Kai Wang, Ph. D. Dabt

Seattle, Washington 98103

Phone: 206-732-1336

kwang@systemsbiology.org

PROFESSIONAL EXPERIENCE:
2012-date: Principal Scientist

Institute for Systems Biology

Institute for Systems Biology

PhenoGenomics Corporation

Darwin Molecular Corp/Celltech Group PLC (Darwin Molecular was acquired by Celltech)

Department of Molecular Biotechnology

University of Washington
POSTDOCTORAL TRAINING:
1990-1992: Senior Research Fellow

Division of Biology

California Institute of Technology
1987-1990: Research Fellow

Division of Biology

California Institute of Technology
EDUCATION:
1987- Ph.D. Biochemistry

Oregon State University, Corvallis, Oregon

National Tsinghua University, Hsinchu, Taiwan

Chungyun Christian University, Chungli, Taiwan

• 
  First place in psoriasis category, 2012 Diagnostics Signature Challenge sponsored by Philip Morris International (PMI) and IBM Research.
  
• 
  Phase I SBIR grant from DOE with Femtogen (2005)
  
• 
  Northwest Cancer Partners “Development of a novel tubulin binding anticancer compound” (2004)
  
• 
  A research award from Taiwanese government “Identifying novel therapeutics from traditional Chinese Medicine” $2M (US dollar) (2003-2006)
  
• 
  Award from Celltech group for scientific discovery (2000)
  
• 
  Proctor and Gamble Fellowship (1987-1989)
  

“From the laboratory to leadership: Developing scientific and corporate leaders” by The Leadership Edge.

• 
  American Association for The Advancement of Science Member since 1990
  
• 
  Sigma Xi The Scientific Research Society Member since 1986
  

• 
  Diplomate, General Toxicology, The American Board of Toxicology (2007-date) - a highly competitive certification program in toxicology.
  
• 
  Board director, The Chinese Institute of Engineers/USA-Seattle chapter.
  
• 
  National council member, The Chinese Institute of Engineers/USA
  
• 
  Board director, LifeSpan Biosciences
  
• 
  Metabolomics:Open Access, an OMICS group journal, Editorial board member
  
• 
  Reviewer for various journals and funding agencies.
  

1. 
   Wang, K., and Pearson, G. D. (1985) Adenovirus sequences required replication in vivo. Nucl. Acids Res. 13 5173-5187.
   

2. 
   Lowry, R. P., Wang, K., Vernooij, B. and Harcus, D. (1989) Lymphokine transcription in vascularized mouse heart grafts: effect of 'tolerance' induction. Transplantation Proceedings 21 72-73.
   

3. 
   Wang, K., Xu, F. Y., Ahern, K. G. and Pearson, G. D. (1991) Inverted repeats direct repair of Adenovirus minichromosome ends. Virology 183 44-51.
   

4. 
   Ahern, K. G., Wang, K., Xu, F. Y., Mathews, C. Z. and Pearson, G. D. (1991) Strands hybridize in post-replicative Adenovirus overlap recombination. Proc. Natl. Acad. Sci. USA 88 105-109.
   

5. 
   Lai, E., Wang, K., Hood, L. and Avdalovic, N. (1991) Rapid restriction map constructions using a modified pWE15 cosmid vector and robotic workstation. BioTechniques 10 212-217.
   

6. 
   Hu, C. H., Xu, F. Y., Wang, K., Pearson, A. N. and Pearson, G. D. (1992) Symmetrical Adenovirus minichromosomes have hairpin replication intermediates. Gene 110 145-150.
   

7. 
   Koop, B. F., Wilson, R. K., Wang, K., Vernooij, B., Zaller, D., Kuo, C. L., Seto, D., Toda, M. and Hood, L. (1992) Organization, structure and function of 95kb of DNA spanning the murine T-cell receptor C and C region. Genomics 13 1209-1230.
   

8. 
   Laug, W. E., Wang, K., Mundi, R., Rideout, W., Kruithof, E. K. O. and Bogenmann, E. (1992) Clonal variation of expression of the genes coding for plasminogen-activators their inhibitors and the urokinase receptor in HT1080 sarcoma cells. Int. J. Cancer 52 298-304.
   

9. 
   Charmley, P., Wang, K., Hood, L. and Nickerson, D. L. (1993) Identification and physical mapping of a polymorphic human T-cell receptor V gene with a frequent null allele. J. Exp. Med. 177 135-143.
   

10. 
    Vernooij, B., Lenstra, J. A., Wang, K., and Hood, L. (1993) Organization of the murine T-cell receptor  locus. Genomics 17 566-574.
    

11. 
    Koop, B. F., Rowen, L., Wang, K., Kuo, C. L., Lenstra, J. A., Seto, D., Howard, S., Wei, S., Wilke, E. and Hood. L. (1994) The human T-cell receptor C/C region: Organization, sequence and evolution of 97.6kb of DNA. Genomics 19 478-493.
    

12. 
    Seto, D., Koop, B. F., Deshpande, P., Howard, S., Seto, J., Wilk, E., Wang, K., and Hood, L. (1994) Organization, sequence, and function of 34.5 kb of genomic DNA encompassing several murine T-cell receptor  variable gene segments. Genomics 20 258-266.
    

13. 
    Wang, K., Klotz, J. L., Kiser, G., Bristol, G., Hays, E., Lai, E., Gese, E. F., Kronenberg, M. and Hood, L. (1994) Organization of the V gene segments in mouse T-cell antigen receptor  locus. Genomics 20 419-428.
    

14. 
    Hood, L. Koop, B. F., Rowen, L. and Wang, K., (1994) Human and mouse T-cell receptor loci: the importance of comparative large-scale DNA sequence analyses. Cold Spring Harb. Symp. Quant. Biol. 58 339-348.
    

15. 
    Wang, K., Kuo, C. L., Cheng, K. C., Lee, M. K., Paeper, B., Koop, B. F., Yoo, T. J. and Hood, L. (1994) Structural analysis of the mouse T-cell receptor TCRAV2 subfamily. Immunogenetics 40 116-122.
    

16. 
    Wang, K., Koop, B. F. and Hood, L. (1994) A simple method using T4 DNA polymerase to clone polymerase chain reaction products. BioTechniques 17 236-238.
    

17. 
    Yoo, T. J., Lee, M. K., Min, Y. S., Chiang, H. J., Wang, K., Fujiyoshi, T., Watanabe, T., Krug, M. S., Seyer, J. and Cheng, K. C. (1994) Epitope specificity and T cell receptor usage in type II collagen induced autoimmune ear disease. J. cell Immunol. 157 249-262.
    

18. 
    Wang, K., Kuo, C. L., Koop, B. F. and Hood, L. (1994) The expression of mouse T-cell receptor TCRDV genes in BALB/c spleen. Immunogenetics 40 271-279.
    

19. 
    Huang, G. M., Wang, K., Kuo, C. L., Paeper, B. and Hood, L. (1994) A high throughput plasmid DNA preparation method. Anal. Biochem. 223 35-38.
    

20. 
    Wang, K., Gan, L., Boysen, C. and Hood, L. (1995) A microtiter plate based high throughput DNA purification method. Anal. Biochem. 226 85-90.
    

21. 
    Roach, J. C., Boysen, C., Wang, K., and Hood, L. (1995) Pairwise end sequencing: A unified approach to genomic mapping and sequencing. Genomics 26 345-353.
    

22. 
    Wang, K., Gan, L., Lee, I. Y. and Hood, L. (1995) Isolation and characterization of the chicken trypsinogen gene family. Biochem. J. 307 471-479.
    

23. 
    Cheng, K. C., Chiang, H. J., Wang, K., Lee, M. K., Yoo, T. J. and Hood, L. (1995) Dominant usage of T-cell receptor a gene segments from one parent in experimental autoimmune encephalomyelitis induced in F1 mice. Ann. N. Y. Acad. Sci. 756 329-330.
    

24. 
    Yoo, T. J., Lee, M. K., Min, Y. S., Chiang, H. J., Wang, K., Fujiyoshi, T., Krug, M. S., Seyer, J. and Cheng, K. C. (1995) Comparison of epitope specificity and T-cell receptor usage in response to type II collagen immunization between H-2q and H-2r mice. Ann. N. Y. Acad. Sci. 756 215-216.
    

25. 
    Levy-Lahad, E., Wasch, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C. E., Jondro, P. D., Schmidt, S. D., Wang, K., Crowley, A. C., Fu, Y. H., Guenette, S. Y., Galas, D., Nemens, E., Wijsman, E. M., Bird, T. D., Schellenberg, G. D. and Tanzi, R. E. (1995) Candidate Gene for the chromosome 1 familial Alzheimer's disease locus. Science 269 973-977.
    

26. 
    Levy-Lahad, E., Poorkaj, P., Wang, K., Fu, Y. H., Oshima, J., Mulligan, J., and Schellenberg, G. D. (1996) Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene. Genomics 34 198-204.
    

27. 
    Wang, K., Gan, L. Kuo, C. L. and Hood, L. (1997) A highly conserved apoptotic suppressor gene is located near the chicken T-cell receptor alpha chain constant region. Immunogenetics 46 376-382.
    

28. 
    Wang, K., Boysen, C., Shizuya, H., Simon, M. I. and Hood, L. (1997) Complete nucleotide sequence of two generations of bacterial artificial chromosome (BAC) cloning vectors. BioTechniques 23 992-994.
    

29. 
    Cheng, K. C., Chiang, H. J., Wang, K., Krug, M. S., Yoo, T. J. and Hood, L. (1997) TCRV and TCRJ gene usage in MBP responding T-cells from (B10.PLxPL/J) F1 mice is biased toward that of B10.PL mice. J. Neuroimmunol. 80 13-22.
    

30. 
    Roach, J. C., Wang, K., Gan, L. and Hood, L. (1997) The molecular evolution of the vertebrate trypsinogens. J. Mol. Evol. 45 640-652.
    

31. 
    Nelson, P. S., Plymate, S. R., Wang, K., True, L. D., Ware, J. L., Gan, L., Liu, A. Y., and Hood, L. (1998) Hevin, an Antiadhesive Extracellular Matrix Protein, Is Down-Regulated in Metastatic Prostate Adenocarcinoma. Cancer Research 58 232-236.
    

32. 
    Kuo, C. L., Chen, M. L., Wang, K., Chou, C. K., Vernooij, B., Seto, D., Koop, B. F. and Hood, L. (1998) A conserved sequences block in murine and human TCR J region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors from tissues and lymphoid cell lines. Proc. Natl. Acad. Sci. USA 95 3839-3844.
    

33. 
    Lee, I. Y., Westaway, D., Smit, A., Wang, K., Seto, J., Chen, l., Acharya, C., Baskin, D., Cooper, C., Yao, H., Prusiner, S. B. and Hood, L. (1998) Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 8 1022-1037.
    

34. 
    Peter S. Nelson, Gan, L., Ferguson, C., Moss, P., Gelinas, R., Hood, L. and Wang, K., (1999) Molecular cloning and characterization of prostase, a novel androgen regulated serine-protease with prostate restricted expression. Proc. Natl. Acad. Sci. USA. 96 3114-3119.
    

35. 
    Wang, K., Gan, L., Jeffery, E., Gayle, M., Gown, A. M., Skelly, M., Nelson, P. S., Ng, W. V., Schummer, M., Hood, L. and Mulligan, J. (1999) Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray. Gene 229 101-108.
    

36. 
    Chun, T., Wang, K., Zuckermann, F. A. and Gaskins, H. R. (1999) Molecular cloning and characterization of a novel CD1 gene from the pig. J. Immunol. 162 6562-6571.
    

37. 
    Moore, R. C., Lee, I. Y., Silverman, G. L., Harrison, P. M., Strome, R., Heinrich, C., Karunaratne, A., Pasternak, S. H., Azhar Chishti, M., Liang, Y., Mastrangelo, P., W Wang, K., Smit, A. F. A., Katamine, S., Carlson, G. A., Cohen, F. E., Prusiner, S. B., Melton, D. W., Tremblay, P., Hood, L. E. Westaway, D. (1999) Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel. J. Mol. Biol. 292 797-817.
    

38. 
    Brewster, J. L., Martin, S. L., Toms, J., Goss, D., Wang, K., Zachrone, K., Davis, A., Carlson, G., Hood, L., and Coffin, J. D. (2000) Deletion of Dad 1 in mice induces an apoptosis-associated embryonic death. Genesis 26 271-278.
    

39. 
    Gan, L., Lee, I. Y., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B. and Wang, K., (2000) Sequencing and expression analysis of a serine protease gene cluster on chromosome 19q13 region. Gene 257 119-130.
    

40. 
    Wang, K., Gan, L., Kunisada, T., Lee, I. Y., Yamagishi, H. and Hood, L. (2001) Characterization of the Japanese pufferfish (Takifugu rubripes) T-cell receptor alpha locus revealed a unique genomic organization. Immunogenetics 53 31-42.
    

41. 
    Glusman, G., Rowen, L., Lee, I., Boysen, C., Roach, J. C., Smit, A. F. A., Wang, K., Koop, B. F. and Hood, L. (2001) Comparative genomics of the human and mouse T-cell receptor loci. Immunity 15 337-349.
    

42. 
    Ting, A. C., Lee, S. F. and Wang, K., (2003) A simple setup for double-slide microarray hybridization. BioTechniques. 35 808-10.
    

43. 
    Rowen, L., Williams, E., Glusman, G., Linardopoulou, E., Friedman, C., Ahearn M. E., Seto J., Boysen, C., Qin, S., Wang, K., Kaur, A., Hood, L. and Trask, B. J. (2005) Interchromosomal Segmental Duplications Explain the Unusual Structure of PRSS3, the Gene for an Inhibitor-Resistant Trypsinogen. Mol Biol Evol. 22 1712-1720.
    

44. 
    Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L. and Galas, D. J. (2009) Circulating microRNAs, a new class of blood biomarker for drug-induced liver injury. Proc. Natl. Acad. Sci. USA. 106 4402-4407
    

45. 
    Wang, K., Lee, I Y., Hood, L., and Galas, D. J. (2010) Systems Biology and Discovery of Diagnostic Biomarkers. Disease Markers 28 199-207
    

46. 
    Wang, K., Zhang, S., Weber, J., Baxter, D. and Galas, D. J. (2010) Export of microRNA and microRNA-protective protein by mammalian cells. Nucl. Acid Res. 38:7248-59
    

47. 
    Lee, L. W., Etheridge, A., Zhang S., Ma, L., Martin, D., Galas, D. J. and Wang, K. (2010) Complexity of the microRNA repertoire revealed by next-generation sequencing. RNA. 16:2170-80.
    

48. 
    Weber, J., Baxter, D., Zhang, S., Huang, K. H., Lee, M. J., Galas, D. J. and Wang, K. (2010) The microRNA spectrum in 12 body fluids. Clin Chem. 56:1733-41.
    

49. 
    Šípová, H., Zhang, S., Dudley, A.M., Galas, D., Wang, K., Homola, J. (2010) Surface Plasmon Resonance Biosensor for Rapid Label-Free Detection of Microribonucleic Acid at Subfemtomole Level. Anal Chem. 82:10110-10115.
    

50. 
    Vêncio, E. F., Pascal, L. E., Page, L. S., Gareth Denyer, G. Wang, A. J., Ruohola-Baker, H., Zhang, S., Wang, K., Galas, D. J. and Liu, A. Y. (2011) Embryonal carcinoma cell induction of miRNA and mRNA changes in co-cultured prostate stromal fibromuscular cells. J Cell Physiol. 226: 1479-1888
    

51. 
    Cho, J. H.^#, Gelinas, R.^#, Wang, K.^#, Etheridge, A., Piper, M. G., Batte, K., Brent, R., Price, J., Bornman, D., Zhang, S., Marsh, C., and Galas, D. J.(2011) Systems Biology of Interstitial Lung Diseases. BMC Med Genomics. 4:8.
    

52. 
    Moussay, E.^#, Wang, K.^#, Berchem, G., and Galas, D. J. (2011) Plasma microRNAs represent new biomarkers in B chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA. 108:6573-6578.
    

53. 
    Etheridge, A., Lee., I. Y., Hood, L. E., Galas, D., and Wang, K. (2011) Extracellular microRNA: a new source of biomarkers. Mutation Res. 717:85-90.
    

54. 
    Gelinas, R., Chesler, E. J., Vasconcelos, D., Miller, D. R., Yuan, Y., Wang, K., and Galas, D. J. A (2011) Genetic Approach to the Prediction of Drug Side Effects: Bleomycin Induces Concordant Phenotypes in Mice of the Collaborative Cross. Pharmacogenomics and Personalized Medicine. 4:35-45.
    

55. 
    Cho, J. H., Wang, K., and Galas, D. J. (2011) An integrative approach to construct biologically meaningful modules. BMC Systems Biology, 26:117-126.
    

56. 
    Ezzie, M. E., Crawford, M., Zhang, S., Cho, J. H., Gelinas, R., Batte, K., Yu, L., Nuovo, G., Galas, D. J., Philip Diaz, P., Wang, K., and Nana-Sinkam, S. P. (2012) Gene expression networks in COPD: microRNA and mRNA regulation. Thorax. 67:122-131.
    

57. 
    Lee, M. J., Gho, J. H., Galas, D. J., and Wang, K., (2012) The systems biology of neurofibromatosis type 1 – Critical roles for microRNA. Exp Neurol. 235:464-468.
    

58. 
    Wang, K., Yuan, Y., Cho, J. H., McClarty, S., Baxter, D., and Galas, D. J. (2012) Comparing the microRNA spectrum between serum and plasma. PLoS One. 7: e41561.
    

59. 
    Chen L. Y., Wei, K. C., Huang, A. C., Wang, K., Huang, C. Y., Yi D., Tang, C. Y., Galas, D. J. and Hood, L. E. (2012) RNASEQR--a streamlined and accurate RNA-seq sequence analysis program. Nucl. Acid Res. 40: e42.
    

60. 
    Wang, K., Li, H., Yuan, Y., Huang, D., Wilmes, P., and Galas, D. J. (2012) The complex exogenous RNA spectra in human plasma: an interface with human gut biota? PLoS One 7(12): e51009.
    

61. 
    Argyropoulos, C., Wang, K., McClarty, S., Huang, D., Bernardo, J., Ellis, D., Orchard, T., Galas, d., Johnson, J. (2013) Urinary MicroRNA profiling in the nephropathy of Type 1 Diabetes. PLoS One 8(1): e54662.
    

62. 
    Zhou, Y., Qin S., Wang, K. (2013) Biomarker of drug-induced liver injury. J. Cur Biomarker Findings 3:1-9.
    

63. 
    Wang, K., Yuan, Y., Cho, J. H., Huang, D., Gray, L., Qin, S. and Galas, D. J. (2013) The spectrum of circulating RNA, a window to systems toxicology. Tox Sci. doi:10.1093/toxsci/kft014
    

64. 
    Chang, W. Y., Etheridge, A., Cho, J. H., Wang, K., Omelyanenko, A., Ling, V., Kwon, S. Y., Chen, L., Huang, A., Pasceri, P., Bradshaw, P., Alvarez, M., Cassar, P. A., Garcha, K., Song, H., Ungrin, M., Hotta, A., Zandstra, P. W., Radisic, M., Meyns, S., Ellis, J., Galas, D. J., Stanford, W. L. Induced-Pluripotent Stem Cells Derived From Hutchinson-Gilford Progeria Syndrome Fibroblasts. Submitted.
    

65. 
    Walters, K., Olsufka, R., Kuestner, R. E., Cho, J. H., Hong, L., Wang, K., Skerrett, S., Ozinksy A. The pulmonary inflammatory response to Francisella tularensis subsp. tularensis is distinct from that elicited by non-lethal respiratory pathogens. Submitted.
    

66. 
    Cho, J. H., Lin, A. and Wang, K. Kernel-based method for feature selection and disease diagnosis using transcriptomics data. Submitted.
    

67. 
    Gomes, C. P. C., Cho, J. H., Hood, L., Franco, O. L., Pereira, R. W., Wang, K. A review of computational tools in microRNA discovery. Submitted.
    

68. 
    Etheridge, A., Gomes, C. P. C., Pereira, R. W., Galas, D., Wang, K. The complexity, function and application of RNA in circulation. Submitted.
    

69. 
    Wang, K. ^#, Lee, I. Y. ^#, Cho, J. H. ^#, Hammamieh, R., Baxter, D., Etheridge, A., Yuan, Y., McClarty, S., Scherler, K., Gautam, A., Jett, M., Hood, L. E. and Galas, D. J. Molecular evidence of stress induced acute heart injury in a mouse posttraumatic stress disorder model.
    

1. 
   Contributor for TIME-LIFE Books Understanding Computers Series 'The Human Body' (1989).
   

2. 
   Hood, L., Koop, B. F., Rowen, L. and Wang, K., (1993) Large-scale DNA sequence analyses of Mammalian T-cell receptor loci. Genome Analysis: Regional Physical Mapping Volume 5 Ed. by K. E. Davies and S. M. Tilghman, Cold Spring Harbor Press. pp.63-87.
   

3. 
   Wang, K., (1996) Using T4 DNA polymerase to generate clonable PCR products. Methods in Molecular Biology Volume 67 PCR cloning protocols Ed. by B. A. White, Humana Press. pp.63-68.
   

4. 
   He, L. and Wang, K., (2002) A 384-well microtiter plate based template preparation and sequencing method. Methods in Molecular Biology Volume 192 PCR cloning protocols 2nd edition Ed by B. Y. Chen and H. W. Janes, Humana Press. pp.411-416.
   

5. 
   Smith, R and Wang, K., (2002) A microtiter plate-based high throughput PCR product purification method. Methods in Molecular Biology Volume 192 PCR cloning protocols 2nd edition Ed by B. Y. Chen and H. W. Janes, Humana Press. pp.417-421.
   

6. 
   Wang, K., (2002) Using T4 DNA polymerase to generate clonable PCR products. Methods in Molecular Biology Volume 192 PCR cloning protocols 2nd edition Ed by B. Y. Chen and H. W. Janes, Humana Press. pp.121-124.
   

7. 
   Wang, K., (2003) Using T4 DNA polymerase to generate clonable PCR products. PCR Protocols 2nd edition Ed by John M. S. Bartlett and David Stirling, Humana Press. pp.469-473
   

8. 
   Glusman, G., Marzolf, B., Wang, K., Cho, J. H., Kutlu, B., and Tian Q (2011) Bioinformatics strategies for understanding gene expression in human pluripotent cells. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual Ed by Gary S. Stein, Wiley-Blackwell Publishers. pp257-272.
   

9. 
   Lee, M. J., Etheridge, A., Galas, D. J. Wang, K. (2012) Molecular Pathogenesis of Neurofibromatosis Type I. Neurofibromatosis Type 1: Symptoms, Treatment and Prognosis. Ed by Matthias Karajannis and Jeffrey Allen Nova Science Publishers, Inc
   

• 
  49^th Annual Meeting of the Society of Toxicology, 2010, Salt Lake City
  
• 
  12^th International Toxicology meeting 2010 Barcelona, Spain
  
• 
  Use of microRNA in toxicological application workshop, ILSI health and environmental science institute. 2010 Arlington
  
• 
  BIT’s Tetra-Congress of MolMed-2010, Session Chair, Shanghai, China
  
• 
  microRNA in Human Disease & Development, Cambridge Healthtech Institute, 2011 Boston
  
• 
  American Association of Pharmaceutical Science annual meeting. 2011, Washington DC.
  
• 
  American Society of Nephology Annual meeting, 2011, Philadelphia
  
• 
  US HUPO 8th annual meeting. 2012, San Francisco
  
• 
  51th SOT Annual Meeting. 2012, San Francisco
  

1. 
   System and method for providing flexible access and retrieval of sequence data from a plurality of biological data repositories. Patent number 6920396
   

2. 
   System and method for transacting and manipulating a multi-sequence search using biological data repositories. Patent number 6922638
   

3. 
   Sampling assembly for simultaneously testing a liquid biological sample for a plurality of hormones and method thereof. Patent number 7090802
   

4. 
   Antibodies for diagnosing psoriasis. Patent number 7585954 B2
   

5. 
   19.5 polypeptide antibodies useful for diagnosing or treating psoriasis Patent number 7879982
   

6. 
   Compositions for protection and cellular delivery of interfering RNA Patent number 8,378,089