Annual Research Institutes Reports



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Research Activity



Muscle Cellular and Molecular Physiology
This research group was new to the Institute and University in 2009 after Professor Mark Lewis moved to the University after 15 years being based in biomedical departments. Within a month of his arrival, the great news arrived that Professor Lewis has been awarded a £0.5 million grant that is to develop a model of “laboratory muscle” that can be stimulated (exercised) like a human being. The grant was awarded by the NC3Rs, a Research Council UK group. The group is now applying this expertise and knowledge to questions relevant to the physiology of human exercise. A major component of the NC3Rs grant was to employ a Post-Doctoral Research Assistant and the group was joined in March 2010 by Dr Samantha Passey. After 4 months of planning, the tissue culture facilities opened for business at the beginning of February 2010.
The group was joined in September 2009 by University Bursary PhD students Darren Player (How can 3D-bioengineered skeletal muscle be used in sports performance research?) and Neil Martin (Satellite cell activation and its role in resistance training) and in January 2010 by University Bursary PhD student Paul Davies (Molecular mechanisms underlying deterioration of muscle performance with age). Neil and Darren are being supervised by Professor Mark Lewis and Dr Paul Castle whilst Paul is being supervised by Mark and Dr Nick Sculthorpe. In addition, James Tuttle (Contribution of Heat and Mechanical Stress to Heat Shock Protein gene expression) started his PhD in December 2009; his project is collaboration between this research group and Applied Sport and Exercise Physiology. His supervisors are Dr Paul Castle and Mark Lewis. To complete the picture, Krishan Vishnolia (Development and characterisation of a 3D culture system for fish muscle cells to investigate their adaptability to different environmental stresses) and Hossam Ali (Effect of different types of physical exercise on dopamine synthesis in MPTP-Induced Parkinson’s disease) joined as joint students with own Universities LIRANS (Institute of Research into Applied and Natural Sciences).
They joined 5 existing PhD students based at UCL where Mark Lewis was appointed as Honorary Professor in October 2009. Two of these UCL students successfully defended their PhD theses in 2010. The group has active collaborations with groups based at UCL, Loughborough University, Cardiff University and University of California, Davis and in this academic year, also developed important links with groups from Cranfield and Chichester Universities.
In a busy year of profile raising, the group attended and presented at the annual conferences of the American College of Sports Medicine (ACSM; Baltimore, USA), the Tissue and Cell Engineering Society (TCES; Manchester, UK), the Physiological Society (Manchester, UK) and the British Association of Sport and Exercise Sciences (BASES) Main (Glasgow, UK) and Student (Aberystwyth, UK) conferences.
Applied Sport and Exercise Physiology
The Applied Sport and Exercise Science group have had an exciting last twelve months, delivering research and support work that has had a positive impact on external clients, and made a major contribution to scientific understanding. The recent refurbishment of the heat chamber has enabled team members to work with the Great Britain Disabled Shooting squad, providing them with support for their 2009 World Championships, whilst obtaining unique data on the physiological adaptations of wheelchair athletes to exercise in the heat, which is currently being analysed for future publication. Corporate funding from Maximuscle Ltd has resulted in data which is now being used by the company to support product claims, with an option for future publication. As well as publishing a number of full papers and abstracts in high impact Journals, the team members have also presented at key academic conferences such as the European College of Sports Sciences 2010 Annual Conference, and the 2010 Annual BASES Conference.
Physical Activity and Health
During 2009-2010 the Physical Activity and Health Research Group were particularly successful in undertaking and developing further research relating to the health of children and adolescents. Firstly, staff and postgraduate students completed a major 2 year intervention study aimed at increasing the physical activity levels of 10-14 year old schoolchildren in Bedfordshire (the Health and Physical Activity Promotion in Youth Study, HAPPY), funded by the Bedford Charity (£84,000 external funding). Some of the early findings from the study were presented at the recent International Congress of Obesity (Stockholm 2010), particularly in relation to the cardiovascular health and potential risk of developing type 2 diabetes, fitness and body composition of the 240 participants. Research was also recently completed to determine the contribution of physical education lessons to moderate and vigorous physical activity levels using objective physical activity monitoring techniques and articles have been submitted to Health Promotion related journals in this field. Both the PE setting research and HAPPY study have included consideration of the psychological determinants of physical activity and such work has recently been presented at the European Health Psychology Conference (Romania 2010), and the Division of Health Psychology Conference (Belfast 2010). Current projects which have attracted external funding (£28,000) include a study to investigate the effectiveness of physical activity and nutritional interventions in overweight post-pubertal adolescents with features of the Metabolic Syndrome. This is in collaboration with the Centre for Obesity Research at Luton and Dunstable Hospital, associated dieticians, and paediatric consultants.

Research Projects





Bid Title

Applicants (ISPAR in bold)

Research Group

Funding Body

Scheme

Total Applied For

Outcome

Molecular mechanisms underlying deterioration of muscle performance with age

Lewis, M.P., Sculthorpe, N., Ferguson, R.

MCMP

University of Bedfordshire

Bursary

£62,370

Successful

How can 3D-bioengineered skeletal muscle be used in sports performance research?

Lewis, M.P., Castle, P.C. and Mudera, V.

MCMP

University of Bedfordshire

Bursary

£62,370 (2009-2012)

Successful

Satellite cell activation and its role in resistance training

Lewis, M.P., Castle, P.C. and Mudera, V.

MCMP

University of Bedfordshire

Bursary

£62,370 (2009-2012)

Successful

Engineering fully functional, integrated skeletal muscle

Lewis, M.P., Mudera, V. and Greensmith, L.

MCMP

NC3Rs

Project Grant

£495,394 (2009 – 2012)

Successful

In-Vitro 3D tissue modelling: insights into Ameloblastoma pathogenesis

Lewis, M.P., Salih, V., Fedele, S., Porter S.R.

MCMP

Biss-Davies Charitable Trust

Studentship

£150,000 (2009-2012)

Successful

Development and characterisation of a 3D culture system for fish muscle cells to investigate their adaptability to different environmental stresses

Lewis, M.P., Spikings, E.

MCMP

Overseas Research Scholarship (India); Match Funding by UoB

Scholarship

£27,900 (2010-2012)

Successful

Driving oral mucosal epithelial cells towards a corneal phenotype for therapeutic transplantation

Lewis, M.P., Daniels, J.T.

MCMP

Fight for Sight

Project Grant

£159,992 (2009-2012)

Successful

Ultrasound upgrade

Sculthorpe, N.

ASEP


University of Bedfordshire

RiT

£13,000 (2009-2010)

Successful

Exercise Therapy in Sub-classifications of chronic lower back pain (CLBP)

Slavin, J, Lewis, M.P., Fletcher, I. and Sculthorpe, N.

ASEP

MCMP


PAH

Chartered Society of Physiotherapists

Project

£248,000

Awaiting Outcome

Walking Leader

Training


Beedie P, Mellor G, Brewer, J. and Hall, N.

ASEP

Natural England

Eastern England and London




Unsuccessful

Evaluation of sports nutrition supplements on human performance

Brewer, J.

ASEP

Maximuscle Ltd

Corporate

£9500 (2009-2010)

Successful

Validation and sensitivity of regional sweat swabs during exercise

Brewer J. and Castle, P.C.

ASEP

HFL Sport science LTD, Cambridge

Partnership




Successful

Improving staff and student research profiles within the Department of Sport & Exercise Sciences

Mauger, L.

ASEP

MCMP PAH


University of Bedfordshire

RiT

£33,050

Successful

Can Wii-Fit improve mobility and stability in Parkinson’s disease?


Ross, E. Smeeton, N. and Castle, P.C.

ASEP

Parkinson’s Disease Society UK

Studentship

£154,000

Awaiting outcome

An integrated approach to muscle aging

Lewis, M.P.

MCMP

MRC

Partnership Grant: Outline Application

£186,847

 




Brewer, J.

ASEP

LARCI

Fellows Scheme

8,820

 

Metabolic syndrome, physical activity and children

Kerr, C. J.,

Savory, L.A.

PAH

Centre for Obesity Research Centre, Luton and Dunstable Hospital




£15,448 (2009-2011)

Successful

Metabolic syndrome, physical activity and children

Kerr, C.J.,

Savory, L.A.

PAH

University of Bedfordshire

Bursary

£15,448

successful

‘Evaluating the psychological determinants of physical activity in 10-14 year old schoolchildren’

Kerr, C.J., Savory, L.A.

PAH

University of Bedfordshire

Bursary Scheme (matched funding to previously successful Bedford Charity Grant (£84,000)

£14,000 (2010-2011)

successful

Project: 'Valuing the physically active life: Developing and sustaining health-based physical education in primary and secondary schools’

Kirk,D. Kerr, C.J., Haerens,L., Armour,K.

Harris, J.

PAH

Bedford Charity

Community Grants Programme (2010).

£80,760

unsuccessful





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