Appendix 2-5: Rejected ecotox bibliography Excluded
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| adulticide applications. This system offers the advantages of cost efficiency, increased ease of deployment, off-season storage, visibility, stability, and ULV collection efficacy. Use of this system ensures that droplet collection and meteorological equipment is at appropriate and consistent heights between trials. The 2 arms of the support allow for placement of multiple cages, light-emitting or reflecting devices, and wind-indicating ribbons to be attached to the station. The support described makes possible deployment of stations over a wider variety of terrains, increasing the extent of field trials. Presentation of the simple design and fabrication of the rotating collection device (impactor), T-station, and its support is provided.
Number of Volumes: 2 ISI Document Delivery No.: 618AA 153. Cole, T. B.; Jansen, K.; Park, S.; Li, W. F.; Furlong, C. E., and Costa, L. G. The Toxicity of Mixtures of Specific Organophosphate Compounds is Modulated by Paraoxonase 1 Status. Department of Medicine and Genome Sciences, University of Washington, Seattle, WA, USA,//: 2009; 660, 47-60. Rec #: 1800 Keywords: REVIEW Call Number: NO REVIEW (CPYO,DZ,MLO) Notes: Chemical of Concern: CPYO,DZ,MLO 154. Cooper, D. and Terrell, Y. Acute Oral LD50 of Fyfanon 77106 KL (Malathion) in Sprague-Dawley Rats. 1979. Rec #: 490 Keywords: NO SOURCE Call Number: NO SOURCE (MLN) Notes: Chemical of Concern: MLN 155. ---. Acute Oral LD50 of Fyfanon 77106 ST L 1 AAR (Malathion) in Sprague-Dawley Rats. 1979. Rec #: 480 Keywords: NO SOURCE Call Number: NO SOURCE (MLN) Notes: Chemical of Concern: MLN 156. Cope, O. B. Malathion and Cutthroat Trout at Jackson, Wyoming. 1965: 59-60 (Publ As 2871). Rec #: 90 Keywords: PUBL AS Call Number: NO PUBL AS (MLN) Notes: Chemical of Concern: MLN 157. Coppage, D. L. Enzyme Systems of Estuarine Organisms. 1970: 31-33. Rec #: 1140 Keywords: NO CONC Call Number: NO CONC (AZ,DZ,MLN,PRT) Notes: Chemical of Concern: AZ,DZ,EPRN,MLN,PRN,PRT 158. Corsini, E. ; Sokooti, M.; Galli, C. L.; Moretto, A., and Colosio, C. Pesticide induced immunotoxicity in humans: A comprehensive review of the existing evidence: Emerging health issues from chronic pesticide exposure: Innovative methodologies and effects on molecular cell and tissue level. 2013 May 10-; 307, (0): 123-135. Rec #: 920 Keywords: REVIEW Notes: Chemical of Concern: MLN Abstract: The immune system can be the target of many chemicals, with potentially severe adverse effects on the host's health. In Western countries pesticides, together with new and modified patterns of exposure to chemicals, have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, certain autoimmune diseases and cancers. Xenobiotics may initiate, facilitate or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors, modifying immune tolerance and activation pathways. Immune system/ Immunotoxicity/ Pesticides http://www.sciencedirect.com/science/article/pii/S0300483X12003599 159. Coscolla, Clara; Castillo, Mercedes; Pastor, Agustin; Yusa, Vicent, and Coscolla, Clara. Determination of 40 Currently Used Pesticides in Airborne Particulate Matter (Pm 10) by Microwave-Assisted Extraction and Gas Chromatography Coupled to Triple Quadrupole Mass Spectrometry. 2011 May 5; 693, (1-2): 72-81. Rec #: 6370 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: A confirmatory and sensitive procedure has been developed for the determination of 40 currently used pesticides (CUPs) in airborne particulate matter (PM 10) at trace level. The proposed method includes extraction of PM 10-bound pesticides by microwave-assisted extraction (MAE) followed by a gel permeation chromatography (GPC) clean-up and determination by GC-MS/MS. The injection mode and the main parameters in MS/MS were optimized. The matrix effect was also evaluated. Recoveries ranged from 70 to 120% except for pyrimethanil and pirimicarb. The limit of quantification (LOQ) ranged from 1.32 to 39.47 pg m[super]-3, when air volumes of 760 m[super]3 were collected. The method was applied to 38 samples collected from a rural station belonging to the atmospheric monitoring network of the Regional Valencia Government (Spain) during April-June 2010. Eighteen out of 40 pesticides investigated were found in at least one sample (bifenthrin, chlorothalonil, chlorpyriphos-e, chlorpyriphos-m, clorpropham, diazinon, dicofol, diphenylamine, fipronil, fludioxonil, folpet, malathion, metalaxyl, penconazole, quinoxyfen, triadimefon, trifluralin, and vinclozoline), with concentrations ranging from 1.32 to 625.80 pg m[super]-3. Keywords: Chromatography Keywords: Spain Keywords: Mass spectrometry Keywords: Particulates Keywords: Atmospheric circulation-oceanic circulation coupled models Keywords: Malathion Keywords: M2 551.510.42:Air Pollution (551.510.42) Keywords: Environment Abstracts; Meteorological & Geoastrophysical Abstracts Keywords: Gas chromatography Keywords: fipronil Keywords: Spain, Valencia Keywords: Pesticides Keywords: Trifluralin Keywords: ENA 01:Air Pollution Keywords: Rural areas English. Date revised - 2011-06-01. Last updated - 2012-03-29. DOI - e178a357-ab57-46a8-8b21csaobj201; 14977508; 0003-2670. SubjectsTermNotLitGenreText - Gas chromatography; Chromatography; Mass spectrometry; Atmospheric circulation-oceanic circulation coupled models; fipronil; Pesticides; Trifluralin; Particulates; Malathion; Rural areas; Spain; Spain, Valencia 160. Coscolla, Clara; Colin, Patrice; Yahyaoui, Abderrazak; Petrique, Olivier; Yusa, Vicent; Mellouki, Abdelwahid; Pastor, Agustin, and CoscollA, Clara. Occurrence of Currently Used Pesticides in Ambient Air of Centre Region (France). 2010 Oct; 44, (32): 3915-3925. Rec #: 6810 Keywords: FATE Notes: Chemical of Concern: MLN Abstract: Abstract: Ambient air samples were collected, from 2006 to 2008 at three rural and two urban sites in Centre Region (France) and analyzed for 56 currently used pesticides (CUPs), of which 41 were detected. The four CUPs most frequently detected were the herbicides trifluralin, acetochlor and pendimethalin and the fungicide chlorothalonil, which were found with frequencies ranging between 52 and 78%, and with average concentrations of 1.93, 1.32, 1.84 and 12.15ngma3, respectively. Among the detected pesticides, concentrations of eight fungicides (spiroxamine, fenpropimorph, cyprodinil, tolyfluanid, epoxiconazole, vinchlozolin, fluazinam, fludioxinil), two insecticides (propargite, ethoprophos), and one herbicide (oxyfluorfen) are, to our knowledge, reported for the first time in the literature. The majority of the CUPs showed a seasonal trend, with most of the detections and the highest concentrations occurring during the spring and early summer. The most important pesticides detected were related to arable crops and fruit orchards, the main cultures in this region, highlighting the fact that the main sources come from local applications. Minor differences were found in the profiles of pesticides within rural areas and between rural and urban areas. Keywords: P 0000:AIR POLLUTION Keywords: Herbicides Keywords: Environmental Studies Keywords: France Keywords: Sulfur dioxide Keywords: Pesticides Keywords: Fungicides Keywords: Air sampling Keywords: M2 551.5:General (551.5) Keywords: summer Keywords: Trifluralin Keywords: Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Environment Abstracts Keywords: Seasonal variations Keywords: pendimethalin Keywords: ENA 01:Air Pollution Keywords: Rural areas English. Date revised - 2011-10-01. Last updated - 2011-12-08. DOI - OB-5898967e-37e0-4e37-99c0csaobj202; 13637768; 1352-2310. SubjectsTermNotLitGenreText - Fungicides; Rural areas; Sulfur dioxide; Pesticides; Air sampling; Trifluralin; summer; Herbicides; pendimethalin; Seasonal variations; France 161. Coscolla, Clara; Yusa, Vicent; Beser, M Isabel; Pastor, Agustin, and Coscolla, Clara. Multi-Residue Analysis of 30 Currently Used Pesticides in Fine Airborne Particulate Matter (Pm 2.5) By Microwave-Assisted Extraction and Liquid Chromatography-Tandem Mass Spectrometry. 2009 Dec 18; 1216, (51): 8817-8827. Rec #: 7260 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: A confirmatory and rapid procedure has been developed for the determination of 30 currently used pesticides (CUP) in fine airborne particulate matter (PM 2.5) at trace level. The proposed method includes extraction of PM 2.5-bound pesticides by microwave-assisted extraction (MAE) followed by a direct injection into LC-MS/MS. The main parameters affecting the MAE extraction (time, temperature and volume of solvent) were optimised using statistical design of experiments (DoE). The matrix effect was also evaluated. Recoveries ranged from 72 to 109% and the limit of quantification (LoQ) was 32.5 pg m super(-3) for chlorpyrifos, 13.5 pg m super(-3) for fenhexamid, imazalil and prochloraz, and 6.5 pg m super(-3) for the rest of pesticides, when air volumes of 760 m super(3) were collected. The method was applied to 54 samples collected from three stations of the atmospheric monitoring network of the Regional Valencia Government (Spain) during April-July 2009. Nineteen out of 30 pesticides investigated were found in at least one sample: omethoate, carbendazim, acetamiprid, thiabendazole, malathion, flusilazole, metalaxyl, azoxystrobin, iprovalicarb, myclobutanil, tebuconazole, triflumizole, cyprodinil, tebufenpyrad, buprofezin, pyriproxyfen, hexythiazox, flufenoxuron and fenazaquin. The measured concentrations ranged from 6.5 to 1208 pg m super(-3). To our knowledge, 11 of the pesticides detected have been reported for the first time in ambient air. Keywords: P 0000:AIR POLLUTION Keywords: Chromatography Keywords: Spain Keywords: Solvents Keywords: Temperature Keywords: Statistical analysis Keywords: Mass spectrometry Keywords: Particulates Keywords: Malathion Keywords: Chlorpyrifos Keywords: M2 551.510.42:Air Pollution (551.510.42) Keywords: Pollution Abstracts; Meteorological & Geoastrophysical Abstracts Keywords: Spain, Valencia Keywords: Pesticides Keywords: Atmospheric monitoring English. Date revised - 2010-03-01. Last updated - 2012-03-29. DOI - MD-0011340607; 11309966; 0021-9673. SubjectsTermNotLitGenreText - Chromatography; Statistical analysis; Mass spectrometry; Chlorpyrifos; Pesticides; Temperature; Solvents; Particulates; Atmospheric monitoring; Malathion; Spain; Spain, Valencia 162. Costa, Michael D; Freitas, Mayara L; Soares, Felix Alexandre Antunes; Carratu, Vanessa Santana; Brandao, Ricardo, and Costa, Michael D. Potential of Two New Oximes in Reactivate Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphate Compounds: an in Vitro Study. 2011 Dec; 25, (8): 2120-2123. Rec #: 3020 Keywords: HUMAN HEALTH Notes: Chemical of Concern: MLN Abstract: Abstract: Organophosphate (OP) compounds exert inhibition on cholinesterase (ChE) activity by irreversibly binding to the catalytic site of the enzyme. Oximes are compounds generally used to reverse the ChE inhibition caused by OP agents. In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion. Oximes used clinically (obidoxime and pralidoxime) were used as positive control. For this study, human blood (erythrocytes for AChE determination and plasma for BChE determination) was used and different concentrations of oximes (1-100 mu M) were tested. The concentrations of OP used were based on the IC50 for AChE and BChE. Results demonstrated that obidoxime was more effective in reactivate the AChE inhibition induced by OP compounds. However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE. For BChE reactivation, none of evaluated oximes achieved positives rates of reactivation, been obidoxime able to reactivate malathion-inhibited BChE only in 24% at the highest concentration. We conclude that both newly developed oximes seem to be promising reactivators of OP-inhibited AChE. Keywords: obidoxime Keywords: Acetylcholinesterase Keywords: Erythrocytes Keywords: Enzymes Keywords: organophosphates Keywords: Cholinesterase Keywords: Malathion Keywords: Chlorpyrifos Keywords: Blood Keywords: oximes Keywords: Active sites Keywords: X 24330:Agrochemicals Keywords: Toxicology Abstracts Keywords: Diazinon English. Date revised - 2011-12-01. Last updated - 2012-03-29. DOI - 24e28ee8-bec7-47cf-9ab4csamfg201; 16058565; 0887-2333. SubjectsTermNotLitGenreText - Chlorpyrifos; Blood; obidoxime; Acetylcholinesterase; oximes; Erythrocytes; Enzymes; organophosphates; Active sites; Cholinesterase; Diazinon; Malathion 163. Cowman, D. F. and Mazanti, L. E. Ecotoxicology of "New Generation" Pesticides to Amphibians. 2000: 233-267. Rec #: 1600 Keywords: REFS CHECKED,REVIEW Call Number: NO REFS CHECKED (ACP,ATZ,AZ,CBF,CBL,CPY,Conazoles,DDVP,DM,DMDP,DMT,DQTBr,DU,DZ,EFV,ES,FNT,FNV,GYP,HXZ,MLN,MLT,MP,MYC,MZB,Maneb,Naled,OML,PMR,PPX,PQT,PRT,PSM,RTN,TFN,TMP,TPR), NO REVIEW (ACP,ATZ,AZ,CBF,CBL,CPY,Conazoles,DDVP,DM,DMDP,DMT,DQTBr,DU,DZ,EFV,ES,FNT,FNV,GYP,HXZ,MLN,MLT,MP,MYC,MZB,Maneb,Naled,OML,PMR,PPX,PQT,PRT,PSM,RTN,TFN,TMP,TPR) Notes: Chemical of Concern: ACP,ATZ,AZ,CBF,CBL,CPY,DBN,DDVP,DM,DMDP,DMT,DQTBr,DU,DZ,EFV,EPRN,ES,FNT,FNTH,FNV,GYP,HXZ,MCPA,MLN,MLT,MP,MSMA,MYC,MZB,Maneb,Naled,OML,PIM,PMR,PPX,PQT,PRN,PRT,PSM,RTN,TBT,TFN,TMP,TPR,TRL 164. Crawford, K. D.; Weinstein, J. E.; Hemingway, R. E.; Garner, T. R., and Globensky, G. A Survey of Metal and Pesticide Levels in Stormwater Retention Pond Sediments in Coastal South Carolina. 2010; 58, 9-23. Rec #: 1700 Keywords: FATE Call Number: NO FATE (AZ,CMPH,CPY,CPYM,Cr,Cr element,Cu,DDVP,DMT,DS,DZ,EP,ES,ESS,MLN,MP,MVP,PIRM,PRT,Zn,Zn element) Notes: Chemical of Concern: AND,AZ,Al,CMPH,CPY,CPYM,Cr,Cr element,Cu,DDE,DDVP,DLD,DMT,DS,DZ,EN,EP,ES,ESS,ETN,FNF,HCCH,HPT,MLN,MP,MVP,MXC,PBDE,PHSL,PIRM,PPCP,PRT,Zn,Zn element 165. Crew, A.; Lonsdale, D.; Byrd, N.; Pittson, R., and Hart, J. P. A screen-printed, amperometric biosensor array incorporated into a novel automated system for the simultaneous determination of organophosphate pesticides. 2011 Feb 15-; 26, (6): 2847-2851. Rec #: 1610 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Organophosphate pesticides present serious risks to human and environmental health. A rapid reliable, economical and portable analytical system will be of great benefit in the detection and prevention of contamination. A biosensor array based on six acetylcholinesterase enzymes for use in a novel automated instrument incorporating a neural network program is described. Electrochemical analysis was carried out using chronoamperometry and the measurement was taken 10 s after applying a potential of 0 V vs. Ag/AgCl. The total analysis time for the complete assay was less than 6 min. The array was used to produce calibration data with six organophosphate pesticides (OPs) in the concentration range of 10ęĆ5 M to 10ęĆ9 M to train a neural network. The output of the neural network was subsequently evaluated using different sample matrices. There were no detrimental matrix effects observed from water, phosphate buffer, food or vegetable extracts. Furthermore, the sensor system was not detrimentally affected by the contents of water samples taken from each stage of the water treatment process. The biosensor system successfully identified and quantified all samples where an OP was present in water, food and vegetable extracts containing different OPs. There were no false positives or false negatives observed during the evaluation of the analytical system. The biosensor arrays and automated instrument were evaluated in situ in field experiments where the instrument was successfully applied to the analysis of a range of environmental samples. It is envisaged that the analytical system could provide a rapid detection system for the early warning of contamination in water and food. Acetylcholinesterase/ Organophosphate/ Screen-printed carbon electrode/ Biosensor/ Chronoamperometry http://www.sciencedirect.com/science/article/pii/S0956566310007827 166. Cui, Na; Zhang, Xiaoxiang; Xie, Qing; Wang, Se; Chen, Jingwen; Huang, Liping; Qiao, Xianliang; Li, Xuehua, and Cai, Xiyun. Toxicity profile of labile preservative bronopol in water: The role of more persistent and toxic transformation products. 2011 Feb; 159, (2): 609-615. Rec #: 1200 Keywords: FATE Notes: Chemical of Concern: MLN Abstract: Transformation products usually differ in environmental behaviors and toxicological properties from the parent contaminants, and probably cause potential risks to the environment. Toxicity evolution of a labile preservative, bronopol, upon primary aquatic degradation processes was investigated. Bronopol rapidly hydrolyzed in natural waters, and primarily produced more stable 2-bromo-2-nitroethanol (BNE) and-ábromonitromethane (BNM). Light enhanced degradation of the targeted compounds with water site specific photoactivity. The bond order analysis theoretically revealed that the reversible retroaldol reactions were primary degradation routes for bronopol and BNE. Judging from toxicity assays and the relative pesticide toxicity index, these degradation products (i.e., BNE and BNM), more persistent and higher toxic than the parent, probably accumulated in natural waters and resulted in higher or prolonging adverse impacts. Therefore, these transformation products should be included into the assessment of ecological risks of non-persistent and low toxic chemicals such as the preservative bronopol. Bronopol/ Transformation products/ Hydrolysis/ Photolysis/ Toxicity http://www.sciencedirect.com/science/article/pii/S0269749110004562 167. Cutkomp, L. K.; Yap, H. H.; Cheng, E. Y., and Koch, R. B. ATPase Activity in Fish Tissue Homogenates and Inhibitory Effects of DDT and Related Compounds. 18279//: 1971; 3, (6): 439-447. Rec #: 980 Keywords: IN VITRO Call Number: NO IN VITRO (DCF,DDVP,MLN) Notes: Chemical of Concern: AND,DCF,DDE,DDT,DDVP,DLD,EN,HPT,MLN,MXC 168. Da Silva, R. L.; Da Silva, C. P., and Navickiene, S. Multiresidue determination of carbamate, organochlorine, organophosphorus, and dicarboximide pesticides in lettuce by GC/MS. 2010; 45, 589-594. Rec #: 12760 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: An extraction method based on matrix solid-phase dispersion was developed to determine pirimicarb, methyl parathion, malathion, procymidone, alpha-endosulfan and beta-endosulfan in lettuce using gas chromatography-mass spectrometry. The best results were obtained using 4.0 g of lettuce, 2.0 g of silica as dispersant sorbent, 0.1 g of activated carbon as clean up sorbent and acetonitrile as eluting solvent. The method was validated using lettuce samples fortified with pesticides at six different concentration levels (0.1 to 2.0 mg/kg). Average recoveries (7 replicates) ranged from 50 to 120 %, with relative standard deviations between 0.6 and 8.0 %. Detection and quantification limits for lettuce ranged from 0.01 to 0.02 mg/kg and 0.04 to 0.10 mg/kg, respectively. Number of Volumes: 6 ISI Document Delivery No.: 675VP 169. Daba, Daniel; Hymete, Ariaya; Bekhit, Adnan a; Mohamed, Abdel Maaboud I; Bekhit, Alaa El-Din a, and Bekhit, Adnan A. Multi Residue Analysis of Pesticides in Wheat and Khat Collected From Different Regions of Ethiopia. 2011 Mar; 86, (3): 336-341. Rec #: 6530 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: The present study investigated the presence and level of pesticide residues in wheat and khat samples collected from various localities of Ethiopia. The khat samples from Galemso and Aseno had p,p'-DDT concentrations ranged from 141.2 to 973.0 mu g/Kg and 194.3-999.0 mu g/Kg, respectively. Diazinon was detected in all the khat samples from BadaBuna (173.9-686.9 mu g/Kg) but not in any of the samples from Galemso and Aseno. Diazinon was detected in all the wheat samples obtained from both Arsi and Bale (125.8 and 125.6 mu g/Kg, respectively) and aldrin levels in these samples were below the quantification limit. Khat may be a contributing factor in the pathological diseases found among khat users. Keywords: Environment Abstracts; Toxicology Abstracts Keywords: Environmental Studies English. Date revised - 2011-03-01. Last updated - 2011-11-09. DOI - OB-ffc09c9e-ec0a-4f8c-b41fmfgefd108; 14444715; 0007-4861; 1432-0800 170. Dai, Ronghua; Ren, Xuedong; He, Xiao; Huo, Yanshuang, and Dai, Ronghua. Convenient Analytical Method for Quantitative Determination of 23 Pesticide Residues in Herbs by Gas Chromatography-Mass Spectrometry. 2011 Jun; 86, (6): 559-564. Rec #: 6300 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: A convenient analytical method for quantitative characterization of 23 pesticides in three herbs has been developed. Pesticides tested included organochlorine, organophosphorus and pyrethroids. Primary secondary amine and graphitized carbon black as dispersive-SPE sorbent were applied to clean up the sample. Analytical method was established by using the technique of gas chromatography coupled with electron impact mass spectrometry in the selected ion monitoring mode (GC-MS-SIM). The recoveries of all pesticides were in the range of 78.4%-119.2% at three spiked levels of 5, 20 and 50 mu g/kg, and the relative standard deviations were below 9.5%. The limits of detections of all pesticides were less than 3.0 mu g/kg. This analytical method could be applied to the analysis of commonly used pesticides in commercial herbs. Keywords: Environment Abstracts; Toxicology Abstracts Keywords: Environmental Studies English. Date revised - 2011-05-01. Last updated - 2011-11-04. DOI - OB-961ec98d-a877-4810-a441mfgefd107; 14884200; 0007-4861; 1432-0800 171. Daly, I. W. A 24-Month Oral Toxicity/Oncogenicity Study of Malaoxon in the Rat via Dietary Administration. 1966. Rec #: 500 Keywords: NO SOURCE Call Number: NO SOURCE (MLO) Notes: Chemical of Concern: MLO 172. ---. A 28-Day Study of Malathion in the Rat via Dietary Administration. 1993. Rec #: 520 Keywords: NO SOURCE Call Number: NO SOURCE (MLN) Notes: Chemical of Concern: MLN 173. ---. A Subchronic (3-Month) Oral Toxicity Study of Malathion in the Rat via Dietary Administration. 1993. Rec #: 510 Keywords: NO SOURCE Call Number: NO SOURCE (MLN) Notes: Chemical of Concern: MLN 174. Daly, J. W. A 24-Month Oral Toxicity/Oncogenicity Study of Malathion in the Rat via Dietary Administration. 1996. Rec #: 530 Keywords: NO SOURCE Call Number: NO SOURCE (MLN) Notes: Chemical of Concern: MLN 175. Dang, Zhichao; Li, Kang; Yin, Haowen; Hakkert, Betty; Vermeire, Theo, and Dang, ZhiChao. Endpoint Sensitivity in Fish Endocrine Disruption Assays: Regulatory Implications. 2011 Apr 10; 202, (1): 36-46. Rec #: 6440 Keywords: REVIEW Notes: Chemical of Concern: MLN Abstract: Abstract: Identifying potential endocrine disrupting chemicals (EDCs) needs screening and testing for mode of action (MOA) and intrinsic toxicological properties. MOA is often indicated by biomarker endpoints, whereas toxicity by apical endpoints. Risk assessment is mainly based on apical but not on biomarker endpoints. The 21-day fish assay (OECD TG229) is considered a screening test. But it includes both biomarker and apical endpoints. This study explores the utility of results of the 21-day fish assay for risk assessment purposes. Endpoint sensitivity was analysed by compiling 142 data sets for 21-day fish assays and 38 data sets for the fish sexual development test (FSDT), encompassing 62 chemicals with different MOAs. Conclusions from this analysis include: (1) vitellogenin (VTG), fecundity and gonad histology are the most sensitive endpoints for fathead minnow, medaka and zebrafish in 21-day fish assays; secondary sex characteristics (SSC) are a less sensitive endpoint and is likely inadequate to detect all known MOAs. (2) Biomarker endpoints like VTG and apical endpoints like fecundity from the 21-day fish assay can be used for risk assessment. (3) Lowest observed effect concentrations (LOECs) of the most chemicals are comparable for the 21-day fish assay and for the FSDT, further supporting that results of 21-day fish assays can be used for risk assessment. However, a significant difference in LOECs was observed for some chemicals, suggesting that chemical specific effects should be taken into account. This paper emphasizes that a weight of evidence approach is important for interpretation of results of the 21-day fish assay. Keywords: Chemicals Keywords: Risk assessment Keywords: Bioindicators Keywords: Sensitivity Keywords: Environment Abstracts; Toxicology Abstracts Keywords: Pharmacy And Pharmacology Keywords: Oryzias latipes Keywords: Data processing Keywords: endocrine disruptors Keywords: Endocrine disruptors Keywords: Toxicity Keywords: biomarkers Keywords: ENA 02:Toxicology & Environmental Safety Keywords: fecundity Keywords: Danio rerio Keywords: Fecundity Keywords: Histology Keywords: Vitellogenin Keywords: Gonads Keywords: Fish Keywords: X 24300:Methods Keywords: Sex English. Date revised - 2011-10-01. Last updated - 2011-12-17. DOI - OB-72094e84-aeb8-4569-884ecsamfg201; 14524896; 0378-4274. SubjectsTermNotLitGenreText - Risk assessment; Data processing; Fecundity; Vitellogenin; Endocrine disruptors; Gonads; Toxicity; biomarkers; Sex; fecundity; Bioindicators; Chemicals; Sensitivity; Histology; endocrine disruptors; Fish; Danio rerio; Oryzias latipes 176. Dang, Zhichao; Ru, Shaoguo; Wang, Wei; Rorije, Emiel; Hakkert, Betty; Vermeire, Theo, and Dang, ZhiChao. Comparison of Chemical-Induced Transcriptional Activation of Fish and Human Estrogen Receptors: Regulatory Implications. 2011 Mar 5; 201, (2): 152-175. Rec #: 6490 Keywords: IN VITRO Notes: Chemical of Concern: MLN Abstract: Abstract: Under the current EU chemical regulation REACH (Registration, Evaluation, Authorization and Restriction of Chemicals), revised plant protection products and biocides directives, evaluation of endocrine disrupting properties of chemicals becomes a regulatory need. Transcriptional activation (TA) testing of estrogen receptors (ERs) could be one important first step in the screening and testing of endocrine disrupting chemicals (EDCs) for regulatory purposes. However up to now there is no consensus on which species or subtype of ERs should be used for TA testing. This study collected data from publications on TA testing with fish and human ERs for 90 chemicals, covering strong, moderate, and weak or non-ER binders. Each chemical has been reported at least twice, with differential ER TA values that result from different cellular contexts, from intra-/inter-species and subtypes of ERs and from intra-/inter-laboratory differences. All assays could distinguish the differential transcriptional activity induced by chemicals of strong, moderate, and weak or non-ER binders. It is concluded that transactivation of ERs in one vertebrate species or one subtype of ERs could be extrapolated to other species or subtypes of ERs for the purpose of chemical screening. It is emphasized that results from ER TA assays can only be used in a weight-of-evidence approach for further testing in regulatory programs. These results are of importance for regulatory testing strategies and decision making for EDCs. Keywords: Decision making Keywords: Data processing Keywords: Pharmacy And Pharmacology Keywords: Plant protection Keywords: Endocrine disruptors Keywords: Biocides Keywords: Estrogen receptors Keywords: Toxicology Abstracts Keywords: X 24300:Methods Keywords: Transcription activation English. Date revised - 2011-10-01. Last updated - 2011-12-12. DOI - OB-1f9f1213-5bf5-4ea9-ac2fcsamfg201; 14365945; 0378-4274. SubjectsTermNotLitGenreText - Decision making; Data processing; Plant protection; Endocrine disruptors; Biocides; Estrogen receptors; Transcription activation 177. Darwish, Ragaa; Sherif, Naima; Hassan, Mona, and Mahrous, Hanan. Chromosomal aberrations as biomarker of exposure to malathion in agriculture workers. 2012 Jun 17-; 211, Supplement, (0): S64. Rec #: 480 Keywords: HUMAN HEALTH Notes: Chemical of Concern: MLN Abstract: http://www.sciencedirect.com/science/article/pii/S0378427412003554 178. Das, Yavuz Kursad; Kaya, Sezai, and Das, Yavuz Kursad. Organophosphorus Insecticide Residues in Honey Produced in Turkey. 2009 Sep; 83, (3): 378-383. Rec #: 7440 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: In this study, a number of 15 organophoshorus (OP) insecticides were investigated in 275 honey samples in 33 different cities of Turkey, using gas chromatography electron capture detector. The limit of determination values was detected between 0.25 and 9.55ngg super(-1). The correlation coefficients obtained from calibration curves of the OP standards were found to be between 0.992 and 0.999. No insecticide residue was detected in the samples analyzed. This result is highly significant because of its impacts on public health and food safety. Keywords: Health & Safety Science Abstracts; Pollution Abstracts; Environment Abstracts; Environmental Engineering Abstracts; Toxicology Abstracts Keywords: Organophosphorus compounds Keywords: Residues Keywords: Food Keywords: Turkey Keywords: Insecticide residues Keywords: EE 10:General Environmental Engineering Keywords: Food contamination Keywords: P 6000:TOXICOLOGY AND HEALTH Keywords: ENA 02:Toxicology & Environmental Safety Keywords: Environmental Studies Keywords: Public health Keywords: Insecticides Keywords: Gas chromatography Keywords: X 24330:Agrochemicals Keywords: H 4000:Food and Drugs Keywords: Honey Keywords: Urban areas English. Date revised - 2010-02-01. Last updated - 2011-10-25. DOI - OB-MD-0010969011; 11767831; 0007-4861; 1432-0800. SubjectsTermNotLitGenreText - Insecticides; Gas chromatography; Food; Honey; Public health; Organophosphorus compounds; Residues; Insecticide residues; Food contamination; Urban areas; Turkey 179. De Bruijn, J. and Hermens, J. Qualitative and Quantitative Modelling of Toxic Effects of Organophosphorous Compounds to Fish. 1991: 441-455. Rec #: 1260 Keywords: QSAR,REFS CHECKED,REVIEW Call Number: NO QSAR (FNT,MLN,MP,PIRM), NO REFS CHECKED (FNT,MLN,MP,PIRM), NO REVIEW (FNT,MLN,MP,PIRM) Notes: Chemical of Concern: FNT,FNTH,MLN,MP,PIRM 180. De, Chandrima; Samuels, Tova A.; Haywood, Tajay L.; Anderson, Ginger A.; Campbell, Keith; Fletcher, Kenneth; Murray, Desmond H., and Obare, Sherine O. Dual colorimetric and electrochemical sensing of organothiophosphorus pesticides by an azastilbene derivative. 2010 Mar 31-; 51, (13): 1754-1757. Rec #: 1750 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: We have investigated the optical and electrochemical changes of the azastilbene, dimethyl-[4-(2-quinolin-2-yl-vinyl)-phenyl]-amine (DQA), with four organothiophosphorus (OTP) pesticides: ethion, malathion, parathion, and fenthion. Significant changes in UVÇôvisible absorbance wavelength and in electrochemical signals indicate the effectiveness of DQA as an OTP sensor. http://www.sciencedirect.com/science/article/pii/S0040403910001486 181. De Llasera, M. P. G.; Cruz-Reyes, L., and Vera-Avila, L. E. A method for the analysis of organophosphorus pesticide residues in Mexican axolotl. 2010; 45, 25-32. Rec #: 12830 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: A method based on matrix solid-phase dispersion (MSPD) was developed for quantitative extraction of three organophosphorus pesticides (OPPs) from the Mexican axolotl, Ambystoma mexicanum. The determination was carried out using high-performance liquid chromatography (HPLC) with diode array spectrophotometric UV detection (DAD). The MSPD extraction with octadecylsilyl (C18) sorbent combined with a silica gel clean-up and acetonitrile elution was optimised for chlorpyrifos, fenthion and methyl parathion. The method was validated, yielding recovery values higher than 90%. The precision, expressed as the relative standard deviation (RSD), was less than or equal to 6% in muscle samples at spiking levels of 10 and 5 ppm. Linearity was studied from 15 to 60 ppm for chlorpyrifos and fenthion, and from 7.5 to 30 ppm for methyl parathion. The limits of detection (LODs) were found to be less than or equal to 0.5 ppm. This method was applied to the analysis of samples from a chlorpyrifos-exposed axolotl, demonstrating its use as an analytical tool for toxicological studies. Number of Volumes: 1 ISI Document Delivery No.: 535WA 182. Debebe, Amsalu; Kuttalam, S, and Debebe, Amsalu. Parameter Validation of Analytical Methods of Insecticide Residue Analyses in Foods of Animal Origin, Feed and Water. 2011 Jun; 86, (6): 571-575. Rec #: 6310 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: The study was conducted to examine the interrelationship and coherence of analytical parameters in method validation. Recovery, sensitivity, linearity, precision and limits of detection (LOD) were tested in six methods for organochlorine and organophosphate insecticides. Compounds that fell out of the stipulated recovery, 70-120%, in a matrix have concurrently failed to meet the requirements for sensitivity ( greater than or equal to 0.7), linearity (R super(2)>0.99) and precision (<0.2) in the same matrix. Highest LOD was recorded in those compounds and matrices. Different from the conventional point estimate, a new approach was introduced for setting upper and lower confidence limits of the LOD in quantitative analyses. Keywords: Environment Abstracts; Toxicology Abstracts Keywords: Environmental Studies English. Date revised - 2011-05-01. Last updated - 2011-11-04. DOI - OB-4d66b010-469d-4a0e-bc06mfgefd107; 14884217; 0007-4861; 1432-0800 183. Dek, Yi; Liu, Yong, and Dek, Yi. Study on Analysis of the Organic Phosphorus Pesticide Residues in Soil. 2012 Mar; 31, (3): 89-93. Rec #: 2750 Keywords: FATE Notes: Chemical of Concern: MLN Abstract: Abstract: An analysis method for nine kinds of organophosphate pesticides residues in soil included dichlorvos, methamidophos, phorate, omethoate, diazinon, dimethoate, parathion-methyl, malathion, parathion, isocatbophos and quinalphos was established in this research. The pesticide residues were extracted from soil samples with acetone; dichloromethane =1:3; separated on a capillary column Hp-5MS (30mx0.25 mmx 0.25 mu m) after concentration and detected by gas chromatography with flame photometric detector (GC-FPD). As a result, the detection limits of this method for nine Organophosphate Pesticides were in the range of 0.397~ 1.60 mu g/mL with relative standard deviations ranging from 5.47% to 10.20% (n=5) and the recoveries were from 68.7% to 110.4%. The results indicated that this method could be used for the determination of organophosphate pesticide residues in soil. Keywords: AQ 00001:Water Resources and Supplies Keywords: SW 3040:Wastewater treatment processes Keywords: Chromatographic techniques Keywords: Laboratories Keywords: Pesticide Residues Keywords: Q5 01502:Methods and instruments Keywords: Malathion Keywords: Agricultural Chemicals Keywords: Organophosphorus Pesticides Keywords: Standard Deviation Keywords: Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts Keywords: Analytical Methods Keywords: Detection Limits Keywords: Pesticides Keywords: Q2 02403:Chemicals from sea water Keywords: Acetone Keywords: Organic phosphorus English. Date revised - 2012-06-01. Number of references - 9. Last updated - 2012-12-28. DOI - db9827a5-af9a-4432-9143csamfg201; 16628754; CS1276943; 1000-0720. SubjectsTermNotLitGenreText - Chromatographic techniques; Pesticides; Acetone; Organic phosphorus; Organophosphorus Pesticides; Agricultural Chemicals; Standard Deviation; Detection Limits; Analytical Methods; Laboratories; Pesticide Residues; Malathion. Bouaid, A, Ramos, L, Gonzalez, M J, Fernandez, P, Camara, C. J. Chromatogr. A. 2001. 17. C. Conçalves and M. F. Alpendurada, Talanta, 2005, 65, 1179-1189. G. Durand, R. Forteza and D. Barcelo. Chromatographia, 1989,28 (11-12 ):597. Edwar Fuentes, Maria E. Baez, Ronnie Labra. J Chromatogr A, 2007, 1169(1-2): 40. Elisabeth Yehouenou A. Pazou, Michel Boko. Environ Int,2006, 32: 616. Klaus Wuchner, Rudy T. Ghijsen, Udo A. Analyst, 1993, 118: 11. Milena Domotorova, Eva Matisova. J Chromatog A, 2008,1207; 1. Wang, S; Zhao, P; Min, G; Fang, G Z. J. Chromatogr. A, 1165. (2007): 166-171. Zhu X L, Yang J, Su Q D. J Chromatogr A,2005, 1092 (2):161 184. Delgado, Y; Forteza, R; Martin, V C; Del Rosario Bruneto, M; Gallignani, M, and Delgado, Y. Multisyringe Flow Injection System for the Solid-Phase Extraction of Organophosphorus Pesticides From Drinking Water and Its Determination by Gc-Ms. 2010 Dec; 18, (4): 280-291. Rec #: 3870 Keywords: CHEM METHODS Notes: Chemical of Concern: MLN Abstract: Abstract: In this work we developed a selective and reproducible method to assess organophosphorus pesticides (POPs) in human drinking water by gas chromatography (GC) with mass spectrometry (MS) detection. The extraction of POPs was performed in a solid-phase extraction disk module placed in a multisyringe flow injection system (MSFIA) that allowed the automation of the analytical procedure with a substantial saving of solvents and time, a reduction in waste generation and cost per analysis. The method was linear over concentration range 0.075-5.0 mu g/L with a limit of detection of 0.01 mu g/L for Diazinon and Chlorpyrifos, and 0.05 mu g/L for Malathion and Methyl Parathion respectively. Quantitative recoveries from spiked water samples were between 91.7 y 102.8% with a C.V. less than or equal to 3.6%. The method was successfully applied for the determination of pesticides in tap water and tap water samples enriched with pesticides in the concentration range between 0.15 and 5.0 mu g/L, with a higher sampling throughput of 10 samples/h.Original Abstract: En el presente trabajo se desarrollo un metodo selectivo y reproducible para evaluar plaguicidas organofosforados (POFs) en aguas de consumo humano por cromatografia de gases (CG) con detection por espectrometria de masa (EM). La extraccion en fase solida de los POFs en disco, se realizo en un sistema de inyeccion en flujo multijeringa (MSFIA) que permitio la automatizacion del procedimiento analitico con un importante ahorro de disolventes y tiempo, una reduccion en la generacion de residuos y del coste por analisis. La validacion del metodo indico linealidad entre 0,075-5,0 mu g/L con limites de detection de 0,01 mu g/L para Diazinon y Clorpirifos y de 0,05 mu g/L para Malation y Metil paration respectivamente. La recuperacion para todos los casos estuvo comprendida entre 91,7 y 102,8% con un C.V. less than or equal to 3,6%. El metodo propuesto se utilizo para analizar aguas de grifo y agua de grifo enriquecidas con los plaguicidas en el intervalo de concentration entre 0,15 y 5,0 mu g/L con una frecuentia de analisis de 10 muestras/hora. Keywords: AQ 00001:Water Resources and Supplies Keywords: Mass Spectrometry Keywords: Water sampling Keywords: Water Analysis Keywords: P 2000:FRESHWATER POLLUTION Keywords: Solvents Keywords: Automation Keywords: Mass spectrometry Keywords: Aqualine Abstracts; Water Resources Abstracts; Pollution Abstracts Keywords: Injection Keywords: Malathion Keywords: Chlorpyrifos Keywords: Drinking Water Keywords: Agricultural Chemicals Keywords: Organophosphorus Pesticides Keywords: Gas chromatography Keywords: Pesticides Keywords: SW 3060:Water treatment and distribution Keywords: Sampling Keywords: Drinking water Keywords: Parathion Spanish. Date revised - 2011-09-01. Last updated - 2012-04-23. DOI - MD-0017328737; 15630796; 1315-2076. SubjectsTermNotLitGenreText - Chlorpyrifos; Water sampling; Gas chromatography; Pesticides; Solvents; Mass spectrometry; Drinking water; Malathion; Parathion; Mass Spectrometry; Organophosphorus Pesticides; Agricultural Chemicals; Drinking Water; Water Analysis; Automation; Sampling; Injection 185. Derbalah, A. S. Efficacy of Some Botanical Extracts Against Trogoderma Granarium in Wheat Grains With Toxicity Evaluation. Rec #: 8340 Keywords: BIOLOGICAL TOXICANT Notes: Chemical of Concern: MLN Abstract: COMMENTS: Cites: Clin Chem. 1969 Jun;15(6):487-95 (medline /5786804) COMMENTS: Cites: Analyst. 1972 Feb;97(151):142-5 (medline /5037807) COMMENTS: Cites: Toxicol Appl Pharmacol. 1982 Sep 30;65(3):413-24 (medline /7157374) COMMENTS: Cites: Am J Clin Pathol. 1957 Jul;28(1):56-63 (medline /13458125) COMMENTS: Cites: Cornell Vet. 1959 Jan;49(1):116-26 (medline /13619298) COMMENTS: Cites: J Nat Prod. 2002 Aug;65(8):1107-10 (medline /12193012) COMMENTS: Cites: Nutr Metab (Lond). 2007;4:4 (medline /17313679) ABSTRACT: In an attempt to find alternative control methods for stored products insects, Directory: pesticides -> nas nas -> Appendix 1-10: Summary of Diazinon Monitoring Data nas -> Description of revision nas -> Appendix 2 Chlorpyrifos Species Sensitivity Distribution Analysis for Fish nas -> Appendix 2 Open Literature Review Summaries for Malathion Download 5.18 Mb. Share with your friends:
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