Immune System
Session 27
Supplemental Instruction
Iowa State University
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Leader:
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Ivy
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Course:
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AnS 214
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Instructor:
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Keating
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Date:
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4/7/11
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COMPLEMENT:
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What part of the immune system (innate, adaptive) is complement a part of?
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What are the major functions of complement?
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Compare the two pathways in which complement is activated:
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Classical Pathway
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Alternative Pathway
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Activated by…
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Results in…
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What is the major function of the following components of complement?
C3a:
C3b:
MAC:
FEVER:
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T/F: Fever is always a dangerous thing for the human body.
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What are the benefits of fever?
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What are the dangers of a high fever?
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What are responsible for resetting the body’s thermostat upward?
Where do these come from?
ADAPTIVE IMMUNITY (general):
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What are the 3 key characteristics of the adaptive immune response?
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Name and define the two overlapping arms of adaptive immunity:
ANTIGENS:
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Compare the two types of antigens of the adaptive immune system:
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Complete Antigens
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Incomplete Antigens (Haptens)
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Immunogenic?
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React in response to…
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Examples
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What is an antigenic determinant?
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How are MHC proteins related to antigens?
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Where would you find Class I MHC proteins?
Where would you find Class II MHC proteins?
LYMPHOCYTES:
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Compare/contrast the two types of lymphocytes:
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B cells
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T cells
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Humoral or Cellular Immunity?
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Originate in…
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Mature in…
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Exported to…
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Major Functions
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In positive selection, what happens if the T cell recognizes the self-MHC?
In positive selection, what happens if the T cell fails to recognize the self-MHC?
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In negative selection, what happens if the T cell recognizes the self-antigen?
In negative selection, what happens if the T cell fails to recognize the self-antigen?
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What happens to self-reactive B cells?
ANTIGEN-PRESENTING CELLS:
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What is the function of APC’s?
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What are some examples of APC’s?
ANTIBODIES:
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Where do antibodies come from?
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What is the functional region of the antibody (recognize antigens)?
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What region of the antibody determines antibody class, binding, and antigen elimination?
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Name the 5 classes of antibodies and the major function for each:
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