100 mg/dL, and in Patients Already



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Netherlands:

  • C. van der Zwaan, Ziekenhuis Rivierenland, Tiel; A. Oomen, Antonius Ziekenhuis, Sneek; R.

  • van de Wal, Ziekenhuis Bernhoven, Uden; M. Magro, Elisabeth-TweeSteden Ziekenhuis,

  • Tilburg; D. Boswijk, Noordwest Ziekenhuisgroep, Den Helder; C. Janus, Vasculair Onderzoek

  • Centrum Hoorn, Hoorn; R. Groutars, Sint Lucas Andreas Ziekenhuis, Locatie Sint Lucas,

  • Amsterdam; W. Tonino, Catharina Ziekenhuis, Eindhoven; J. H. Cornel, Noordwest

  • Ziekenhuisgroep, Alkmaar; A. Oude Ophuis, Canisius-Wilhelmina Ziekenhuis, Nijmegen; R.

  • Troquay, VieCuri Medisch Centrum, Venlo; A. Liem, Franciscus Gasthuis, Rotterdam; I. 838 Westendorp, Rode Kruis Ziekenhuis, Beverwijk; M. Van Hessen, Groene Hart Ziekenhuis, 839 Gouda; D. Lok, Deventer Ziekenhuis, Deventer; C. De Nooijer, Maxima Medisch Centrum, 840 Veldhoven; F. Den Hartog, Ziekenhuis Gelderse Vallei, Ede; E. Van Beek, Sint Jansdal

    841 Ziekenhuis, Harderwijk; P. Bendermacher, Elkerliek Ziekenhuis, Helmond; R. Jansen,

    842 Slingeland Ziekenhuis, Doetinchem; T. Römer, Alrijne Ziekenhuis, Leiden; B. Rensing, Sint

    843 Antonius Ziekenhuis, locatie Nieuwegein, Nieuwegein; F. Hersbach, Maasstad Ziekenhuis,

    844 Rotterdam; J. Herrman, Onze Lieve Vrouwe Gasthuis, Amsterdam; G. Ladyjanskaia, Ziekenhuis 845 Amstelland, Amstelveen; I. Karalis, Leids Universitair Medisch Centrum, Leiden; G. Linssen, 846 Ziekenhuisgroep Twente, Almelo; M. Bokern, Waterland Ziekenhuis, Purmerend; A. Visman, 847 Beatrix Ziekenhuis, Gorinchem; A. Kooij, Bethesda Diabetes Research Center, Hoogeveen; H. 848 Monajemi, Rijnstate, Arnhem; A. Lieverse, Maxima Medisch Centrum, Eindhoven.

    849

    850 New Zealand:



    851 R. Scott, Lipid and Diabetes Research Group, Christchurch; J. Baker, Middlemore Hospital,

    852 Papatoetoe, Auckland; S. Tie, Tauranga Hospital, Tauranga.

    853

    854 Norway:



    855 K. Risberg, Skedsmo Medisinske Senter, Skedsmokorset; J. Hysing, Sykehuset Telemark, Skien;

    856 T. Pedersen, Oslo universitetssykehus, Oslo; H. O. Hoivik, M3 Helse, Hamar; P. Norheim,

    857 Forusakutten-Kolibri, Stavanger; L. Solnor, Heiaklinikken, Lierskogen; A. Hovland,

    858 Nordlandssykehuset, Bodø; T. Kjaernli, Medi 3 Klinikk, Ålesund.

    859

    860 Philippines:



    861 G. Jocson, J. Sibal, Angeles University Foundation, Angeles; R. M. Coching, Davao Doctors 862 Hospital, Davao City; E. Batalla, Davao Doctors Hospital, Davao City; A. Go, Baguio General 863 Hospital, Baguio City; R. Habaluyas, Amang Rodriguez Memorial Medical Center, Marikiina; 864 R. Barcinas, Alexian Brothers Health and Wellness Center, Davao City; R. A. Sy, Ospital ng

    865 Makati, Makati City; R. A. Estepar, St Pauls Hospital Iloilo, Iloilo; G. Rogelio, St Lukes Medical

    866 Center, Quezon City; A. Germar, Veterans Memorial Medical Center, Quezon City.

    867


    868 Poland:

    869 J. Trebacz, Centrum Medyczne Zdrowa, Krakow; K. Szymkowiak, Synexus Polska Spzoo,

    870 Wroclaw; R. Wnetrzak-Michalska, Synexus Polska Spzoo, Katowice; J. Kopaczewski, 871 Specjalistyczne Gabinety Lekarskie Medicor Plus - Jerzy Kopaczewski, Wloclawek; M. 872 Przekwas-Jaruchowska, Synexus Polska Spzoo, Gdynia; G. Kania, Centrum Medyczne 873 Ogrodowa, Skierniewice; M. Zabowka, Centrum Szybkiej Diagnostyki Kardiologicznej 874 Kardiomed M Zabowka E Zabowka Spolka cywilna, Tarnow; E. Mirek-Bryniarska,

    875 Specjalistyczny Gabinet Lekarski Ewa Mirek-Bryniarska, Krakow; M. Dabrowska, Synexus

    876 Polska Spzoo, Warszawa; P. Napora, Centrum Badan Klinicznych Przychodnia Badan

    877 Klinicznych, Wroclaw; M. Konieczny, KO-MED Marek Konieczny Centrum

    878 Wielospecjalistycznej Opieki Ambulatoryjnej z AmbulatorOsrodkZabieg, Pulawy; J. Spyra, 879 NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna, Ruda Slaska; 880 R. Lysek, Lecznice Citomed Spzoo, Torun; Z. Pijanowski, NZOZ Twoja Przychodnia Spzoo,

    881 Lublin; B. Grzegorzewski, Centrum Medyczne Clinport, Katowice; Z. Bednarkiewicz, 882 Wojewodzki Specjalistyczny Szpital im dr Wl Bieganskiego w Lodzi, Lodz; Z. Gaciong, 883 Samodzielny Publiczny Centralny Szpital Kliniczny, Warszawa; L. Kinasz, Polsko-

    884 Amerykanskie Kliniki Serca, Bielsko-Biala; K. Antkowiak-Piatyszek, Synexus Polska Spzoo, 885 Poznan; K. Stania, Nyskie Centrum Sercowo Naczyniowe Polsko-Amerykanskich Klinik Serca, 886 Nysa; M. Szpajer, Poliklinika Evi-Med, Gdynia; P. Staneta, NZOZ Specjalistyczna Przychodnia 887 Lekarska Medikard, Plock; G. Skonieczny, Wojewodzki Szpital Zespolony im Ludwika

    888 Rydygiera w Toruniu, Torun; E. Ksiezycka-Majczynska, Instytut Kardiologii im Prymasa 889 Tysiaclecia Stefana Kardynala Wyszynskiego, Warszawa; T. Blicharski, Lubelskie Centrum 890 Diagnostyczne, Swidnik; M. Piepiorka, Gabinet Kardiologiczno-Internistyczny, Gdynia; B.

    891 Wozakowska-Kaplon, NZOZ Centrum Usług Medycznych Promont-Med, Kielce; T. Zechowicz,

    892 Zechowicz Medeusz-Plus Lekarska Spolka Partnerska, Olsztyn; J. Ilkowski, NZOZ Neuro-Kard,

    893 Poznan; B. Lubiszewska, Instytut Kardiologii im Prymasa Tysiaclecia Stefana Kardynala 894 Wyszynskiego, Warszawa; J. Hiczkiewicz, NZOZ Kardiologia Nowa Sol, Nowa Sol; K. 895 Wierzbicka, Specjalistyczny Osrodek Medycyny Wieku Dojrzalego Spzoo, Warszawa; D. 896 Kosior, Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych w Warszawie,

    897 Warszawa; P. Garbocz, Medica Centrum Spzoo, Pszczyna; J. Kubica, Szpital Uniwersytecki nr 1

    898 im dr Antoniego Jurasza w Bydgoszczy, Bydgoszcz; G. Raczak, Uniwersyteckie Centrum

    899 Kliniczne, Gdansk; I. Wozniak, KO-MED Centra Kliniczne Staszow, Staszow; J. Cygler, NZOZ 900 Medica, Gizycko; E. Kramarczuk, KO-MED Centra Kliniczne Zamosc, Zamosc; L. Bystryk, 901 Wojewodzkie Centrum Szpitalne Kotliny Jeleniogorskiej, Jelenia Gora; J. Pentela-Nowicka,

    902 Somed Lodzkie Centrum Osteoporozy, Lodz; M. Dabrowski, SPZOZ Szpital Bielanski im

    903 Ksiedza Jerzego Popieluszki, Warszawa; P. Podolec, Krakowski Szpital Specjalistyczny im Jana

    904 Pawła II, Krakow; B. Zieba, Gdanskie Centrum Zdrowia, Gdansk; J. Mosiewicz, Centrum

    905 Medyczne Luxmed Spzoo, Lublin; T. Pasierski, Miedzyleski Szpital Specjalistyczny w

    906 Warszawie, Warszawa; W. Dubaniewicz, Pomorskie Centra Kardiologiczne, Starogard Gdanski; 907 M. Banach, SPZOZ Uniwersytecki Szpital Kliniczny, Lodz; G. Tyszecka, Wromedica, Wroclaw; 908 T. Lepich, Indywidualna Specjalistyczna Praktyka Lekarska Roman Spyra, Katowice; A.

    909 Rychlewska-Hanczewska, Ai Centrum Medyczne, Poznan; T. Guzik, Malopolskie Centrum

    910 Alergii i Immunoterapii Allmedis Sp. z o.o, Krakow.

    911


    912 Portugal:

    913 P. Monteiro, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra; H. Pereira, Hospital 914 Garcia de Orta, EPE, Almada; L. Oliveira, Centro Hospitalar Cova da Beira, EPE - Hospital Pero 915 da Covilha, Covilha; P. Matos, Hospital Cuf Infante Santo, Lisboa; S. Soares Goncalves, Centro 916 Hospitalar de Setubal EPE Hospital de Sao Bernardo, Setubal; A. Leitao, Centro Hospitalar de 917 Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier, Lisboa; J. Ferreira, Centro Hospitalar de 918 Lisboa Ocidental, EPE - Hospital de Santa Cruz, Carnaxide; A. Vasco Salgado, Hospital

    919 Professor Doutor Fernando Fonseca, EPE, Amadora; A. T. Timoteo, Centro Hospitalar de Lisboa

    920 Central, E.P.E. - Hospital de Santa Marta, Lisboa.

    921

    922 Romania:



    923 E. Pintilei, Consultmed SRL, Iasi; E. Badila, Policlinica Center for Clinical and Basic Research 924 SRL, Bucuresti; C. Militaru, Cardiomed SRL, Craiova; M. Tudoran, Spitalul Clinic Judetean de 925 Urgenta Timisoara, Timisoara; C. Arsenescu-Georgescu, Institutul de Boli Cardiovasculare Prof 926 Dr George I.M. Georgescu Iasi, Iasi; F. Mitu, Spitalul Clinic de Recuperare Iasi, Iasi; D.

    927 Zdrenghea, Spitalul Clinic de Recuperare Cluj-Napoca, Cluj-Napoca; D. Lighezan, Spitalul

    928 Clinic Municipal de Urgenta Timisoara, Timisoara; I. Teodorescu, Spitalul Clinic de Urgenta Sf 929 Ioan Bucuresti, Bucuresti; A. G. Dan, Spitalul Clinic Colentina, Bucharest; M. I. Popescu, Spital 930 Clinic Judetean de Urgenta Oradea, Oradea; I. Coman, Alcor Med SRL, Bucuresti; M. M.

    931 Vintila, Spitalul Clinic de Urgenta Sfantul Pantelimon, Bucuresti.

    932

    933 Russia:



    934 A. Vishnevsky, Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital, 935 Saint-Petersburg; Y. Lukyanov, SBEI of HPE First Saint-Petersburg State Medical University na 936 Academic I P Pavlov of MoH of the RF, Saint-Petersburg; A. Blokhin, FSBI Outpatient Clinic 3 937 of Russian Federation Presidents Management Department, Moscow; V. Kostenko, Saint

    938 Petersburg State Budget Healthcare Institution City Polyclinic 109, Saint-Petersburg; Y. Shvarts, 939 Clinical Hospital named after S R Mirotvortsev, Saratov; V. Markov, FSBSI Research Institute 940 for ical Hospi, Tomsk; I. Motylev, SBHI of Nizhniy Novgorod region City Clinical Hospital 33 941 of city Nizhniy Novgorod Leninskyi region, Nizhniy Novgorod; D. Dronov, Budget Healthcare 942 Institution of Omsk region Medical-sanitary unit 9, Omsk; A. Sherenkov, Spb SBHI Medical and 943 sports dispensary of Krasnogvardeisky district of Saint Petersburg, Saint Petersburg; O.



    1. Barbarash, FSBI Heart and Vessels Diseases complex problems Scientific Research Institution,

    2. Kemerovo; E. Shutemova, Regional Budget Healthcare Institution Cardiology Dispensary,

    3. Ivanovo; O. Bolshakova, SBEI of HPE First Saint-Petersburg State Medical University na

    4. Academic I P Pavlov of MoH of the RF, Saint Petersburg; Z. Kobalava, SBHI of Moscow City

    5. clinical hospital 64 of Moscow Healthcare department, Moscow; M. Ezhov, FSBI Russian

    6. Cardiology Research and Production Complex, Moscow; M. Voevoda, FSBI SRI of Therapy of 950 Siberian Branch of RAMS, Novosibirsk; T. Treshkur, FSBI V.A.Almazov Federal Center of 951 heart, blood and endocrinology of Ministry of Health and SD of RF, Saint Petersburg; K.

    952 Zrazhevskiy, Saint Petersburg SBHI City Hospital 38 named after N A Semashko, Saint-

    953 Petersburg; L. Pimenov, BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of

    954 healthcare of Republic Udmurtiya, Izhevsk; O. Solovev, Kirov Regional State Budget Healthcare

    955 Institution Kirov City Clinical Hospital 1, Kirov; N. Tarasov, FSHI Medical-sanitary unit of

    956 Chief Administration of IA of Kemerovo region, Kemerovo; M. Arkhipov, State Budget Medical 957 Institution Sverdlovsk Regional Clinical Hospital N1, Ekaterinburg; M. Freidlin, SBHI of SR 958 SPC of specialized types of medical care Ural cardiology institute, Ekaterinburg; S. Shalaev,

    959 State Autonomy Health care Institution of Tyumen region Scientific and Practical Medical

    960 Center, Tyumen; P. Yakhontova, SBHI of Novosibirsk Region Novosibirsk regional clinical 961 cardiology dispensary, Novosibirsk; S. Shustov, FSMEI of HPE Military Medical Academy n.a. 962 S.M.Kirov of Ministry of Defense of RF, St. Petersburg; B. Goloshchekin, St Petersburg State 963 Budget Institution of Public Health City Hospital 15, Saint Petersburg; A. Panov, FSBI

    964 V.A.Almazov Federal Center of heart, blood and endocrinology of Ministry of Health and SD of 965 RF, Saint-Petersburg; B. Bart, Diagnostic and Clinical Center No1 Moscow Health Department, 966 branch No2, Moscow; M. Bubnova, FSBI State Scientific Research Center for Preventive

    967 Medicine of MoH of RF, Moscow; I. Gordeev, Moscow SBHI City Clinical Hospital 15 n a O M 968 Filatov of Moscow Healthcare Department, Moscow; I. Osipova, NSHI Departmental Hospital at 969 the station Barnaul of OJSC Russian Railways, Barnaul; S. Tereshenko, FSBI Russian

    970 Cardiology Research and Production Complex, Moscow; E. Solovieva, FSBI Russian

    971 Cardiology Research and Production Complex, Moscow; A. Meshkov, FSBI State Scientific

    972 Research Center for Preventive Medicine of MoH of RF, Moscow; D. Zateyshchikov, Moscow



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    State Budget Healthcare Institution City Clinical Hospital 51 of Moscow Healthcare Department, Moscow.
    Singapore:

    L. Tay, Changi General Hospital, Singapore; J. L. Tan, National Heart Centre Singapore, Singapore; T. Subramaniam, Khoo Teck Puat Hospital, Singapore.


    Slovakia:

    D. Pella, Cardio D and R sro Kosice, Kosice; P. Fulop, Interna SK sro, Svidnik; L. Antalik, Nemocnica s poliklinikou Brezno, no, Brezno; A. Dzupina, Alian sro, Bardejov; A. Banikova, KardioMed sro, Lucenec; D. Sosovec, Diab sro, Roznava; L. Urgeova, Kardiomed, NZ sro, Nove Zamky; J. Mazur, Kardio - Onkologia sro, Dolny Kubin; M. Hranai, Kardiocentrum Nitra s.r.o., Nitra; M. Banik, Medi M and M sro, Moldava nad Bodvou; D. Vinanska, Medispol sro, Presov; J. Lennerova, Medilex sro, Rimavska Sobota; F. Kovar, Univerzitna nemocnica Martin, Martin; E. Pastrnakova, Agto spol sro, Kosice; R. Uhliar, Nemocnica svateho Michala as, Bratislava; P. Blasko, MUDr Peter Blasko sro, Banovce nad Bebravou; S. Filipova, Narodny ustav srdcovych a cievnych chorob, a.s., Bratislava; J. Gonsorcik, NZZ - internistu, kardiologa, Kosice; J. Lukacova, Mediluk sro, Snina; R. Oriesek, CardiOr sro, Trencin; K. Hatalova, Cardioconsult sro, Bratislava.


    South Africa:

    M. du Toit, Synexus Clinical Research South Africa, Val de Grace; L. Burgess, Tygerberg Hospital, Parow; I. Ebrahim, Unitas Hospital, Centurion; G. Vawda, Inkosi Albert Luthuli Central Hospital, Durban; S. Lipschitz, Apollo Clinical Research Pty Ltd, Johannesburg; S. Blignaut, Paarl Research, Paarl; J. Engelbrecht, Doctor JM Engelbrecht, Somerset West; T. F. Coetzer, Clinresco Centres Suites, Kempton Park; M. Pretorius, Tiervlei Trial Centre, Cape Town; D. Urbach, Synexus Helderberg Clinical Research Centre, Somerset West; A. Badat, Wits Clinical Research, Soweto; S. Pillay, Seadoone Medical Centre, Amanzimtoti; L. Van Zyl, Clinical Projects Research South Africa, Worcester; M. Abelson, Vergelegen Mediclinic, Somerset West; E. van der Walt, Medicross Roodeport Research Centre, Johannesburg; R. Moodley, Umhlanga Hospital Netcare, Durban; A. Jacovides, Midrand Medical Centre, Midrand; W. M. Oosthuysen, Limaro Research, Bloemfontein; E. Klug, Sunninghill Hospital, Sunninghill; H. Lottering, SCION Clinical Research, Pretoria; J. Kok, Union Hospital, Alberton;

    J. Saaiman, Kuils River Hospital, Kuils River; S. Dawood, Vincent Pallotti Hospital, Cape Town; D. M. De Jong, Jongaie Research, Pretoria west; C. Kapp, Cardiology Clinical Research, Alberton; E. Makotoko, Universitas Hospital, Bloemfontein; J. Bayat, Durban Medical Centre, Durban; A. Badat, Wits Clinical Research, Soweto; M. Sarvan, Mediclinic Victoria, Tongaat; E. Klug, Sunward Park Hospital, Boksburg; T. Vally, Synexus SA - Stanza Bopape Clinical Research Centre, Pretoria; A. Stapelberg, Syzygy Clinical Research Services Pty Ltd, Pretoria.
    South Korea:

    M. Kim, Dong-A University Hospital, Busan, Seo-gu; J. Bae, Konyang University Hospital, Daejeon; Y. Cho, Seoul National University Bundang Hospital, Seongnam-si; S. Kim, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul; K. H. Han, Asan Medical Center, Seoul; S. Her, The Catholic University of Korea Daejeon St Marys Hospital, Daejeon; D. Choi, Yonsei University Health System Severance Hospital, Seoul; B.



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    Kim, Kangbuk Samsung Hospital, Seoul; S. Lee, Ilsan-Paik Hospital, Goyang-si, Gyeonggi-do;

    B. Hong, Gangnam Severance Hospital, Seoul; W. Kim, Kyung Hee University Hospital, Seoul;

    S. Rha, Korea University Guro Hospital, Seoul; M. Jeong, Chonnam National University Hospital, Gwangju; G. J. Shin, Ewha Womans University Mokdong Hospital, Seoul.
    Spain:

    M. Vida Gutierrez, Hospital Virgen del Mar, Almeria; J. Lopez Miranda, Hospital Universitario Reina Sofia, Cordoba; M. Valdes Chavarri, Hospital Universitario Virgen de la Arrixaca, El Palmar; X. Pinto Sala, Hospital Universitari de Bellvitge, L Hospitalet de Llobregat; J. R. Gonzalez Juanatey, Hospital Clinico Universitario de Santiago, Santiago de Compostela; F. Civeira Murillo, Hospital Universitario Miguel Servet, Zaragoza; J. L. Zamorano Gomez, Hospital Universitario Ramon y Cajal, Madrid; I. Lekuona Goya, Hospital de Galdakao, Galdakao; A. Iñiguez Romo, Hospital Alvaro Cunqueiro, Vigo; A. Cordero Fort, Hospital Universitario San Juan de Alicante, San Juan de Alicante; J. F. Ascaso Gimilio, Hospital Clinico Universitario de Valencia, Valencia; J. Millan Nuñez-Cortes, Hospital General Universitario Gregorio Marañon, Madrid.


    Sweden:

    C. Lindholm, Capio Citykliniken, Lund; L. Nilsson, University Hospital, Linköping; Å. Olsson, A-plus Science AB, Stockholm; S. Söderberg, Norrlands Universitetssjukhus, Umeå; A. Suutari, Höglandssjukhuset Eksjö, Eksjö; S. Berglund, Falu Lasarett, Falun; T. Mooe, Östersunds sjukhus, Östersund; D. Kusiak, Länssjukhuset Ryhov, Jönköping; S. Bandh, Västmanland sjukhus Västerås, Västerås; G. Dahlén, Vårdcentralen Silentzvägen, Uddevalla; S. Olsson, Helsingborgs lasarett, Helsingborg; N. Witt, Södersjukhuset, Stockholm; P. Tydén, Skånes Universitetssjukhus, Lund; P. Johansson, Sunderby Sjukhus, Luleå; S. Cizinsky, Universitetssjukhuset Örebro, Örebro; G. Falck, Aleris Specialistvård Bollnäs, Bollnäs; S. I. Pettersson, Mälarsjukhuset, Eskilstuna; G. Rasmanis, Karolinska Universitetssjukhuset Huddinge, Stockholm; J. Östergren, Karolinska University Hospital, Stockholm.


    Switzerland:

    F. Mach, Hopitaux Universitaires de Geneve, Geneva 14; T. Moccetti, G. Ponti, Fondazione Cardiocentro Ticino, Lugano; H. J. Beer, K. Steden, Kantonsspital Baden, Baden; F. Eberli, C. Liedtke, Stadtspital Triemli, Zurich; S. Krähenbühl, Universitaetsspital Basel, Basel; A. Linka,

    B. Brinkers, Kantonsspital Winterthur, Winterthur; D. Ackermann, M. Winter-Pauling, Inselspital Bern, Bern; P. Michel, Centre Hospitalier Universitaire Vaudois, Lausanne.
    Taiwan:

    H. Yeh, Mackay Memorial Hospital Tamsui Branch, New Taipei City; C. F. Tsai, K. Ueng, Chung Shan Medical University Hospital, Taichung City; M. Charng, Taipei Veterans General Hospital, Taipei; C. Wu, C. J. Chen, C. I. Cheng, C. H. Yang, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung; C. Hsia, Changhua Christian Hospital, Changhua; J. Juang, F. Chiang, National Taiwan University Hospital, Taipei; I. Hsieh, Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan; W. Lai, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung; C. Huang, Cathay General Hospital, Taipei; Y. Hsieh, Chi Mei Medical Center, Tainan.



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    Turkey:

    T. Sahin, Kocaeli Universitesi Tip Fakultesi, Kocaeli; M. Duzenli, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya; Z. Yigit, Istanbul University Cardiology Institute, Istanbul; M. Demir, Cukurova Universitesi Tip Fakultesi, Adana; M. B. Yilmaz, Cumhuriyet Universitesi Tip Fakultesi, Sivas; I. H. Muderrisoglu, Baskent Universitesi Ankara Hastanesi, Ankara; C. Kirma, Kartal Kosuyolu Yuksek Ihtisas Egitim ve Arastirma Hastanesi, Istanbul; E. Ercan, Izmir Medicalpark Hastanesi, Izmir; L. Kayikcioglu, Ege Universitesi Tip Fakultesi, Izmir; Y. Balbay, Turkiye Yuksek Ihtisas Hastanesi, Ankara; S. Tokgozoglu, Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara.


    Ukraine:

    1. Kraydashenko, Communal Institution City Clinical Hospital No 6, Zaporizhzhia; I. Lymar, Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi, Kyiv; O. Kulynych, Communal Institution Zaporizhzhia Regional Clinical Hospital of Zaporizhzhia Regional Council, Zaporizhzhya; O. Prokhorov, Communal Healthcare Institution Kharkiv City Clinical Hospital No27, Kharkiv; O. Karpenko, Kyiv City Clinical

    Hospital 1, Kyiv; I. Kraіz, Railway Transport Kharkiv Clinical Hospital No1 of Healthcare

    Center Branch of Public Joint Stock, Kharkiv; I. Vakaliuk, vano-Frankivsk Regional Clinical Cardiological Dispensary, Ivano-Frankivsk; M. Stanislavchuk, Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University, Vinnytsia; O. Korzh, Medical and Sanitary Unit of Open Joint Stock Company Kharkiv S Ordzhonikidze Tractor Plant, Kharkiv; I. Rudyk, Government Institution L T Malaya Therapy National Institute of NAMS of Ukraine, Kharkiv; S. Zhurba, Cherkasy Region Cardiological Center, Cherkasy; Y. Svishchenko, State Institution National Scientific Center Acad Strazhesko Institute of Cardiology, Kyiv; V. Tseluyko, Communal Healthcare Institution Kharkiv City Clinical Hospital No8 Kharkiv Medical Academy of Post g, Kharkiv; O. Gyrina, Limited Liability Company Treatment and Diagnostic Center Adonis plus, Kyiv; D. Reshotko, Oleksandrivska Clinical Hospital of Kyiv, Kyiv; M. Kopytsya, Government Institution L T Malaya Therapy National Institute of NAMS of Ukraine, Kharkiv; V. Volkov, Government Institution L T Malaya Therapy National Institute of NAMS of Ukraine, Kharkiv; G. Myshanych, Synexus State Institution Road Clinical Hospital 2 of Kyiv Station, Kyiv; B. Rebrov, Luhansk Regional Clinical Hospital State Institution Luhansk State Medical University, Lugansk; M. Rishko, Transcarpathian Regional Clinical Cardiological Dispensary, Uzhgorod; L. Rudenko, Kyiv City Clinical Emergency Medical Care Hospital, Kyiv; V. Shatylo, State Institution D F Chebotariov Institute of Gerontology of NAMS of Ukraine, Kyiv; O. Parkhomenko, State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr, Kyiv; L. Yena, State Institution D F Chebotariov Institute of Gerontology of NAMS of Ukraine, Kyiv; O. Golovchenko, Medical Clinical Investigational Center of Medical Center Health Clinic LLC, Vinnytsia; I. Sorokina, Synexus Medical Center of Private Educational Institution Institute, Kyiv; Y. Malynovsky, Communal Inst regional Medical Centre of Cardiovascular Diseases of Zaporizhzhia Regional Council, Zaporizhzhia.


    United Kingdom:

    1. Ivan, Synexus Merseyside Clinical Research Centre, Liverpool; M. Blagden, Ashgate Medical Practice, Chesterfield; H. Dear, Synexus Scotland Clinical Research Centre, Glasgow; A. Mathew, Synexus Midlands Clinical Research Centre, Birmingham; S. Lagocki, Synexus

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    Lancashire Clinical Research Centre, Chorley; V. Kondagunta, Synexus Thames Valley Clinical Research Centre, Reading; A. Ahsan, Nottingham City Hospital, Nottingham; C. McKinnon, Castlemilk Group Practice, Glasgow; F. Douglas, Synexus North East Clinical Research Centre, Hexham; S. Thom, Imperial College Healthcare NHS Trust, London; G. Fiore, Synexus Manchester Clinical Research Centre, Manchester; M. Caulfield, D. Collier, Barts Health NHS Trust, London; M. Lynch, Lister Hospital, Stevenage; H. Thomas, Synexus Wales Clinical Research Centre, Cardiff; S. Bain, Singleton Hospital, Swansea; A. Hall, Leeds General Infirmary, Leeds; D. McNally, Ormeau Health Centre, Belfast; M. Fisher, Royal Liverpool University Hospital, Liverpool; P. Keeling, Torbay Hospital, Torquay; A. Al-Bahrani, A. Baksi, St Marys Hospital, Newport; G. Lip, City Hospital, Birmingham; A. Ellery, Cape Cornwall Surgery, Penzance; J. Purohit, Brannel Surgery, St Austell; C. Travill, Luton and Dunstable NHS Foundation Trust Hospital, Luton; F. Cappuccio, University Hospital Coventry, Coventry; G. Davis, Aintree University Hospital, Liverpool; R. Gaunt, Rowden Surgery, Chippenham; D. Adlam, Glenfield Hospital, Leicester; N. Asamoah, P. Harvey, S. Maxwell, Crouch Oak

    Family Practice, Addlestone; F. Jaafar, R. Falk, South Axholme Practice, Haxey, Doncaster; T. McCormack, Whitby Group Practice, Whitby; B. Jupp, D. Jenkinson, Royal Bournemouth Hospital, Bournemouth; M. Pye, York Hospital, York; P. Ainsworth, Sherbourne Medical Centre, Leamington Spa; A. Chauhan, Blackpool Teaching Hospital, Blackpool; D. Connolly, Sandwell General Hospital, West Bromwich; N. Paul, Ashfield Primary Care Centre, Sandbach;

    H. Fairlie, Connor Downs Surgery, Hayle; C. Fox, Northampton General Hospital, Northampton;

    S. Muzulu, Rotherham General Hospital, Rotherham; J. Trevelyan, Worcestershire Royal Hospital, Worcester; R. Aggarwal, Basildon University Hospital, Basildon; B. Issa, Wythenshawe Hospital, Manchester; P. Saravanan, George Eliot Hospital, Nuneaton; K. Cruickshank, Guys and St Thomas NHS Foundation Trust, London; D. Gorog, Queen Elizabeth II Hospital, Welwyn Garden City; S. Heller, Northern General Hospital, Sheffield; D. Newby, Edinburgh Royal Infirmary, Edinburgh; A. Nicolson, West Suffolk Hospital, Bury St Edmunds;

    P. O Hare, Hospital of St Cross, Rugby; P. Donnelly, Ulster Hospital, Belfast; S. Rutherfurd, N. Armstrong, Morrab Surgery, Penzance; M. de Belder, James Cook University Hospital, Middlesbrough; J. Finlayson, Highlands Clinical Research Facility, Inverness; J. Harvey, Wrexham Maelor Hospital, Wrexham; A. Hoye, Castle Hill Hospital, Cottingham; D. Kingston,

    P. Cormie, Penalverne Surgery, Penzance; D. Sarkar, Derriford Hospital, Plymouth; A. Negahban, A. Ahmed, M. Al-Bazzaz, Barnsley Hospital, Barnsley; P. Saravanan, M. Banerjee, Arrowe Park Hospital, Wirral; J. Webster, Aberdeen Royal Infirmary, Aberdeen; N. Wyatt, The Bradford on Avon and Melsham Health Partnership, Wiltshire; S. Muir, Southern General Hospital, Glasgow; M. Cummings, Queen Alexandra Hospital, Portsmouth; I. Mackenzie, T. MacDonald, Ninewells Hospital and Medical School, Dundee; R. Senior, Northwick Park Hospital, Harrow; N. Capps, Princess Royal Hospital, Telford; K. Fotherby, New Cross Hospital, Wolverhampton; H. McIntyre, Conquest Hospital, St. Leonards-on-Sea; J. Aldegather, Portmill Surgery, Hitchin; L. Dixon, Royal Victoria Hospital, Belfast; R. Saksena, Colchester General Hospital, Colchester; R. Butler, University Hospital of North Staffordshire, Stoke-on-Trent.


    United States:

    D. Ramstad, Hampton Roads Center for Clinical Research, SUFFOLK, VA; B. Pierpont, Advance Medical Research, Saint Petersburg, FL; D. Levinson, Apex Medical Research Incorporate, Chicago, IL; A. Mohammed, Apex Medical Research, Inc, Springfield, OH; T. Haddad, Virginia Heart, Falls Church, VA; A. Goel, Kansas City Veterans Affairs Medical



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    Center, Kansas City, MO; K. Dave, Heart Care Associates, Hopewell, VA; W. H. Haught, Heart Center Research LLC, Huntsville, AL; A. Desire, Andre P Desire MD PA, Wichita Falls, TX; K. Hershon, North Shore Diabetes and Endocrine Associates, New Hyde Park, NY; M. Napoli, Clinical Trials of America Inc, Monroe, LA; L. Tami, M. Abdurrahman, Research Physicians Network Alliance, Hollywood, FL; R. Rothschild, Cabrillo Cardiology Medical Group, Oxnard, CA; S. Khurana, Healthy Heart Cardiology, Grandville, MI; D. Gupta, Tennessee Center for Clinical Trials, Tullahoma, TN; D. Cheung, Long Beach Center for Clinical Research, Long Beach, CA; S. Hearne, Delmarva Heart Research Foundation Inc, Salisbury, MD; S. Grubb, Tabor City Family Medicine, Tabor City, NC; A. Miller, Alta Pharmaceutical Research Center Inc, Dunwoody, GA; I. Baird, Remington Davis Clinical Research Inc, Columbus, OH; A. Marcus, South Orange County Endocrinology, Laguna Hills, CA; S. Srivastava, Pentucket Medical Associates, Haverhill, MA; L. Forgosh, HealthEast Medical Research Institute, Saint Paul, MN; R. Fritz, Kootenai Heart Clinics, LLC, Coeur D'Alene, ID; M. Mays, Portland Preventive Cardiology, Portland, OR; B. Bertolet, Cardiology Associates Research LLC, Tupelo, MS; J. Reddy, Sierra Clinical Research, Roseville, CA; M. Khan, AngioCardiac Care of Texas, Houston, TX; S. Nakhle, Palm Research Center Inc, Las Vegas, NV; S. Dill, S Bar D Inc, Pryor, OK; G. Fishbein, Dayton Heart Center, Dayton, OH; B. Khan, Atlanta Clinical Research Centers LLC, Atlanta, GA; H. Marais, Beaver Medical Group, Banning, CA; M. Reschak, Medex Healthcare Research Inc- St Louis, Saint Louis, MO; M. Malone, Charlotte Heart Group Research Center, Port Charlotte, FL; V. Nadar, Capital Area Research LLC, Camp Hill, PA; R. Whitney, Bryan Heart, Lincoln, NE; A. Reichman, Clinical Trial Network, Houston, TX; H. Reyes, MediSphere Medical Research Center LLC, Evansville, IN; M. El Shahawy, Cardiovascular Center of Sarasota, Sarasota, FL; A. Rabinowitz, South Texas Cardiovascular Consultants, Kerrville, TX; D. Weinstein, Zasa Clinical Research, Boynton Beach, FL; N. Farhat, North Ohio Heart Center-Elyria, Elyria, OH; D. Onyema, Healthwise Medical Associates, NewYork, NY; R. Potu, Nature Coast Clinical Research LLC, Crystal River, FL; L. Runquist, Piedmont Medical Group Research of Charleston, Charleston, SC; O. Barnum, Keyser Avenue Medical Park Medical Research Inc, Natchitoches, LA; T. Crater, Hutchinson Clinic PA, Hutchinson, KS; J. Fialkow, Cardiovascular Research Center of South Florida, Miami, FL; A. Shah, Piedmont Research Partners, Indian Land, SC; C. Thompson, Craig S Thompson MD LLC, Marion, OH; A. Wiseman, Eastern Maine Medical Center, Bangor, ME; T. Doyle, Northeast Ohio Heart Associates, LLC, Willoughby, OH; D. Henderson, Cardiology Research Associates Daytona Beach, FL; W. Herzog, Johns Hopkins University, Columbia, MD; R. Schnitzler, Mercury Medical LLC, San Antonio, TX; K. Carr, Carr Cardiology, Oceanside, CA;

    M. Davis, Rochester Clinical Research Inc, Rochester, NY; N. Nagajothi, Aultman Cardiology Clinical Trials, Canton, OH; S. Olsen, Utah Cardiology PC, Layton, UT; W. Rogers, University of Alabama at Birmingham Medical Center, Birmingham, AL; J. Rubino, Piedmont Medical Group Research of Raleigh, Raleigh, NC; I. Singh, Mercy Medical Group, Sacramento, CA; G. Tarleton, Clinical Trials of America Inc, Winston-Salem, NC; R. Bhagwat, Cardiovascular Research of Northwest Indiana LLC, Munster, IN; D. Clardy, Sanford Heart Center, Fargo, ND;

    M. Jardula, Desert Medical Group, Palm Springs, CA; J. Robinson, The University of Iowa College of Public Health, Iowa City, IA; M. Torres, A Plus Research Inc, Miami, FL; N. Vijay, Aurora Denver Cardiology Associates PC, Denver, CO; N. Farris, The Research Group of Lexington LLC, Lexington, KY; J. Lillo, Elite Clinical Studies LLC, Phoenix, AZ; P. Moriarty, University of Kansas Medical Center, Kansas City, KS; C. Recknor, Chris Recknor MD PC,


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    Gainesville GA; P. Berlacher, ProMedica Northwest Ohio Cardiology Consultants, Toledo, OH;

    T. Christensen, Calabash Medical Center, Calabash, NC; N. Gabra, Burke Internal Medicine and Research, Burke, VA; M. Issa, Clinical Research of Hollywood PA, Pembroke Pines, FL; M. Janik, Piedmont Medical Group Research of Wilmington, Wilmington, NC; A. Lawless, Biofortis Inc, Addison, IL; D. Molter, North Myrtle Beach Family Practice, North Myrtle Beach, SC; E. Stout, Crossroads Clinical Research Inc, Mooresville, NC; B. Brezina, Southeastern Clinical Research and Management LLC, Augusta, GA; E. Claxton, Maine Research Associates, Auburn, ME; R. Linsky, University of Colorado Memorial Health System, Colorado Springs, CO; J. Poock, Northeast Iowa Medical Education Foundation, Waterloo, IA; R. Remler, Fellows Research Alliance Inc, Savannah, GA; H. Roseman, Cardiology Wellness Center, Nashville, TN;

    E. Schramm, D. Schlager, St Johns Center for Clinical Research, Ponte Vedra, FL; T. Al-Joundi, Gateway Cardiovascular Research Center Inc, St Louis, MO; J. Amin, Clearwater Cardiovascular and Interventional Consultants Bardmoor, Largo, FL; J. Hitchcock, Belleville Family Medical Associates, Belleville, IL; S. Isserman, Clinical Trials of America Inc, Hickory, NC; J. Kirstein, Advanced Clinical Research, West Jordan, UT; J. Rider, Cardiology Associates of Bellin Health, Green Bay, WI; M. Shalek, Legacy Heart Center Plano, Plano, TX; H. Sherman, Southern Maine Health Care, Biddeford, ME; M. Bernstein, Louisiana Heart Center, Slidell, LA; L. Chandra, Chicago Medical Research LLC, Hazel Crest, IL; R. Hatharasinghe, Piedmont Healthcare, Statesville, NC; H. Ibrahim, North Ohio Heart Center-Sandusky, Sandusky, OH; B. Iteld, Louisiana Heart Center, Hammond, LA; K. Linzmeyer, St Lukes Idaho Cardiology Associates, Meridian, ID; B. Seaton, Research Institute of the Carolinas, Mooresville, NC; S. Zeig, Pines Clinical Research Inc, Hollywood, FL; E. Christofides, Endocrinology Associates Inc, Columbus, OH; R. Dunbar, Perelman Center for Advanced Medicine, Philadelphia, PA; S. Griffin, Head to Toe Research and Wellness LLC, Athens, GA;

    N. Kohli, Discovery Clinical Trials, Austin, TX; M. Koren, Jacksonville Center for Clinical Research, Jacksonville, FL; W Pharr, Medication Management LLC, Greensboro, NC; D. Purdy, Black Hills Cardiovascular Research, Rapid City, SD; R. Spencer, Cardiology Consultants, Pensacola, FL; G. Yeoman, Founders Research Corporation, Philadelphia, PA; S. Banerjee, Veterans Affairs North Texas Health Care System, Dallas, TX; H. B. Cheek, University of North Carolina Regional Physicians Carolina Cardiology, High Point, NC; E. Engel, Bayview Research Group LLC, Valley Village, CA; G. Hamroff, New York University Langone at Hudson Valley Cardiology, Cortlandt Manor NY; R. Huling, Olive Branch Family Medical Center, Olive Branch, MS; L. Kozlowski, Buffalo Medical Group, Buffalo, NY; P. Levin, Model Clinical Research Inc, Baltimore, MD; S. Makam, Mid Hudson Medical Research PLLC, New Windsor, NY; M. Meengs, Mercy Health Partners, Muskegon, MI; R. Bhushan, Metabolic Center of Louisiana Research Foundation, Baton Rouge, LA; B. Erickson, Saint Cloud Hospital, Saint Cloud, MN; L. Herman, Herman Clinical Research LLC, Suwanee, GA; E. Lo, Edgewater Medical Research, Edgewater, FL; E. McDowell, Ilumina Clinical Associates, Indiana, PA; F. McGrew, Stern Cardiovascular Foundation Inc, Germantown, TN; M. Miller, University of Maryland Medical Center, Baltimore, MD; J. Ord, Aurora Denver Cardiology Associates, Aurora, CO; R. Webel, University of Missouri Health System, Columbia, MO; G. Wilhoit, PMG Research of Charleston, Moncks Corner, SC; J. Wise, Crescent City Clinical Research, Metairie, LA; E. Yang, University of Washington, Seattle, WA; M. Budoff, Harbor University of California Medical Center, Torrance, CA; J. Collins, Saint Marys of Michigan, Saginaw, MI; I. Dauber, South Denver Cardiology Associates, Littleton, CO; L. Dobkin, Clinical Trials Research Services LLC, Pittsburgh, PA; A. Focil, Diverse Research Solutions, Oxnard, CA; W. Gandy,



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    Ellipsis Group, Atlanta, GA; J. Pasquini, Novant Health Heart and Vascular Institute, Charlotte, NC; M. Ramos, Intercoastal Medical Group, Sarasota, FL; D. Rodriguez, Advanced Research Institute Inc, New Port Richey, FL; R. Rosenson, Mount Sinai Medical Center, New York, NY;

    1. Sanford, Project Management Institute of Health Inc, Atlanta, GA; A. Schlau, Palm Harbor Medical Associates, Palm Harbor, FL; B. Snyder, Southgate Medical Group, West Seneca, NY;

    2. Stonesifer, Larry D Stonesifer MD Inc PS, Federal Way, WA; A. Tang, Chambersburg Hospital, Chambersburg, PA; J. De Souza, Glacier View Research Institute Endocrinology, Kalispell, MT; M. Elam III, Memphis Veterans Affairs Medical Center, Memphis, TN; J. French, Cor Healthcare Medical Associates, San Pedro, CA; J. Guyton, Duke University Medical Center, Durham, NC; E. Hage Korban, Kore Cardiovascular Research, Jackson, TN; D. Kereiakes, The Christ Hospital, Cincinnati, OH; M. King, Clearwater Cardiovascular Consultants, Clearwater, FL; I. Loh, Westlake Medical Research, Thousand Oaks, CA; J. Navarro, Genesis Clinical Research Inc, Tampa, FL; R. Simons, Nanticoke Cardiology Associates, Seaford, DE; T. Tobin, Portland Preventive Cardiology, LLC, Longview, TX; L. Younis, Gateway Cardiology, PC, Jerseyville, IL; R. Aboufakher, Altru Health System, Grand Forks, ND; D. Baldari, Cardiology Partners Clinical Research Institute, Wellington, FL; C. Ballantyne, Baylor College of Medicine, Houston, TX; S. Banerjee, University of Texas Southwestern Medical Center, Dallas, TX; R. Broughton, CB Flock Research Corporation, Mobile, AL; C. Eaton, Memorial Hospital of Rhode Island, Pawtucket, RI; J. Johnston, Arrowhead Health Centers, Glendale, AZ; W. Simon, Professional Research Network Of Kansas, Wichita, KS; S. Thomson, Southern Arizona Veterans Administration Health Care System, Tuscon, AZ; K. Vora, Research Integrity LLC, Owensboro, KY; D. Youngman, Kansas Nephrology Research Institute LLC, Wichita, KS; O. Alzohaili, Alzohaili Medical Consultants, Dearborn, MI; E. Auerbach, Oklahoma Heart Institute, Tulsa, OK; C. Brown, Mobile Heart Specialists PC, Mobile, AL; B. Burrough, McFarland Clinic PC, Ames, IA; Y. Chen, Bendel Medical Research Center, Lafayette, LA; M. Gilpatrick, Neurocare Center for Research, Newton, MA; J. Landzberg, Westwood Cardiology Associates, Westwood, NJ; C. Mitchell, MedTrial, LLC, Columbia, SC; L. Rice, Clinical Study Center of Asheville, LLC, Asheville, NC; M. Rubenfire, University of Michigan Health System, Dominos Farms, Ann Arbor, MI; C.

    W. Sofley, Internal Medicine Associates of Anderson PA, Anderson, SC; D. Strobl, Sparrow Clinical Research Institute, Lansing, MI; K. Atassi, Porter Physician Services, Valparaiso, IN;

    W. Davila, Fleming Island Center for Clinical Research, Fleming Island, FL; J. Diogo, New England Center for Clinical Research/ Internal Medicine and Cardiology Associates, LLC, Fall River, MA; T. Fagan, Arizona Endocrine and Rheumatology Associates, Tucson, AZ; I. Joffe, Lourdes Cardiology Services, Voorhees, NJ; J. Krishna, UnityPoint Health Meriter Heart and Vascular Institute, Madison, WI; E. Osea, Innovative Clinical Research, Harbor City, CA; W. Penny, Veterans Affairs San Diego Healthcare System, San Diego, CA; W. Rowe, Great Falls Clinic LLP, Great Falls, MT; M. Shapiro, Oregon Health and Science University, Portland, OR;

    J. Welker, Anne Arundel Medical Center, Annapolis, MD; R. Benton, Capital Cardiology Associates, Troy, NY; D. Dobratz, College Park Family Care Center Physicians Group, Overland Park, KS; F. Fortuin, Mayo Clinic Hospital, Phoenix, AZ; J. Graham, Saint Francis Medical Group Indiana Heart Physicians, Indianapolis, IN; B. Henry, Therapeutic Research Institute of Orange County, Laguna Hills, CA; B. Kusnick, Cardiovascular Associates Research LLC, Covington, LA; M. Lutskiy, Beacon Clinical Research LLC, Quincy, MA; A. McRae, Centennial Heart Cardiovascular Consultants, LLC, Nashville, TN; K. Sanford, Health First Physicians Inc, Atlanta; W. Saway, Columbia Medical Practice, Columbia, MD; J. Scott,


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    National Clinical Research Richmond Inc, Richmond, VA; M. Shah, Shah Associates, MD LLC, Charlotte Hall, MD; B. Weinberg, Community Hospital South, Indianapolis, IN; S. Zarich, Bridgeport Hospital, Bridgeport, CT; R. Acheatel, Escondido Cardiology Associates Incorporated, Escondido, CA; C. Case, Jefferson City Medical Group PC, Jefferson City, MO; J. Earl, Piedmont Medical Group Research of Hickory LLC, Hickory, NC; S. Fernandez, State University of New York- University at Buffalo, Buffalo, NY; G. Giugliano, Baystate Medical Practice, Springfield, MA; Y. Handelsman, Metabolic Institute of America, Tarzana, CA; P. Hermany, Grand View Lehigh Valley Health Services, Sellersville, PA; S. Holder, International Clinical Research LLC, Sanford, FL; M. Kashyap, Veterans Affairs Long Beach Healthcare System, Long Beach, CA; A. Khan, The Iowa Clinic, PC, Des Moines, IA; E. Lader, Mid Valley Cardiology, Kingston, NY; J. Peniston, Feasterville Family Health Care Center, Feasterville, PA;

    T. Raoof, TJoseph Raoof MD Inc Encino Research Center, Encino, CA; J. Sacco, Stratton Veterans Affairs Medical Center, Albany, NY; K. Shore, Kenneth A Shore, MD, Plano, TX; D. Spriggs, Clearwater Cardiovascular and Interventional Consultants Countryside, Safety Harbor, FL; S. Stringam, Saint Lukes Regional Medical Center, Nampa, ID; N. Tahirkheli, South Oklahoma Heart Research, Oklahoma City, OK; E. Delgado, Family Medical Center dba Discovery Clinical Trials, Orlando; W. Derian, Quincy Medical Group, Quincy, IL; J. Greenwald, Medex Healthcare Research Inc, New York, NY; M. Harris, Bend Memorial Clinic, Bend, OR; R. Jackson, Dominion Medical Associates Incorporated, Richmond, VA; G. Marhefka, Thomas Jefferson University Hospital, Philadelphia, PA; W. McElveen, Bradenton Research Center, Bradenton, FL; A. Mooss, Chi Health Alegent Creighton Clinic, Omaha, NE;

    P. Morris, Medical University of South Carolina, Charleston, SC; J. Murray, Meharry Medical College, Nashville, TN; P. Pearlstein, Pearl Clinical Research Inc, Norristown, PA; A. Raisinghani, University of California San Diego Medical Center, San Diego, CA; S. Rezkalla, Marshfield Clinic, Marshfield, WI; L. Sakhrani, Comprehensive Research Institute, Alhambra;

    D. Schreibman, Sarasota Memorial Hospital Clinical Research Center, Sarasota, FL; E. Shaoulian, Pacific Coast Cardiology and Research, Newport Beach, CA; J. Steinsapir, Metabolic Research Institute Inc, West Palm Beach, FL; A. Yataco, IRC Clinics Inc, Towson, MD; A. De La Cruz, Genesis Research Center LLC, Miami, FL; M. Fredrick, HealthCare Partners Department of Research, Huntington Beach, CA; E. Goldenberg, Christiana Care Health System, Christiana Hospital, Newark, DE; D. Lee, California Cardiac Institute Medical Group, Glendale, CA; K. McCullum, York Hospital, York, PA; B. McLellan, Saint Charles Heath Center, Bend, OR; L. Stephens, Palmetto Clinical Trial Services, LLC, Fountain Inn, SC; S. Wilson, Partners in Clinical Research, Cumberland, RI; A. Alfieri, Alfieri Cardiology Research Company Inc, Wilmington, DE; M. Mandviwala, Northwest Heart Center, Tomball, TX; D. ORourke, Veterans Affairs Medical Center, White River Junction, VT; A. Samal, Northwest Houston Cardiology, Houston, TX; K. Sanford, Blair Medical Associates, Atlanta, GA; J. Schmedtje, Roanoke Heart Institute, Roanoke, VA; F. Waxman, GSA Medical Research LLC, Hollywood; R. Carhart, State University of New York Upstate Medical University, Syracuse, NY; B. Clements, Intermountain Medical Center, Murray, UT; C. Dyke, Alaska Heart Institute, Anchorage, AK; J. Ghali, Mercer University School of Medicine, Macon, GA; L. Gruberg, Stony Brook University Medical Center, Stony Brook, NY; T. Hack, Primary Care Cardiology Research, Inc, Ayer; A. Jehle, International Heart Institute of Montana, Missoula, MT; B. Pogue, Selah Medical Center, Boise;

    C. Schooley, Centrura Health Research Center, Colorado Springs, CO; G. Shifrin, Cleveland Clinic Cardiology Associates, Atlantis.






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    Table S1 – Efficacy Outcomes With Evolocumab vs. Placebo Stratified by Baseline LDL-C





    Baseline LDL-C <70 mg/dLa

    (N=2034)

    Baseline LDL-C >70 mg/dL (N=25529)




    Outcome

    Evolocumab (N=1030)

    Placebo (N=1004)

    Hazard Ratio (95% CI)

    Evolocumab (N=12754)

    Placebo (N=12775)

    Hazard Ratio (95% CI)


    PINT

    Primary endpointb

    86 (8.3)

    106 (10.6)

    0.80 (0.60-1.07)

    1258 (9.9)

    1457 (11.4)

    0.86 (0.79-0.92)

    0.65

    Key secondary endpointc

    48 (4.7)

    68 (6.8)

    0.70 (0.48-1.01)

    768 (6.0)

    945 (7.4)

    0.81 (0.73-0.89)

    0.44

    Other endpoints






















    Cardiovascular death

    14 (1.4)

    14 (1.4)

    0.97 (0.46-2.04)

    237 (1.9)

    226 (1.8)

    1.05 (0.87-1.26)

    0.88

    Myocardial infarction

    25 (2.4)

    43 (4.3)

    0.58 (0.35-0.94)

    443 (3.5)

    596 (4.7)

    0.74 (0.65-0.84)

    0.32

    Stroke

    17 (1.7)

    20 (2.0)

    0.85 (0.44-1.62)

    190 (1.5)

    242 (1.9)

    0.78 (0.65-0.95)

    0.84

    Hospitalized for unstable angina

    16 (1.6)

    19 (1.9)

    0.84 (0.43-1.64)

    220 (1.7)

    220 (1.7)

    1.00 (0.83-1.20)

    0.63

    Coronary revascularization

    51 (5.0)

    65 (6.5)

    0.78 (0.54-1.13)

    708 (5.6)

    900 (7.0)

    0.78 (0.71-0.86)

    0.97

    Baseline LDL-C data were not available for one patient randomized to placebo. To convert LDL-C to millimoles per liter, multiply by 0.0259.

    Data shown are n (%)



    a By trial design, these patients had non-HDL-C > 100 mg/dL

    b Cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization

    c Cardiovascular death, myocardial infarction, stroke

    1349

    Table S2: Patient Characteristics Stratified Potency of Background Statina


    Characteristics

    Maximal (N=7533)

    Submaximal (N=20031)

    P-value

    Age, mean + SD – yr

    61.1 + 8.9

    63.0 +9.0

    <0.001

    Male

    5722 (76.0)

    15073 (75.2)

    0.22

    White raceb

    7027 (93.3)

    16431 (82.0)

    <0.001

    Region







    <0.001

    North America

    1877 (24.9)

    2694 (13.4)




    Europe

    4862 (64.5)

    12473 (62.3)




    Latin America

    180 (2.4)

    1643 (8.2)




    Asia, Pacific, South Africa

    614 (8.2)

    3221 (16.1)




    Type of atherosclerosisc










    Myocardial infarction

    6499 (86.3)

    15852 (79.1)

    <0.001

    Non-hemorrhagic stroke

    1182 (15.7)

    4155 (20.7)

    <0.001

    Peripheral artery disease

    1012 (13.4)

    2630 (13.1)

    0.51

    Cardiovascular risk factors










    Hypertension

    6019 (79.9)

    16065 (80.2)

    0.57

    Diabetes mellitus

    2536 (33.7)

    7545 (37.7)

    <0.001

    Current cigarette use

    2067 (27.4)

    5710 (28.5)

    0.079

    Statin intensity at baselined







    NA

    High

    7533 (100)

    11570 (57.8)




    Moderate

    0

    8392 (41.9)




    Low, unknown, or no data

    0

    69 (0.3)




    Ezetimibe

    672 (8.9)

    768 (3.8)

    <0.001

    Other cardiovascular medications










    Aspirin, P2Y12 inhibitor, or both

    7122 (94.6)

    18310 (91.5)

    <0.001

    Beta-blocker

    6056 (80.4)

    14759 (73.8)

    <0.001

    Renin-angiotensin-aldosterone inhibitor

    6016 (79.9)

    15517 (77.5)

    <0.001

    Median lipid measures in mg/dL [IQR]










    LDL cholesterol

    93.0 [80.0,

    111.5]


    91.0 [79.5, 107.5]

    <0.001

    Total cholesterol

    168.0 [150.5,

    190.5]


    167.0 [151.0, 187.5]

    0.004

    HDL cholesterol

    43.0 [36.5, 51.5]

    44.0 [37.0, 53.0]

    <0.001

    Triglycerides

    133.0 [98.5, 181.0]

    133.0 [100.0, 182.0]

    0.19

    LDL cholesterol < 70 mg/dL at baseline

    524 (7.0)

    1510 (7.5)

    0.10




    1350

    1351


    1352

    1353


    1354

    1355


    Table S2 – Efficacy Outcomes With Evolocumab vs. Placebo Stratified by Potency of Background Statin





    Maximal Potency Background Statin

    Submaximal Potency Background Statin





    Outcome

    Evolocumab (N=3758)

    Placebo (N=3775)

    Hazard Ratio (95% CI)

    Evolocumab (N=10026)

    Placebo (N=10005)

    Hazard Ratio (95% CI)


    PINT

    Primary endpointa

    421 (11.2)

    489 (13.0)

    0.86 (0.75-0.98)

    923 (12.4)

    1074 (13.9)

    0.85 (0.78-0.93)

    0.88

    Key secondary endpointb

    246 (6.5)

    315 (8.3)

    0.78 (0.66-0.92)

    570 (7.9)

    698 (9.7)

    0.81 (0.72-0.90)

    0.71

    Other endpoints






















    Cardiovascular death

    74 (2.0)

    67 (1.8)

    1.11 (0.80-1.54)

    177 (2.6)

    173 (2.3)

    1.02 (0.83-1.26)

    0.67

    Myocardial infarction

    141 (3.8)

    222 (5.9)

    0.63 (0.51-0.78)

    327 (4.3)

    417 (5.8)

    0.78 (0.67-0.90)

    0.11

    Stroke

    60 (1.6)

    60 (1.6)

    1.00 (0.70-1.44)

    147 (2.3)

    202 (2.8)

    0.72 (0.58-0.89)

    0.11

    Hospitalized for unstable angina

    75 (2.0)

    90 (2.4)

    0.84 (0.62-1.14)

    161 (2.4)

    149 (1.9)

    1.08 (0.86-1.35)

    0.20

    Coronary revascularization

    248 (6.6)

    316 (8.4)

    0.78 (0.66-0.93)

    511(6.5)

    649 (8.8)

    0.78 (0.69-0.88)

    0.95

    Maximal potency statin = atorvastatin 80 mg or rosuvastatin 40 mg daily. Data shown are n (%).

    aCardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization

    bCardiovascular death, myocardial infarction, stroke


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