Title: Scandinavian Journal of Rheumatology

Title: Scandinavian Journal of Rheumatology

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? Kristensen, L.E., Jakobsen, A.K., Bartels, E.M., Geborek, P., Bliddal, H., Saxne, T., nneskiold-Samsoe, B. and Christensen, R. (2011), The number needed to treat for second-generation biologics when treating established rheumatoid arthritis: A systematic quantitative review of randomized controlled trials. Scandinavian Journal of Rheumatology, 40 (1), 1-7.

Abstract: Objective: To evaluate the number needed to treat (NNT) and the number needed to harm (NNH) of the second-generation biologics abatacept, certolizumab, golimumab, rituximab, and tocilizumab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX). Methods: A systematic literature search of MEDLINE, EMBASE, Web of Science, and the Cochrane Register of Controlled Trials was conducted up to 1 November 2009. We selected any published randomized, double-blind, MTX-controlled study including RA patients with a mean disease duration of at least 5 years before entering a pivotal trial on second-generation biological therapy. Studies eligible for inclusion involved patients, who had previously shown inadequate response to conventional disease-modifying anti-rheumatic drug (DMARD) therapy. Pre-specified binary outcomes were extracted with a preference for 1-year data (6-month data were used if no data were available for 1 year). Two reviewers independently extracted the data necessary to estimate the absolute measures in a non-responder intention-to-treat OM analysis. Results: Five randomized controlled trials, one for each of the drugs, were selected and data extracted according to published data at endpoint for American College of Rheumatology 50% (ACR50)-responding patients, and withdrawals due to adverse events. NNT ranged from four to six treated patients to achieve one ACR50 response, while withdrawals due to adverse events were few and non-significant compared to the placebo group, except for rituximab administered as 1000 mg. Conclusion: Comparable efficacy was shown by the five biological agents studied, with few adverse events. However, for rituximab, tocilizumab, and golimumab, only 6-month data were available, hampering the external validity with regard to long-term efficacy and tolerability. A low dose (500 mg) of rituximab may be as effective as the recommended dose of 1000 mg.

Keywords: Analysis, Arthritis, Clinical-Practice, Cochrane, Costimulation Modulator Abatacept, Disease, Disease-Activity, Double-Blind, Drug, Drugs, Efficacy, Embase, Inadequate Response, Interleukin-6 Receptor Inhibition, Literature, Medline, Methods, Methotrexate, Modifying Antirheumatic Drugs, Nonresponder, Outcomes, Patients, Phase-III, Quantitative, Randomized Controlled Trials, Review, Science, Systematic, Therapy, Validity, Web of Science

Title: Scandinavian Journal of Social Medicine

Full Journal Title: Scandinavian Journal of Social Medicine

ISO Abbreviated Title: Scand. J. Soc. Med.

JCR Abbreviated Title: Scand J Soc Med

ISSN: 0300-8037

Issues/Year: 4

Journal Country Sweden

Language: English

Publisher: Scandinavian University Press

Publisher Address: PO Box 2959 Toyen, Journal Division Customer Service, N-0608 Oslo, Norway

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Public, Environmental & Occupational Health: Impact Factor 0.632, 65/85

? Hornquist, J.O. and Hansson, B. (1991), Long-term sick-listing, medical rehabilitation and life quality change: A patient-evaluation. Scandinavian Journal of Social Medicine, 19 (2), 99-104.

Full Text: Sca J Soc Med19, 99.pdf

Abstract: This evaluation of the health service at one of the hospitals of the National Insurance Board in Sweden is primarily based on the perspective of the patient. One interview group of 32 patients (I-group) made life quality ratings before-after their hospital stay. In responding to a postal questionnaire one year after discharge from hospital, another group of 93 former patients (Q-group) made parallel self-ratings. Due to prolonged sick-listing, the patients had been admitted to the hospital for rehabilitation/examination according to paragraph 2: 11 in the general insurance law. The basis for their sick-listing was hereby critically reviewed. Within the framework of additional examinations (interview and structured general questions), more than 40% of the respondents stated that the hospital stay was mainly satisfying and a great majority appreciated the nursing care. However, the self-ratings showed that the patients did not ascribe any particularly great significance to the hospital stay. In the short term, it even seemed to have a certain negative impact on the life quality of the patients. No obvious positive bias seems to be built into the ratings. Thus, the assessment package applied may also work well in similar evaluative settings.

Keywords: Evaluation, Quality of Life, Rehabilitation

? Käsmä Ronkainen, L. and Virokannas, H. (1996), Concern about the environment among medical students. Scandinavian Journal of Social Medicine, 24 (2), 121-123.

Full Text: Sca J Soc Med24, 121.pdf

Abstract: The aim of this study was to survey concern about the environment among medical students in Oulu in northern Finland. A questionnaire was filled in by 181 (74%) students. Most of the students were very concerned about the environment. Over half of the students were very concerned about water pollution and destruction of the rain forests. Female gender, membership in any environmental organisations and a good knowledge about the health effects of environmental factors were found to be significant independent factors to increase the concern.

Keywords: Environmental Activity, Environmental Attitudes

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