Harvard Medical School Curriculum Vitae Date Prepared: October 6, 2011 Name



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Honors and Prizes

1998

Boehringer Ingelheim Research Award

Boehringer Ingelheim

Awarded for outstanding tropical medicine research project on shistosomiasis

1999

Ralph A. Neal Memorial Prize, LSHTM Medicine/UK

London School for Hygiene and Tropical Medicine, UK

Awarded for Outstanding Performance in Molecular Biology and best Masters Thesis

2001

Travel award recipient

8th Conference on Retroviruses and Opportunistic Infections 2001, Chicago

Awarded for top abstracts submitted in basic research tract

2001

Travel award recipient

Keystone conference: “HIV Vaccines”, Keystone Colorado

Awarded for top abstracts submitted in basic research tract

2002

Travel award recipient


9th Conference on Retroviruses and Opportunistic Infections 2002, Seattle

Awarded for top abstracts submitted in basic research tract

2002

Keystone Symposia Scholarship

Keystone Symposia Scholarship, “HIV-1 Control by Vaccination”

Awarded for top abstracts submitted in basic research tract

2002

Young Investigator Award

International AIDS Society

Best abstract in scientific track with oral presentation at the World AIDS Conference in Barcelona, July 2002

2002

Junior Investigator Award, 40th IDSA, Chicago

Infectious Diseases Society of America (IDSA)

Awarded for best abstract in basic research track and Oral research presentation.

2003

Keystone Symposia Scholarship

Keystone Symposia“ HIV-1 Vaccine Development Immunological and Biological challenges”

Awarded for top abstracts submitted in basic research tract

2003

Travel grant recipient


10th Conference on Retroviruses and Opportunistic Infections 2003, Boston

Awarded for top abstracts submitted in basic research tract -Oral research presentation

2003

Claflin Distinguished Scholar award


MGH/ ECOR

Awarded to support research endeavors for junior faculty during time of childrearing

2004

Maxwell Finland Award


Massachusetts Infectious Diseases Society

Awarded for Excellence in Infectious Diseases Research

2008

Edward H. Kass Award


Massachusetts Infectious Diseases Society

Awarded for Clinical Excellence during clinical ID fellowship (best clinical performance of the fellowship year)

2010

Boston Fellows program 2010


The Partnership Inc.

The Fellows Program trains mid-career professionals how to expand their leadership capacity. Selection by invitation, nomination and competitive application only.

Report of Funded and Unfunded Projects
Funding Information
Past:

1998-1999

PI: MM. Addo - German Academic Exchange Program (DAAD)

Postgraduate Study Grant for a MSC in Applied Molecular Biology of Infectious Diseases



2000-2002

PI: MM. Addo -German Research Council (DFG)

Emmy Noether-Research Grant

“Cytotoxic T lymphocyte responses directed against HIV-1 regulatory proteins”


1999-2005

Co-investigator (PI: P. J. R. Goulder)

NIH-ROI AI46995-01A1

“CTL-Mediated Control of Pediatric and Adult C-Clade Infection”


2002-2004

PI: MM. Addo - American Foundation for AIDS Research (AmfAR)

Research Fellow Grant

“CTL against regulatory and accessory proteins”


2002-2003

PI: MM. Addo - Concerned parents for AIDS Research (CPFA)

Research Fellow Grant

“Correlates of protection in HIV-1 Controllers” ()


2002-2006

Co-investigator (PI: Michael J. Kilby )-NIH

UAB AIDERP RFA-AI01008

“Immune control and escape in Acute Infection”


2003-2004

PI: MM. Addo – NIH-Harvard Center for AIDS Research

CFAR Fellow Award ()

“GB-Virus-C Coinfection in HIV-1 infected individuals”


2003-2005

PI: MM. Addo – MGH/Harvard

Claflin Distinguished Scholar Award

“HIV-1-specific T cell responses in HIV-1 Long-term Nonprogressors (LTNP)”


2008-2009

PI: MM. Addo - Partners AIDS Research Center

International Collaboration Innovation Award



“Impact of Tim-3 on T Cell Regulation in HIV-1 B and C Clade Infection”



Present:

2007-2011

“T Cell Regulation: CD4+ CD25 + FOX3 + T Cells in Acute and Chronic HIV-1 Infection”

NIH/NIAID - KO8 AI 074405-02

PI: MM. Addo ($482,000)

Investigation of T cell immunity in adult HIV-1 infection with the goal to provide insights for future immunotherapeutic interventions and vaccine research



2008-2010

“Analysis of regulatory T cell function in HIV-1 infected children- Implications for pediatric HIV vaccine design”

Elisabeth Glaser Pediatric AIDS Foundation – HIV Vaccine research program grant

PI: MM. Addo ($200,000)

The major goal of this study is to investigate Treg-function in HIV-1 positive infants with the aim to understand if modulation of Tregs could ultimately become a target for immunotherapy or HIV-vaccines.



2008-2012

“The Role of T cell Regulation in the Control of HIV-1”

MGH/MGH ECOR/ MAO Physician Scientist Development Award

PI: MM. Addo ($120,000)

These studies will contribute to our understanding of the regulation of protective T cell immunity in HIV-1 infection, and will provide important insights to guide the design of future immunotherapeutic interventions and vaccine strategies.



2009-2010

“Role of the Tim-3/Galectin-9 Pathway in HIV-1 immunopathogenesis”

Ragon Institute of MGH, MIT and Harvard/ Ragon Innovation award

PI: MM. Addo ($100,000)

This grant aims at investigating the impact of Tim-3 polymorphisms on HIV-1 disease progression.



2009-2010

“T Cell Regulation: CD4+ CD25 + FOX3 + T Cells in Acute and Chronic HIV-1 Infection”- Tregs in the GALT

NIH/NIAID ARRA Supplement to KO8 AI 074405-02

PI: MM. Addo ($50,000)

Investigation of tissue based Tregs in HIV-1 infection.



2010-2011

“T Cell Regulation: CD4+ CD25 + FOX3 + T Cells in Acute and Chronic HIV-1 Infection”- Gene expression profiles in Tregs

NIH/NIAID ARRA Supplement to KO8 AI 074405-02

PI: MM. Addo ($50,000)

Investigation of gene expression profiling of Treg in HIV-1 infections.



2010-2011

“Harvard Center for AIDS Research: MicroRNAs and protection from HIV”

NIH/NIAID ARRA Supplement to P30 AI060354-07S1

PI: Bruce Walker ($134,000)- Co-PIs M.M. Addo and Demetre Daskalakis

Harvard University CFAR: MicroRNAs and protection from HIV-1



2010-2012

“Role of HO-1 specific CD8+ regulatory T cells in the control of HIV-1 infection”

Ragon Institute- Ragon Fellowship Award for Mathieu Angin

PI: M.M. Addo ($160,000)

Investigation of hemoxygenase-1 specific regulatory T cells in HIV-1 infection



2011-2012

Role of IDO-specific cytotoxic T cells as immune regulators in HIV-1 infection

NIH/NIAID

Harvard Center for AIDS Research Scholar Award

PI: M.M. Addo ($50,000)

Investigation of the role of tryptophan metabolism in HIV-1 infection


Current Unfunded Projects

10/2008-

Co-Investigator

Innate Immunity to intranasal influenza vaccination

I am the recruiting and consenting physician on this study and perform all aspects of clinical follow up for this interventional trial.

10/2008-

Co-investigator

HIV-1 immunity in lymphatic tissues

I am co investigator on the IRB protocol, responsible for consenting and recruitment, but also involved in regulatory T cell work related to GALT.

Report of Local Teaching and Training

Teaching of Students in Courses

2009

Invited seminar on Work life balance/career choices as a working mother and physician scientist

Harvard combined MD/PhD program lunch series





Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)

2001-2009


Lectures and Journal Club presentations at the Massachusetts General Hospital HIV clinical conferences ( Two lectures per academic year/various titles)

2002-2009

Seminar presentations for the Massachusetts General Hospital Infectious Diseases conference (1-2 lectures per academic year/various titles)

2005

Lectures and formal teaching of medical students and medical residents at Edendale Hospital, Edendale, RSA

Lecture titles:



  • “Managing acute coronary syndromes”

  • “The approach to the diabetic patient”

  • “Management of MDR TB”

  • “HIV pathogenesis “

  • “Management of HIV related opportunistic infections”

2009

Lectures and formal teaching of graduate students and postdocs at the HIV Pathogenesis Program at the Nelson Mandela Medical School of the University of Kwazulu Natal (during summer mini sabbatical)

Lecture titles:



  • “Regulatory T cells in human disease”

  • “Immunoregulatory networks”

  • “How to write a grant proposal”

  • “Role of Tim-3 in viral infections”

Laboratory and Other Research Supervisory and Training Responsibilities

2001

Supervision and training of one MIT undergraduate summer student and lectures in seminar series for all Partners AIDS Research Center summer students

2002-present

Supervision and training of one summer student working in the lab and lectures in seminar series for all Partners AIDS Research Center summer students. Sponsor and mentor for the student’s Elisabeth Glaser Pediatric AIDS Foundation summer intern award

2002-2004

Supervisor and mentor for Harvard undergraduate student who performed her senior thesis 2004 in my lab. Student received prestigious HOOPES prize for this work

2010

External PhD Thesis reviewer and examiner for Dr. Andrew Prendergast, DPhil, University of Oxford



Formally Supervised Trainees


  • 05/2002-06/2004

Molly R. Perkins, BSc

PhD student in immunology at NIH/Oxford joint graduate program

Mentor and supervisor for Harvard senior thesis about GBV-C-Student received prestigious HOOPES prize for this work. Poster presentations at international meetings, manuscript in preparation.

  • 01/2008- 6/2011

Fang Wen, BSc

Masters student in Biotechnology at Harvard extension school

Several scientific presentations at local and international conferences and supervision of Masters thesis.

  • 08/2008-

Eshia Moodley, MSc

PhD student at the HIV Pathogenesis Program in Durban/RSA

I am one of her PhD supervisors. 1 joint research publication, 2 manuscripts in preparation

  • 02/2009-

Mathieu Angin, PhD

Postdoc in my laboratory at the Ragon Institute of MGH, Harvard and MIT

8 accepted abstracts at International conferences, 2 papers submitted, 2 manuscripts in preparation

  • 07/2010-

Isabel Sada, PhD

Senior Postdoc from Mexico

Our joint grant application for a “Creative and Novel Ideas in HIV Research Award” with me serving in the role of the project mentor and collaborating CFAR supervisor was selected for funding on 6/11/2010 ($100,000) x 2 years.

  • 09/2010-

Anahita Fathi

Medical student from Germany who will spend a year in my laboratory at the Ragon Institute of MGH, Harvard and MIT to work on her doctoral thesis.

Two joint grants to fund her doctoral thesis work were accepted. She will start on September 15, 2010.



Local Invited Presentations

2004

“Correlates of protection in HIV-1 long-term nonprogressors”

Invited speaker at the Chester Pierce Research Society lecture Series, Boston, USA



2009

“Impact of T cell regulation on control of HIV-1 infection”

Invited speaker at the Chester Pierce Research Society meeting, MGH, Boston, MA



2010

“Update on regulatory T cells in HIV-1 infection”

Invited speaker at the Vaccine research institute seminar series, BI, Boston, MA



4/2011

Managing Parenthood panel discussion: “Dual career families”, Office for women’s careers, MGH, Boston, MA

10/2011

Managing Parenthood panel discussion: "Making career travel work for you and your family." Office for women’s careers, MGH, Boston, MA


Report of Regional, National and International Invited Teaching and Presentations
Invited Presentations and Courses
Regional

2000

“The role of cellular immune responses in HIV-1 infection”

Fall River Annual Conference, MA




National

2000

“Cellular immune responses during acute HIV infection and Structured Treatment Interruptions ”

DIA 36th Annual Meeting, San Diego



2002

“Role of the regulatory and accessory proteins for HIV-vaccine development”,

NIH Symposium on Regulatory and Accessory Proteins



2002

“Evaluation of Correlates of Protection in HIV-1 infected individuals spontaneously controlling plasma viral load in the absence of antiretroviral therapy”,

40th Annual Meeting of the Infectious Diseases Society of America, Chicago



2003

“ HIV-1 long-term nonprogression”

Physician’s research Network, New York, USA



2004

“Genetic and immunological determinants of HIV-1 long-term nonprogression”

National Cancer Institute, Institute for Genetics, Frederick, MD, USA




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