HangYing Dong 8851 n oracle Rd. Ap

Working Experience and Professional Activities

Informatics/IS  ActivityBase administrator, responsible for

Application Specialist protocols/templates design and implementation for

Aventis lead discovery data management in both HTS and LTS Pharmaceuticals databases.

Tucson, AZ  Close collaboration with chemists and lead discovery

biologists to identify key requirements for automated

data capture, quality control, result analysis and

sharing data globally across projects.

• 
  Daily problem solving, user training and
  

Informatics Research  Large cheminformatics database (IDBS ActivityBase) Scientist administrator, responsible for database setup, Computational Drug maintenance, trouble-shooting and customization.

Discovery  Assay protocol design and implementation for efficient

Exelixis, Inc. scientific data management, including automatic data

South San Francisco, import into the database, quality control, appropriate CA data analysis and result interpretation. Have designed

UHTS, HTS and other standard protocols for High

Throughput Screening, Dose-response IC50/EC50 measurements(including curve fitting), In vitro ADMET, In vivo PK/ADME and Efficacy assays.

• 
  Close collaboration with chemists and new leads
  

development by adding Excel Macros and the other web

based applications.

• 
  Structure-Activity report generation, data mining and
  

• 
  Web based application development for data analysis
  

• 
  Internal informatics user training and daily problem
  

evaluate, deploy and test new software, databases and

other informatics tools for new needs.


08/1999 – 08/2000

Software Engineer  Oracle database administrator and server application

IBM AIX RS/6000 developer using Oracle PL/SQL Web Toolkit. Web based

Server Group, IBM reporting system development for users to get info

Austin, TX from databases on the web.

 AIX Program product build and packaging.

Software Engineer  Sequence analysis software development (LaserGene,

Madison, WI SeqMan II) for genetic research on Windows and Apple

DNASTAR Inc. Macintosh platforms using C programming language.

Software Engineer  Established test suites using MUMPS programming

Sanchez Computer language and Shell scripts for testing various

Associates, Inc. features of GT.M database system (a Greystone

Malvern, PA Technology Corporation's implementation of standard

MUMPS for UNIX and VAX/VMS systems) in UNIX and

VMS platforms.

11/1994 – 01/1999

Assistant Researcher  Research projects: "Regulation of tumor cell kinetics

Lab Manager using in vitro and in vivo models". Study on a series

Clinical Science Ctr. of kinetics parameters, such as Tumor Potential

University of Doubling Time (Tpot), Length of S phase (Ts),

Wisconsin at Madison Ki-67, AgNOR, for providing useful estimators of

intra-treatment tumor proliferation capacity. The

parameters were determined using in situ labeling of

tumor DNA with halogenated pyrimidines followed by

flow cytometric analysis, silver or immunostaining

methods.

• 
  Responsible for experiment design, supervising, assay
  

Research Assistant  Ph.D thesis study on mechanisms of cytotoxicity and

INSERM U.139 DNA damage induced by asbestos and other chemicals Environmental using in vivo and in vitro models.

Toxicology

Créteil, France

Education

May 1999 Master’s Degree in Computer Sciences, GPA 3.9

University of Wisconsin – Madison
May 1994 Ph.D. in Cell Biology and Molecular Toxicology

University of Paris XII, Créteil, France

Nanjing Medical College, P.R China

Nanjing Medical College, P.R China

Computer technical skills

Programming C/C++, Java, Python, VB/VBA, MUMPS, PL/SQL, QBE, UNIX Shell

Languages: (C Shell and KornShell), PERL, HTML, XML, JavaScript, Excel programming
Platforms: SUN/AIX/HP UNIX Workstations, X Window, VAX/VMS,

LINUX, Windows NT/2000 and Macintosh Programming

Bioinformatics BLAST, sequence alignment, contig assembly, primer design,

Tools: LIMS, Phred, Phrap, DANStar SegMan II, LaserGene

Cheminformatics MDL ISIS database, IDBS ActivityBase, SARgen, Scitegic

Tools: Pipeline Pilot, Spotfire, XLFit

OTHER Programming Projects

Database  Implemented Buffer Manager (manages buffer pool), Heap

Projects: File Manager, B+ Trees, Sort Merge Join on a DBMS in C++.  Designed and implemented Disk Space Manager (allocation

and deallocation of pages within a database), Buffer

Manager, Heap File Manager on a DBMS in Java.
Operating System  Developed protocols for interprocess communication and

Projects: synchronization using pipes, semaphores in C++.

 Simulated and evaluated different page replacement

algorithms using real memory trace data from UNIX systems

in C++.

 Measured kernel performance using extended lmbenchmark

in C.

 Developed a prefetching protocol for Web access streams by aged probability graphs in C.

 Designed a parallel workload generator, an analyzer and a

cpu scheduler for a parallel computer with a graphic user

interface in Java.
Networking  Developed a Client-Server protocol with UDP as its Projects: transport layer protocol using BSD Socket and Posix thread

in C.

 Built a reliable transport layer protocol over a

virtual-circuit(VC) based network layer protocol in C++.

File Transfer Application (FTP) was linked to protocols

Which supported reliable file transfers between nodes

across an unreliable network.

Publications

Dong HY, Saint-Etienne L, Renier A, Billon-Galland MA, Brochard P and Jaurand MC. Air samples from a building with asbestos containing material: Asbestos content and in vitro toxicity on rat pleural mesothelial cells. Fundamental and Applied Toxicology, 22:178-185, 1994.

Dong HY, Buard A, Renier A, Saint-Etienne L and Jaurand MC. Role of oxygen derivatives in the cytotoxicity and DNA damage produced by asbestos on rat pleural mesothelial cells in vitro. Carcinogenesis, 15:1251-1255, 1994.
Dong HY, Yegles M, Renier A, Bignon J and Jaurand MC. Cytotoxic and genotoxic effects of vitreous microbeads with different iron content on rat pleural mesothelial cells in culture. ILSI (International Life Sciences Institute) Series, Eds by Mohr,U.; Dungworth,D.L.; Oberdorester,G. In: Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI Press, Washington D.C., p.419-422, 1994.
Dong HY, Buard A, Levy F, Renier A, Laval F and Jaurand MC. Synthesis of poly(ADP-ribose) in asbestos-treated rat pleural mesothelial cells in culture. Mutation Research, 331:197-204, 1995.
Dong HY, Bertler C, Schneider E and Ritter MA. Assessment of cell proliferation by AgNOR scores and Ki-67 labeling indices and a comparison with potential doubling times. Cytometry, 28:280-288, 1997.

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