Honors and Prizes
1998
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Boehringer Ingelheim Research Award
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Boehringer Ingelheim
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Awarded for outstanding tropical medicine research project on shistosomiasis
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1999
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Ralph A. Neal Memorial Prize, LSHTM Medicine/UK
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London School for Hygiene and Tropical Medicine, UK
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Awarded for Outstanding Performance in Molecular Biology and best Masters Thesis
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2001
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Travel award recipient
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8th Conference on Retroviruses and Opportunistic Infections 2001, Chicago
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Awarded for top abstracts submitted in basic research tract
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2001
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Travel award recipient
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Keystone conference: “HIV Vaccines”, Keystone Colorado
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Awarded for top abstracts submitted in basic research tract
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2002
| Travel award recipient |
9th Conference on Retroviruses and Opportunistic Infections 2002, Seattle
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Awarded for top abstracts submitted in basic research tract
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2002
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Keystone Symposia Scholarship
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Keystone Symposia Scholarship, “HIV-1 Control by Vaccination”
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Awarded for top abstracts submitted in basic research tract
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2002
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Young Investigator Award
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International AIDS Society
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Best abstract in scientific track with oral presentation at the World AIDS Conference in Barcelona, July 2002
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2002
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Junior Investigator Award, 40th IDSA, Chicago
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Infectious Diseases Society of America (IDSA)
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Awarded for best abstract in basic research track and Oral research presentation.
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2003
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Keystone Symposia Scholarship
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Keystone Symposia“ HIV-1 Vaccine Development Immunological and Biological challenges”
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Awarded for top abstracts submitted in basic research tract
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2003
| Travel grant recipient |
10th Conference on Retroviruses and Opportunistic Infections 2003, Boston
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Awarded for top abstracts submitted in basic research tract -Oral research presentation
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2003
| Claflin Distinguished Scholar award |
MGH/ ECOR
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Awarded to support research endeavors for junior faculty during time of childrearing
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2004
| Maxwell Finland Award |
Massachusetts Infectious Diseases Society
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Awarded for Excellence in Infectious Diseases Research
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2008
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Massachusetts Infectious Diseases Society
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Awarded for Clinical Excellence during clinical ID fellowship (best clinical performance of the fellowship year)
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2010
| Boston Fellows program 2010 |
The Partnership Inc.
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The Fellows Program trains mid-career professionals how to expand their leadership capacity. Selection by invitation, nomination and competitive application only.
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Report of Funded and Unfunded Projects
Funding Information
Past:
1998-1999
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PI: MM. Addo - German Academic Exchange Program (DAAD)
Postgraduate Study Grant for a MSC in Applied Molecular Biology of Infectious Diseases
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2000-2002
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PI: MM. Addo -German Research Council (DFG)
Emmy Noether-Research Grant
“Cytotoxic T lymphocyte responses directed against HIV-1 regulatory proteins”
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1999-2005
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Co-investigator (PI: P. J. R. Goulder)
NIH-ROI AI46995-01A1
“CTL-Mediated Control of Pediatric and Adult C-Clade Infection”
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2002-2004
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PI: MM. Addo - American Foundation for AIDS Research (AmfAR)
Research Fellow Grant
“CTL against regulatory and accessory proteins”
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2002-2003
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PI: MM. Addo - Concerned parents for AIDS Research (CPFA)
Research Fellow Grant
“Correlates of protection in HIV-1 Controllers” ()
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2002-2006
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Co-investigator (PI: Michael J. Kilby )-NIH
UAB AIDERP RFA-AI01008
“Immune control and escape in Acute Infection”
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2003-2004
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PI: MM. Addo – NIH-Harvard Center for AIDS Research
CFAR Fellow Award ()
“GB-Virus-C Coinfection in HIV-1 infected individuals”
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2003-2005
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PI: MM. Addo – MGH/Harvard
Claflin Distinguished Scholar Award
“HIV-1-specific T cell responses in HIV-1 Long-term Nonprogressors (LTNP)”
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2008-2009
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PI: MM. Addo - Partners AIDS Research Center
International Collaboration Innovation Award
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“Impact of Tim-3 on T Cell Regulation in HIV-1 B and C Clade Infection”
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Present:
2007-2011
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“T Cell Regulation: CD4+ CD25 + FOX3 + T Cells in Acute and Chronic HIV-1 Infection”
NIH/NIAID - KO8 AI 074405-02
PI: MM. Addo ($482,000)
Investigation of T cell immunity in adult HIV-1 infection with the goal to provide insights for future immunotherapeutic interventions and vaccine research
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2008-2010
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“Analysis of regulatory T cell function in HIV-1 infected children- Implications for pediatric HIV vaccine design”
Elisabeth Glaser Pediatric AIDS Foundation – HIV Vaccine research program grant
PI: MM. Addo ($200,000)
The major goal of this study is to investigate Treg-function in HIV-1 positive infants with the aim to understand if modulation of Tregs could ultimately become a target for immunotherapy or HIV-vaccines.
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2008-2012
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“The Role of T cell Regulation in the Control of HIV-1”
MGH/MGH ECOR/ MAO Physician Scientist Development Award
PI: MM. Addo ($120,000)
These studies will contribute to our understanding of the regulation of protective T cell immunity in HIV-1 infection, and will provide important insights to guide the design of future immunotherapeutic interventions and vaccine strategies.
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2009-2010
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“Role of the Tim-3/Galectin-9 Pathway in HIV-1 immunopathogenesis”
Ragon Institute of MGH, MIT and Harvard/ Ragon Innovation award
PI: MM. Addo ($100,000)
This grant aims at investigating the impact of Tim-3 polymorphisms on HIV-1 disease progression.
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2009-2010
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“T Cell Regulation: CD4+ CD25 + FOX3 + T Cells in Acute and Chronic HIV-1 Infection”- Tregs in the GALT
NIH/NIAID ARRA Supplement to KO8 AI 074405-02
PI: MM. Addo ($50,000)
Investigation of tissue based Tregs in HIV-1 infection.
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2010-2011
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“T Cell Regulation: CD4+ CD25 + FOX3 + T Cells in Acute and Chronic HIV-1 Infection”- Gene expression profiles in Tregs
NIH/NIAID ARRA Supplement to KO8 AI 074405-02
PI: MM. Addo ($50,000)
Investigation of gene expression profiling of Treg in HIV-1 infections.
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2010-2011
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“Harvard Center for AIDS Research: MicroRNAs and protection from HIV”
NIH/NIAID ARRA Supplement to P30 AI060354-07S1
PI: Bruce Walker ($134,000)- Co-PIs M.M. Addo and Demetre Daskalakis
Harvard University CFAR: MicroRNAs and protection from HIV-1
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2010-2012
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“Role of HO-1 specific CD8+ regulatory T cells in the control of HIV-1 infection”
Ragon Institute- Ragon Fellowship Award for Mathieu Angin
PI: M.M. Addo ($160,000)
Investigation of hemoxygenase-1 specific regulatory T cells in HIV-1 infection
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2011-2012
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Role of IDO-specific cytotoxic T cells as immune regulators in HIV-1 infection
NIH/NIAID
Harvard Center for AIDS Research Scholar Award
PI: M.M. Addo ($50,000)
Investigation of the role of tryptophan metabolism in HIV-1 infection
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Current Unfunded Projects
10/2008-
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Co-Investigator
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Innate Immunity to intranasal influenza vaccination
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I am the recruiting and consenting physician on this study and perform all aspects of clinical follow up for this interventional trial.
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10/2008-
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Co-investigator
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HIV-1 immunity in lymphatic tissues
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I am co investigator on the IRB protocol, responsible for consenting and recruitment, but also involved in regulatory T cell work related to GALT.
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Report of Local Teaching and Training
Teaching of Students in Courses
2009
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Invited seminar on Work life balance/career choices as a working mother and physician scientist
Harvard combined MD/PhD program lunch series
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Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)
2001-2009
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Lectures and Journal Club presentations at the Massachusetts General Hospital HIV clinical conferences ( Two lectures per academic year/various titles)
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2002-2009
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Seminar presentations for the Massachusetts General Hospital Infectious Diseases conference (1-2 lectures per academic year/various titles)
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2005
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Lectures and formal teaching of medical students and medical residents at Edendale Hospital, Edendale, RSA
Lecture titles:
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“Managing acute coronary syndromes”
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“The approach to the diabetic patient”
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“Management of MDR TB”
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“HIV pathogenesis “
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“Management of HIV related opportunistic infections”
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2009
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Lectures and formal teaching of graduate students and postdocs at the HIV Pathogenesis Program at the Nelson Mandela Medical School of the University of Kwazulu Natal (during summer mini sabbatical)
Lecture titles:
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“Regulatory T cells in human disease”
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“Immunoregulatory networks”
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“How to write a grant proposal”
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“Role of Tim-3 in viral infections”
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Laboratory and Other Research Supervisory and Training Responsibilities
2001
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Supervision and training of one MIT undergraduate summer student and lectures in seminar series for all Partners AIDS Research Center summer students
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2002-present
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Supervision and training of one summer student working in the lab and lectures in seminar series for all Partners AIDS Research Center summer students. Sponsor and mentor for the student’s Elisabeth Glaser Pediatric AIDS Foundation summer intern award
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2002-2004
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Supervisor and mentor for Harvard undergraduate student who performed her senior thesis 2004 in my lab. Student received prestigious HOOPES prize for this work
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2010
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External PhD Thesis reviewer and examiner for Dr. Andrew Prendergast, DPhil, University of Oxford
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Formally Supervised Trainees
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Molly R. Perkins, BSc
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PhD student in immunology at NIH/Oxford joint graduate program
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Mentor and supervisor for Harvard senior thesis about GBV-C-Student received prestigious HOOPES prize for this work. Poster presentations at international meetings, manuscript in preparation.
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Fang Wen, BSc
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Masters student in Biotechnology at Harvard extension school
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Several scientific presentations at local and international conferences and supervision of Masters thesis.
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Eshia Moodley, MSc
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PhD student at the HIV Pathogenesis Program in Durban/RSA
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I am one of her PhD supervisors. 1 joint research publication, 2 manuscripts in preparation
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Mathieu Angin, PhD
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Postdoc in my laboratory at the Ragon Institute of MGH, Harvard and MIT
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8 accepted abstracts at International conferences, 2 papers submitted, 2 manuscripts in preparation
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Isabel Sada, PhD
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Senior Postdoc from Mexico
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Our joint grant application for a “Creative and Novel Ideas in HIV Research Award” with me serving in the role of the project mentor and collaborating CFAR supervisor was selected for funding on 6/11/2010 ($100,000) x 2 years.
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Anahita Fathi
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Medical student from Germany who will spend a year in my laboratory at the Ragon Institute of MGH, Harvard and MIT to work on her doctoral thesis.
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Two joint grants to fund her doctoral thesis work were accepted. She will start on September 15, 2010.
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Local Invited Presentations
2004
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“Correlates of protection in HIV-1 long-term nonprogressors”
Invited speaker at the Chester Pierce Research Society lecture Series, Boston, USA
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2009
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“Impact of T cell regulation on control of HIV-1 infection”
Invited speaker at the Chester Pierce Research Society meeting, MGH, Boston, MA
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2010
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“Update on regulatory T cells in HIV-1 infection”
Invited speaker at the Vaccine research institute seminar series, BI, Boston, MA
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4/2011
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Managing Parenthood panel discussion: “Dual career families”, Office for women’s careers, MGH, Boston, MA
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10/2011
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Managing Parenthood panel discussion: "Making career travel work for you and your family." Office for women’s careers, MGH, Boston, MA
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Report of Regional, National and International Invited Teaching and Presentations
Invited Presentations and Courses
Regional
2000
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“The role of cellular immune responses in HIV-1 infection”
Fall River Annual Conference, MA
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National
2000
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“Cellular immune responses during acute HIV infection and Structured Treatment Interruptions ”
DIA 36th Annual Meeting, San Diego
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2002
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“Role of the regulatory and accessory proteins for HIV-vaccine development”,
NIH Symposium on Regulatory and Accessory Proteins
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2002
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“Evaluation of Correlates of Protection in HIV-1 infected individuals spontaneously controlling plasma viral load in the absence of antiretroviral therapy”,
40th Annual Meeting of the Infectious Diseases Society of America, Chicago
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2003
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“ HIV-1 long-term nonprogression”
Physician’s research Network, New York, USA
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2004
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“Genetic and immunological determinants of HIV-1 long-term nonprogression”
National Cancer Institute, Institute for Genetics, Frederick, MD, USA
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