My N. Helms, Ph.D.
Address: Emory University School of Medicine
Department of Physiology
Center for Cell and Molecular Signaling
615 Michael Street, Suite 650
Atlanta, GA 30322-3110
Phone (Office): (404) 727-3912
Fax: (404) 727- 2648
Emory University School of Medicine, Atlanta, GA
Department of Physiology, Center for Cell and Molecular Signaling
Principal Investigator: Dr. Douglas C. Eaton
Dartmouth Medical School, Lebanon, NH
Department of Molecular, Cellular, and Systems Physiology
Thesis Advisor: Dr. Anikó Náray Fejes-Tóth
Thesis Title: Serum and Glucocorticoid Inducible Kinase 1 (SGK1) is an important determinant of sodium channel activity in the mammalian collecting duct.
University of North Carolina at Chapel Hill, Chapel Hill, NC
University Trademark Scholarship (1993-1997)
Senior Thesis Title: Differentiating between models of recombinant Adeno-Associated Virus (rAAV) integration from one end versus both ends of the genome.
SMALL (RENAL) GROUP InSTRUCTOR, 2006
Emory Medical School- Department of Physiology, Atlanta GA
Externship Supervisor, 2002
Vermont Technical College- Department of Biotechnology, Randolph Center, VT
Biochemistry & Physiology Tutor, 2001-2002
Dartmouth Medical School-Academic Assistance Program, Hanover, NH
Laboratory TECHNICIAN, 1997-1998
Dartmouth Medical School- Department of Physiology, Lebanon, NH
Laboratory Assistant, 1996-1997
UNC Gene Therapy-Virus Vector Core Lab, Chapel Hill, NC
Helms MN, Self J.L., Bao H.F., Job L., Jain L., and Eaton D.C.
Dopamine Activates Amiloride-Sensitive Sodium Channel (ENaC) in Alveolar Type1
Cells examined in situ. Accepted in Am J Physiol Lung Cell Mol Physiol. (April 2006).
Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, Jain L, Dobbs LG, Eaton DC.
Functional ion channels in pulmonary alveolar type I cells support a role for
type I cells in lung ion transport.
Proc Natl Acad Sci U S A. 2006 Mar 20; [Epub ahead of print]
Helms MN, Chen XJ, Ramosevac S, Eaton DC, Jain L.
Dopamine Regulation of Amiloride-Sensitive Sodium Channels in Lung Cells.
Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L710-22. PMID: 16284210
Helms MN, Liu L, Liang YY, Al-Khalili O, Vandewalle A, Saxena S, Eaton DC,
Phosphatidylinositol-3,4,5-trisphosphate (PIP3) mediates aldosterone
stimulation of epithelial sodium channel (ENAC) and interacts with gamma -ENAC. J Biol Chem. 2005 Dec 9;280(49):40885-91. PMID: 16204229
Helms MN, Yu L, Malik B, Kleinhenz DJ, Hart CM, Eaton DC.
Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia. Am J Physiol Cell Physiol. 2005 Sep;289(3):C717-26. PMID: 15843443
Helms MN, Self J.L., Yu L., Guidot D.M., and Eaton, D.C. Chronic ethanol ingestion impairs sodium permeable non-selective cation channels in alveolar type 1 cells. Alcoholism: Clin Exp Res. abstract 2005 (29S).
Helms MN, Fejes-Toth G, Naray-Fejes-Toth A.
Hormone-regulated transepithelial Na+ transport in mammalian CCD cells requires SGK1 expression. Am J Physiol Renal Physiol. 2003 Mar;284(3):F480-7. PMID: 12429555
Naray-Fejes-Toth A, Helms MN, Stokes JB, Fejes-Toth G.
Regulation of sodium transport in mammalian collecting duct cells by
aldosterone-induced kinase, SGK1: structure/function studies.
Mol Cell Endocrinol. 2004 Mar 31;217(1-2):197-202. PMID: 15134818
Manuscripts submitted or in preparation:
Helms MN, Yu L., Bao H.F., and Eaton D.C.
Aldosterone mediated superoxide production regulates epithelial Na+ channel (ENaC) activity in A6 distal nephron cells. Manuscript in preparation.
Yu, L. Helms MN, Eaton, D.C.
Divalent heavy metals regulate epithelial Na channel (ENaC) activity in A6 cells. Manuscript in preparation.
INVITED ORAL PRESENTATIONS:
American Thoracic Society International Conference, San Diego, CA 2006
Dopamine Activates Amiloride-Sensitive Sodium Channels in Alveolar Type 1 Cells in Lung Slice Preparation.
Regulation of Renal Transport by Aldosterone and Vasopressin, Pre-EB Meeting
San Francisco, CA (2006)
Aldosterone regulation of superoxide production regulates epithelial Na channel (ENaC) activity in A6 distal nephron cells.
Telluride Conference on Epithelial Cell Biology and Physiology, Telluride, CO (2005)
Superoxide regulation of epithelial sodium channels.
Research Society on Alcoholism Meeting, Santa Barbara, CA (2005)
Chronic ethanol ingestion impairs sodium permeable non-selective cation channels in alveolar type 1 cells.
Experimental Biology Meeting and International Congress of Physiological Sciences, San Diego, CA (2005) The Role of SGK1 in nitric oxide inhibition of ENaC in Na+ transporting epithelial cells.
International Aldosterone Conference, Philadelphia, CA (2003). SGK1 regulates proliferative gene expression and functions under serum and hormone deprived conditions in aldosterone target cells.
Experimental Biology Meeting, San Diego, CA (2003). Serum and Glucocorticoid-Induced Kinase (SGK-1): A Requisite for Transepithelial Na+ Transport.
New England Endocrinology Conference, Amherst, MA (2002). Hormone regulated transepithelial Na+ transport in mammalian cortical collecting duct cells requires SGK1 expression.
Annual Symposium of Ryan Fellows at Squam Lake, Holderness, NH (2001). SGK (Serum- and Glucocorticoid- Inducible Protein Kinase) Regulates Sodium Current in Mammalian Cortical Collecting Duct Cells.
▪Parker B. Francis Fellowship (2006-2009)
▪Strohbehn Medal for Excellence in Biomedical Research Nominee (2003)
▪American Physiological Society Young Investigator Travel Award; Endocrine and Metabolism Section (2003)
▪Albert J. Ryan Foundation- Fellowship Award (2001-2003)
▪29th New England Endocrinology Conference- Oral Presentation Award (2002)
▪Endocrine Society Travel Grant Award (2002)
MEMBERSHIPS (professional and non-professional):
▪American Physiological Society ▪Atlanta Track Club
▪American Thoracic Society ▪Atlanta High Museum of Art
▪Atlanta Lawn Tennis Association (ALTA)
▪Albert J. Ryan Fellowship for graduate research
Award period: 2001-2003
▪NIH-sponsored T32 Training Grant T32AA013528
Award period: 07/2003-06/2005
▪Parker B. Francis Fellowship in Pulmonary Research:
Award period: 07/2006-06/2009
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