International
2000
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“CTL responses directed against the HIV-1 regulatory proteins Tat and Rev”
Immunology Conference, University of Natal, Durban, South Africa |
2001
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“HIV-1 regulatory and accessory proteins as vaccine candidates””
1st Harvard/Natal University HIV Symposium: “Controlling pediatric HIV infection in South Africa”, University of Natal, Durban, South Africa |
2001
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“Treatment of acute HIV-1 infection and Structured Treatment Interruptions ”
2nd ZAPP symposium, “Antiretroviral Therapy in Africa now” Harare, Zimbabwe |
2001
| “CTL responses directed against the regulatory and accessory proteins in HIV-1 infection”, 8th German AIDS Conference, Berlin, Germany |
2002
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Keynote address: “Antiretroviral therapy in developing countries: Harvard Consensus Statement” , 9th Munich AIDS Conference, Munich, Germany
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2002
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“What HIV does in the body”
Journalist To Journalist training program, National Press Foundation, Barcelona, Spain
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2002
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“Evaluation of Correlates of Protection in HIV-1 infected individuals spontaneously controlling plasma viral load in the absence of antiretroviral therapy.”
Invited oral presentation-40th Annual Meeting of the Infectious Diseases Society of America, October 24 - 27, 2002 in Chicago.
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2002
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“Whole genome analysis of HIV-1 specific cytotoxic T lymphocyte (CTL) responses on single epitope level in different groups of HIV-1 infected individuals.“
ward presentation, XIV International AIDS Conference, Barcelona Spain, July 2002
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2003
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Chair of the HIV Pathogenesis Program Immunology Session at the nelson Mandela Medical School in Durban, South Africa
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2004
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“Genetic determinants in HIV-1 controllers and long-term non-progressors.”
11th Conference on Retroviruses and Opportunistic Infections 2004, San Francisco.
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2004
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“Does HIV-1 long-term nonprogression start in acute HIV-1 infection?”
1st International symposium on acute HIV-1 infection. Berlin, Germany
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2008
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“Up-regulation of Tim-3 expression on T cells from HIV-1 infected individuals.”
Oral late breaker at the XVII International AIDS Conference, Mexico City 2008
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2009
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“Scientific Track A overview for Community Delegates”
International AIDS Society Meeting in Capetown, RSA
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2009
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Keynote lecture for Women’s month event: “Women in science- yes we can”
Nelson Mandela Medical School, Durban, RSA
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2010
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“T cell immunity in Exposed Uninfected: Lessons learned from discordant couples in Zambia”
NIH/NIAID Satellite symposium on HIV elite controllers and HIV Exposed seronegatives (HESN)
International “AIDS Vaccine 2010” Conference, Atlanta, GA
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5/2011
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“Harvard Center for AIDS Research- Update on International Program activities”
1st Sub-Saharan Africa CFAR Conference, Kampala, Uganda
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9/2011
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“Update on T cell regulation in HIV-1 infection”
HIV pathogenesis program seminar series, Doris Duke Medical Research Institute, Nelson Mandela Medical School, UKZN, Durban, South Africa
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Report of Clinical Activities and Innovations
Current Licensure and Certification
1999
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Diploma in Tropical Medicine and Hygiene (DTM&H)
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2007-2017
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Board Certification in Internal Medicine
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2009-2019
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Board Certification in Infectious Diseases
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2009-
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Massachusetts Board of Registration Full medical license
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Practice Activities
2006-
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Infectious Diseases Ambulatory Care Outpatient clinic
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MGH Infectious Disease Associates
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1 session q2week
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2010-
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Infectious Diseases inpatient consult service
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MGH Infectious Disease Division
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3-6 weeks/ academic year
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Clinical Innovations
2004/
Implementation of bedside Patient identification boards
-Edendale Hospital, Pietermaritzburg, South Africa
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During a 2 month international clinical elective in Pietermaritzburg, South Africa, I implemented patient identification cards at each bedside on internal medicine wards. During the time of my stay in Edendale hospital, patients were often not able to be identified as they were comatose and non-verbal and their clinical documentation was often not correctly assigned. The example of these dry-marker erasable patient/bed ID cards was widely adopted in the hospital and led to vast improvement of workflow and decrease in medical errors at this teaching hospital.
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Report of Technological and Other Scientific Innovations
2003/”Cytotoxic T cell epitopes of HIV-1”
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Patent: Altfeld M, Addo M, Yu X, Walker B, inventors:
“Cytotoxic T cell epitopes of HIV-1.” US Serial NO: 10/442,909.2003 May 20
During my postdoc with Dr. Bruce Walker we identified several novel CTL epitopes for potential HIV vaccination or immunotherapeutic intervention, some of which are included in this patent
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Report of Education of Patients and Service to the Community
Activities
2010
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Project DeliverUS (http://www.projectdeliverus.com/)
I served as one of the HIV experts in workshops aimed at HIV prevention for City youth through ART. The project sponsored a citywide arts competition “ARTicipation” to engage youth across the city to make art about their thoughts and feelings vis-à-vis HIV and AIDS.
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Educational Material for Patients and the Lay Community
May include a brief, one-sentence description of each role if needed (optional)
Year(s)
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Organization or institution / Role (Sponsor, if any)
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One sentence description (optional)
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2003-2004
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Development of High school biology curriculum for Milton Academy students and organization of High school Lab day 2004
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Report of Scholarship
Peer Reviewed Publications in print
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Boerlin P, Boerlin-Petzold F, Durussel C, Addo MM, Pagani J-L, Chave JP, and Bille J. A cluster of oral atypical Candida albicans in a group of HIV-positive drug users. J Clin Microbiol. 1995;1129-1135
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Boerlin P, Addo MM, Boerlin-Petzold F, Durussel C, Pagani J-L, Chave JP, and Bille J. Transmission of oral Candida albicans strains between HIV-positive patients. Lancet 1995; 345: 1052-1053.
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Altfeld M, Rockstroh JK, Addo MM, Kupfer B, Pult I, Will H, Spengler U.: Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal. J Hepatol. 1998 Aug;29(2):306-9.
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Berthold HK, Parhofer KG, Ritter MM, Addo MM, Wasmuth JC, Schliefer K, Spengler U, Rockstroh JK. Influence of protease inhibitor therapy on lipoprotein metabolism. J Intern Med. 1999 Dec;246(6):567-75
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Altfeld M, Addo MM, Kreuzer KA, Rockstroh JK, Dumoulin FL, Schliefer K, Leifeld L, Sauerbruch T, Spengler U. T(H)1 to T(H)2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linked immunosorbent assay under nonstimulated conditions. J Acquir Immune Defic Syndr. 2000 Apr 1;23(4):287-94.
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Altfeld M, Trocha A, Eldridge RL, Rosenberg ES, Phillips MN, Addo MM, Sekaly RP, Kalams SA, Burchett SA, McIntosh K, Walker BD, Goulder PJ: Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.J Virol 2000 Sep;74(18):8541-9
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Altfeld M, Rosenberg ES, Shankarappa R, Mukherjee JS, Hecht F, Eldridge RL, Addo MM, Poon SH, Phillips MN, Robbins GK, Sax PE, Boswell S, Kahn JO, Brander C, Goulder PJ, Levy JA, Mullins JI, Walker BD: Cellular Immune Responses and Viral Diversity in Individuals treated During Acute and Early HIV-1 Infection. J Exp Med 2001, jan 15;193(2):169-180
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Altfeld M, Livingston B, Reshamwala N, Nguyen T, Addo MM, Shea A, Newman M, Fikes J, Sidney J, Wentworth P, Chesnut R, Eldridge RL, Rosenberg ES, Robbins ES, Flynn T, Buchbinder S, Goulder PJR, Walker BD, Sette A, Kalams SA: Identification of novel HLA-A2-restricted HIV-1-specific CTL epitopes predicted by the HLA-A2 supertype peptide-binding motif. J Virol 2001, Feb 1; 75(3):1301-1347
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Goulder PJ, Altfeld M, Rosenberg ES, Nguyen T, Tang Y, Eldridge RL, Addo MM, He S, Muckerjee JS, Phillips MN, Bunce M, Kalams SA, Sekaly R, Walker BD, Brander C: Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med 2001; 193(2):181-194
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Goulder, PJR, Addo MM, Altfeld M, Rosenberg ES, Tang Y, Govender U, Mngqundaniso N, Annamalai K, Hammond M, Bunce M, Coovadia HM, Walker BD. Rapid identification of 5 novel HLA-A*3002 restricted HIV-1-specific CTL epitopes by Elispot and intracellular cytokine staining. J Virol 2001, Feb 1; 75(3)
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Goulder PJR, Brander C, Tang Y, Tremblay C, Colbert R, Addo MM, Rosenberg ES, Nguyen P, Trocha A, He S, Bunce M, Funkhauser R, Pelton SI, Burchett SK, McIntosh K, Korber BTM, Walker BD. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature 2001; 418; 334-337
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Addo MM, Altfeld M, Rosenberg ES, Eldridge RL, Philips MN, Habeeb K, Khatri A, Brander C, Trocha A, Mazzara GP, Goulder PJ, Walker BD: Analysis of cytotoxic T-lymphocyte (CTL) responses against the regulatory HIV-1 proteins Rev and Tat in HIV-1-infected individuals. PNAS 2001 Feb 13;98(4):1781-1786
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Altfeld M., Addo MM, Eldridge RL, Philips MN, Yu X, Thomas S, Khatri A, Strick D, Phillips MN, Cohen G, Islam S, Christian Brander C, Goulder PJR, Rosenberg ES, Walker BD. Vpr is preferentially targeted by CTL during HIV-1 infection. J Immunol. 2001, 167:2743-2752
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Yu XG, Addo MM, Shang H, Eldridge RL, Phillips MN, Feeney ME, Strick D, Brander GB, Goulder PJ, Rosenberg ES, Walker BD, Altfeld M: Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. AIDS, 2002, Feb 15;16(3):321-8
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Addo MM, Rathod A, Yu M, Rosenberg ES, Walker BD, Altfeld M. HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes (CTL) in HIV-1-infection. AIDS 2002; May 3;16(7):1071-3
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Xu G. Yu, MM. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld Strick, Philip J. R. Goulder, Bruce D. Walker1, Marcus Altfeld. Consistent patterns in the development and immunodominance of HIV-1-specific CD8+ T cell responses following acute HIV-1 infection. J. Virol. 2002;76 8690-8701
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Yusim K, Kesmir C, Gaschen B, Addo MM, Altfeld M, Brunak S, Chigaev A, Detours V, and Korber BT. Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation. J. Virol. 2002;76 8757-8768
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Addo MM, Yu XG, Rosenberg ES, Walker BD, Altfeld M. Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection. DNA Cell Biol. 2002 Sep;21(9):671-8
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Geiben-Lynn R, Kursar M, Brown NV, Addo MM, Shau H, Lieberman J, Luster AD, Walker BD. HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. J Biol Chem. 2002 Nov 5
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Draenert R, Altfeld M, Brander C, Basgoz N, Corcoran C, Wurcel AG, Stone DR, Kalams SA, Trocha A, Addo MM, Goulder PJR, Walker BD. Broadly directed CD4 and CD8 T cell responses to HIV-1 Nef but lack of correlation with control of viremia. J Immunol Methods. 2003 Apr 1;275(1-2):19-29.
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Robbins GK, Addo MM, Troung H., Rathod A, Habeeb K, Davis BT, Basgoz N, Heller H, Walker BD, Rosenberg ES. Augmentation of HIV-1-specific T helper cell responses in chronic HIV infection by therapeutic immunization. AIDS 2003; May 23; 17(8):1121-6
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Bobbitt KR, Addo MM, Altfeld M, Filzen T, Onafuwa AA, Walker BD, Collins KL. Rev activity determines sensitivity of HIV-1infected primary T cells to anti-Gag CTL killing. Immunity 2003 Feb;18(2):289-99
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Altfeld M, Addo MM, Rosenberg ES, Hecht F. M., Lee PK, Vogel M, Yu XG, Draenert R., Johnston MN, Strick D, Allen TM, Feeney M. E, Kahn J. O., Sekaly R. P., Levy J. A., Goulder PJ, Walker BD. Influence of HLA-B57 on clinical presentation and viral control during acute infection. AIDS 2003, 17:1-11
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Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, Johnston MN, Corcoran C, Wurcel AG, Fitzpatrick CA, Feeney ME, Rodriguez WR, Basgoz N, Draenert R, Stone DR, Brander C, Goulder PJ, Rosenberg ES, Altfeld M, Walker BD. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol. 2003 Feb;77(3):2081-92.
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Addo MM*, Altfeld M*, Shankarappa R, Lee PK, Allen TM, Yu XG, Rathod A, Harlow J, O'Sullivan K, Johnston MN, Goulder PJ, Mullins JI, Rosenberg ES, Brander C, Korber B, Walker BD. Enhanced detection of HIV-1-specific T cell responses to highly variable regions using peptides based on autologous virus sequences. J Virol. 2003 Jul;77(13):7330-40. (*these authors contributed equally)
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Delgado JC, Leung JY, Baena A, Clavijo OP, Vittinghoff E, Buchbinder S, Wolinsky S, Addo MM, Walker BD, Yunis EJ, Goldfeld AE. The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. Immunogenetics. 2003 Oct;55(7):497-501. Epub 2003 Sep 27
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Draenert R, Verrill CL, Tang Y, Allen TM, Wurcel AG, Boczanowski M, Lechner A, Kim AY, Suscovich T, Brown NV, Addo MM, Walker BD. Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J Virol. 2004 Jan;78(2):630-41.
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Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, John AS, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ. HIV evolution: CTL escape mutation and reversion after transmission. Nat Med. 2004 Mar;10(3):282-9. Epub 2004 Feb 08
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Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV, SenGupta D, Piechocka-Trocha A, Simonis T, Marincola FM, Wurcel AG, Stone DR, Russell CJ, Adolf P, Cohen D, Roach T, StJohn A, Khatri A, Davis K, Mullins J, Goulder PJ, Walker BD, Brander C. Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities.J Virol. 2004 Mar 1;78(5):2187-2200.
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Yu XG, Addo MM, Perkins BA, Wej F, Rathod A, Geer SC, Parta M, Cohen D, Stone DR, Russell CJ, Tanzi G, Mei S, Wurcel AG, Frahm N, Lichterfeld M, Heath L, Mullins JI, Marincola F, Goulder PJ, Brander C, Allen T, Cao Y, Walker BD, Altfeld M. Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians. AIDS Res Hum Retroviruses. 2004 May;20(5):557-64.
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Hess C, Altfeld M, Thomas SY, Addo MM, Rosenberg ES, Allen TM, Draenert R, Eldrige RL, van Lunzen J, Stellbrink HJ, Walker BD, Luster AD. HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet. 2004 Mar 13;363(9412):863-6.
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Kaufmann D., Altfeld M, Addo MM, Walker BD, Rosenberg ER. HIV-1 specific CD4 T cell responses preferentially target HIV-1 Nef and -Gag. J Virol. 2004 May 1;78(9):4463-4477.
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Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ Processing mutation in an HIV-1 specific CTL epitope. J Exp Med. 2004 Apr 5;199(7):905-15
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Lichterfeld, Xu G. Yu1, Michael T. Waring1, Stanley K. Mui1, Mary N. Johnston1, Daniel Cohen, Addo M.M. , John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, Marcus Altfeld1HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8+ T cells producing both interferon-J and tumor-necrosis factor-D. Blood. 2004 Apr 1
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Norris PJ, Kaufmann .D, Clark M. Addo MM., Yang O., Rosenberg ES. Cytotoxic HIV-1 specific CD4 T cells. J Virol 2004 J Virol. 2004 Aug;78(16):8844-51.
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Addo MM*, William R. Rodriguez*, Cecily A. Fitzpatrick, Almas Rathod, Xu G. Yu, Eric S. Rosenberg, Marcus Altfeld and Bruce D. Walker CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J Transl Med. 2004. 21;2(1):15. (*these authors contributed equally)
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Lichterfeld M, Yu XG, Cohen D, Addo MM, Malenfant J, Perkins B, Pae E, Johnston MN, Strick D, Allen TM, Rosenberg ES, Korber B, Walker BD, Altfeld M. HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. AIDS. 2004. 2;18(10):1383-92.
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Hess C, Means TK, Autissier P, Woodberry T, Altfeld M, Addo MM, Frahm N, Brander C, Walker BD, Luster AD. IL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood. 2004 Aug 3
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Kaufmann DE, Lichterfeld M, Altfeld M, Addo MM, Johnston MN, Lee PK, Wagner BS, Kalife E, Strick D, Rosenberg ES, Walker BD. Limited Durability of Viral Control following Treated Acute HIV Infection. PLOS Medicine 2004, Nov;1(2):e36. Epub 2004 Oct 26.
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Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld M. Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med. 2004. 20;200(6):701-12.
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Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BD. The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T cell count in HIV-1 coinfected individuals.Blood. 2004 Sep 30
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Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, Altfeld M, James I, Mallal S, Bunce M, Barber LD, Szinger J, Day C, Klenerman P, Mullins J, Korber B, Coovadia HM, Walker BD, Goulder PJR: Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 2004
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Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, Sette A, Rosenberg ES, Goulder PJ, Brander C, Walker BD. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J Virol. 2005 Apr;79(8):5000-5.
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Sumida SM, Truitt DM, Lemckert AA, Vogels R, Custers JH, Addo MM, Lockman S, Peter T, Peyerl FW, Kishko MG, Jackson SS, Gorgone DA, Lifton MA, Essex M, Walker BD, Goudsmit J, Havenga MJ, Barouch DH. Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein. J Immunol. 2005 Jun 1;174(11):7179-85.
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Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld M. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection.Blood. 2005 Nov 15;106(10):3366-9. Epub 2005 Jul 7.
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Ramduth D, Chetty P, Mngquandaniso NC, Nene N, Harlow JD, Honeyborne I, Ntumba N, Gappoo S, Henry C, Jeena P, Addo MM, Altfeld M, Brander C, Day C, Coovadia H, Kiepiela P, Goulder P, Walker B. Differential Immunogenicity of HIV-1 Clade C Proteins in Eliciting CD8+ and CD4+ Cell Responses. J Infect Dis. 2005 Nov 1;192(9):1588-96. Epub 2005 Sep 30.
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Meyer-Olson D, Brady KW, Bartman MT, O'sullivan KM, Simons BC, Conrad JA, Duncan CB, Lorey S, Siddique A, Draenert RA, Addo MM, Altfeld M, Rosenberg E, Allen TM, Walker BD, Kalams SA. Fluctuations of functionally distinct CD8+ T cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.Blood. 2005 Dec 1;
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Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, Marincola FM, Moore C, Mallal S, Carrington M, Heckerman D, Allen TM, Mullins JI, Korber BT, Goulder PJ, Walker BD, Brander C. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol. 2006 Feb;7(2):173-8. 2005 Dec
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Schwarze-Zander C, Blackard JT, Zheng H, Addo MM, Lin W, Robbins GK, Sherman KE, Zdunek D, Hess G, Chung RT; AIDS Clinical Trial Group A5071 Study Team. GB Virus C (GBV-C) Infection in Hepatitis C Virus (HCV)/HIV-Coinfected Patients Receiving HCV Treatment: Importance of the GBV-C Genotype. J Infect Dis. 2006 Aug 15;194(4):410-9. Epub 2006 Jul 12.
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Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD. HIV-specific CD8 T cells express low levels of IL-7Ralpha: Implications for HIV-specific T cell memory. Virology. 2006 Jul 21;
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Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R, Reddy S, Bishop K, Moodley E, Nair K, van der Stok M, McCarthy N, Rousseau CM, Addo M, Mullins JI, Brander C, Kiepiela P, Walker BD, Goulder PJ. Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes. J Virol. 2007 Apr;81(7):3667-72. Epub 2007 Jan 24.
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Addo MM, Draenert R, Rathod A, Verrill CL, Davis BT, Gandhi RT, Robbins GK, Basgoz NO, Stone DR, Cohen DE, Johnston MN, Flynn T, Wurcel AG, Rosenberg ES, Altfeld M, Walker BD. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE. 2007 Mar 28;2:e321.
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Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, Baker B, Trocha A, Rosenberg R, Mackey E, Ueda P, Lu Z, Cohen D, Wrin T, Petropoulos CJ, Rosenberg ES, Walker BD.Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.J Infect Dis. 2008 Feb 15;197(4):563-71.
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Miura T, Brockman MA, Brumme CJ, Brumme ZL, Carlson JM, Pereyra F, Trocha A, Addo MM, Block BL, Rothchild AC, Baker BM, Flynn T, Schneidewind A, Li B, Wang YE, Heckerman D, Allen TM, Walker BD. Genetic Characterization of Human Immunodeficiency Virus type 1 in Elite Controllers: Lack of gross genetic defects or common amino acid changes.J Virol. 2008 Jun 18.
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Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, Walker BD, Carrington M, Altfeld M. HIV-1-specific CD8+ T cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. J Virol. 2009 May 20
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Kawashima Y, Pfafferott K, Frater J, Matthews P, Payne R, Addo MM, Gatanaga H, Fujiwara M, Hachiya A, Koizumi H, Kuse N, Oka S, Duda A, Prendergast A, Crawford H, Leslie A, Brumme Z, Brumme C, Allen T, Brander C, Kaslow R, Tang J, Hunter E, Allen S, Mulenga J, Branch S, Roach T, John M, Mallal S, Ogwu A, Shapiro R, Prado JG, Fidler S, Weber J, Pybus OG, Klenerman P, Ndung'u T, Phillips R, Heckerman D, Harrigan PR, Walker BD, Takiguchi M, Goulder P. Adaptation of HIV-1 to human leukocyte antigen class I. Nature. 2009 Apr 2;458(7238):641-5. Epub 2009 Feb 25.
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Julg B, Pereyra F, Buzón MJ, Piechocka-Trocha A, Clark MJ, Baker BM, Lian J, Miura T, Martinez-Picado J, Addo MM, Walker BD. Infrequent recovery of HIV from, but robust exogenous infection of activated CD4+ T-cells from HIV elite controllers. CID 2010
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The International HIV Controllers Study (Addo MM-co-author). The major genetic determinants influencing HIV-1 control map to discrete amino acids involved in HLA class I peptide presentation. Science. 2010 Dec 10;330(6010):1551-7. Epub 2010 Nov 4
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Addo MM, Altfeld M, Brainard DM, Rathod A, Piechocka-Trocha A, Fideli U, Mulenga J, Shutes E, Alvino DM, Hunter E, Allen SA, Walker BD. Lack of detectable HIV-1-specific CD8 T cell responses in Zambian HIV-1 exposed seronegative partners of HIV-1 positive individuals. J Infect Dis. 2011 Jan;203(2):258-62. Epub 2010 Dec 9.
Submitted/In review:
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Angin M, Kwon D, Streeck H, Wen F, Pyo A, Trocha A, Toth I, Pereyra FP, Alter G, Kaufmann DE, Altfeld M, Walker BD, Addo MM. Regulatory T cell frequencies correlate with T cell activation, but not HIV-1 specific immunity in chronic HIV-1 infection (at JID # 48803)
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Angin M, Streeck H, Wen F, Trocha A, Toth I, Pereyra FP, Kaufmann DE, Altfeld M, Walker BD, Addo MM. Regulatory T cell frequencies do not correlate with magnitude or breadth of the HIV-1 specific T cell response (at AIDS)
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Kwon DS, Angin M, Brockman MA, Tighe DP, Pavlik DF, Kavanagh DG, Walker BD, Addo MM, Kaufmann DE. Role of Tregs in IL-10 mediated T cell impairment in chronic HIV-1 infection. (at J virol JVI06251-11 )
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Streeck H, Brumme C, Brumme Z, Gao X, Qi Y, Kwon DE, Addo MM, Rychert J, Pyo A, Flanders M, Axten K, Boutwell C, Yassine-Diab B, Routy JP, Little S, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Rosenberg ES, Allen TM, Harrigan R, Walker BD, Carrington M, Altfeld M. HIV Adaptation to HLA results in decreased CTL-mediated control in primary infection. (at Nat Med)
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4 further manuscripts in preparation
Non-peer reviewed scientific or medical publications/materials in print or other media
Reviews, chapters, monographs and editorials
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Yu X, Addo MM, Lichterfeld M., Altfeld M. "Regulatory and Accessory HIV-1 proteins: Potential targets for HIV-1 vaccines?", Current Medicinal Chemistry 2005 Curr Med Chem. 2005;12(6):741-7.
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Addo MM and Rosenberg ES. Cellular immune responses in transplantation-associated chronic viral infections. Transpl Infect Dis 2002:4:31-40
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Spengler U, Addo M.M., Reichel U. Therapie und Diagnostik der Hepatischen Encephalopathie. Der Gastroenterologe 1999
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Books/Textbooks for the medical or scientific community
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Altfeld M., Addo MM, Walker BD. Cellular Immune Responses in HIV-1. In: Immunotreatment and Gene Therapy of HIV Infection. U. Hengge (Ed) Unimed Science. Unimed Verlag. Bremen, Germany (2004). First edition (p25-38).
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Addo MM. Book chapter „Mycoses“ in Opportunistische Infektionen und Tumore im Verlauf der HIV-Infektion. Rockstroh J.K. and Spengler U. (Eds). Unimed Science. Unimed Verlag. Bremen, Germany (2002) p76-98. Second edition.
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Addo MM. Book chapter „Mycoses“ in Opportunistische Infektionen und Tumore im Verlauf der HIV-Infektion. Rockstroh J.K. and Spengler U. (Eds). Unimed Science. Unimed Verlag. Bremen, Germany (1999) p76-98. First edition.
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