Appendix 2-5: Rejected ecotox bibliography Excluded
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Rec #: 5410 Keywords: HUMAN HEALTH Notes: Chemical of Concern: MLN Abstract: Abstract: Uncovering SNP (single nucleotide polymorphisms)-environment interactions can generate new hypotheses about the function of poorly characterized genetic variants and environmental factors, like pesticides. We evaluated SNP-environment interactions between 30 confirmed prostate cancer susceptibility loci and 45 pesticides and prostate cancer risk in 776 cases and 1,444 controls in the Agricultural Health Study. We used unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Multiplicative SNP-pesticide interactions were calculated using a likelihood ratio test. After correction for multiple tests using the False Discovery Rate method, two interactions remained noteworthy. Among men carrying two T alleles at rs2710647 in EH domain binding protein 1 (EHBP1) SNP, the risk of prostate cancer in those with high malathion use was 3.43 times those with no use (95% CI: 1.44-8.15) (P-interaction = 0.003). Among men carrying two A alleles at rs7679673 in TET2, the risk of prostate cancer associated with high aldrin use was 3.67 times those with no use (95% CI: 1.43, 9.41) (P-interaction = 0.006). In contrast, associations were null for other genotypes. Although additional studies are needed and the exact mechanisms are unknown, this study suggests known genetic susceptibility loci may modify the risk between pesticide use and prostate cancer. Keywords: SCIENCES: COMPREHENSIVE WORKS Keywords: Health sciences Keywords: Men Keywords: Skin cancer Keywords: Studies Keywords: Iowa Keywords: Confidence intervals Keywords: Family medical history Keywords: Mens health Keywords: Prostate cancer Keywords: Insecticides Keywords: Risk factors Keywords: North Carolina Keywords: Pesticides Keywords: Health risk assessment Keywords: Hypotheses English. Copyright - © 2013 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Citation: Koutros S, Berndt SI, Hughes Barry K, Andreotti G, Hoppin JA, et al. (2013) Genetic Susceptibility Loci, Pesticide Exposure and Prostate Cancer Risk. PLoS ONE 8(4): e58195. doi:10.1371/journal.pone.0058195. Last updated - 2013-04-27. 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Pritchard, J K; Stephens, M; Donnelly, P; Pritchard, J K. Inference of population structure using multilocus genotype data. Genetics, 155. 2 (2000): 945-959. Schumacher, Fredrick R.; Stram, Daniel O.; Henderson, Brian E.; Haiman, Christopher A.; et al. Genome-wide association study identifies new prostate cancer susceptibility loci. Human Molecular Genetics, 20. 19 (2011): 3867-3875. Oxford University Press. SETTIMI, Laura; MASINA, Alceste; ANDRION, Alberto; AXELSON, Olav. Prostate cancer and exposure to pesticides in agricultural settings. International journal of cancer, 104. 4 (2003): 458-461. Wiley-Liss. Sotelo, Jose; Esposito, Dominic; Duhagon, Maria Ana; Banfeld, Kelley; et al. Long-range enhancers on 8q24 regulate c-Myc. Proceedings of the National Academy of Sciences of the United States of America, 107. 7 (2010): 3001-3005. National Academy of Sciences. Sun, Jielin; Zheng, Siqun Lilly; Wiklund, Fredrik; Isaacs, Sarah D.; et al. Sequence Variants at 22q13 Are Associated with Prostate Cancer Risk. CANCER RESEARCH, 69. 1 (2009): 10-15. AMER ASSOC CANCER RESEARCH. THOMAS, Gilles; JACOBS, Kevin B.; YEAGER, Meredith; KRAFT, Peter; et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nature genetics, 40. 3 (2008): 310-315. Nature Publishing Group. Thomsen, Martin K.; Francis, Jeffrey C.; Swain, Amanda. The role of Sox9 in prostate development. DIFFERENTIATION, 76. 6 (2008): 728-735. BLACKWELL PUBLISHING. Thomsen, Martin K.; Butler, Christopher M.; Swain, Amanda; Ambroisine, Laurence; et al. SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Research, 70. 3 (2010): 979-987. American Association for Cancer Research Inc. Van Maele-Fabry, G; Willems, J L. Prostate cancer among pesticide applicators: a meta-analysis. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 77. 8 (2004): 559-570. SPRINGER. Xu, Xiaohui; Dailey, Amy B.; Talbott, Evelyn O.; Ilacqua, Vito A.; et al. Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults. Environmental Health Perspectives, 118. 1 (2010): 60-66. Public Health Services, US Dept of Health and Human Services. YEAGER, Meredith; CHATTERJEE, Nilanjan; CIAMPA, Julia; JACOBS, Kevin B.; et al. Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature genetics, 41. 10 (2009): 1055-1057. Nature Publishing Group 372. Kozawa, K.; Aoyama, Y.; Mashimo, S., and Kimura, H. Toxicity and actual regulation of organophosphate pesticides. 2009; 28, 245-254. Directory: pesticides -> nas nas -> Appendix 1-10: Summary of Diazinon Monitoring Data nas -> Description of revision nas -> Appendix 2 Chlorpyrifos Species Sensitivity Distribution Analysis for Fish nas -> Appendix 2 Open Literature Review Summaries for Malathion Download 5.18 Mb. Share with your friends:
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