Appendix 2-5: Rejected ecotox bibliography Excluded



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Rec #: 14220
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: MLN
Abstract: Abstract: Organophosphate pesticides (OPs) are widely used as agricultural or domestic insecticides and are necessary for maintaining a good-quality, stable supply of harvested farm products. OPs can, however, exert significant adverse effects on human health. Thus, it may be necessary to regulate usage of OPs and other chemical pesticides. In this review, to better understand the effects of pesticides including OPs on humans, we focus on their toxicity and actual regulation.
Number of Volumes: 4
ISI Document Delivery No.: 536MH ://CCC:000273048000003

373. Krieger, Robert Irving and Hayes, Wayland J.: 2 v (xxxvii, 2342 p ) : ill , port ; 29 cm.


Rec #: 10870
Keywords: REVIEW
Notes: Chemical of Concern: MLN
Abstract: Abstract: The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.
Book

374. Krishnakumar, N. K. and Srinivasan, K. Efficacy and Economics of Pest Control in Okra with Conventional and Synthetic Pyrethroid Insecticides. SOIL; 1987; 15, (1): 81-83.


Rec #: 200
Keywords: MIXTURE
Call Number: NO MIXTURE (CBL,CYP,DM,DMT,ES,FNV,MLN,PMR,SFR)
Notes: Chemical of Concern: CBL,CYP,DM,DMT,ES,FNV,MLN,PMR,SFR

375. Krishnamurthy, B. S.; Achuthan, C.; Ramarao, T. S.; Chandrahas, R. K., and Krishnaswami, A. K. Investigation on Plague in Kolar District (Mysore State). 3. Comparative Evaluation of D.D.T., B.H.C. and Diazinon Water Dispersible Powder and Dust Formulations Against Rat-Fleas in Villages Near Kolar Town (Mysore State). 1963; 17, 205-214.


Rec #: 1550
Keywords: NO CONC,NO DURATION
Call Number: NO CONC (DZ,MLN), NO DURATION (DZ,MLN)
Notes: Chemical of Concern: DDT,DZ,MLN

376. Krishnamurthy, V and Krishnamurthy, V. Combined Effect of Malathion and Nitrate on Survivability of Tadpoles of Indian Cricket Frog Fejervarya Limnocharis. 2012 May 20.


Rec #: 2650
Keywords: ABSTRACT
Notes: Chemical of Concern: MLN
Abstract: Keywords: Juveniles
Keywords: Nitrate
Keywords: Frogs
Keywords: Amphibiotic species
Keywords: Gryllidae
Keywords: Anura
Keywords: Fejervarya limnocharis
Keywords: Malathion English. Date revised - 2013-02-26. Last updated - 2013-02-28. DOI - CPI-6154336; 6154336

377. Kudom, Andreas Adutwum; Mensah, Ben a; Agyemang, Thomas Kwaku, and Kudom, Andreas Adutwum. Characterization of Mosquito Larval Habitats and Assessment of Insecticide-Resistance Status of Anopheles Gambiae Senso Lato in Urban Areas in Southwestern Ghana . 2012 Jun; 37, (1): 77-82.


Rec #: 5750
Keywords: SURVEY
Notes: Chemical of Concern: MLN
Abstract: Abstract: The study was carried out to characterize potential larval habitats in the city of Sekondi with the aim of assessing the relative importance of anthropogenic and natural water bodies as larval habitats. Insecticide-resistance status of Anopheles gambiae senso lato in the southwestern part of the coastal savannah zone in Ghana was also assessed against four different classes of insecticides. Larval surveys were carried out in two communities that are separated by a lagoon. Although the lagoon was a potential mosquito larval habitat, we showed that it was not an important mosquito breeding site. The major larval habitats were anthropogenic, resulting from human behavior. Some of the organically polluted breeding sites were inhabited by both An. gambiae s.l. and Culex quinquefasciatus larvae. The data also showed that An. gambiae s.l. has currently developed a strong resistance to DDT and pyrethroid insecticides in southwestern Ghana, where the species was reported to be susceptible about a decade ago. The use of insecticides in households was implicated as a possible cause of the development of resistance among An. gambiae s.l. populations in the area. The management of insecticide resistance among malaria vectors needs urgent attention if insecticide-treated materials can continue to be used for malaria control.
Keywords: Culex quinquefasciatus
Keywords: Data processing
Keywords: Z 05350:Medical, Veterinary, and Agricultural Entomology
Keywords: Vectors
Keywords: Entomology Abstracts; Ecology Abstracts
Keywords: Malaria
Keywords: Habitat
Keywords: Lagoons
Keywords: Anopheles gambiae
Keywords: Savannahs
Keywords: Insecticides
Keywords: Breeding sites
Keywords: D 04040:Ecosystem and Ecology Studies
Keywords: DDT
Keywords: Pyrethroids
Keywords: Biology English. Date revised - 2012-05-01. Last updated - 2012-05-31. DOI - OB-19d38c55-aeec-4795-ba4dcsamfg201; 16724416; 1081-1710. SubjectsTermNotLitGenreText - Savannahs; Data processing; Insecticides; Breeding sites; DDT; Vectors; Malaria; Pyrethroids; Habitat; Lagoons; Culex quinquefasciatus; Anopheles gambiae

378. Kuhn, J. O. Fyfanon Purified. 1996.


Rec #: 690
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

379. Kulluru, P P; Das, B S; Panda, R K, and Kulluru, P P. Evaluation of Sorption and Leaching Potential of Malathion and Atrazine in Agricultural Soils of India. 2010; 4, (1): 75-90.


Rec #: 4440
Keywords: CHEM METHODS
Notes: Chemical of Concern: MLN
Abstract: Abstract: Movement of pesticides through soils to groundwater and surface water has long been considered a potentially serious environmental problem in different parts of the world. Remediation of such problems requires monitoring of site specific data. Considering these facts a laboratory based investigation was carried out to determine the sorption and leaching parameters of two contrasting and widely used pesticides (malathion and atrazine) in three different agricultural soils: loamy sand (Typic Xerosament), sandy loam (Acid Lateritic Haplustalf) and clay loam (Hyperthermic Typic Haplusterts). Standard batch sorption technique was used to determine the sorption coefficient (K sub(d)) and organic carbon distribution coefficient (K sub(oc)). Miscible displacement experiments were conducted to determine the transport parameters such as pore water velocity ( upsilon ), dispersion coefficient (D), retardation factor (R) and degradation rate constant ( lambda ). The results of batch sorption experiments revealed that malathion had higher K sub(d) values as compared to atrazine for all soils. The grouping of soils according to sorption capacity followed the order: clay loam > sandy loam > loamy sand, for both malathion and atrazine. The results of miscible displacement experiments revealed that malathion could leach up to 30 cm depth whereas atrazine could leach up to 65 cm depth in the test soils. The values of transport parameters determined by method of moments ranged from 0.79 to 1.63 cm/h for upsilon and 3.15 to 12.26, cm super(2)/h for D in the test soils. The R values of malathion obtained using K sub(d were) 3.1 to 3.4 times higher than atrazine for the test soils. The half life of malathion and atrazine obtained from lambda ranged from 0.3 to 1.7 days and 50 to 64 days, respectively in the above mentioned soils.
Keywords: Pore water
Keywords: Bioremediation
Keywords: Degradation
Keywords: Surface water
Keywords: P 5000:LAND POLLUTION
Keywords: Organic carbon
Keywords: Loam
Keywords: Malathion
Keywords: Clays
Keywords: Toxicology Abstracts; Pollution Abstracts; Environment Abstracts; Aqualine Abstracts; Environmental Engineering Abstracts
Keywords: India
Keywords: Soil
Keywords: sandy soils
Keywords: Agricultural Chemicals
Keywords: Carbon
Keywords: Sand
Keywords: Ground water
Keywords: X 24330:Agrochemicals
Keywords: Testing Procedures
Keywords: EE 40:Water Pollution: Monitoring, Control & Remediation
Keywords: Sorption
Keywords: Clay
Keywords: Leaching
Keywords: Data processing
Keywords: Velocity
Keywords: Herbicides
Keywords: agricultural land
Keywords: AQ 00003:Monitoring and Analysis of Water and Wastes
Keywords: ENA 06:Food & Drugs
Keywords: loam
Keywords: Surface-groundwater Relations
Keywords: Atrazine
Keywords: Pesticides
Keywords: Groundwater English. Date revised - 2010-02-01. Last updated - 2011-11-08. DOI - OB-MD-0012696733; 11852048; 1735-6865. SubjectsTermNotLitGenreText - India; Atrazine; Malathion; Sorption; Testing Procedures; Surface-groundwater Relations; Sand; Loam; Agricultural Chemicals; Pesticides; Soil; Herbicides; loam; Clay; agricultural land; Leaching; Surface water; Degradation; Bioremediation; Groundwater; Pore water; sandy soils; Organic carbon; Velocity; Clays; Carbon; Data processing; Ground water

380. Kynoch, S. R. Acute Dermal Toxicity to Rats of Malathion (Fyfanon) Technical. 1985.


Rec #: 700
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

381. ---. Acute Oral Toxicity to Rats of Malathion (Fyfanon) Technical. 1985.


Rec #: 720
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

382. Kynoch, S. R. and Smith, P. A. Delayed Contact Hypersensitivity in the Guinea-Pig with Malathion (Fyfanon) Technical. 1985.


Rec #: 710
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

383. Lagisz, M.; Port, G., and Wolff, K. Living in a jar: genetic variation and differentiation among laboratory strains of the red flour beetle. 2011; 135, 682-692.


Rec #: 14320
Keywords: NO TOXICANT
Notes: Chemical of Concern: MLN
Abstract: Abstract: The red flour beetle, Tribolium castaneum, is a common pest, which has become an important model study organism, especially in genetic, ecological and evolutionary research. Although almost all studies on this species have been conducted using established laboratory strains, very little is known about the loss of genetic diversity within the strains and genetic divergence between different laboratory stocks. In this study, five long-term laboratory strains and one wild strain were examined for genetic variation at 12 microsatellite loci, which were designed using publicly available sequences. One of the laboratory strains is resistant to phosphine and one to organophosphorous insecticides. All strains had significant amounts of molecular variation, but genetic diversity in the laboratory strains was lower than in the wild-derived strain used as control. We observed significant molecular divergence among the strains, however, the relationship between them reflected resistance status rather than geographic origins. We found no evidence for recent bottlenecks, but the wild-derived population showed signs of demographic expansion. A novel multivariate method, multiple co-inertia analysis, revealed that the two loci contributing most to the divergence between the resistant strains were located on the eighth chromosome, near genes associated with insecticide resistance.
Number of Volumes: 9
ISI Document Delivery No.: 851ST ://CCC:000297291900005

384. Laila, A. R. Chronic Toxic Effects of Malathion on Fish Carbohydrate Metabolism. 1998; 36, (2): 1211-1221.


Rec #: 730
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

385. Lajmanovich, R. C.; Peltzer, P. M.; Junges, C. M.; Attademo, A. M.; Sanchez, L. C., and Basso, A. Activity Levels of B-Esterases in the Tadpoles of 11 Species of Frogs in the Middle Parana River Floodplain: Implication for Ecological Risk Assessment of Soybean Crops. 2010; 73, (7): 1517-1524.


Rec #: 1840
Keywords: IN VITRO
Call Number: NO IN VITRO (MLO)
Notes: Chemical of Concern: MLO

386. Lamb, I. C. An Acute Neurotoxicity Study of Malathion in Rats. 1994.


Rec #: 740
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

387. ---. A Subchronic (13-Week) Neurotoxicity Study of Malathion in Rats. 1994.


Rec #: 750
Keywords: NO SOURCE
Call Number: NO SOURCE (MLN)
Notes: Chemical of Concern: MLN

388. Lambert, M. R. K. Effects of Pesticides on Amphibians and Reptiles in Sub-Saharan Africa. 1997; 150, 31-73.


Rec #: 210
Keywords: REFS CHECKED,REVIEW
Call Number: NO REFS CHECKED (CPY,CYF,DM,ES,FNT,MLN,PMR,TCF,TMP), NO REVIEW (CPY,CYF,DM,ES,FNT,MLN,PMR,TCF,TMP)
Notes: Chemical of Concern: BDC,CPY,CYF,DDE,DDT,DLD,DM,ES,FNT,HCCH,HPT,MLN,PMR,PPCP,TCF,TMP,TXP

389. Latif, Yawar; Sherazi, S. T. H., and Bhanger, M. I. Assessment of pesticide residues in commonly used vegetables in Hyderabad, Pakistan. 2011 Nov; 74, (8): 2299-2303.


Rec #: 1590
Keywords: CHEM METHODS
Notes: Chemical of Concern: MLN
Abstract: The aim of present study was to assess pesticide residues in vegetables in the Hyderabad region of Pakistan. The concentrations of six pesticides were determined by gas chromatography coupled with mass selective detector (GCÇôMSD) in locally produced vegetables purchased from wholesale markets. A total of 200 samples of eight vegetables viz. cauliflower, green chilli, eggplant, tomato, peas, bitter gourd, spinach and apple gourd were analyzed for pesticide residues. The results indicated that almost all samples were contained pesticides, only 39% contained pesticide residues at or below maximum residue limits (MRLs), and 61% contained pesticide residues above MRLs. From the six analyzed pesticides, carbofuran and chlorpyrifos were found above to MRLs with concentrations ranging from 0.01Çô0.39 and 0.05Çô0.96 mg/kg, respectively. The results provided important information on the current pesticide contamination status of some commonly used vegetables and pointed an urgent need to control the use of some excessively applied and potentially persistent pesticides, such as carbofuran and chlorpyrifos. Pesticide residues/ Vegetables/ Ultrasonic assisted extraction/ GCÇôMS http://www.sciencedirect.com/science/article/pii/S014765131100217X

390. Latifah, a M; Musa, R David; Latiff, P a, and Latifah, A M. Gas Chromatography Mono Spectrometry Study of Malathion Residues in Centella Asiatica. 2011; 8, (1): 57.


Rec #: 3740
Keywords: CHEM METHODS
Notes: Chemical of Concern: MLN
Abstract: Abstract: Centella asiatica is a herbaceous plant and known as pegaga in Malaysia. It was commonly used as a healing agent and constituent to improve mental ability because contains polyphenols and triterpenes. Malathion is an insecticide that helped to increase value and yields of Centella. asiatica by control the damage caused by crop pests. Study was done in MARDI Serdang to measure malathion residue in Centella. asiatica with different treatment methods using GC-MS. Six plots were randomly selected and samples were taken a day before, a day, three days and five days after the application of malathion. The samples were divided into treated (soaked in tap water and salted water), and untreated groups. The sample was extracted through the liquid-liquid extraction and underwent a clean-up process by a silica gel. The residues were found in; three samples treated with salt water (A1= 19.78 mu g/kg, C1 = 8.53 mu g/kg and E1= 0.99 mu g/kg), one sample treated with tap water (E1=0.44 mu g/kg) and two unwashed samples (E1=0.0053 mg/kg and F1=0.0077 mg/kg). Therefore the safest way to consume is by soaked with tap water compared with soaked in salt water and unwashed. However the malathion residue found were below the Maximum Residue Limits set up by US EPA.
Keywords: Residues
Keywords: P 2000:FRESHWATER POLLUTION
Keywords: Malathion
Keywords: Crops
Keywords: Spectrometry
Keywords: Salts
Keywords: EPA
Keywords: pests
Keywords: Insecticides
Keywords: Malaysia
Keywords: Centella asiatica
Keywords: Pollution Abstracts
Keywords: Drinking water English. Date revised - 2011-07-01. Last updated - 2012-03-29. DOI - a86abc4c-7698-4552-8a04mfgefd107; 14908124; 1735-1979. SubjectsTermNotLitGenreText - EPA; Salts; pests; Insecticides; Residues; Drinking water; Crops; Malathion; Spectrometry; Centella asiatica; Malaysia

391. Latifi, a M ; Khodi, S; Mirzaei, M; Miresmaeili, M; Babavalian, H, and Latifi, A M. Isolation and Characterization of Five Chlorpyrifos Degrading Bacteria. 2012 Feb 14; 11, (13): 3140-3146.


Rec #: 2810
Keywords: BACTERIA
Notes: Chemical of Concern: MLN
Abstract: Abstract: Several strains of bacteria were successfully isolated from effluent storage pools of factories producing pesticides and from soil moisture around them. The isolates were capable of utilizing chlorpyrifos (Cp) as the sole source of carbon, phosphorus and energy. Isolates were identified based on 16SrRNA sequence analysis and were named IRLM.1, IRLM.2, IRLM.3, IRLM.4, and IRLM.5. IRLM.1 was able to grow at concentrations of chlorpyrifos up to 2000 mg/L and was selected as a preferable isolate for further analysis. The amount of the degraded Cp and the amount of metabolite 3,5,6-trichloropyridinol (TCP) produced were assessed in IRLM.1 by using high performance liquid chromatography (HPLC) techniques. Additionally, the location of the chlorpyrifos-degrading enzyme was determined by comparing the activity of intact bacteria to cytoplasm activity. Our study reveals that Cp-degrading enzyme of IRLM.1 is cytoplasmic and 10 mu l cytoplasm isolated from 0.05 g dry-weight bacteria can degrade 50% of 2 mM Cp in 2 min. Furthermore, the HPLC analysis showed accumulation of TCP in the medium, revealing that IRLM.1 was able to degrade Cp without being affected by the antimicrobial activity of TCP. Moreover, results show that the IRLM.1 isolate could grow and utilize diazinon and malathion as the sole source of carbon, phosphorus and energy. Thus IRLM.1 can successfully participate in efficient degradation of organophosphorus compounds (OPs).
Keywords: A 01380:Plant Protection, Fungicides & Seed Treatments
Keywords: High-performance liquid chromatography
Keywords: Antimicrobial activity
Keywords: Organophosphorus compounds
Keywords: Phosphorus
Keywords: Enzymes
Keywords: Metabolites
Keywords: Effluents
Keywords: Malathion
Keywords: J 02450:Ecology
Keywords: Chlorpyrifos
Keywords: Carbon
Keywords: Cytoplasm
Keywords: Energy
Keywords: Pesticides
Keywords: Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts
Keywords: W 30915:Pharmaceuticals & Vaccines
Keywords: Soil moisture
Keywords: Diazinon English. Date revised - 2012-06-01. Last updated - 2013-03-11. DOI - MD-0018775914; 16778191; 1684-5315. SubjectsTermNotLitGenreText - High-performance liquid chromatography; Antimicrobial activity; Organophosphorus compounds; Phosphorus; Enzymes; Metabolites; Effluents; Malathion; Chlorpyrifos; Carbon; Cytoplasm; Energy; Pesticides; Soil moisture; Diazinon

392. Laws, E. R. Jr.; Sedlak, V. A.; Miles, J. W.; Joseph, C. R.; Lacomba, J. R., and Rivera, A. D. Field Study of the Safety of Abate for Treating Potable Water and Observations on the Effectiveness of a Control Programme Involving both Abate and Malathion. 1968; 38, (3): 439-445.


Rec #: 1690
Keywords: HUMAN HEALTH
Call Number: NO HUMAN HEALTH (MLN,TMP)
Notes: Chemical of Concern: MLN,TMP

393. Lazarevi-ç-Pa+íti, Tamara; Momi-ç, Tatjana; Radojevi-ç, Milo+í M., and Vasi-ç, Vesna. Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase. (0).


Rec #: 460
Keywords: HUMAN HEALTH
Notes: Chemical of Concern: MLN
Abstract: Abstract Organophosphate/ Pesticide/ Inhibition/ Myeloperoxidase/ Malathion http://www.sciencedirect.com/science/article/pii/S0048357513000886

394. Lazarevi-ç-Pa+íti, Tamara D.; Bond++i-ç, Aleksandra M.; Pa+íti, Igor A., and Vasi-ç, Vesna M. Indirect electrochemical oxidation of organophosphorous pesticides for efficient detection via acetylcholinesterase test. 2012 Nov; 104, (3): 236-242.


Rec #: 720
Keywords: CHEM METHODS
Notes: Chemical of Concern: MLN
Abstract: Organothiophosphorous pesticides diazinon, malathion, chlorpyrifos, azinphos-methyl and phorate, have been indirectly electrochemically oxidized in aqueous media using anodically evolved Cl2, Br2 or I2 as a pre-step for their detection via acetylcholinesterase-based test. The presence of single oxidation product, corresponding oxo-form, was confirmed by UPLC analysis, as well as its stability with respect to hydrolysis. Comparing different halogens, the best results were obtained using Br2 as the oxidant due to high reactivity of HOBr, which is formed upon chemical reaction of anodically formed Br2 with water. Limits of detection of five analyzed pesticides were lowered upon indirect electrochemical oxidation with Br2 for two orders of magnitude or more, comparing to unoxidized parental thio-forms. In fact, the lowest possible detection limits for all five pesticides using proposed analytical procedure were achieved, as being determined by detection limits of corresponding oxo forms. Comparison of here proposed electrochemical oxidation pre-step with earlier reported ones is provided and discussed. Organophosphate/ Pesticide/ Oxidation/ Halogen/ Acetylcholinesterase/ Myeloperoxidase http://www.sciencedirect.com/science/article/pii/S0048357512001381

395. Lazareviae-Pasti, Tamara; Coloviae, Mirjana; Saviae, Jasmina; Momiae, Tatjana; Vasiae, Vesna, and LazareviAe-Pasti, Tamara. Oxidation of Diazinon and Malathion by Myeloperoxidase. 2011 Jun; 100, (2): 140-144.


Rec #: 3430
Keywords: FATE
Notes: Chemical of Concern: MLN
Abstract: Abstract: The aim of the work was to investigate the in vitro oxidation of diazinon and malathion, organophosphorous pesticides (OPs) containing phosphorthioate group, catalyzed by enzyme myeloperoxidase (MPO). The oxidation was performed in the presence of hydrogen peroxide. The products were identified as oxon derivatives (phosphates), where the sulfur atom from thioate group was substituted by an oxygen atom. No hydrolysis products were detected after enzyme - induced oxidation. The oxidation efficiency was controlled using acethylcholinesterase (AChE) bioassay for determination of oxon derivatives concentration. The influence of OPs concentration, incubation time of OPs with MPO, as well as MPO concentration on the yield of oxo forms was investigated. Kinetic constants of MPO in oxidation of malathion and diazinon were estimated. The maximum concentration of oxo forms was achieved after 10min incubation of OPs in 50mM phosphate buffer (pH 6.0) with 100nM MPO.


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