Professional educational materials or reports, in print or other media

Professional educational materials or reports, in print or other media

Theses

1. PhD Thesis 1998, University of Bonn, Germany:

2. 
   MSc Thesis, 1999, London School for Hygiene and Tropical Medicine, UK:
   

1. 
   Addo MM, Wen FT, Meier A, Streeck H, Alter G, Anderson DE, Altfeld M,. Hafler DA, Walker BD. 1. Up-regulation of Tim-3 expression on T cells from HIV-1 infected individuals. Oral presentation at the XVII International AIDS Conference, Mexico City from 3-8 August 2008- LATE BREAKER oral presentation
   
2. 
   Streeck H, Jolin JJ, Yassine-Diab B, Ying Qi, Kwon D. Addo MM, Johnson R, Walker BD, Carrington M, Altfeld M and the Acute HIV Infection Network. Early CTL responses determine viral set point in acute HIV-1 infection.
   
3. 
   Addo MM, Wen FT, Meier A, Streeck H, Alter G, Anderson DE, Altfeld M,. Hafler DA, Walker BD. Increased Tim-3 expression on T cells in chronic HIV-1 infection. AIDS Vaccine 2008 Conference, October 13 – 16 2008 at Cape Town, International Convention Centre in Cape Town, South Africa.
   
4. 
   M Chevalier, A Pyo, JS Jolin, MM Addo, DS Kwon, I Toth, B Walker and H Streeck. Skewed HIV-1-specific CD4+ Th2 helper cell contribution in progressive HIV-1 infection. AIDS Vaccine 2009, Paris, France
   
5. 
   Mathieu Angin, Hendrik Streeck, Fang Wen, Augustine Pyo, Alicja Trocha, Ildiko Toth, Douglas Kwon, Florencia Pereyra, Galit Alter, D.E. Kaufmann, M. Altfeld, Bruce D. Walker, Marylyn M. Addo. Regulatory T cell frequencies correlate with T cell activation in chronic HIV-1 infection. 1^st meeting on Immune tolerance, Boston, October 2009
   
6. 
   Mathieu Angin, Hendrik Streeck, Fang Wen, Augustine Pyo, Alicja Trocha, Ildiko Toth, Douglas Kwon, Florencia Pereyra, Galit Alter, M. Altfeld, D.E. Kaufmann, Bruce D. Walker, Marylyn M. Addo. Higher peripheral Treg frequencies and T cell activation but lower absolute Tregs numbers in HIV-1 chronic progressors compared to elite controllers. HIV vaccine Keystone conference 2010, Banff Canada 2010.
   
7. 
   Mathieu Angin, Ashley Rezai, Bruce D. Walker, Marylyn M. Addo. Isolation, expansion and characterization of peripheral CD4+ Tregs from HIV-1 positive donors. Late breaker presentation at the International AIDS Vaccine 2010 Meeting in Atlanta, Georgia.
   
8. 
   M Angin; A Rezai; M King; A Piechocka-Trocha; I Toth; B Walker; MM Addo. Regulatory T cells can be successfully expanded from HIV-1 infected individuals while maintaining suppressive function and phenotype. Keystone symposia, HIV Evolution, Genomics and Pathogenesis (X7)
   Whistler, British Columbia
   
9. 
   M Angin, A Fathi, M King, MM Addo. Increased Plasma Levels of Hemoxygenase-1 (HO-1) and Presence of HO-1-Specific Regulatory in acute HIV-1 infection. AIDS Vaccine 2011, Bangkok, Thailand – October 2011
   
   

The major focus of my research activities at the Ragon Institute of MGH, MIT and Harvard involves basic and translational research examining the adaptive cellular immune response to HIV-1, with particular interest in factors related to spontaneous control of HIV-1 infection and T cell regulation. As a double boarded physician scientist in Medicine and Infectious diseases, I currently spend 80% of my time in basic bench research and research related activities, 10% in clinical service and clinical activities at the MGH Department of Infectious Diseases and 10% in teaching and performing administrative work.

My initial laboratory work on T cell immunity to HIV-1 included the characterization of cytotoxic T lymphocyte (CTL) responses in natural HIV-1 infection. Using a unique cohort of individuals who spontaneously control viremia in the absence of antiretroviral therapy (“HIV elite controllers”) I investigated the cellular immune responses and other genetic and viral determinants associated with the spontaneous control of HIV-1 infection and HIV-1 long-term nonprogression (LTNP). This valuable cohort with now over 1000 individuals recruited nationally and internationally was established by me and has served as a valuable resource for the wider HIV research community (www.hivcontrollers.org). A GWAS study on determinants of HIV control on the basis of this cohort was recently accepted for publication (Science 2010).

This area of investigation led to several important findings: It was shown that the early expressed regulatory and accessory HIV-1 proteins are frequently targeted by HIV-1 specific cytotoxic T lymphocytes (PNAS 2001- paper was named by the NIH as one of the top 5 papers in all of AIDS research and top 20 of all medical research in 2001- and AIDS 2002, Immunity 2003). Both Elite controllers and HIV progressors were found to have broadly directed HIV-1-specifc CD8 T cell responses directed against all expressed HIV-1 proteins (J Virol 2003-1, JID 2008), which are more effectively measured with peptides corresponding to the autologous virus sequence (J Virol 2003-2). However, the quality of the immune response and T cell maturation was different in HIV controllers vs progressors (Plos One 2007). During these projects I was able to identify and characterize several novel CTL epitopes within HIV-1 (e.g. J Virol 2001, J Immunol 2001, J Transl med 2004), and GBV-C that may be associated with improved viral control. Since my return to the lab after leaving the bench for 3 years from 2004-2007 in pursuit of residency and ID fellowship training at MGH, I have now expanded my research activities to the study of regulatory T cells and pathways in HIV-1 infection. These studies are currently supported by six active grants, including a KO8 award through NIAID and have led to several presentations at international meetings. Based on these more recent research activities was published in JID in 2011 and I currently have 4 submitted/under review and and additional 4 manuscripts in preparation. The plan for the coming year will be to pursue independent NIH RO1 funding.

My teaching activities are primarily directed towards mentoring of students and postdocs/fellows at the Ragon Institute and at the HIV Pathogenesis Program in Durban, South Africa. I teach HMS students, MGH residents and clinical fellows during my clinical activities and have started establishing my role as a mentor by supervision of undergraduate and 2 PhD students as well as postdoctoral research fellows.

Based on my background in international research, I was recently nominated as the Associate Director of the CFAR International Program and serve on the HMS Advisory Committee on Global and Community Health and the Standing Committee on African Studies at Harvard/FAS. I am also an active member of the Joint Committee for the Status of Women at Harvard (JCSW) and the Office for Women’s Careers at MGH. In summary, I have started to establish a career as an independent physician-scientist overseeing a small lab with a postdoc, technician and a graduate student. I have been able to acquire independent research funding, have demonstrated scientific productivity and have started to assume leadership roles at HMS and MGH.