Personal Research Database Bibliometric

Title: Tumor Biology

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? Liu, C.B. and Liu, L. (2011), Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: A meta-analysis. Tumor Biology, 32 (6), 1233-1240.

Full Text: 2011\Tum Bio32, 1233.pdf

Abstract: Common genetic variations in the leptin (LEP), leptin receptor (LEPR), and paraoxonase 1 (PON1) genes have been considered to be implicated in the development of breast cancer. However, the results were inconsistent. In this study, a meta-analysis was performed to assess the associations of five polymorphisms, including LEP G2548A, LEPR Q223R, LEPR Lys109Arg, PON1 L55M, and PON1 Q192R polymorphisms, with breast cancer risk. Published literature from PubMed, ISI Web of Science, Embase databases, CNKI, and Wanfang Data were retrieved. All studies evaluating the association between LEP G2548A, LEPR Q223R, LEPR Lys109Arg, PON1 L55M, or PON1 Q192R polymorphism and breast cancer risk were included. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effects model. Three studies (2,003 cases and 1,967 controls) for LEP G2548A polymorphism, nine studies (4,627 cases and 5,476 controls) for LEPR Q223R polymorphism, five studies (2,759 cases and 2,573 controls) for LEPR Lys109Arg polymorphism, four studies (1,517 cases and 1,379 controls) for PON1 L55M polymorphism, and five studies (1,575 cases and 2,283 controls) for PON1 Q192R polymorphism were included in the meta-analysis. Overall, the results showed null significant association between LEP G2548A, LEPR Q223R, LEPR Lys109Arg, or PON1 Q192R polymorphism and breast cancer risk; however, PON1 L55M was significantly associated with breast cancer risk overall (MM vs. LL: OR=2.16; 95% CI, 1.76-2.66). For LEPR Q223R polymorphism, further subgroup analysis suggested that the association was only statistically significant in East Asians (OR=0.50; 95% CI, 0.36-0.70) but not in Caucasians (OR=1.06; 95% CI, 0.77-1.45) or Africans (OR=1.30; 95% CI, 0.83-2.03). The present meta-analysis suggested that LEPR Q223R polymorphism might be implicated in the development of breast cancer in East Asians; PON1 L55M might increase breast cancer risk. However, given the limited sample size, the findings warrant further investigation.

Keywords: Adiponectin, Analysis, Association, Breast Cancer, Cancer, Databases, Development, Disease, Genes, Genetic, ISI, ISI Web of Science, Leptin, Leptin Receptor, Literature, Meta Analysis, Meta-Analysis, Model, Paraoxonase, Paraoxonase 1, Polymorphism, Polymorphisms, Pubmed, Ratio, Receptor Gene, Risk, Science, Serum Leptin, Web of Science, Weight, Women

? Dong, X.F., Qiu, X.C., Liu, Q. and Jia, J. (2013), Bibliometric analysis of nanotechnology applied in oncology from 2002 to 2011. Tumor Biology, 34 (6), 3273-3278.

Full Text: 2013\Tum Bio34, 3273.pdf

Abstract: Innovation in the last decade has endowed nanotechnology with an assortment of tools for drug delivery system, imaging, and sensing in cancer research. These rapidly emerging tools are indicative of a burgeoning field ready to expand into medical applications. The aim of this study is to analyze the applications of nanotechnology in oncology with bibliometric methods and evaluate development in this field. Literature search was performed using PubMed search engines with MeSH terms (all)-nanotechnology, nanomedicine, nanoparticle, nanocapsules, micellar systems, and oncology or cancer or neoplasms. Within 2,543 articles from 2002 to 2011 in over 50 medical magazines from over 30 countries, we did a series analysis on these articles’ countries, keywords, and authors. Our results show that articles in nanotechnology in oncology are increasing year by year, especially in recent years. Quantity and quality of the articles are becoming more and influential. In the global research, the USA is leading in this field, accounting for half above of the whole articles, followed by countries like Japan, Germany, and France and also some emerging nations like China, in the second place, and India. Subjects like nanoparticles, tumor marker, and drug delivery are the common research focus. So, with more and more scientists’ interests and attention drawn to this field, it is likely to make major breakthroughs in the coming years.

Keywords: Analysis, Attention, Authors, Bibliometric, Bibliometric Analysis, Bibliometric Methods, Brain, Cancer, Cells, China, Cytotoxicity, Delivery, Delivery System, Development, Drug, Drug Delivery, Drug Delivery System, Drug-Delivery, Field, France, Gene Delivery, Germany, Global, Imaging, India, Innovation, Japan, Life, Literature, Magazines, Medical, Methods, Mice, Nanocapsules, Nanomedicine, Nanoparticle, Nanoparticles, Nanotechnology, Nations, Neoplasms, Netherlands, Oncology, Pubmed, Quality, Quality Of, Quantity, R, Recent, Research, Review, Scientists, Solid Lipid Nanoparticles, Systems, Tumor, Usa, Van

? Xia, P., Wang, J.J., Zhao, B.B. and Song, C.L. (2013), The role of beclin-1 expression in patients with gastric cancer: A meta-analysis. Tumor Biology, 34 (6), 3303-3307.

Full Text: 2013\Tum Bio34, 3303.pdf

Abstract: Beclin-1 has been identified as a reliable biomarker in monitoring the prognosis for tumors. We carried out a meta-analysis focusing on the relationship between beclin-1 and the clinical characteristics of patients with gastric cancer. We identified articles in MEDLINE, PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases by using the following strategy: (“beclin 1” or “beclin-1” or “ATG6”) and (“gastric cancer” or “stomach cancer”). We conducted a final analysis of 1,254 patients from seven studies. The pooled odds ratio (OR) indicated a significant association between beclin-1 expression and the differentiation of gastric cancer (pooled OR = 0.23; 95 % confidence interval (CI) = 0.07-0.73) or tumor-node-metastasis staging of gastric cancer (pooled OR = 0.62; 95 % CI = 0.48-0.79). Beclin-1 expression was different in intestinal- and diffuse-type gastric cancer (pooled OR = 0.55; 95 % CI = 0.39-0.77). No association between beclin-1 and tumor size (pooled OR = 0.73; 95 % CI = 0.45-1.17) or lymph node metastasis (pooled OR = 0.59; 95 % CI = 0.17-1.99) was observed.

Keywords: Adenocarcinomas, Analysis, Article, Association, Autophagy, Beclin-1, Biomarker, Cancer, Carcinoma, Characteristics, China, Chinese, Clinical, Confidence, Databases, Differentiation, Esophageal, Expression, Gastric, Gastric Cancer, Gene Beclin-1, Interval, ISI, ISI Web of Science, Knowledge, Medline, Meta Analysis, Meta-Analysis, Metaanalysis, Metastasis, Monitoring, Netherlands, Odds Ratio, Oncology, P, Patients, Poor-Prognosis, Prognosis, Protein, Pubmed, R, Role, Science, Size, Strategy, Tnm Staging, Tumor, Van, Web of Science

? Xu, H., Li, S., Qiu, J.Q., Gao, X.L., Zhang, P. and Yang, Y.X. (2013), The VDR gene FokI polymorphism and ovarian cancer risk. Tumor Biology, 34 (6), 3309-3316.

Full Text: 2013\Tum Bio34, 3309.pdf

Abstract: the polymorphism of vitamin D receptor (VDR) gene is demonstrated to affect the activity of its encoding protein and the subsequent downstream effects mediated by vitamin D. Mutations in VDR gene FokI have been suggested in the development of various cancers. Whether the polymorphism of the VDR gene FokI confers risk to ovarian cancer still remains controversial across the published studies in different ethnicity. The aim of this meta-analysis was to determine the role of VDR gene FokI variant in the susceptibility to ovarian cancer. Six publications with 14 individual case-control studies involving a total of 10,964 subjects were finally included into our study after a comprehensive literature search of the PubMed, Embase, Web of Science, and Wanfang databases. The strength of the association between the VDR gene FokI polymorphism and ovarian cancer risk was estimated under the allelic (T vs. C), homozygous (TT vs. CC), additive (CT vs. CC), recessive (TT vs. CC + CT), and dominant (CT + TT vs. CC) gene models. The overall odds ratios (ORs) for the contrast models of T vs. C, TT vs. CC, CT vs. CC, and CT + TT vs. CC indicated that the VDR gene FokI variant was related to an increased risk of ovarian cancer (ORT vs. C = 1.09, 95 % confidence interval (CI) 1.03-1.15, P (OR) = 0.004; ORTT vs. CC = 1.17, 95 % CI 1.04-1.32, P (OR) = 0.011; ORCT vs. CC = 1.10, 95 % CI 1.01-1.20, P (OR) = 0.027; ORCT + TT vs. CC = 1.12, 95 % CI 1.03-1.21, P (OR) = 0.007). The stratified analysis among the Caucasians also identified a significant association between the VDR gene FokI polymorphism and the susceptibility to ovarian cancer. The present meta-analysis with large available published data has revealed that the VDR gene FokI polymorphism confers susceptibility to ovarian cancer, particularly among the Caucasian population.

Keywords: Activity, Analysis, Article, Association, Cancer, Case-Control, Case-Control Studies, Caucasian, China, Confidence, Consortium, Ct, Data, Databases, Development, Disease, Effects, Epidemiology, Ethnicity, Foki, Gene, Interval, Literature, Literature Search, Meta Analysis, Meta-Analysis, Metaanalysis, Models, Netherlands, Oncology, Ovarian Cancer, P, Pathogenesis, Polymorphism, Population, Prevention, Promoter, Protein, Publications, Pubmed, R, Risk, Role, Science, Strength, Susceptibility, Tumor, Van, Variants, Vitamin, Vitamin D, Vitamin D Receptor, Vitamin-D-Receptor, Web of Science

? Xu, C., Yuan, L.T., Tian, H.L., Cao, H.L. and Chen, S.W. (2013), Association of the MTHFR C677T polymorphism with primary brain tumor risk. Tumor Biology, 34 (6), 3457-3464.

Full Text: 2013\Tum Bio34, 3457.pdf

Abstract: Methylenetetrahydrofolate reductase (MTHFR) gene plays key roles not only in folate metabolism but also in carcinogenesis. The single nucleotide polymorphism MTHFR C677T has been indicated in the development of various tumors. The effect of the MTHFR C677T polymorphism on brain tumors remains poorly understood. We performed the present meta-analysis and aimed to provide a better understanding of the pathogenesis of brain tumors. A literature search of the PubMed, Embase, Web of Science, and Wanfang databases was carried out for potential relevant publications. We calculated the pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) to assess the association of MTHFR C677T with the susceptibility to brain tumors. We also performed stratified analysis and sensitivity analysis to further estimate the genetic association. All statistical analyses were conducted by the use of STATA 11.0 (STATA Corporation, College Station, TX, USA). Eight case-control studies involving a total of 3,059 cases and 3,324 controls were retrieved according to the inclusion criteria. The overall ORs suggested that the MTHFR C677T variant can exert a risk effect on brain tumor development under the following contrast models (ORTC vs. CC = 1.14, 95 % CI 1.02-1.27, P (OR) = 0.018; ORTT + TC vs. CC = 1.23, 95 % CI 1.01-1.51, P (OR) = 0.043). No significant correlation was identified among the Caucasians, but not among the Asians. In addition, the TC genotype carriers were more susceptible to meningioma when compared with the CC genotype carriers (ORTC vs. CC = 1.38, 95 % CI 1.15-1.65, P (OR) < 0.001). The MTHFR C677T polymorphism seemed to exert no effect on glioma risk. The current meta-analysis firstly provides evidence that the MTHFR C677T polymorphism may modify the risk for brain tumors, particularly meningioma. The role of the MTHFR C677T variant in brain tumor pathogenesis across diverse ethnicities needs further elucidation by more future studies with large sample size.

Keywords: Analyses, Analysis, Article, Association, Brain, Brain Tumor, Brain Tumors, Cancer Risk, Case-Control, Case-Control Studies, China, Confidence, Correlation, Criteria, Databases, Development, Evidence, Folate Metabolism, Gene, Gene Polymorphism, Genetic, Glioblastoma-Multiforme, Glioma, Glioma, Graphical Test, Interval, Literature, Literature Search, Meningioma, Meningioma, Meta Analysis, Meta-Analysis, Metaanalysis, Metabolism, Methylenetetrahydrofolate Reductase, Methylenetetrahydrofolate Reductase Mthfr, Models, Mthfr C677t, Needs, Netherlands, Odds Ratio, Oncology, P, Pathogenesis, Polymorphism, Potential, Primary, Publications, Pubmed, R, Risk, Role, Sample Size, Science, Sensitivity, Sensitivity Analysis, Shanghai, Size, Statistical Analyses, Susceptibility, Tumor, Understanding, Usa, Van, Web of Science

? Wang, D., Velez de-la-Paz, O., Zhai, J.X. and Liu, D.W. (2013), Serum 25-hydroxyvitamin D and breast cancer risk: A meta-analysis of prospective studies. Tumor Biology, 34 (6), 3509-3517.

Full Text: 2013\Tum Bio34, 3509.pdf

Abstract: There were some case-control studies, nested case-control studies, and cohort studies with controversial results on the association between serum 25-hydroxyvitamin D [25(OH)D] and breast cancer risk. Case-control studies are prone to selection bias, which limit the strength and quality of the evidence. To overcome the shortcoming of the case-control studies, the meta-analysis of prospective studies including nested case-control studies and cohort studies was conducted. PubMed, Embase, and Web of Science databases were searched, and the last retrieval date was March 24, 2013. For the highest versus the lowest level of serum 25(OH)D, the relative risks (RRs) and its 95 % confidence intervals (CIs) from each study were used to estimate summary RR and its 95 % CI. Subgroup analyses by geographic region, menopausal status, and adjusted status of RR were also performed, respectively. A dose-response association between serum 25(OH)D concentration and breast cancer risk was assessed. Fourteen articles with 9,110 breast cancer cases and 16,244 controls were included in the meta-analysis. Overall, serum 25(OH)D levels were inversely significantly associated with breast cancer risk (RR = 0.845, 95 % CI = 0.750-0.951). Inversely statistically significant associations were observed in North American studies, postmenopausal women, and studies with adjusted and unadjusted RR, respectively. No statistically significant associations were observed in European studies and premenopausal women, respectively. Dose-response analysis showed that every 10 ng/mL increment in serum 25(OH)D concentration was associated with a significant 3.2 % reduction in breast cancer risk. This meta-analysis provides evidence of a significantly inverse association between serum 25(OH)D concentration and breast cancer risk.

Keywords: 25-Hydroxyvitamin D, Analyses, Analysis, Article, Association, Bias, Breast Cancer, Breast Cancer Risk, Calcium, Cancer, Case-Control, Case-Control Studies, China, Cohort, Concentration, Confidence, Confidence Intervals, Databases, Disease, Evidence, Health, Intervals, Meta Analysis, Meta-Analysis, Metaanalysis, Nested, Netherlands, North, Oncology, Postmenopausal, Postmenopausal Women, Prevention, Prospective, Prospective Studies, Pubmed, Quality, Quality Of, R, Reduction, Region, Risk, Risks, Science, Selection, Serum, Strength, Tumor, Van, Vitamin D, Vitamin-D, Web of Science, Web of Science Databases, Women

? Niu, Y.H., Huang, T.R., Lian, F. and Li, F.H. (2013), Contrast-enhanced ultrasonography for the diagnosis of small hepatocellular carcinoma: A meta-analysis and meta-regression analysis. Tumor Biology, 34 (6), 3667-3674.

Full Text: 2013\Tum Bio34, 3667.pdf

Abstract: the aim of this study is to determine the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) for diagnosis of small (a parts per thousand currency sign2 cm in diameter) hepatocellular carcinoma (HCC) through a meta-analysis of published studies. A comprehensive literature search of PubMed, Embase, Web of Science, and China BioMedicine databases was conducted on articles published before 1 March 2013. Data from selected studies were pooled to yield summary sensitivity, specificity, positive and negative likelihood ratio (LR), diagnostic odds ratio (DOR), and receiver operating characteristic (SROC) curve. Statistical analyses were performed using Meta-Disc version 1.4 and STATA version 12.0 softwares. Fifteen studies were included with a total of 908 cirrhotic patients with 1,032 small hepatic nodules. All lesions were histologically confirmed through liver biopsies after CEUS. The pooled sensitivity was 0.81 (95 % CI = 0.78-0.85); the pooled specificity was 0.86 (95 % CI = 0.82-0.89). The pooled positive LR was 5.90 (95 % CI = 3.90-8.94); the pooled negative LR was 0.20 (95 % CI = 0.14-0.29). The pooled DOR was 37.07 (95 % CI = 24.79-55.44). The area under the SROC curve was 0.93 (SE = 0.01). Meta-regression analysis showed that the number of lesions may be a major source of heterogeneity. No publication bias was detected in this meta-analysis. This meta-analysis indicates that CEUS is a useful diagnostic tool with high sensitivity and specificity for identifying small HCC.

Keywords: Accuracy, Analyses, Analysis, Article, Bias, China, Cirrhosis, Clinical-Practice Recommendations, Computed-Tomography, Contrast-Enhanced Ultrasonography, Databases, Diagnosis, Diagnostic Accuracy, Epidemiology, Focal Liver-Lesions, Guidelines, Hepatocellular Carcinoma, Heterogeneity, Less-Than-Or-Equal-To-2 Cm, Likelihood Ratio, Literature, Literature Search, Liver, Meta Analysis, Meta-Analysis, Meta-Regression, Metaanalysis, Netherlands, Odds Ratio, Oncology, Patients, Publication, Publication Bias, Pubmed, R, Risk-Factors, Science, Se, Sensitivity, Shanghai, Small, Small Hepatic Nodules, Source, Specificity, Tumor, Ultrasonography, Ultrasound, Ultrasound Ceus, Update 2012, Van, Version, Web of Science

? Pei, J., Li, F. and Wang, B.Z. (2013), Single nucleotide polymorphism 6q25.1 rs2046210 and increased risk of breast cancer. Tumor Biology, 34 (6), 4073-4079.

Full Text: 2013\Tum Bio34, 4073.pdf

Abstract: the onset and development of breast cancer (BC) are influenced by many factors, including the single nucleotide polymorphism (SNP) rs2046210 at 6q25.1. However, studies of the potential association between rs2046210 at 6q25.1 and risk of BC have given inconsistent results. We performed a meta-analysis to address this controversy. PubMed, EMBASE, and Web of Science were systematically searched to identify relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to assess the strength of the association between this SNP and risk of BC. A total of 14 studies are included in the meta-analysis, involving 123,085 cases and 120,761 controls. The A-allele, AA/GA, and AA genotypes were significantly associated with increased risk of BC (A-allele vs. G-allele: OR = 1.20, 95%CI = 1.15-1.25, P for heterogeneity < 0.0001; AA/GA vs. GG: OR = 1.22, 95%CI = 1.16-1.28, P for heterogeneity < 0.0001; AA vs. GA/GG: OR = 1.18, 95%CI = 1.13-1.24, P for heterogeneity = 0.064). In further stratified analysis by ethnicity, the elevated risks were found in Europeans and Asians, while there was no significant association detected in African population. In the subgroup analysis based on sample size and source of control, significant results were observed in all the subgroups. There was evidence of heterogeneity (P < 0.10), which largely disappeared after stratification by ethnicity. In summary, this meta-analysis suggests the participation of rs2046210 at 6q25.1 in the susceptibility for BC, especially in Europeans and Asians.

Keywords: 6q25.1, Alleles, Analysis, Article, Association, Bc, Brca2 Mutation Carriers, Breast Cancer, Cancer, China, Common Genetic-Variants, Confer Susceptibility, Confidence, Confidence Intervals, Control, Development, Disease, Embase, Estrogen-Receptor, Ethnicity, Evidence, Genome-Wide Association, Heterogeneity, Intervals, Meta Analysis, Meta-Analysis, Metaanalysis, Netherlands, Oncology, Onset, P, Participation, Polymorphism, Population, Postmenopausal Women, Potential, Pubmed, R, Risk, Risks, Rs2046210, Sample Size, Science, Single Nucleotide Polymorphism, Size, Snp, Source, Stratification, Strength, Susceptibility Loci, Tumor, Van, Variant and Breast Cancer (Bc), Web of Science

? Cai, Q.L., Wu, T., Zhang, W., Guo, X.M., Shang, Z.Q., Jiang, N., Tian, J. and Niu, Y.J. (2013), Genetic polymorphisms in glutathione S-transferases P1 (GSTP1) Ile105Val and prostate cancer risk: A systematic review and meta-analysis. Tumor Biology, 34 (6), 3913-3922.

Full Text: 2013\Tum Bio34, 3913.pdf

Abstract: Numerous epidemiological studies have evaluated the association between the glutathione S-transferases P1 (GSTP1) Ile105Val polymorphisms and prostate cancer (PCa) risk. However, these studies have yielded conflicting results. A comprehensive search was conducted through researching MEDLINE, PubMed, Web of Science, and EMBASE, and a total of 13 studies including 3,227 cases and 3,945 controls were identified. A meta-analysis was performed to obtain a summary of estimated odds ratios (ORs) and 95 % confidence intervals (CIs) of GSTP1 polymorphisms for PCa, with attention to study quality and publication bias. The GSTP1 Ile158Val variant genotypes are less associated with increased risk of PCa for the homozygote model (Val/Val vs Ile/Ile: OR = 1.42; I (2) = 63.7 %; 95 % CI = 1.02-1.97) and the recessive model (OR = 1.41; I (2) = 45.5 %; 95 % CI = 1.10-1.80). However, no associations were detected for other genetic models. In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PCa risk were also found among Caucasians for Val/Val vs Ile/Ile comparison (OR = 1.22; I (2) = 0.0 %; 95 % CI = 1.02-1.47) and for the recessive model (OR = 1.26; I (2) = 0.0 %; 95 % CI = 1.06-1.49), while there were no associations found for other genetic models. However, no associations were found in Asians and African-Americans for all genetic models when stratified by ethnicity. In conclusion, our meta-analysis provides evidence that GSTP1 Ile105Val gene polymorphisms contributed to PCa susceptibility.

Keywords: African Americans, African-Americans, Analysis, Article, Association, Attention, Bias, Cancer, China, Comparison, Confidence, Confidence Intervals, Embase, Ethnicity, Evidence, Gene, Genetic, Glutathione, Gstm1, Gstp1 Polymorphism, Gstt1, Hyperplasia, Ile105val, Intervals, M1, Medline, Meta Analysis, Meta-Analysis, Metaanalysis, Model, Models, Molecular Epidemiology, Netherlands, North Indian Population, Oxidative Stress, PCA, Polymorphism, Polymorphisms, Prostate Cancer, Publication, Publication Bias, Pubmed, Quality, R, Review, Risk, Science, Susceptibility, Systematic Review, T1, Tumor, Van, Variants, Web of Science

? Wang, H., Wang, W.J., Yang, D.J. and Wang, S.M. (2014), TaqI polymorphism of VDR gene contributes to breast cancer risk. Tumor Biology, 35 (1), 93-102.

Full Text: 2014\Tum Bio35, 93.pdf

Abstract: Previous studies on the association of Vitamin D receptor (VDR) TaqI gene polymorphism with breast carcinogenesis have yielded inconsistent and inconclusive findings. The current meta-analysis was performed to provide a more precise assessment on the role of VDR TaqI polymorphism in breast cancer risk. 20 eligible case-control studies involving 9,055 cases and 10,516 controls were identified after a comprehensive literature search of the PubMed, Embase, Web of Science, and Wanfang databases. The pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated. Stratified analyses by ethnicity and study quality were conducted for further estimation. All statistical analyses were conducted by use of STATA (STATA Corporation, College Station, TX, Version 11.0). The overall ORs showed that the variant t allele and tt genotype were related to an increased risk of breast cancer (ORt vs. T = 1.05, 95 % CI 1.01-1.10, P (OR) = 0.025; ORtt vs. TT = 1.12, 95 % CI 1.03-1.23, P (OR) = 0.011; ORtt vs. Tt + TT = 1.10, 95 % CI 1.01-1.20, P (OR) = 0.023). Stratified analyses of studies in Caucasians and with high-quality further confirmed the results. However, no significant relationship was observed among Asians. This meta-analysis suggests that the VDR TaqI polymorphism confers risk effect on the breast cancer development, particularly in Caucasians.

Keywords: Analyses, Assessment, Association, Breast Cancer, Cancer, Case-Control, Case-Control Studies, Confidence, D Hormone, Databases, Development, Ethnicity, Gene, Gene Polymorphism, Genomic Actions, Graphical Test, Interval, Literature, Literature Search, Meta Analysis, Meta-Analysis, Metaanalysis, Odds Ratio, P, Polymorphism, Polymorphisms, Population, Prostate-Cancer, Pubmed, Quality, Recombination Repair Genes, Risk, Role, Science, Statistical Analyses, T, Taqi, Variants, Vitamin D, Vitamin D Receptor, Vitamin-D-Receptor, Web of Science

? Chen, K.J., Fan, F., Wang, Y., Wei, G.T., Hu, L. and Xu, F. (2014), GSTT1 null genotype contributes to hepatocellular carcinoma risk: A meta-analysis. Tumor Biology,