Personal Research Database Bibliometric


Title: Tropical Medicine & International Health



Download 1.67 Mb.
Page37/101
Date19.10.2016
Size1.67 Mb.
#4778
1   ...   33   34   35   36   37   38   39   40   ...   101

Title: Tropical Medicine & International Health


Full Journal Title: Tropical Medicine & International Health, Tropical Medicine & International Health

ISO Abbreviated Title:

JCR Abbreviated Title:

ISSN:


Issues/Year:

Journal Country/Territory:

Language:

Publisher:

Publisher Address:

Subject Categories:

: Impact Factor

? Van der Stuyft, P. (1996), Editorial: Academic excellence and societal influence in the field of tropical medicine and international health. Tropical Medicine & International Health, 1 (6), 737.

Full Text: 1996\Tro Med Int Hea1, 737.pdf

? Schoonbaert, D. (1996), Roelants, Gilbert. Citation analysis for measuring the value of scientific publications: Quality assessment tool or comedy of errors? Tropical Medicine & International Health, 1 (6), 739-752.

Full Text: 1996\Tro Med Int Hea1, 739.pdf

Abstract: Summary: the basic concepts of citation analysis and journal impact factors are discussed in the light of quality assessment of scientific publications, individual scientists and research units. The major controversies concerning this topic are addressed: technical limitations, database selectivity, time and discipline-related biases, language and publication type biases, multiple authorship merits and citing motivations. Both positive and negative aspects are put into perspective. The authors conclude that citation analysis, even when based on journal impact factors, can be a worthwhile criterion for evaluating publication records of individual scientists or research units, as long as some of the problems discussed are sufficiently taken into account. However, this conclusion in no way implies that citation analysis may be considered as the one and only evaluation criterion.

? Gulmezoglu, A.M. and Garner, P. (1998), Trichomoniasis treatment in women: A systematic review. Tropical Medicine & International Health, 3 (7), 553-558.

Full Text: 1998\Tro Med Int Hea3, 553.pdf

Abstract: OBJECTIVE To compare the effectiveness of various treatment strategies for trichomoniasis in women. DATA SOURCES MEDLINE from 1966 to1996, Embase from 1986 to 1996, Science Citation Index from 1990 to 1996; reference lists of existing reviews; through the manufacturers of metronidazole and tinidazole in the UK, the Cochrane Controlled Trials Register until October 1997 and informal discovery. STUDY SELECTION Any randomized or quasi-randomized trial in nonpregnant women with trichomoniasis where different treatment strategies were compared. 45 of the 124 identified studies met the criteria and were included ill the review. DATA EXTRACTION Settings, diagnostic methods, exclusions, loss to follow-up and partner treatment strategies were extracted. Outcomes sought were parasitological cure, clinical cure and side-effects of treatment. RESULTS Most trials were small, with only two trials containing more than 100 women in each comparison group. Only 11 trials followed up women for more than cine month. Oral nitroimidazoles were effective in achieving parasitological cure. Fourteen trials compared different treatment strategies with the remainder comparing different doses or different drugs. Partner treatment was effective ill decreasing longer-term reinfection rates in the one trial testing this. CONCLUSIONS Parasitological cure rail je achieved by a single oral dose of nitroimidazoles. There is, however, very little data on partner treatment strategies and long-term cure rates after initial treatment. Further research should test various partner treatment strategies to prevent re-infections and reduce trichomoniasis prevalence.

Keywords: Citation, Clinical-Trial, Double-Blind, Metronidazole, Nitroimidazoles, Ovules, Placebo, Research, Review, Science Citation Index, Systematic Review, Trichomonas Vaginalis, Vaginal Trichomoniasis

Schoonbaert, D. (2004), Citation patterns in tropical medicine journals. Tropical Medicine & International Health, 9 (11), 1142-1152.

Full Text: 2004\Tro Med Int Hea9, 1142.pdf

Abstract: Selections of most important journals in the field of tropical medicine have previously been identified with the help of resources such as bibliographical and citation databases. This article uses ISI’s Journal Citation Reports (JSR) for 2002 to analyse the citation characteristics of the Tropical Medicine category. According to these data, this small but diverse group of 12 journals bestows some 40% more citations than it receives. Its six typical core journals tend to cite one another heavily, but they also refer a lot to multidisciplinary science and general medicine journals, and to infectious diseases and parasitology journals. Looking at the sources from which JCR’s tropical medicine journals derive their citations, it is clear that in this reverse direction, the specialty’s literature is still more concentrated. Apart from the typical core, this JCR category also contains a number of journals with more idiosyncratic citing patterns, focused on specialties such as paediatrics, a single disease (leprosy) and a representative of Latin American and Francophone biomedical science each. Implications of concentrated citedness and language biases are discussed briefly. This paper features a selection of bibliometric parameters relating to the tropical medicine journals and lists of the 80 journals most citing and cited by them.

Keywords: Tropical Medicine, Biomedical Literature, Journals, Bibliometrics, Citation Analysis, Journal Citation Reports

Notes: JJournal

Glover, S.W. and Bowen, S.L. (2004), Bibliometric analysis of research published in Tropical Medicine and International Health 1996–2003. Tropical Medicine & International Health, 9 (12), 1327-1330.

Full Text: 2004\Tro Med Int Hea9, 1327.pdf

Abstract: We examine the bibliometric profile of Tropical Medicine and International Health using the subjects of the articles published and the geographical distribution of the authors. The most common subject areas of papers published during 1996–2003 are highlighted, and the most cited papers indicated.

Keywords: Analysis, Authors, Bednets, Bibliometric, Bibliometric Analysis, Bibliometrics, Children, Citation Analysis, Distribution, Historical Article, Impact, Malaria, Mortality, Nations, Papers, Periodicals, Publishing, Randomized-Trial, Research

? Rabie, T. and Curtis, V. (2006), Handwashing and risk of respiratory infections: A quantitative systematic review. Tropical Medicine & International Health, 11 (3), 258-267.

Full Text: 2006\Tro Med Int Hea11, 258.pdf

Abstract: To determine the effect of handwashing on the risk of respiratory infection. We searched PUBMED, CAB Abstracts, EMBASE, Web of Science, and the Cochrane library for articles published before June 2004 in all languages. We had searched reference lists of all primary and review articles. Studies were included in the review if they reported the impact of an intervention to promote hand cleansing on respiratory infections. Studies relating to hospital-acquired infections, long-term care facilities, immuno-compromised and elderly people were excluded. We independently evaluated all studies, and inclusion decisions were reached by consensus. From a primary list of 410 articles, eight interventional studies met the eligibility criteria. All eight eligible studies reported that handwashing lowered risks of respiratory infection, with risk reductions ranging from 6% to 44% [pooled value 24% (95% CI 6-40%)]. Pooling the results of only the seven homogenous studies gave a relative risk of 1.19 (95% CI 1.12%-1.26%), implying that hand cleansing can cut the risk of respiratory infection by 16% (95% CI 11-21%). Handwashing is associated with lowered respiratory infection. However, studies were of poor quality, none related to developing countries, and only one to severe disease. Rigorous trials of the impact of handwashing on acute respiratory tract infection morbidity and mortality are urgently needed, especially in developing countries.

Keywords: Acute, Cochrane, Control Program, Controlled-Trial, Day-Care-Centers, Developing Countries, Disease, Elderly, Elderly People, Environmental Surfaces, Hand, Handwashing, Impact, Infection, Intervention, Long-Term Care, Meta-Analysis, Morbidity, Mortality, Parainfluenza Virus Vaccine, Primary, Pubmed, Quantitative, Relative Risk, Respiratory, Respiratory Infections, Review, Rhinovirus Colds, Risk, Science, Syncytial Virus, Systematic, Systematic Review, Tract, Transmission, Web of Science

? Hwang, J., Bitarakwate, E., Pai, M., Reingold, A., Rosenthal, P.J. and Dorsey, G. (2006), Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: A systematic review. Tropical Medicine & International Health, 11 (6), 789-799.

Full Text: 2006\Tro Med Int Hea11, 789.pdf

Abstract: OBJECTIVE To compare the efficacies against uncomplicated falciparum malaria of chloroquine (CQ), amodiaquine (AQ), sulfadoxine-pyrimethamine (SP) and combinations of these inexpensive drugs. METHODS We searched MEDLINE, EMBASE, Cochrane CENTRAL Register of Controlled Trials, BIOSIS, Web of Science, African Index Medicus, DARE, Digital Dissertations and Current Controlled Trials for randomised or quasi-randomised controlled trials conducted between 1991 and June 2004 regardless of language and geography. We also contacted malaria experts, searched reference lists, and contacted individual authors for unreported stud), characteristics and additional data. Unpublished data were sought and included in the analyses. RESULTS Thirteen randomised trials (n = 4248) were identified and the summary relative risks of treatment failure at 28 days were calculated. There was marginal benefit in adding CQ to SP, compared with SP monotherapy (RR = 0.74, 95% CI 0.54-1.02). Combining AQ with SP was associated with a significantly lower risk of treatment failure than SP monotherapy (RR = 0.35, 95% CI 0.15-0.82) and AQ monotherapy (RR = 0.59, 95% CI 0.42-0.83). AQ plus SP was associated with a significantly lower risk of treatment failure than CQ plus SP (RR = 0.42, 95% CI 0.25-0.72). Serious adverse events were rare and did not increase with combination therapy. CONCLUSION Amodiaquine plus SP remains an efficacious, affordable and safe option for treating malaria in certain settings.

Keywords: Amodiaquine, Antimalarial-Drugs, Artesunate, Authors, Children, Chloroquine, Cochrane, Combination Therapy, Combination Therapy, Dissertations, Drugs, Efficacy, Malaria, Monotherapy, Plasmodium-Falciparum Malaria, Plus Chloroquine, Randomized Trial, Review, Risk, Science, Sub-Saharan Africa, Sulfadoxine-Pyrimethamine, Systematic, Systematic Review, Therapy, Treatment, Uganda, Web of Science

? Shahmanesh, M., Patel, V., Mabey, D. and Cowan, F. (2008), Effectiveness of interventions for the prevention of HIV and other sexually transmitted infections in female sex workers in resource poor setting: A systematic review. Tropical Medicine & International Health, 13 (5), 659-679.

Full Text: 2008\Tro Med Int Hea13, 659.pdf

Abstract: OBJECTIVE To systematically review the evidence for effectiveness of HIV and sexually transmitted infection (STI) prevention interventions in female sex workers in resource poor settings. METHODS Published and unpublished studies were identified through electronic databases (Cochrane database, MEDLINE, EMBASE, and Web of Science), hand searching and contacting experts. Randomized-controlled-trials and quasi-experimental studies were included if they were conducted in female sex workers from low and middle income settings; if the exposure was described; if the outcome was externally measurable, it was after the discovery of HIV, and if follow-up was longer than 6 months. A priori criteria were used to extract data. Meta-analysis was not performed due to the heterogeneity of studies. RESULTS Twenty-eight interventions were included. Despite methodological limitations, the evidence suggested that combining sexual risk reduction, condom promotion and improved access to STI treatment reduces HIV and STI acquisition in sex workers receiving the intervention. Strong evidence that regular STI screening or periodic treatment of STIs confers additional protection against HIV was lacking. It appears that structural interventions, policy change or empowerment of sex workers, reduce the prevalence of STIs and HIV. CONCLUSION Rigorous evaluation of HIV/STI prevention interventions in sex workers is challenging. There is some evidence for the efficacy of multi-component interventions, and/or structural interventions. The effect of these interventions on the wider population has rarely been evaluated.

Keywords: 100-Percent Condom Program, Bali Std, Aids, Behavioral Intervention, Cochrane, Databases, Effectiveness, Efficacy, Evaluation, Exposure, Female Sex Workers, Follow-up, Hand, HIV, Hiv Prevention, Human-Immunodeficiency-Virus, Income, Infection, Intervention, Interventions, Meta Analysis, Meta-Analysis, Mining Community, Northern Thailand, Outcome, Peer Education, Policy, Prevalence, Prevention, Promotion, Prospective Cohort, Randomized Controlled Trials, Randomized Controlled-Trial, Resource Poor Settings, Review, Risk, Risk Reduction, Science, Screening, Sexually Transmitted Infections, Std Services, Systematic, Systematic Review, Treatment, Web of Science

? Chisti, M.J., Tebruegge, M., La Vincente, S., Graham, S.M. and Duke, T. (2009), Pneumonia in severely malnourished children in developing countries - mortality risk, aetiology and validity of WHO clinical signs: A systematic review. Tropical Medicine & International Health, 14 (10), 1173-1189.

Full Text: 2009\Tro Med Int Hea14, 1173.pdf

Abstract: OBJECTIVES To quantify the degree by which moderate and severe degrees of malnutrition increase the mortality risk in pneumonia, to identify potential differences in the aetiology of pneumonia between children with and without severe malnutrition, and to evaluate the validity of WHO-recommended clinical signs (age-specific fast breathing and chest wall indrawing) for the diagnosis of pneumonia in severely malnourished children. METHODS Systematic search of the existing literature using a variety of databases (MEDLINE, EMBASE, the Web of Science, Scopus and CINAHL). RESULTS Mortality risk: Sixteen relevant studies were identified, which universally showed that children with pneumonia and moderate or severe malnutrition are at higher risk of death. for severe malnutrition, reported relative risks ranged from 2.9 to 121.2; odds ratios ranged from 2.5 to 15.1. for moderate malnutrition, relative risks ranged from 1.2 to 36.5. Aetiology: Eleven studies evaluated the aetiology of pneumonia in severely malnourished children. Commonly isolated bacterial pathogens were Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and Haemophilus influenzae. The spectrum and frequency of organisms differed from those reported in children without severe malnutrition. There are very few data on the role of respiratory viruses and tuberculosis. Clinical signs: Four studies investigating the validity of clinical signs showed that WHO-recommended clinical signs were less sensitive as predictors of radiographic pneumonia in severely malnourished children. CONCLUSIONS Pneumonia and malnutrition are two of the biggest killers in childhood. Guidelines for the care of children with pneumonia and malnutrition need to take into account this strong and often lethal association if they are to contribute to the UN Millennium Development Goal 4, aiming for substantial reductions in childhood mortality. Additional data regarding the optimal diagnostic approach to and management of pneumonia and malnutrition are required from regions where death from these two diseases is common.

Keywords: Aetiology, B Conjugate Vaccine, Bacterial Etiology, Chest Indrawing, Childhood Pneumonia, Children, Community-Acquired Pneumonia, Databases, Developing Countries, Diagnosis, Embase, Fast Breathing, Filipino Children, Frequency, Gambian Children, Hospitalized Children, Interobserver Agreement, Literature, Malnutrition, Management, Mortality, Nigerian Children, Pneumonia, Respiratory, Respiratory-Tract Infections, Review, Risk, Science, Scopus, Sensitivity, Signs, Specificity, Systematic, Systematic Review, Tuberculosis, Validity, Web of Science, Who

? Esu, E., Lenhart, A., Smith, L. and Horstick, O. (2010), Effectiveness of peridomestic space spraying with insecticide on dengue transmission; systematic review. Tropical Medicine & International Health, 15 (5), 619-631.

Full Text: 2010\Tro Med Int Hea15, 619.pdf

Abstract: P>Objective To review the evidence on effectiveness of peridomestic space spraying of insecticides in reducing wild Aedes populations and interrupting dengue transmission. Methods Comprehensive literature search of MEDLINE, EMBASE, LILACS, Web of Science, WHOLIS, MedCarib and CENTRAL, and a manual search of reference lists from identified studies. Duplicates were removed and abstracts assessed for selection. All field evaluations of peridomestic space spraying targeting wild adult Aedes vectors in dengue endemic countries were included. Data were extracted, and the methodological quality of the studies was assessed independently by two reviewers. Results Fifteen studies met the inclusion criteria. Outcome measures were heterogeneous, foregoing the possibility of meta-analysis. Thirteen studies showed reductions in immature entomological indices that were not sustained for long periods. The remainder showed space spray interventions to be ineffective at reducing adult and/or immature entomological indices. Only one study measured human disease indicators, but its outcomes could not be directly attributed to space sprays alone. Conclusion Although peridomestic space spraying is commonly applied by national dengue control programmes, there are very few studies evaluating the effectiveness of this intervention. There is no clear evidence for recommending peridomestic space spraying as a single, effective control intervention. Thus, peridomestic space spraying is more likely best applied as part of an integrated vector management strategy. The effectiveness of this intervention should be measured in terms of impact on both adult and immature mosquito populations, as well as on disease transmission.

Keywords: Adult, Aedes, Aedes-Aegypti Diptera, Control, Culicidae, Dengue, Disease, Effectiveness, Efficacy, Embase, Emergency Control, Ground Aerosols, Human, Human Blood, Impact, Insecticides, Intervention, Interventions, Literature, Malathion, Management, MEDLINE, Meta Analysis, Meta-Analysis, Methods, Outcomes, Review, Science, Strategy, Systematic, Systematic Review, Thermal Fog, Ultra-Low-Volume, Vector, Vector Control, Web of Science

? González-Block, M.A., Vargas-Riaño, E.M., Sonela, N., Idrovo, A.J., Ouwe-Missi-Oukem-Boyer, O. and Monot, J.J. (2011), Research capacity for institutional collaboration in implementation research on diseases of poverty. Tropical Medicine & International Health, 16 (10), 1285-1290.

Full Text: 2011\Tro Med Int Hea16, 1285.pdf

Abstract: OBJECTIVE To assess the capacity for research collaboration and implementation research in strengthening networks and institutions in developing countries. METHODS Bibliometric analysis of implementation research on diseases of poverty in developing countries from 2005 to 2010 through systematically searching bibliographic databases. Methods identified publication trends, participating institutions and countries and the cohesion and centrality of networks across diverse thematic clusters. RESULTS Implementation research in this field showed a steadily growing trend of networking, although networks are loose and a few institutions show a high degree of centrality. The thematic clusters with greatest cohesion were for tuberculosis and malaria. CONCLUSIONS the capacity to produce implementation research on diseases of poverty is still low, with the prominence of institutions from developed countries. Wide ranges of collaboration and capacity strengthening strategies have been identified which should be put into effect through increased investments.

Keywords: Analysis, Bibliographic, Bibliographic Databases, Bibliometric, Bibliometric Analysis, Bibliometrics, Capacity, Centrality, Collaboration, Databases, Developing Countries, Health, Health Systems, Implementation, Implementation Research, Malaria, Methods, Networks, Poverty, Publication, Publication Trends, Research, Research Capacity, Research Collaboration, Systems, Trend, Trends, Tuberculosis

? Santa-Ana-Tellez, Y., DeMaria, L.M. and Galarraga, O. (2011), Costs of interventions for AIDS orphans and vulnerable children. Tropical Medicine & International Health, 16 (11), 1417-1426.

Full Text: 2011\Tro Med Int Hea16, 1417.pdf

Abstract: OBJECTIVE To review the published and grey literature for information regarding the costs and cost-effectiveness of interventions aimed at improving the welfare of orphans and vulnerable children owing to HIV/AIDS in low- and middle-income countries. METHOD We carried out a search of the peer-reviewed literature through PubMed, EconLit, and Web of Science for the period January 2000 to December 2010. We also extensively reviewed the grey literature through generalized web searches and consultations with experts and searches of the web pages of the main organizations active in providing services to orphans and vulnerable children (OVC). The search yielded 216 articles; cross-sectional or longitudinal studies and articles that did not address specific interventions were not considered. The remaining 21 articles were categorized by domain and by type of intervention strategy. RESULTS All studies reviewed were carried out in sub-Saharan Africa. All outcomes are expressed as cost per child per year (in 2010 USD). Foster care estimates range from $614 to $1921. Educational support for primary school ranged from $30 to $75. Health interventions that would ensure child survival can be delivered for about $55. CONCLUSION More research is needed to improve planning and delivery of interventions for OVC. The paucity of cost and cost-effectiveness data reflects the limited number of effectiveness studies. Nevertheless, this systematic literature review shows evidence that suggests that in the area of housing, foster care appears to be more cost effective than institutional care (orphanages).

Keywords: Africa, AID, AIDS, Care, Child, Children, Cost-Effectiveness, Costs, Effectiveness, Health, HIV, AIDS, Information, Intervention, Interventions, Literature, Literature Review, Longitudinal Studies, Low- and Middle-Income Countries, Orphan and Vulnerable Children, Outcomes, Primary, Primary School, Pubmed, Research, Review, Science, Strategy, Sub-Saharan Africa, Survival, Systematic, Systematic Literature Review, Web of Science

? Gichuhi, S., Sagoo, M.S., Weiss, H.A. and Burton, M.J. (2013), Epidemiology of ocular surface squamous neoplasia in Africa. Tropical Medicine & International Health, 18 (12), 1424-1443.

Full Text: 2013\Tro Med Int Hea18, 1424.pdf

Abstract: ObjectivesTo describe the epidemiology and an aetiological model of ocular surface squamous neoplasia (OSSN) in Africa. MethodsSystematic and non-systematic review methods were used. Incidence was obtained from the International Agency for Research on Cancer. We searched PubMed, EMBASE, Web of Science and the reference lists of articles retrieved. Meta-analyses were conducted using a fixed-effects model for HIV and cigarette smoking and random effects for human papilloma virus (HPV). ResultsThe incidence of OSSN is highest in the Southern Hemisphere (16 degrees South), with the highest age-standardised rate (ASR) reported from Zimbabwe (3.4 and 3.0 cases/year/100000 population for males and females, respectively). The mean ASR worldwide is 0.18 and 0.08 cases/year/100000 among males and females, respectively. The risk increases with exposure to direct daylight (2-4h, OR=1.7, 95% CI: 1.2-2.4 and 5h OR=1.8, 95% CI: 1.1-3.1) and outdoor occupations (OR=1.7, 95% CI: 1.1-2.6). Meta-analysis also shows a strong association with HIV (6 studies: OR=6.17, 95% CI: 4.83-7.89) and HPV (7 studies: OR=2.64, 95% CI: 1.27-5.49) but not cigarette smoking (2 studies: OR=1.40, 95% CI: 0.94-2.09). The effect of atopy, xeroderma pigmentosa and vitamin A deficiency is unclear. ConclusionsAfrica has the highest incidence of OSSN in the world, where males and females are equally affected, unlike other continents where male disease predominates. African women probably have increased risk due to their higher prevalence of HIV and HPV infections. As the survival of HIV-infected people increases, and given no evidence that anti-retroviral therapy (ART) reduces the risk of OSSN, the incidence of OSSN may increase in coming years.

Keywords: Africa, African Women, Agency, Anti-Retroviral Therapy, Antiretroviral Therapy, Art, Association, Atopy, Cancer, Cell Carcinoma, Conjunctival Intraepithelial Dysplasia, Conjunctival Intraepithelial Neoplasia, Conjunctival Intraepithelial Neoplasia, Conjunctival Squamous Cell Carcinoma, Disease, Effects, Embase, Environmental, Epidemiology, Evidence, Exposure, Fixed Effects Model, Health, HIV, HPV, Human, Human Papilloma Virus, Human-Papillomavirus Infection, Immunodeficiency-Virus Infection, Incidence, Infections, Int, Kenya, Male, Medicine, Meta-Analysis, Methods, Model, Occupational Health, Ocular Surface Epithelial Dysplasia, Ocular Surface Squamous Neoplasia, Orbital Exenteration, Polymerase-Chain-Reaction, Population, Prevalence, Pubmed, Reference, Reference Lists, Research, Review, Risk, Risk Factors, River, Science, Smoking, Surface, Survival, Therapy, Tropical Medicine, Ultraviolet-Radiation, USA, Vitamin, Vitamin A, Vitamin-A, Web of Science, Women, World, Xeroderma-Pigmentosum, Zimbabwe

? Wilkinson, L.S., Skordis-Worrall, J., Ajose, O. and Ford, N. (2015), Self-transfer and mortality amongst adults lost to follow-up in ART programmes in low- and middle-income countries: Systematic review and meta-analysis. Tropical Medicine & International Health, 20 (3), 365-379.



Full Text: 2015\Tro Med Int Hea20, 365.pdf

Abstract: ObjectiveTo ascertain estimates of adult patients, recorded as lost to follow-up (LTFU) within antiretroviral treatment (ART) programmes, who have self-transferred care, died or truly stopped ART in low- and middle-income countries. MethodsPubMed, EMBASE, Web of Science, Science Direct, LILACS, IndMed and AIM databases (2003-2013) and IAS/AIDS conference abstracts (2011-2013) were searched for tracing studies reporting the proportion of traced patients found to have self-transferred, died or stopped ART. These estimates were then combined using random-effects meta-analysis. Risk of bias was assessed through subgroup and sensitivity analyses. ResultsTwenty eight studies were eligible for inclusion, reporting true outcomes for 10806 traced patients attending approximately 258 ART facilities. None were from outside sub-Saharan Africa. Twenty three studies reported 4.5-54.4% traced LTFU patients self-transferring care, providing a pooled estimate of 18.6% (95% CI 15.8-22.0%). A significant positive association was found between rates of self-transfer and LTFU in the ART cohort. The pooled estimates for unreported deaths were 38.8% (95% CI 30.8-46.8%; 27 studies) and 28.6% (95% CI 21.9-36.0%; 20 studies) for patients stopping ART. A significant decrease in unreported deaths from 50.0% (95% CI 41.5-58.4%) to 30.0% (95% CI 21.1-38.9%) was found comparing study periods before and after 31 December 2007. ConclusionsSubstantial unaccounted for transfers and deaths amongst patients LTFU confirms that retention and mortality is underestimated where the true outcomes of LTFU patients are not ascertained. ObjectifVerifier les estimations sur les patients adultes enregistres comme perdus au suivi (PS) dans les programmes de traitement antiretroviral (ART), qui se sont auto-transferes ailleurs pour des soins, sont decedes ou ont reellement cesse l’ART, dans les pays a revenus faibles et intermediaires. MethodesLes sources PubMed, Embase, Web of Science, Science Direct, LILACS, IndMed, AIM databases (2003-2013) et les resumes de conferences IAS/SIDA (2011-2013) ont ete consultees pour retrouver des etudes rapportant sur la proportion de patients retrouves comme s’etant auto-transferes, decedes ou ayant arrete l’ART. Ces estimations ont ensuite ete combinees en utilisant la meta-analyse des effets aleatoires. Le risque de biais a ete evalue par des analyses de sous-groupes et de sensibilite. Resultats28 etudes etaient eligibles pour inclusion, rapportant de veritables resultats sur 10 806 patients retrouves et frequentant environ 258 etablissements ART. Toutes les etudes portaient sur l’Afrique subsaharienne. 23 etudes ont rapporte de 4,5 a 54,4% de patients PS retrouves comme s’etant auto-transferes pour les soins, fournissant ainsi une estimation poolee de 18,6% (IC95%: 15,8 a 22,0%). Une association positive significative a ete trouvee entre les taux d’auto-transferts et les PS dans la cohorte ART. Les estimations poolees pour les deces non declares etait de 38,8% (IC95%: 30,8 a 46,8%; 27 etudes) et 28,6% (IC95%: 21,9 a 36,0%; 20 etudes) pour les patients ayant arrete l’ART. Une diminution significative des deces non declares de 50,0% (IC95%: 41,5 a 58,4%) a 30,0% (IC95%: 21,1 a 38,9%) a ete trouvee en comparant les periodes d’etudes avant et apres le 31/12/2007. ConclusionsUn nombre manquant important de transferts et de deces parmi les PS confirme que la retention et la mortalite sont sous-estimees la oU les vrais resultats des PS ne sont pas verifies. ObjetivoCalcular para paises con ingresos bajos y medios, el numero de pacientes adultos, registrados como perdidos durante el seguimiento (PDS) dentro de los programas de terapia antirretroviral (TAR), que se han autotransferido a otro centro, han muerto o realmente han abandonado el TAR. MetodosSe realizaron busquedas en bases de datos de PubMed, EMBASE, Web of Science, Science Direct, LILACS, IndMed y AIM (2003-2013) y de resumenes de conferencias IAS/AIDS (2011-2013), con el fin de encontrar estudios en los que se reportara la proporcion de pacientes que se habian autotransferido, habian o habian abandonado el TAR. Estos calculos se combinaron mediante un meta-analisis de efectos aleatorios. El riesgo de sesgo se evaluo mediante analisis de subgrupos y de sensibilidad. Resultados28 estudios eran elegibles para ser incluidos, y reportaban resultados reales para 10,806 pacientes rastreados, atendidos en aproximadamente 258 centros de TAR. Ninguno estaba fuera de africa subsahariana. 23 estudios reportaban haber rastreado entre 4.5-54.4% pacientes perdidos durante el seguimiento como autotransferidos, con una estimacion agrupada del 18.6% (IC 95% 15.8-22.0%). Se observo una asociacion significativamente positiva entre las tasas de autotransferencia y perdida durante el seguimiento en la cohorte de TAR. La estimacion agrupada para muertes sin reportar era del 38.8% (IC 95% 30.8-46.8%; 27 estudios) y 28.6% (IC 95% 21.9-36.0%; 20 estudios) para pacientes que abandonaban el TAR. Se observo una disminucion significativa en las muertes sin reportar del 50.0% (IC 95% 41.5-58.4%) al 30.0% (IC 95% 21.1-38.9%) al comparar periodos de estudio antes y despues del 31/12/2007. ConclusionesUn numero sustancial de transferencias y muertes, no tenidas en cuenta, de pacientes perdidos durante el seguimiento, confirma que se subestiman la retencion y la mortalidad al determinar los resultados reales de los pacientes perdidos durante el seguimiento.

Keywords: Abstracts, Adult, Adults, Africa, Analyse Systematique, Analyses, Antiretroviral, Antiretroviral Therapy, Antiretroviral Treatment Program, Art, Association, Bias, Care, Cohort, Conferences, Continuidad De Cuidados, Continuite Des Soins, Continuity Of Care, Databases, El, Embase, Estimates, Facilities, Follow-Up, From, Global, Hiv Programs, Human Immunodeficiency Virus, Lost To Follow-Up, Low- And Middle-Income Countries, Mar, Meta Analysis, Meta-Analysis, Metaanalysis, Mortalidad, Mortalite, Mortality, Outcomes, Patient Retention, Patients, Pd, Perdida Durante El Seguimiento, Perdu Au Suivi, Prisma Statement, Programmes, Pubmed, Rates, Reporting, Retention, Review, Revision Sistematica, Risk, Risk Of Bias, Risk-Factors, Rural South-Africa, Scale-Up, Science, Sensitivity, Sources, South Africa, Sub-Saharan Africa, Systematic, Systematic Review, Terapia Antirretroviral, Therapie Antiretrovirale, Therapy, Treatment, True Outcomes, Vih, Web, Web Of Science




Download 1.67 Mb.

Share with your friends:
1   ...   33   34   35   36   37   38   39   40   ...   101




The database is protected by copyright ©ininet.org 2024
send message

    Main page