Annual Research Institutes Reports
Report of LIRANS Institute of Research in the Applied Natural Sciences (2009-10)
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Report of LIRANS Institute of Research in the Applied Natural Sciences (2009-10)LIRANS research activities for the reporting period were focused on the implementation of the University of Bedfordshire Research Strategy (2009-2013) including maintaining high levels of research outputs and particularly publications, grant applications and increase of research student numbers. 65 publications were produced during the reporting period including 25 published refereed journal papers. In addition, 22 presentations and invited lectures were made at international conferences. Following a record number of research degree completions in 2008/09, LIRANS recruited a record number of research students in 2009/10 and the details of LIRANS current research degrees can be found at the end of this report. LIRANS continue to generate significant funding from industry and other sources through our research, product development, services, consultancy and postgraduate training activities. A large number of grant applications (16 in total) was also made to various funding bodies during the reporting period (see details below). LIRANS presently consists of 20 staff and 12 visiting professors and fellows. The current LIRANS structure and research areas are detailed below (names of group leaders are underlined): Cell and Cryobiology Research Group (Prof Tiantian Zhang, Prof David Rawson, Dr Emma Spikings, Tiziana Zampolla, Kunjan Desai, Siji Anil)
Sensor Research Group (Dr Barry Haggett, Prof David Rawson, Prof Brian Birch, Prof Les Ebdon, Dr Roberto Andres, Dr Simon Bloxham, Ms Gowri Dep)
Biomedicine and Nutrition Research Group (Prof Jan Domin, Dr Bushra Ahmed, Dr Robin Maytum, Dr John Reynolds, Dr Shaobo Zhou, Dr Zheying Zhu) The research interests of the group are currently diverse and include
Environmental Monitoring Research Group (Prof James Crabbe, Prof Angus Duncan)
LIRANS visiting professors and fellows are listed below: Dr Greg Elgar, Queen Mary University. Visiting professor, cell and cryobiology Dr Arnold Fogg (Loughborough University). Visiting professor, sensor technology Prof Barry Fuller, Royal Free and University College Medical School. Visiting professor, cell and cryobiology Prof Bill Holt, Institute of Zoolog. Visiting professor, cell and cryobiology Prof David Pegg (University of York). Visiting professor, cell and cryobiology Dr Robert Porter, National Physical Laboratory. Visiting senior researcher, sensor technology Dr Hugh Pritchard, Royal Botanic Garden Kew. Visiting professor, cell and cryobiology Prof Gordon Reid, North of England Zoological Society. Visiting professor, cell and cryobiology Dr Glyn Stacey, National Institute for Biological Standards and Control. Visiting professor, cell and cryobiology Dr Keith Straughan, University Centre Milton Keynes. Visiting professor Dr Robert Yu Wang, Visiting senior researcher, cell and cryobiology Professor Paul Watson, Royal Veterinary College. Visiting professor, cell and cryobiology Research activities New External appointments/activities Crabbe MJC continues as Editor of Computational Biology and Chemistry, and has been appointed a member of the Editorial Board of the Journal of Marine Science: Research and Development. Crabbe MJC has been appointed a member of the NERC steering committee of the Coral Reef Aquarist Network (CARN). Crabbe MJC has been appointed as a Patron of Coral Cay Conservation. Domin J Honorary Reader, Imperial College London Duncan A M External examiner for PhD at University College London. Haggett B Grant Referee for BBSRC, 2009. Marriott SB Vice President and Trustee of the Geological Society of London. Book series editor and council member, Geologists’ Association. Marriot SB Associate editor, Journal of Sedimentary Research and Sedimentology Rawson DMR Organiser and chair of Biobanking Session, CRYO 2010, Bristol, July 2010. Zampolla T Reviewer for Journal of Animal Reproduction Science (2005-). Reviewer for Cryoletters (2010-). Zhang T continues as Assistant Editor of CryoLetters and Editorial Board member of Animal Reproduction Science. Zhang T Elected Fellow of Society of Biology. Zhang T Appointed as member of Editorial Board for Journal of Aquaculture Research. Zhang T Organising Committee Member and Session Chair at Society for Cryobiology Annual Conferences, Cryo2010, Bristol UK, Sept 2010. Zhang T PhD Supervisor, Federal University of Rio Grande do Sul, Brazil Zhang T Elected Fellow of Chinese Life Science Society UK Zhou S Reviewer of Journal of Nutritional Biochemistry (2010-) Zhou S Visiting Research Fellow. 2010-2013, King’s College London. Research output Books and book chapters Crabbe MJC, Walker ELL and Stephenson DB. (2009) El-niño and coral reefs. In: (Eds. J.A. Long and D.S.Wells) Ocean circulation and El-niño: New research. Pp. 265-274. Nova Science Publishers, New York, USA. Domin J (2010) Phosphoinositide 3-kinase enzymes as downstream targets of the EGF receptor In Epidermal Growth Factor Signalling Networks in Cancer Therapy. Humana Press Gullick W and Halley J ed. Al Ghasyah H, Duncan AM, Chester DK 2010 United Arab Emirates: Disaster management with regard to rapid onset natural disasters. In Advanced ICTs for Disaster Management and Threat Detection: Collaborative and Distributed Frameworks. (eds E Asimakopoulou & N Bessis) 65-79. Chester DK, Duncan AM, Sangster H (2010) Religion, faith communities and disaster. In Routledge Handbook on Natural Hazards (eds J-C Gaillard & B Wisner) Hillier RD, Marriott SB and Williams BPJ (2010). Pedogenic and non-pedogenic calcretes in the Devonian Ridgeway Conglomerate Formation of SW Wales UK: a cautionary tale. In: Davidson, S.K., Leleu, S. and North, C.P. (Eds) From River to Rock record: the preservation of fluvial sediments and their subsequent interpretation. SEPM Special Publication. Marriott SB (2010). The Roadside Geology of Wales, Guide Book 69 by Jim Talbot and John Cosgrove. Geologists’ Association, London (in press). Marriott SB (2010). The Geology of London, Guide Book 68 by Diana Clements. Geologists’ Association, London (in press). Marriott SB (2009). The Dalradian of Scotland. Guide Book 67 by Jack Treagus. Geologists’ Association, London 212pp. Gemeinholzer B, Rey I, Weising K, Grundmann M, Muellner A N, Zetzsche H, Droege G, Seberg O, Petersen G, Rawson DM, Weigt LA (2010). Organizing specimen and tissue preservation in the field for subsequent molecular analyses. ABC Taxa. Royal Belgian Institute of Natural Sciences, Brussels, Belgium. (In press). Refereed publications Crabbe MJC (2010) Coral Ecosystem Resilience, Conservation and Management on the Reefs of Jamaica in The Face of Anthropogenic Activities and Climate Change. Diversity 2, 881-896. Crabbe MJC (2010) Linking the ceramic industry, creativity and education in Jingdezhen, China. Creative Industries Journal. 2, 305-311. Crabbe MJC (2010) Sustainable tourism and management for coral reefs: preserving diversity and plurality in a time of climate change. Journal of Service Science and Management 3, 250-256. Crabbe MJC (2010) Computational Biology approaches to plant metabolism and photosynthesis: applications for corals in times of climate change and environmental stress. Journal of Integrative Plant Biology. 52, 698-703. Crabbe MJC, Martinez E, Garcia C, Chub J, Castro L and Guy J (2010) Is capacity building important in policy development for sustainability? A case study using action plans for sustainable Marine Protected Areas in Belize. Society and Natural Resources. 23, 181-190. Crabbe MJC (2010) Topography and spatial arrangement of reef-building corals on the fringing reefs of North Jamaica may influence their response to disturbance from bleaching. Marine Environmental Research. 69, 158-162. Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P (2010) The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol 190, 307-15 . Chavele KM, Martinez-Pomares L, Domin J, Pemberton S, Haslam SM, Dell A, Cook HT, Pusey CD, Gordon S, Salama AD (2010) Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice. J Clin Invest. 120, 1469-78. Leibiger B, Moede T, Uhles S, Barker CJ, Creveaux M, Domin J, Berggren PO, Leibiger IB.(2010) Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion. FASEB J. 24, 1824-37. Skobridis K, Kinigopoulou M, Theodorou V, Giannousi E, Russell A, Chauhan R, Sala R, Brownlow N, Kiriakidis S, Domin J, Tzakos AG, Dibb NJ (2010) Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors. ChemMedChem. 5, 130-9. Banfic H, Visnjic D, Mise N, Balakrishnan S, Deplano S, Korchev YE, Domin J. (2009) Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus. Biochem J. 422, 53-60. Chester DK & Duncan AM (2009) The Bible, theology and religious responses to historic and contemporary earthquakes and volcanic eruptions. Environmental Hazards 8, 1-29 Chester DK & Duncan AM (2010) Coping with disasters within the Christian tradition, with reference to volcanic eruptions and earthquakes. Religion 40, 85-95. Guan M, Rawson DM and Zhang T (2010). Cryopreservation of zebrafish (Danio rerio) oocytes by vitrification. Cryoletters, 31(3), 230-238. Rawson DM and Genome 10K Community of Scientists (2009). Genome 10K: a proposal to obtain whole genome sequence for 10,000 vertebrate species. Journal of Heredity 2009 100(6):659-674; doi:10.1093/jhered/esp086 Hillier RD, Waters RA, Marriott SB and Davies JR (2010). Alluvial fan and wetland interactions: evidence of seasonal slope wetlands from the Silurian of south central Wales, UK. Sedimentology, illier, R.d., Wa(doi: 10/1111/j.1365-3091.2010.01184.x). Zhao Y, Marriott SB and Zhang X (2009). Phase change and remobilization of heavy metals in floodplain sediments of UK river systems after frequent flooding. Progress in Environmental Sciences, 2, 979-985. Tsai S, Rawson DM and Zhang T (2010). Development of in vitro culture method for early stage zebrafish (Danio rerio) ovarian follicles for use in cryopreservation studies. Theriogenology, 74(2), 290-303. Reynolds J, Abbott DS, Karegli J, Evans DJ, Pusey CD. (2009) Mucosal tolerance induced by an immunodominant peptide from rat 3(IV)NC1 in experimental autoimmune glomerulonephritis Am J Pathol 174:2202-2210 Tsai S, Spikings E, Kuo FW, Lin NC, Lin C (2010) Use of adenosine triphosphate assay and simultaneous staining with fluorescein diacetate and propidium iodide to evaluate the effect of cryoprotectants on hedgehog coral (Echinopora sp.) oocytes. Theriogenology, 73: 605-611. Tsai S, Spikings E, Hwang CC, Lin C (2010) Effects of the controlled slow cooling procedure on freezing parameters and ultrastructural morphology of Taiwan shoveljaw carp (Varicorhinus barbatulus) sperm. Aquatic Living Resources 23: 119-124. Tsai S, Spikings E, Huang IC, Lin C (2010) Study on the mitochondrial activity and membrane potential after exposing later stage oocytes of two gorgonian corals (Junceella juncea and Junceella fragilis) to cryoprotectants. Cryoletters, in press. Zampolla Z, Spikings E, Zhang T, Rawson DM (2009). Effect of methanol and Me2SO exposure on mitochondrial activity and distribution in stage III ovarian follicles of zebrafish (Danio rerio). Cryobiology 59 (2), 188-194 LU Y, Zhou S, Li B, (2010) Environmental Hexachlorocyclohexane (HCH) and Dichlorodiphenyltrichloroethane (DDT) Exposure on Children in a Rural Area in North East of China: 8 Metabolites Levels of HCH and DDT in Serum and the Risk Factors Analysis. Biochemical and Environmental Science, 23 (3), 230-233. Tian Z, Li Z, Zhou S, Liang Y, Wang D, He D (2010) Altered Proteins of MCF-7 Cells in G1 Phase After Receiving Chinese Herbal Medicine Zilongjin Treatment. Proteomics Clin. Appl. 4, 550–559. Submitted manuscripts Anil S, Ghafari F, Zampolla T, Rawson DM, Zhang T (2010). Studies on cryoprotectant toxicity to zebrafish (Danio rerio) ovarian tissue fragments. Cryoletters, submitted. Rawson DM, Reid GM, Lloyd RE (2010). Conservation rationale, research applications and techniques in the cryopreservation of lower vertebrate biodiversity from marine and freshwater environments. Research in Zoos, International Zoo Yearbook, submitted Reynolds J, Sando GS, Marsh O, Salama AD, Pusey CD. Manipulation of the PD1/PDL1 negative T cell costimulatory pathway in treatment of established experimental autoimmune glomerulonephritis. J Am Soc Nephrol (in revision)
Lin C, Arno M, Zhou S, Emery P, Preedy V, Wiseman H. The effect of daidzein and ethanol on gene expression in the rat liver using Affymetrix microarray. Journal of Nutrition, submitted. Favé G, Beckmann M, Zhou S, Lloyd AJ , Harold G, Lin W, Tailliart K, Draper J Mathers J. Characterization and control of inter-individual variability 1 to aid measurement of metabolomic changes in response to food ingestion. Am J Clin Nutri, submitted. C. Lin, T. Zhang, F.W. Kuo, S. Tsai (2010). Studies on oocytes chilling sensitivity of two gorgonian coral species (Junceella juncea and Junceella fragilis). Cryoletters, submitted. Other publications Anil S, Ghafari F, Zampolla T, Rawson DM, Zhang T (2010). Studies on cryoprotectant toxicity to zebrafish (Danio rerio) ovarian tissue fragments. Cryobiology, in press. [Abstract] Crabbe MJC (2010) Coral ecosystem resilience, conservation and management on reefs in the Caribbean and in Indonesia in the face of anthropogenic activities and climate change. Abstracts of the 2010 Meeting of the Association for Tropical Biology and Conservation, 23. Crabbe MJC (2010) Creativity and Critical Thinking, and their relevance to the creative industries in China. Abstracts of the 16th International Reflective Practice Conference, 14. Crabbe MJC (2010) Reflection in Southern Belize: From personal development to changing government policy. Abstracts of the 16th International Reflective Practice Conference, 13. Crabbe MJC (2010) Environmental influences on coral growth – from Indonesia to the Caribbean. Proceedings of the 1st Coral Aquarist Research Network Conference, 9. Crabbe MJC (2010) It’s not all doom and gloom! Coral resilience on the fringing reefs of North Jamaica. Proceedings of Oceanology International 2010: Marine Environment, 1-9. Desai D, Spikings E, Rawson DM, Zhang T (2010). Studies on impact of chilling on sox gene expression in zebrafish (Danio rerio) embryos. Cryobiology, in press. [Abstract] Ghafari F, Spikings E, Rawson DM and Zhang T (2009). Effect of cryoprotectant treatment and chilling on oxidative stress in zebrafish (Danio rerio) early ovarian follicles. Cryobiology, 59(3), 415 [Abstract]. Catt M, Haggett BGD and Roxborough HE Disposable sensor for liquid samples. World Intellectual Property Organisation WO 2009/021907 A1, 19 February 2009. Catt M, Haggett BGD, O’Connor A.M. and Roxborough H.E. Disposable enzymatic sensor for liquid samples. World Intellectual Property Organisation WO 2009/021908 A3, 19 February 2009. Haggett B, Birch B, Andres R and Baskeyfield D. Strip for an electrochemical meter. World Intellectual Property Organisation WO 2009034284 A8, 19 March 2009. Haggett B, Birch B, Andres R and Baskeyfield D. Electrochemical strip for use with a multi-input meter. US Patent Application 2009/0302872 A1, 10 December 2009. Haggett B, Birch B, Andres R and Baskeyfield D. System for electrochemically measuring an analyte in a sample material. US Patent Application 2009/0302873 A1, 10 December 2009. Haggett B, Birch B, Andres R and Baskeyfield D. Method for manufacturing a strip with a multi-input meter. US Patent Application 2009/0325307 A1, 31 December 2009. Haggett B, Birch B, Andres R and Baskeyfield D. Strip for an electrochemical meter. Chinese Patent Application CN 101680875(A), 4 March 2010. Rawson DM, Zhang T and Zampolla T (2010). Cryo-banking of cells and tissues from freshwater and marine fish in the UK waters. Biopreservation and Biobanking, 7(4), 185. [Abstract]. Spikings E, Zhang T, Rawson DM (2009) Effect of methanol on expression of mitochondrial DNA replication factors and mitochondrial DNA replication in zebrafish embryos. Cryoletters, 31(2), 173-174. [Abstract] Chester DK & Duncan AM 2010 The impact of the Eyjafjallajokull volcanic eruption on air transport. Royal Geographical Society Geographical Journal invited on line commentary http://geographicaljournal.rgs.org/index.php/home/93-the-impact-of-the-eyjafjallajoekull-volcanic-eruption-on-air-transport Spikings E, Vishnolia K, Rawson DM and Zhang T (2010). Effect of methanol and chilling on expression of mitochondrial DNA replication factors and mitochondrial DNA replication in zebrafish embryos. Cryobiology, in press. [Abstract] Spikings E, Zhang T, Rawson DM (2009) Effect of methanol on expression of mitochondrial DNA replication factors and mitochondrial DNA replication in zebrafish embryos. Cryoletters, 31(2), 173-174 Zampolla T, Spikings E, Zhang T, Rawson DM (2010). Investigation of methanol impact on mitochondrial transport and cytoskeleton proteins in zebrafish (Danio rerio) stage III ovarian follicles Cryobiology, [Abstract], in press. Zampolla T, Spikings E, Zhang T, Rawson DM (2009). Effect of methanol and DMSO exposure on mitochondrial activity and distribution in stage III ovarian follicles of zebrafish (Danio rerio). Cryobiology, 59(3), 413 [Abstract]. Davies J, Zhang T, Fuller B and Pillai R (2009). To perform a pilot study to develop a quality assessment protocol for optimisation studies and for routine post cryopreservation use in cardiovascular tissue banking. Cryoletters, 30 (2), 153. [Abstract] Conference presentations/invited lectures Ahmed BY, Choudry Z, Chalimoniuk M. and Langfort J. “The Role of Caspases & Exercise in Parkinson’s disease. Abstr. XVIII International Parkinson Congress, Miami, Florida, USA (December 2009). Fathy S.M., Chalimoniuk M., Abd-Elkader I. Langfort J and Ahmed BY “Can exercise improve facial motoneuronal deterioration in MPTP-injected rat model of Parkinson Disease? Abstr. XVIII International Parkinson Congress, Miami, Florida, USA (December 2009). Ahmed BY, Chalimoniuk M, Choudry Z, Ali H and Langfort J. “Exercise as a neuroprotective mechanism in Parkinson’s disease” Abstr. SPRING Exercise International conference, London, UK (September 2009) Hossam Ali, Langfort J., Chalimoniuk M. and Ahmed BY “Endurance exercise suppresses dopaminergic neuronal loss in the chronic rat model of Parkinsonism” Abstr. SPRING Exercise International conference, London, UK (September 2009) Samah Fathy., Chalimoniuk M, Langfort J. Ibrahim Abd-Elkader and Ahmed BY “Repression of NF-H hyperphosporylation by endurance exercise in facial motoneurons in a parkinsonian model” Abstr. SPRING Exercise International conference, London, UK (September 2009) Anil S, Ghafari F, Zampolla T, Rawson DM, Zhang T. Studies on cryoprotectant toxicity to zebrafish (Danio rerio) ovarian tissue fragments. Cryo2010 47th Annual Meeting of the Society for Cryobiology. Bristol, UK, July 2010. Crabbe MJC Invited Speaker at Oceanology International 2010 (Excel Centre, London); Invited Speaker at Association for Tropical Biology and Conservation meeting, Bali. Crabbe MJC Invited Speaker in Computational Systems Biology for the 2010 International Photosynthesis Congress in Beijing. Desai D, Spikings E, Rawson DM, Zhang T. Studies on impact of chilling on sox gene expression in zebrafish (Danio rerio) embryos. Cryo2010 47th Annual Meeting of the Society for Cryobiology. Bristol, UK. Mise, N. Kuemper, S. Shousha, S. Lam E W-F. Coombes, RC. Ridley, AJ and Domin J. “The class II phosphoinositide 3-kinase enzyme PI3K-C2 regulates cell-cell adhesion and migration of breast cancer cells”Miami 2010 Winter Symposium “Targeting Cancer Invasion and Metastasis”Feb 21-24 2010 Miami Beach Florida USA Coutinho R, Chester D, Wallenstein N, Duncan A The impact and responses to the 1957/1958 Capelinhos volcanic eruption and associated earthquake activity on Faial, Azores. Cities on Volcanoes 6 |Conf., Tenerife June 2010 Ghafari F, Spikings E, Rawson D and Zhang T. Effect of cryoprotectant and chilling on oxidative stress in stage I zebrafish (Danio rerio) ovarian follicles. Controversies in Cryopreservation of Stem Cells, Reproductive Cells, Tissues and Organs. Valencia, Spain, April 2010. Maytum R The 50th Anniversary Symposium of the British Biophysical Society. Robinson College, Cambridge, July 16th-18th, 2010. Rawson D, Zhang T, Zampolla T. Cryo-Banking of Cells and Tissues from Freshwater and Marine Fish in the UK Waters. Diversity in Biobanking: Embracing Differences, Harnessing Commonalities. Annual Meeting of International Society of Biological and Environmental Repositories. Rotterdam, Netherlands, May 2010. Rawson DM. Environmental Specimen Cryobanking. CRYO-2010, Bristol, July 2010. Spikings E, Vishnolia K, Rawson DM and Zhang T. Effect of methanol and chilling on expression of mitochondrial DNA replication factors and mitochondrial DNA replication in zebrafish embryos. Cryo2010 47th Annual Meeting of the Society for Cryobiology. Bristol, UK. Spikings E, Zampolla T, Wang Y, Rawson D, Zhang T. Methanol disrupts mitochondrial organisation in zebrafish ovarian follicles. Controversies in Cryopreservation of Stem Cells, Reproductive Cells, Tissues and Organs. Valencia, Spain, April 2010. Spikings E, Zhang T, Rawson DM. Effect of methanol on expression of mitochondrial DNA replication factors and mitochondrial DNA replication in zebrafish embryos. Society for Low Temperature Biology Scientific Meeting, Hannover, Germany. Sept 2009. Zampolla T, Rawson DM, Srirangarajah S, Ramesh S, Zhang T (2010) Effect of cryoprotectant exposure and cryopreservation on zebrafish (Danio rerio) ovarian fragments. Presented at CRYO 22 - 25 April, 2010 Valencia, Spain. Zampolla T, Spikings E, Zhang T, Rawson DM (2010). Investigation of methanol impact on mitochondrial transport and cytoskeleton proteins in zebrafish (Danio rerio) stage III ovarian follicles presented at Cryo 2010, 47TH Annual Meeting of the Society for Cryobiology, 17-20 July 2010, Bristol, UK. Zampolla T, Zhang T, Rawson DM (2010) Cryoconservation and species biodiversity. Presented at the. Fish and Climate Change, Annual International Symposium of the Fisheries society of the British Isles, Queen’s University, 26-30 July 2010, Belfast, UK Zhang T (2010). Latest development on cryopreservation of zebrafish (Danio rerio) gamates. Presented at CLSS-UK, London, Sept 2010. Zhou S Progress of Zinc nutrition research, 1rst initiated Zinc-UK meeting, University College of London. April, 2010 Camilla Pease, Zheying Zhu, Christine Goetz, Pierre Aeby, Paul Carmichael, Daniel Duche, Carsten Goebel, Stefan Pfuhler, Kerstin Reisinger, Robert Edwards and Ellen Fritsche (2009). Human skin metabolism and its relevance to safety assessment of topically applied chemicals: learning from the COLIPA skin metabolism project. Present at 7th World Congress on Alternatives to Animal Testing, Rome, Italy. Funded research programmes Ahmed BY (2009-2010), Thompsett A., Alsam S. and Zhou S. (Principal Investigator for the grant achieved for the Division of Science) Research-informed Teaching grant £5, 216.University of Bedfordshire Mason R, Domin J and Bou-Gharios G. (2008- 2011) Project Grant Diabetes UK £ 206,181 “The interaction of connective tissue growth factor with neurotrophin receptors – a possible therapeutic target in diabetic nephropathy” Haggett BGD, Dep G, Bloxham S, Andres R (2007-2011) Johnson & Johnson £440,000. Development of biosensors for well being. Reynolds J (2009-2010) Research Service Grant UCB UCB Celltech R&D Ltd £10,000 “Effect of anti-IL6 monoclonal antibody therapy in a mouse model of experimental autoimmune glomerulonephritis” Spikings E, Lewis M. (2009-2011) Jointly funded by Axiom Pharmaceuticals Ltd and University of Bedfordshire. Research Degree Program £42,000 Development and characterisation of a 3D culture system for zebrafish muscle cells to investigate their adaptability to different environmental stresses. Zhang T, Ghafari F (2009-2011) Jointly funded by PARS Evidence Based Veterinary Medicine Centre and University of Bedfordshire. Research Degree Program £42,000 In vitro maturation and cryopreservation of canid species. Zhou S, Zhang T (2009-2011) Jointly funded by Chinese Nutrition Society and University of Bedfordshire. Research Degree Program. £48,000 Studies on biomarkers for the assessment of zinc status using proteomic techniques. Edwards RJ and Zhu Z (2007-2010): COLIPA £380,000 “Expression of drug metabolism enzymes in human skin and 3D skin models”. Bidding activities Ahmed BY and S.A.Kazmi “Mitochondrial dysfunction in Parkinson's disease: a study of cellular, molecular and redox status in human dopaminergic neurons”. British Council grant INSPIRE: (International Strategic Partnerships in Research & Education Pakistan Strategic Partnership Awards) Joint with H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan (Submitted on July 30th, 2010, £ 60,942.3) Andres R, Haggett BGD, Randle W, Spikings E, Zampolla T Confocal microscopy. Merck Sharp & Dohme £2,138. Successful. Marriott SB April 2010 Economic and environmental impact reports for Bedfordshire sub-region, quarterly reports to be submitted from April 2010. Proposal submitted to local UAs (with R Durbarry, UoB) (awaiting decision) Marriott SB March 2010 Functional and evolutionary significance of symbiotic fungal associations in lower land plants. Application to NERC (Long-term Co-evolution of Life and the Planet), with D Beerling, D Read (University of Sheffield) J Marshall (University of Southampton) (awaiting decision) Marriott SB Feb 2010 Project EAST: environmental awareness and sustainability training for behavioural change, application submitted to HEFCE for 2-year project (unsuccessful) Marriott SB Feb 2010 Newton Fellowship – application to the Royal Society for 2-year post-doctoral research project on alluvial architecture, with E Beilinson (Argentina) (awaiting decision) Marriott SB Dec 2009 Zero Carbon Castle, monitoring and evaluation contribution to Low Carbon Communities Challenge proposal submitted to Department of Energy and Climate Change (with P Vann, Bedford County Council) (unsuccessful) Marriott SB Nov 2009 Bid to EEDA for capital funding to equip an elemental analysis laboratory for environmental monitoring projects (unsuccessful) Marriott SB Oct 2009 Proposal to BG Group for matched funding PhD student to work on Australian sedimentary basins (unsuccessful) Marriott SB Oct 2009 Economic and environmental impact reports for Bedfordshire sub-region, quarterly reports to be submitted from April 2009. Proposal submitted to local UAs (with R Durbarry, UoB) (successful) Marriott SB Sept 2009 PEARL: Bridging the Gaps to promote Participation in the Environment through Active Rural Leisure research, proposal submitted to EPSRC (unsuccessful) Desai K, Spikings E PhD student sponsorship scheme funded by Primer Design (£3000 PCR consumables and training). December 2009. Successful. Spikings E PhD studentship (£3750 consumables allowance + stipend) from the Fisheries Society of the British Isles: “Sex Determination in zebrafish (Danio rerio) and Impact of Cryopreservation”. Submitted January 2010, not awarded. Zampolla T (£40,000).. Investigation of vitellogenesis process in fish. The Leverhulme Trust. Early Carrer Felloships. March 2010. (unsuccessful). Fuller B, Morris J, Zhang T ($587,000). Cryopreservation of multicellular co-ordinated biological systems. Paul Allen Foundation. Feb 2010, not awarded. Rawson DM (£172,294). A national environmental specimen cryo-bank for UK fish species. Esmee Fairbairn Foundation March 2010, not awarded. Zhang T, Lin C (£24,000). Cryopreservation of gorgonian coral oocytes. The Royal Society. March 2010, not awarded. Callaghan J, Zhang T (£30,000). Freezing the Future. The Wellcome Trust, April 2010, not awarded. Zhou S (£42,000). Match Funding Research Studentship. Jointly funded by Enlong Ltd and University of Bedfordshire. Successful. LIRANS Services and Consultancy LIRANS Services is a new initiative to provide external businesses and others with facilitated access to the range of specialist equipment available at 250 Butterfield. Currently, emphasis is being placed on access to the confocal microscopes made available by capital funding from the East of England Development Agency. Delegates from businesses – and from universities – across the region were attracted to the three training days made available in the first half of 2010 (March, May and July) and there are more sessions to come in the following months. Co-ordinated by Dr Andres, the training sessions enjoy time and support from a wide range of LIRANS staff/students. The enterprise continues to benefit from the unstinting support of the Innovation Director (Dr Randle) and the first customers for the microscopy services have arrived. A web-site has been set up at www.beds.ac.uk/reserach/lirans/services and it is planned that the training/marketing approach used for the confocal microscopes be extended to other key pieces of equipment. For consultancy activities, three quarterly reports were produced for Central Bedfordshire and Bedford unitary authorities by Prof S. Marriott and Dr Ramesh Durbarry (Div. of Tourism) over the reporting period on economic and environmental impacts for Luton and generated consultancy income of £20,000. Other Activities BY Ahmed Supervised Samah Fathy, through Split PhD program with Fayoum University, supported by Egypt Government. Title of thesis “Detailed anatomical study on the cranial nerves and related structures of a vertebrate model”. BY Ahmed Invited by Egypt Government to visit Fayoum University, Egypt for 2 weeks (September 2010). Domin J Supervisor of Sanjeevi Balakrishnan, Imperial College London Domin J Supervisor of Dr Simona Deplano, Imperial College London Directory: about-us about-us -> Prisoner loan: next-of-kin estimate of monthly income and expenditure about-us -> Optus pre-paid mobile broadband service about-us -> Department of Transport Annual Report 2013-14 about-us -> Optus mobile broadband service about-us -> Optus Pre-Paid Mobile Service Service Description about-us -> Table of Contents 1 Introduction and Background 7 about-us -> Annual Review for 2014 Summary Report about-us -> East Asia regional development cooperation report 2009 October 2010 about-us -> East Asia Regional Organisations and Programs Annual Program Performance Report 2011 Download 2.58 Mb. Share with your friends:
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