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Course Code: PHT 1210
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Course Title: Pharmacology-II
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Credits = 3
|
L
|
T
|
P
|
Semester: V
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Total contact hours: 45
|
2
|
1
|
0
|
List of Prerequisite Courses
|
|
Pharmacology I
|
|
List of Courses where this course will be prerequisite
|
|
Pharmacology III
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|
Description of relevance of this course in the B.Pharm. Program
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To train the students with the basics of Chemotherapy
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Course contents (Topics and subtopics)
|
Reqd. hours
|
1
|
Chemotherapy: Basic concepts and general principles
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3
|
2
|
Antibiotics and Principles of antibacterial
|
3
|
3
|
Chemotherapy of Sulfonamides – Trimethoprim
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3
|
4
|
Quinolones and fluroquinolones
|
3
|
5
|
Penicillins and Cephalosporins
|
5
|
6
|
Macrolides, Tetracyclines, Chloramphenicols
|
5
|
7
|
Antifungal agents
|
3
|
8
|
Antiviral agents
|
5
|
9
|
Anticancer agents
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7
|
10
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Chemotherapy of Parasitic diseases, Amoebiasis, Antimalarial, Anthelmentics
|
5
|
11
|
Chemotherapy of Tuberculosis/Leprosy
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3
|
List of Text Books/Reference Books
|
1
|
Rang and Dale, Textbook of Pharmacology,8thedition, Elsevier, 2015
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2
|
Tripathi K D., Essentials of Medical Pharmacology, 7thedition, Published by Jaypee brothers, 2013
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3
|
Lippincott’s Illustrated Reviews, Pharmacology 6th edition, Wolters Kluwer, 2015
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4
|
R.S.Satoskar, S.D.Bhandarkar, Pharmacology and Pharmacotherapeutics 24th Edition, 2015
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5
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F.S.K.Barar, Essentials of Pharmacotherapeutics 1st edition, S.Chand and Company Ltd, 2004
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Course Outcomes (students will be able to )
|
1
|
Understand basic concepts and general principles of antibiotics, antibacterials, chemotherapy and sulfonamides.
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2
|
Understand concepts and principles of Quinolones, fluoroquinolones, penicillins, cephalosporins, macrolides, tetracyclins, chloramphenicols and antifungal agents.
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3
|
Understand concepts of antiviral agents, anticancer agents, chemotherapy of parasitic diseases, amoebiasis, Antimalarial, anthelmintics and chemotherapy of tuberculosis and leprosy.
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|
Course Code: BST1203
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Course Title: Molecular Biology and Biotechnology
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Credits = 3
|
L
|
T
|
P
|
Semester: V
|
Total contact hours: 45
|
2
|
1
|
0
|
List of Prerequisite Courses
|
|
10th std. Biology; 12th std Chemistry
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|
List of Courses where this course will be prerequisite
|
|
Applied Molecular Biotechnology
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|
Description of relevance of this course in the B. Tech./B.Pharm. Program
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To familiarize students with the genetic tools available to express heterologous proteins in prokaryotic and eukaryotic model host organisms
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Sr. No.
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Course contents (Topics and subtopics)
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Reqd. hours
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1
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DNA replication and transcription
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5
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2
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Protein biosynthesis
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5
|
3
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Recombinant DNA technology: Tools of rDNA technology, Restriction endonucleases, DNA modifying enzymes
Generation of a recombinant fragment plasmid cloning vectors, creating and screening a library, cloning DNA sequences that encode eukaryotic proteins,
Vectors for cloning large pieces of DNA, genetic transformation of prokaryotes
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5
3
2
|
4
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Manipulation of gene expression in prokaryotes: Expression vectors, gene expression from strong and regulatable promoters
Fusion proteins, expression vectors
Increasing protein stability and secretion of proteins, DNA introduction and integration into the host genome
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5
2
3
|
5
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Heterologous protein production in eukaryotic cells: Post-translational modification of eukaryotic proteins, general features of eukaryotic expression systems, yeast- and filamentous fungus-based expression systems, baculovirus-insect cell expression systems, mammalian cell expression systems
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5
|
6
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Bioinformatics: Molecular databases, gene and protein analysis tools, protein modeling
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5
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7
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Introduction to synthetic biology for biomanufacturing
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5
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List of Text Books/Reference Books
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1
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Glick and Paternak, Molecular Biotechnology: Principles and Applications of Recombinant DNA, 3rd edition, ASM Press, 2003
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|
2
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R.W. Old, S.B. Primrose, Principles of gene manipulation : An introduction to genetic engineering, 5th Edition, Blackwell Scientific, 1994
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3
|
T A Brown, Gene Cloning and DNA Analysis: An Introduction, 7th edition, Wiley-Blackwell, 2015
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Course Outcomes (students will be able to )
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1
|
Choose gene cloning strategies to express heterologous proteins
|
|
2
|
Analyze vector sequences and determine their functional characteristics
|
|
3
|
Explain and employ the techniques used to transfer genetic elements in animal cells
|
|
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