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Course Code : PHT 1504
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Course Title: Pharmacognosy I
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Credits = 3
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L
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T
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P
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Semester: VI
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Total contact hours: 45
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2
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1
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0
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List of Prerequisite Courses
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HSC Biology and Chemistry
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List of Courses where this course will be prerequisite
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All pharmacognosy, phytochemistry and medicinal natural product courses
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Description of relevance of this course in B-Pharm Program
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To train the students with the basics of pharmacognosy and phytochemistry
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Sr. No.
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Course contents (Topics and subtopics)
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Reqd Hours
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1
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General Pharmacognosy: Definition, history, indigenous systems of medicine. Source of drugs, organized drugs and unorganized drugs, nutraceuticals, functional food, food supplements, etc.
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3
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2
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Scope of Pharmacognosy: Origin, geographical source & habitat, history, cultivation, pest control, preparation for market, identification, chemical constituents, uses, allied drugs, substitutes, adulterants
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3
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3
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Plant growth regulators/ Hormones
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2
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4
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Cell cultures as source of drugs and propagation
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2
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5
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Classification of crude drugs: Alphabetical, biological, morphological, pharmacological, chemical, chemo-taxonomical, etc.
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5
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6
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Standardization of drugs of natural origin: Organoleptic, microscopic, macroscopic, biological, chemical, spectral, and physical methods. Application of chromatographic techniques in evaluation of herbal drugs. Evaluation of crude drugs, extracts and phytoconstituents, etc.
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5
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7
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Plant description, morphology, cell differentiation and ergastic cell contents: Study of plant parts, cell and tissue, underground or subterranean drugs, roots, rhizomes, corms, bulb, tubers, stolen, runners, and suckers; Leaves: Simple and compound, stomata, stomata number, stomatal index, palisade - ratio, hydathodes and water pores, epidermal trichomes, calcium oxalate crystals, vein-islet number, vein termination number; Inflorescence and flowers; Fruits; Seeds; Barks, and wood.
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3
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8
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Unorganised drugs: Dried latex, dried juices, dried extracts, gums and mucilages, resins, etc.
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2
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9
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Phytochemistry: General properties, structures, classification, methods of extraction, etc. of Carbohydrates, proteins, enzymes, lipids, volatile oils, glycosides (anthraquinone, cyanogenic, steroidal, etc.
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5
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10
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General properties, structures, classification, methods of extraction, etc. Of triterpenoidal, coumarin, flavonoid, glucosinolate, etc.) tannins, alkaloids, etc.
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5
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11
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Biosynthesis: Building blocks, reactions involved in the biosynthesis, biosynthesis of building blocks. (acetate, isopenntenyl pyrophosphate, phenyl propane, etc.,)
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5
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12
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Extraction: Methods employed for the extraction of natural products mentioned under phytochemistry. Types of extracts. Methods used for separation of phytoconstituents
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3
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13
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Minerals- Kiselghur, Chalk, Talc, and Bentonite
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2
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List of Text Books/ Reference Books
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1.
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Dewick, Paul M. Medicinal natural products: a biosynthetic approach. 2nd edition, John Wiley &Sons, 2002
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2.
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Bruneton J, Pharmacognosy & Phytochemistry Medicinal Plants,2nd edition, Lavoisier Publishing Inc. 1999
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3.
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Harborne J.B. Phytochemical Methods- A Guide to modern techniques of Plant analysis, 3rd edition,Springer, 1998
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4.
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Ikan R., Natural Products- A Laboratory Guide, 2nd edition, Academic Press, 1994
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5.
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Tyler V.E., Pharmacognosy, 8th edition, Lea & Febiger, 1981
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6.
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Trease & Evans, Textbook of Pharmacognosy, 16th edition, Harcourt Publishers, 2009
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7.
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Wallis, Thomas Edward, Textbook of Pharmacognosy, 5th edition, J. & A. Churchill Ltd,1967
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8.
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Wagner, Hildebert, and Sabine Bladt. Plant drug analysis: a thin layer chromatography atlas. Springer Science & Business Media, 1996.
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9.
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Wealth of India (11 volumes), Publications and Information Directorate, CSIR, 1992
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10.
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Jackson B.P., DW.Snowdon, Atlas of Microscopy of Medicinal Plants, Culinary Herbs and Spices, CBS Publishers, 1990
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11.
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The Merck Index, Merck Research Laboratories, 13th edition, Merck & Co., Inc, 2001
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12.
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Indian Pharmacopoeias, 2010, Government of India, Controller of Publications, Delhi
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13.
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Ayurvedic Pharmacopoeia of India, AYUSH, CCRAS
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14.
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Quality Standards of Indian Medicinal Plants, all volumes, ICMR
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15.
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Indian Medicinal Plants, Kiritikar and Basu
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Course Outcome (students will be able to...)
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1
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Undertake systematic identification of different plant / herbal material.
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2
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Describe the requirement of cultivation and collection of herbal drugs.
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3
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Describe post harvest treatment for preparation for market.
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4
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Evaluate purity and safety of plant material.
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5
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Describe comprehensive requirement for setting up of extraction plant
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Course Code:PHP1115
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Pharmaceutics/ Biopharmaceutics Laboratory - III
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Credits = 2
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L
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T
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P
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Semester: VI
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Total contact hours: 60
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0
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0
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4
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List of Prerequisite Courses
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Pharmaceutics-I, Pharmaceutics-II , Pharmaceutics-III, , Pharmaceutics Laboratory – I, Pharmaceutics Laboratory – II
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List of Courses where this course will be prerequisite
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Pharmaceutics-V, Pharmaceutics-VI, Pharmaceutics Laboratory – IV, Pharmaceutics Laboratory – V
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Description of relevance of this course in the B. Pharmacy
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To train the students with respect to practical aspects of pharmaceutical solid unit dosage form development and quality control thereof. Introduction to practical applications and calculations related to biopharmaceutics
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Sr. No.
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Course Contents (Topics and subtopics)
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Reqd. hours
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1
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Representative examples of granules ready for compression (Preparation, packaging and evaluation)
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8
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2
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Representative examples of tablets (Preparation, packaging and evaluation)
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24
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3
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Representative examples of tablet coating (Preparation, packaging and evaluation)
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8
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4
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Representative examples of capsules (Preparation, packaging and evaluation)
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8
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5
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Representative examples of microencapsulation (Preparation, packaging and evaluation)
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8
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6
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Dissolution testing:
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Conventional marketed formulations representing- soluble drug, poorly soluble drug (selection of medium)
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4
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Course Outcomes (students will be able to…..)
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1
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Prepare and evaluate granules ready for compression
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2
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Prepare, evaluate and label pharmacopoeial and non pharmacopoeial solid oral dosage forms
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3
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Perform microencapsulation
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3
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Perform dissolution testing for oral dosage forms
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Course Code: PHP1205
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Course Title: – Pharmacology Laboratory-I
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Credits = 2
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L
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T
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P
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Semester: VI
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Total contact hours: 60
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0
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0
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4
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List of Prerequisite Courses
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Anatomy, Physiology & Pathophysiology-Laboratory
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List of Courses where this course will be prerequisite
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Pharmacology Laboratory-II
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Description of relevance of this course in the B.Pharm. Program
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To teach students the practical aspects of pharmacology: ex vivo and in vivo experiments
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Sr. No.
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Course contents (Topics and subtopics)
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Reqd. hours
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1
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Ideal animal house maintainance, animal care and handling and acute and subacute toxicity. In accordance with CPCSEA. OECD guidelines and Schedule Y
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2*4
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2
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Dose response curve on isolated tissue preparation
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4*4
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3
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Nature of agonist/ antagonist activity
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2*4
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4
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PA2 value calculation
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2*4
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5
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Demonstration of routes of administration
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2*4
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6
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Demonstration of experiments on rabbit eye
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1*4
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7
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Effect of drugs on normal and hypodynamic heart (Demonstration)
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1*4
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8
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Effect of drugs on perfused isolated heart (Demonstration)
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1*4
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List of Text Books/Reference Books
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1
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Kulkarni, Shrinivas Krishnarao. Hand book of experimental pharmacology. 3rd edition, Vallabh prakashan, 1999.
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2
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R.K.Goyal, Practicals in Pharmacology, 6th,edition, B.S.Shah Prakashan, Ahmedabad, 2006- 2007
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3
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U.K.Seth, N.K.Dadkar, Usha G.Kamat, Selected Topics in Experimental Pharmacology, 1st edition, Kothari Book Depot Mumbai, 1972
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4
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Ghosh M.N, Fundamentals of Experimental Pharmacology, 3rd edition, Hilton and Co, Kolkata, 2005
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Course Outcomes (students will be able to )
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1
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Understand ideal animal house maintainance, animal care, handling and acute and subacute toxicity in accordance with CPSCEA, OECD guidelines and schedule Y.
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2
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Perform dose response curve on isolated tissue preparation; interpret the nature of agonist / antagonist activity and calculate PA2 value.
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3
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Identify different routes of administration of drugs in mice/rats and understand the effect of autonomic drugs on rabbit’s eye.
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4
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Understand the effect of drugs on normal and hypodynamic heart and perfused isolated heart using suitable experiments.
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