Unique Identifier 10994901 Medline Identifier 20448367 Authors Sevick MA. Bradham DD. Muender M. Chen GJ. Enarson C. Dailey M. Ettinger WH Jr. Institution Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA. msevick@wfubmc.edu Title Cost-effectiveness of aerobic and resistance exercise in seniors with knee osteoarthritis. Source Medicine & Science in Sports & Exercise. 32(9):1534-40, 2000 Sep. Abstract PURPOSE: The purpose of this study was to determine, in a randomized clinical trial of 439 individuals with knee osteoarthritis, the incremental cost-effectiveness of aerobic versus weight resistance training, compared with an education control intervention. METHODS: Cost estimates of the intervention were based upon the cost of purchasing from the community similar services to provide exercise or health education. Effect at 18 months was measured using several variables, including: self-reported disability score, 6-min walking distance, stair climb, lifting and carrying task, car task, and measures of pain frequency and pain intensity on ambulation and transfer. RESULTS: The total cost of the educational intervention was $343.98 per participant. The aerobic exercise intervention cost $323.55 per participant, and the resistance training intervention cost $325.20 per participant. On all but two of the outcome variables, the incremental savings per incremental effect for the resistance exercise group was greater than for the aerobic exercise group. CONCLUSION: The data obtained from this study suggest that, compared with an education control, resistance training for seniors with knee osteoarthritis is more economically efficient than aerobic exercise in improving physical function. However, the magnitude of the difference in efficiency between the two approaches is small. <36> Unique Identifier 11427782 Medline Identifier 21320891 Authors Vuori IM. Institution UKK Institute for Health Promotion Research, Tampere, Finland. ilkka.vuori@uta.fi Title Dose-response of physical activity and low back pain, osteoarthritis, and osteoporosis. [Review] [269 refs] Source Medicine & Science in Sports & Exercise. 33(6 Suppl):S551-86; discussion 609-10, 2001 Jun. Abstract PURPOSE: The purpose of this study was to examine the evidence for causal relationships between physical activity (PA) and low back pain (LBP), osteoarthritis (OA), and osteoporosis (OP), and for dose-response relations involved. METHODS: Computer database searches and personal retrieval systems were used to locate relevant literature. RESULTS: PA can be effective in preventing LBP (Category A) but prolonged, heavy loading can lead to LBP (Category C). Specific exercises have not been found effective in treatment of acute LBP (Category A), but PA can be effective in chronic LBP (Category B), especially for diminishing the effects of deconditioning. No evidence indicates that PA directly prevents OA. Large amounts of intensive PA involving high impacts or torsional loadings or causing injuries increases risk of OA (Category C). Light or moderate PA does not increase the risk of OA (Category C). PA can be effective in the treatment and rehabilitation of OA (Category B). High-intensity loading is osteogenic and possibly useful in prevention of OP (Category A) at the loaded site, but low to moderate loading is not osteogenic (Category D). Static efforts and slow movements are ineffective or less effective than fast application of force (Category B). The types of PA to attain the effects mentioned above are known except in the case of prevention of LBP, but dose-response relationships are poorly known; at best, semiquantitatively on the basis of just a few studies. CONCLUSION: Given the shown primary and/or secondary preventative effectiveness of PA regarding LBP, OA, and OP, research to elucidate the inadequately known dose-response relations should be given high priority. [References: 269] <37> Unique Identifier 10673576 Medline Identifier 20139578 Authors Sharkey NA. Williams NI. Guerin JB. Institution Associate Professor, Center for Locomotion Studies and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802-5702, USA. nas9@psu.edu Title The role of exercise in the prevention and treatment of osteoporosis and osteoarthritis. [Review] [68 refs] Source Nursing Clinics of North America. 35(1):209-21, 2000 Mar. Abstract Osteoporosis and osteoarthritis are two distinctly different rheumatic conditions that target elderly, primarily female, populations. This article examines the scientific evidence supporting the use of exercise as a specific therapeutic modality, the general physiologic and psychological benefits of exercise, and the exercise programs currently recommended to combat these prevalent musculoskeletal disorders. Exercise is a valuable adjunct to treatment programs aimed at alleviating the risks and symptoms of osteoporosis and osteoarthritis. In addition to its potential impact on the disease processes themselves, exercise improves general health and well being, enhances quality of life, and preserves physical independence. [References: 68] <38> Unique Identifier 10989515 Medline Identifier 20444658 Authors O'Grady M. Fletcher J. Ortiz S. Institution Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. mogrady@emory.edu Title Therapeutic and physical fitness exercise prescription for older adults with joint disease: an evidence-based approach. [Review] [137 refs] Source Rheumatic Diseases Clinics of North America. 26(3):617-46, 2000 Aug. Abstract Aging with joint disease does necessarily result in chronic pain, adoption of a sedentary lifestyle, and functional dependency. Several randomized controlled trials clearly show that regular exercise does not exacerbate pain or accelerate disease progression. On the contrary, these studies suggest that exercise training may increase the physiologic reserve and reduce the risk for functional dependency in older adults with joint disease. The goals for an exercise program should be directed toward increasing flexibility, muscle strength, endurance, and cardiovascular fitness. An exercise training program that is tailored specifically to an older adult's physical limitations may achieve these goals, and by optimizing patient safety lead to improve long-term exercise compliance. [References: 137] <39> Unique Identifier 10356425 Medline Identifier 99284913 Authors Minor MA. Institution Department of Physical Therapy, School of Health Related Professions, School of Medicine, University of Missouri, Columbia, USA. minorm@missouri.edu Title Exercise in the treatment of osteoarthritis. [Review] [64 refs] Source Rheumatic Diseases Clinics of North America. 25(2):397-415, viii, 1999 May. Abstract Exercise, both therapeutic and recreational, is an effective therapy in successful management of osteoarthritis. Exercise is integral in reducing impairment, improving function, and preventing disability. Benefits of flexibility, muscular conditioning, and cardiovascular exercise and the role of regular physical activity in maintaining general health are discussed. Exercise recommendations and safety considerations are provided. [References: 64] <40> Unique Identifier 11426016 Medline Identifier 21319587 Authors Pool AJ. Axford JS. Institution Academic Unit for Musculoskeletal Disease, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK. Title The effects of exercise on the hormonal and immune systems in rheumatoid arthritis. Source Rheumatology. 40(6):610-4, 2001 Jun. <41> Unique Identifier 11886964 Medline Identifier 21884536 Authors Bearne LM. Scott DL. Hurley MV. Institution Physiotherapy Division, School of Biomedical Sciences, Guy's, King's and St Thomas' School of Medicine, King's College London, London, UK. Title Exercise can reverse quadriceps sensorimotor dysfunction that is associated with rheumatoid arthritis without exacerbating disease activity. Source Rheumatology. 41(2):157-66, 2002 Feb. Abstract OBJECTIVES: To compare quadriceps sensorimotor function, lower limb functional performance and disability in patients with rheumatoid arthritis (RA) and healthy subjects, and to investigate the efficacy and safety of a brief rehabilitation regime. METHODS: Quadriceps strength, voluntary activation, proprioceptive acuity and the aggregate time [aggregate functional performance time (AFPT)] taken to perform four common activities [aggregate functional performance time (AFPT)] were compared between 103 RA patients who had lower limb involvement and 25 healthy subjects. In addition, disability (Health Assessment Questionnaire), clinical disease activity and the plasma concentration of proinflammatory cytokines were measured in the RA patients. In a follow-on randomized controlled trial of rehabilitation, these variables were used as baseline data for 93 of the RA patients, who were randomized to a rehabilitation or a control group. Changes in the variables were analysed within and between groups. RESULTS: Compared with healthy subjects, RA patients had weaker quadriceps [mean difference 157 N; 95% confidence interval (CI) 125-189], poorer activation (8%, 95% CI 4.5-15) and proprioceptive acuity (0.8 degrees, 95% CI 0.4-1.3) and took longer to perform the AFPT (34 s, CI 23.5-44.8). Rehabilitation increased quadriceps strength (mean increase 61 N, 95% CI 28-95) and voluntary activation (8%, 95% CI 3-12.4) and decreased the AFPT (12.3 s, 95% CI -2 to 27.7) and subjective disability (0.21 HAQ points, 95% CI 0-0.35) without exacerbating disease activity. All the improvements were maintained at the 6-month follow-up. There was no change during the control period. CONCLUSIONS: Patients with RA that affected their lower limb had quadriceps sensorimotor deficits that were associated with lower limb disability. A clinically applicable rehabilitation regime increased quadriceps sensorimotor function and decreased lower limb disability without exacerbating pain or disease activity. For patients with well-controlled RA that causes lower limb involvement, the regime is effective and safe. 41>40>39>38>37>36>
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