Appendix 2-5: Rejected ecotox bibliography Excluded



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Aquatic risk assessment was based on the Risk Quotient (RQ = MEC/PNEC) deterministic method regarding three trophic levels: algae, aquatic invertebrates and fish. Non-acceptable risk for 10 compounds was observed when maximum concentrations were used. Compliance to EC environmental quality standards is also discussed. [PUBLICATION ABSTRACT]
Keywords: Agriculture
Keywords: Risk assessment
Keywords: Lakes
Keywords: Greece
Keywords: Drainage
Keywords: Pesticides
Keywords: Analytical chemistry
Keywords: Land use
Keywords: Environmental Studies English. Copyright - Copyright Taylor & Francis Group 2013. Last updated - 2013-05-24. DOI - 2978791241; 78995652; 105337; IJEA; INODIJEA0000712663. SubjectsTermNotLitGenreText - Greece

640. Thompson, Charles M; Prins, John M, and George, Kathleen M. Mass Spectrometric Analyses of Organophosphate Insecticide Oxon Protein Adducts. 2010 Jan; 118, (1): 11-9.


Rec #: 7200
Keywords: CHEM METHODS
Notes: Chemical of Concern: MLN
Abstract: Abstract: Organophosphate (OP) insecticides continue to be used to control insect pests. Acute and chronic exposures to OP insecticides have been documented to cause adverse health effects, but few OP-adducted proteins have been correlated with these illnesses at the molecular level. Our aim was to review the literature covering the current state of the art in mass spectrometry (MS) used to identify OP protein biomarkers. We identified general and specific research reports related to OP insecticides, OP toxicity, OP structure, and protein MS by searching PubMed and Chemical Abstracts for articles published before December 2008. A number of OP-based insecticides share common structural elements that result in predictable OP-protein adducts. The resultant OP-protein adducts show an increase in molecular mass that can be identified by MS and correlated with the OP agent. Customized OP-containing probes have also been used to tag and identify protein targets that can be identified by MS. MS is a useful and emerging tool for the identification of proteins that are modified by activated organophosphate insecticides. MS can characterize the structure of the OP adduct and also the specific amino acid residue that forms the key bond with the OP. Each protein that is modified in a unique way by an OP represents a unique molecular biomarker that with further research can lead to new correlations with exposure.
Keywords: Insecticides -- toxicity
Keywords: Organophosphorus Compounds -- analysis
Keywords: Animals
Keywords: Cholinesterases -- chemistry
Keywords: Cholinesterases
Keywords: Humans
Keywords: Amino Acid Sequence
Keywords: Environmental Pollutants -- analysis
Keywords: Insecticides -- analysis
Keywords: Environmental Studies
Keywords: Environmental Pollutants
Keywords: Environmental Monitoring
Keywords: Proteins -- drug effects
Keywords: Organophosphorus Compounds
Keywords: Cholinesterases -- drug effects
Keywords: Proteins -- chemistry
Keywords: Insecticides
Keywords: Molecular Sequence Data
Keywords: Environmental Exposure
Keywords: Mass Spectrometry -- methods
Keywords: Organophosphorus Compounds -- toxicity
Keywords: Proteins
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641. Thompson, Thomas S a Thomas Sthompson; Dimock, Rick a Rick Dimock; Bradbury, Robert W a Robert Wbradbury; Rieve, Richard a Richard Rieve; Fehr, Mark a Mark Fehr, and Dimock, Rick a Rick Dimock. Pesticides in Fresh Potatoes Sold in Farmers' Markets in Alberta, Canada. 2011 Nov; 87, (5): 580-585.



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