regulation of mitotic cell cycle

53

Poly(A) RNA polymerase gld-2 homolog B

6

52 (33)

Q9VYS4

mRNA processing

54

Spastin

5

51 (33)

B4G437

Cell cycle

55

Serine protease nudel

6

51 (33)

P98159

Toll signaling pathway

56

FACT complex subunit spt16

5

51 (33)

Q8IRG6

Transcription regulation

57

Protein lava lamp

13

35 (33)

Q8MSS1

Cellularization/Golgi apparatus

58

Cyclin-T

4

49 (33)

O96433

Actin filament organization

59

Dual specificity tyrosine-phosphorylation-regulated kinase 2

5

49 (33)

Q9V3D5

Olfactory behavior

60

Lysine-specific demethylase lid

5

48 (33)

Q9VMJ7

Histone H3-K4 demethylation

61

Lateral signaling target protein

3

47 (33)

B4IC49

Negative regulator of epidermal growth factor receptor (EGFR) signaling

62

Myosin heavy chain 95F

5

46 (33)

Q01989

Actin cytoskeleton organization

63

Protein suppressor of variegation 3-7

2

33 (32)

P20193

Dose-limiting factor in position-effect variegation

64

Proteasome-associated protein ECM29

7

70 (26)

Q9V677

Protein catabolic process

65

Uncharacterized protein CG31531

5

44 (33)

Q0KIC3

Not known

66

Glutamate [NMDA] receptor

3

43 (33)

B4KD90

Ion transport

67

Caprin

11

42 (33)

Q9I7D3

Monolayer-surrounded lipid storage body

68

Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase GL17147

3

42 (33)

B4GGF2

Protein deglycosylation

69

Homeobox protein extradenticle

3

42 (33)

P40427

Transcription

70

Kinesin-like protein CG14535

6

42 (33)

Q9VLW2

Microtubule-based movement

71

GDP-fucose transporter

2

41 (33)

Q9VHT4

Sugar transport/Golgi apparatus

72

Pituitary homeobox 1

12

41 (33)

O18400

Transcription

73

Protein furry

7

40 (33)

Q9VT28

Transcription regulation/Phosphoprotein

74

Gamma-aminobutyric acid receptor alpha-like

4

40 (33)

Q24352

Ion transport

75

Sodium- and chloride-dependent GABA transporter ine

3

39 (33)

Q9VR07

Differentiation/Neurogenesis

76

Protein tramtrack, alpha isoform

6

30 (29)

P42282

Transcription regulation


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