Appendix 2-5: Rejected ecotox bibliography Excluded
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- review the literature covering the current state of the art in mass spectrometry
| Aquatic risk assessment was based on the Risk Quotient (RQ = MEC/PNEC) deterministic method regarding three trophic levels: algae, aquatic invertebrates and fish. Non-acceptable risk for 10 compounds was observed when maximum concentrations were used. Compliance to EC environmental quality standards is also discussed. [PUBLICATION ABSTRACT]
Keywords: Agriculture Keywords: Risk assessment Keywords: Lakes Keywords: Greece Keywords: Drainage Keywords: Pesticides Keywords: Analytical chemistry Keywords: Land use Keywords: Environmental Studies English. Copyright - Copyright Taylor & Francis Group 2013. Last updated - 2013-05-24. DOI - 2978791241; 78995652; 105337; IJEA; INODIJEA0000712663. SubjectsTermNotLitGenreText - Greece 640. Thompson, Charles M; Prins, John M, and George, Kathleen M. Mass Spectrometric Analyses of Organophosphate Insecticide Oxon Protein Adducts. 2010 Jan; 118, (1): 11-9. Rec #: 7200 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: Organophosphate (OP) insecticides continue to be used to control insect pests. Acute and chronic exposures to OP insecticides have been documented to cause adverse health effects, but few OP-adducted proteins have been correlated with these illnesses at the molecular level. Our aim was to review the literature covering the current state of the art in mass spectrometry (MS) used to identify OP protein biomarkers. We identified general and specific research reports related to OP insecticides, OP toxicity, OP structure, and protein MS by searching PubMed and Chemical Abstracts for articles published before December 2008. A number of OP-based insecticides share common structural elements that result in predictable OP-protein adducts. The resultant OP-protein adducts show an increase in molecular mass that can be identified by MS and correlated with the OP agent. Customized OP-containing probes have also been used to tag and identify protein targets that can be identified by MS. MS is a useful and emerging tool for the identification of proteins that are modified by activated organophosphate insecticides. MS can characterize the structure of the OP adduct and also the specific amino acid residue that forms the key bond with the OP. Each protein that is modified in a unique way by an OP represents a unique molecular biomarker that with further research can lead to new correlations with exposure. Keywords: Insecticides -- toxicity Keywords: Organophosphorus Compounds -- analysis Keywords: Animals Keywords: Cholinesterases -- chemistry Keywords: Cholinesterases Keywords: Humans Keywords: Amino Acid Sequence Keywords: Environmental Pollutants -- analysis Keywords: Insecticides -- analysis Keywords: Environmental Studies Keywords: Environmental Pollutants Keywords: Environmental Monitoring Keywords: Proteins -- drug effects Keywords: Organophosphorus Compounds Keywords: Cholinesterases -- drug effects Keywords: Proteins -- chemistry Keywords: Insecticides Keywords: Molecular Sequence Data Keywords: Environmental Exposure Keywords: Mass Spectrometry -- methods Keywords: Organophosphorus Compounds -- toxicity Keywords: Proteins Keywords: Biological Markers English. 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YOUNG, Jessica G.; ESKENAZI, Brenda; GLADSTONE, Eleanor A.; BRADMAN, Asa; et al. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology (Park Forest South), 26. 2 (2005): 199-209. Elsevier. Zwiener, R J; Ginsburg, C M. ORGANO-PHOSPHATE AND CARBAMATE POISONING IN INFANTS AND CHILDREN. PEDIATRICS, 81. 1 (1988): 121-126. AMER ACAD PEDIATRICS 641. Thompson, Thomas S a Thomas Sthompson; Dimock, Rick a Rick Dimock; Bradbury, Robert W a Robert Wbradbury; Rieve, Richard a Richard Rieve; Fehr, Mark a Mark Fehr, and Dimock, Rick a Rick Dimock. Pesticides in Fresh Potatoes Sold in Farmers' Markets in Alberta, Canada. 2011 Nov; 87, (5): 580-585. Directory: pesticides -> nas nas -> Appendix 1-10: Summary of Diazinon Monitoring Data nas -> Description of revision nas -> Appendix 2 Chlorpyrifos Species Sensitivity Distribution Analysis for Fish nas -> Appendix 2 Open Literature Review Summaries for Malathion Download 5.18 Mb. 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