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Ibuprofen, CAS No. 15687-27-1
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| Page | 2/2 | | Date | 03.03.2018 | | Size | 182.71 Kb. | | #42054 |
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Ibuprofen, CAS No. 15687-27-1
Acute Studies
Organism
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Benchmark
μg/L
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Duration of Study
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Reference
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Comments
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algae
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S. capricornutum
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>32
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72-hr
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Brun
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EC25 Highest conc. tested
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S. capricornutum
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>30,000
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96-hr
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H-S; IUCLID
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NEL
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D. subspicatus
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315,000
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72-hr
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Cleuvers 2003
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EC50
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D. subspicatus
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342,200
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72-hr
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Cleuvers 2004
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EC50
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S. costatum
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7,100
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96-hr
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H-S; IUCLID
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EC50 (saltwater diatom)
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S. costatum
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39,900
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5-d
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H-S; IUCLID
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EC50 (NOEC 20,500 μg/L)
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H. attenuata
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25,000
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96-hr
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Quinn 2008a
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LC50 Adult survival
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H. attenuata
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1,000
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96-hr
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Quinn 2008b
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NOEC fetal development
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crustacean
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D. magna
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9,060
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48-hr
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H-S; IUCLID
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EC50
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D. magna
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11,500
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48-hr
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IUCLID
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EC50
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D. magna
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>32
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48-hr
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Brun
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LC50
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D. magna
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107,700
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48-hr
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Heckmann
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LC50
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D. magna
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132,600
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48-hr
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Han
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LC50
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D. magna
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108,000
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48-hr
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Cleuvers 2003
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EC50
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D. magna
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101,200
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48-hr
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Cleuvers 2004
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EC50
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M. bahia
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>100,000
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96-hr
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H-S; IUCLID
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EC50 (NOEC of 30,000 μg/L)
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P. carinatus
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17,100
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96-hr
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Pounds
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EC50
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frog
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R. catesbeiana
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41,500
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96-hr
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Veldhoen
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fish
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D. rerio
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23,900
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48-hr
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Kehrer
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LC50
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L. machrochirus
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173,000
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96-hr
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H-S; IUCLID
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LC50 (NOEC 10,000 μg/L)
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C. variegatus
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>300,000
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96-hr
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H-S; IUCLID
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NEL
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C. mrigala
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142,000
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24-hr
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Saravanan
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LC50
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Chronic studies
Organism
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Benchmark
μg/L
|
Duration of Study
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Reference
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Comments
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S. capricornutum
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10
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72-hr
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Brun 2006
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NOEC (32 μg/L =LOEC)
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S. capricornutum
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>30,000
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96-hr
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IUCLID
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No Effect Level
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Isochrysis galbana
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500,000
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Aguirre-Martinez 2015
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NOEC not used – seawater species
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S. subspicatus
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40,700*
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72-hr
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Aguirre-Martinez 2015
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Moro 2014
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D. subspicatus
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72,900*
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72-hr
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Cleuvers 2004
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EC05 growth
EC50 = 342,000
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Skeletonema costatum
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20,500
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5-d
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IUCLID
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EC50 = 39,900 μg/L
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L. gibba
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1,000*
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7-d
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Brain 2004
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NOEC
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L. minor
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1,000*
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7-d
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Pomati 2004
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NOEC
EC50 = 4,000 μg/L?
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L. minor
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22,000*
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7-d
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Cleuvers 2003
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EC50 (NOEC not indicated)
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H. vulgaris
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1,000
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7-d
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Pascoe
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NOEC - survival
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H. vulgaris
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1,000*
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17-d
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Pascoe
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NOEC – feeding & budding
10 μg/L* NOEC for polyp regeneration (only conc.)
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H. attenuata
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1,000*
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96-hr
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Quinn 2008
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NOEC growth
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D. magna
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108,000
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7-d
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Cleuvers 2003
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EC50 (NOEC not indicated)
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D. magna
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80,000
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10-d
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Hayashi 2008
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NOEC - survival
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D. magna
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40,000
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10-d
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Hayashi 2008
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NOEC – reproduction (during 10-d recovery)
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D. magna
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40,000
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12-d
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Heckmann
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NOEC - survival
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D. magna
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10,000
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12-d
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Heckmann
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NOEC - growth
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D. magna
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2,040*
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12-d
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Heckmann
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NOEC - reproduction
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14-d
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Heckmann 2007
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Check 12-d?
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D. magna
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20,000
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21-d
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Han 2006
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NOEC - survival
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D. magna
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20,000
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21-d
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Han 2006
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NOEC - reproduction
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D. magna
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33,300
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21-d
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Han 2010
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NOEC – survival
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D. magna
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1,230*
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21-d
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Han 2010
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NOEC lowest NOEC for reproduction
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C. dubia
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>32
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7-d
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Brun 2006
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NOEC (EC25) highest conc.
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M. macrocopa
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50,000
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7-d
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Han 2010
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NOEC – survival no lowest NOEC
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M. macrocopa
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25,000*
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7-d
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Han 2010
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NOEC - reproduction
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P. carinatus
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5,360
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21-d
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Pounds 2008
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NOEC - survival
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P. carinatus
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2,430
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21-d
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Pounds 2008
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NOEC - hatch
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P. carinatus
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1,020*
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21-d
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Pounds 2008
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NOEC - growth
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O. latiptes
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100
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6-wk
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Flippin 2007
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NOEC- survival not lowest NOEC
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O. latiptes
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10*
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Flippin 2007
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NOEC - reproduction
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O. latipes
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0.1
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120-d
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Han 2010
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NOEC – survival invalid study
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O. latipes
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1
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Han 2010
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NOEC – repro. Invalid study
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P. promelas
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3,000*
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32-d
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Gallagher 2010 / Maack 2011
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NOEC
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P. promelas
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680*
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32-d
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Overturf 2012
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NOEC
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Note: * indicates value used in SSD
Percentiles, μg/L
0.05
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HC05,95% LCL
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0.10
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0.25
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0.50
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39.0
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2.3
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85.5
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318
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1368
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