Curriculum vitae my N. Helms, Ph. D. Address
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CURRICULUM VITAE My N. Helms, Ph.D. Address: Emory University School of Medicine Department of Physiology Center for Cell and Molecular Signaling 615 Michael Street, Suite 650 Atlanta, GA 30322-3110
2003-present Emory University School of Medicine, Atlanta, GA Department of Physiology, Center for Cell and Molecular Signaling Principal Investigator: Dr. Douglas C. Eaton
1999-2003 Dartmouth Medical School, Lebanon, NH Department of Molecular, Cellular, and Systems Physiology Thesis Advisor: Dr. Anikó Náray Fejes-Tóth Thesis Title: Serum and Glucocorticoid Inducible Kinase 1 (SGK1) is an important determinant of sodium channel activity in the mammalian collecting duct. Undergraduate 1993-1997 University of North Carolina at Chapel Hill, Chapel Hill, NC B.S. Biology University Trademark Scholarship (1993-1997) Senior Thesis Title: Differentiating between models of recombinant Adeno-Associated Virus (rAAV) integration from one end versus both ends of the genome. WORK EXPERIENCE: SMALL (RENAL) GROUP InSTRUCTOR, 2006 Emory Medical School- Department of Physiology, Atlanta GA Externship Supervisor, 2002 Vermont Technical College- Department of Biotechnology, Randolph Center, VT Biochemistry & Physiology Tutor, 2001-2002 Dartmouth Medical School-Academic Assistance Program, Hanover, NH Laboratory TECHNICIAN, 1997-1998 Dartmouth Medical School- Department of Physiology, Lebanon, NH Laboratory Assistant, 1996-1997 UNC Gene Therapy-Virus Vector Core Lab, Chapel Hill, NC PUBLICATIONS: Helms MN, Self J.L., Bao H.F., Job L., Jain L., and Eaton D.C. Dopamine Activates Amiloride-Sensitive Sodium Channel (ENaC) in Alveolar Type1 Cells examined in situ. Accepted in Am J Physiol Lung Cell Mol Physiol. (April 2006).
Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport.
PMID: 16549766 Helms MN, Chen XJ, Ramosevac S, Eaton DC, Jain L. Dopamine Regulation of Amiloride-Sensitive Sodium Channels in Lung Cells. Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L710-22. PMID: 16284210 Helms MN, Liu L, Liang YY, Al-Khalili O, Vandewalle A, Saxena S, Eaton DC, Ma HP.
Phosphatidylinositol-3,4,5-trisphosphate (PIP3) mediates aldosterone stimulation of epithelial sodium channel (ENAC) and interacts with gamma -ENAC. J Biol Chem. 2005 Dec 9;280(49):40885-91. PMID: 16204229 Helms MN, Yu L, Malik B, Kleinhenz DJ, Hart CM, Eaton DC. Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia. Am J Physiol Cell Physiol. 2005 Sep;289(3):C717-26. PMID: 15843443 Helms MN, Self J.L., Yu L., Guidot D.M., and Eaton, D.C. Chronic ethanol ingestion impairs sodium permeable non-selective cation channels in alveolar type 1 cells. Alcoholism: Clin Exp Res. abstract 2005 (29S). Helms MN, Fejes-Toth G, Naray-Fejes-Toth A. Hormone-regulated transepithelial Na+ transport in mammalian CCD cells requires SGK1 expression. Am J Physiol Renal Physiol. 2003 Mar;284(3):F480-7. PMID: 12429555 Naray-Fejes-Toth A, Helms MN, Stokes JB, Fejes-Toth G. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies.
Aldosterone mediated superoxide production regulates epithelial Na+ channel (ENaC) activity in A6 distal nephron cells. Manuscript in preparation. Yu, L. Helms MN, Eaton, D.C. Divalent heavy metals regulate epithelial Na channel (ENaC) activity in A6 cells. Manuscript in preparation. INVITED ORAL PRESENTATIONS: American Thoracic Society International Conference, San Diego, CA 2006 Dopamine Activates Amiloride-Sensitive Sodium Channels in Alveolar Type 1 Cells in Lung Slice Preparation. Regulation of Renal Transport by Aldosterone and Vasopressin, Pre-EB Meeting San Francisco, CA (2006) Aldosterone regulation of superoxide production regulates epithelial Na channel (ENaC) activity in A6 distal nephron cells. Telluride Conference on Epithelial Cell Biology and Physiology, Telluride, CO (2005) Superoxide regulation of epithelial sodium channels. Research Society on Alcoholism Meeting, Santa Barbara, CA (2005) Chronic ethanol ingestion impairs sodium permeable non-selective cation channels in alveolar type 1 cells. Experimental Biology Meeting and International Congress of Physiological Sciences, San Diego, CA (2005) The Role of SGK1 in nitric oxide inhibition of ENaC in Na+ transporting epithelial cells. International Aldosterone Conference, Philadelphia, CA (2003). SGK1 regulates proliferative gene expression and functions under serum and hormone deprived conditions in aldosterone target cells. Experimental Biology Meeting, San Diego, CA (2003). Serum and Glucocorticoid-Induced Kinase (SGK-1): A Requisite for Transepithelial Na+ Transport. New England Endocrinology Conference, Amherst, MA (2002). Hormone regulated transepithelial Na+ transport in mammalian cortical collecting duct cells requires SGK1 expression. Annual Symposium of Ryan Fellows at Squam Lake, Holderness, NH (2001). SGK (Serum- and Glucocorticoid- Inducible Protein Kinase) Regulates Sodium Current in Mammalian Cortical Collecting Duct Cells. ACADEMIC AWARDS: ▪Parker B. Francis Fellowship (2006-2009) ▪Strohbehn Medal for Excellence in Biomedical Research Nominee (2003) ▪American Physiological Society Young Investigator Travel Award; Endocrine and Metabolism Section (2003) ▪Albert J. Ryan Foundation- Fellowship Award (2001-2003) ▪29th New England Endocrinology Conference- Oral Presentation Award (2002) ▪Endocrine Society Travel Grant Award (2002)
▪American Thoracic Society ▪Atlanta High Museum of Art ▪Atlanta Lawn Tennis Association (ALTA)
Award period: 2001-2003 ▪NIH-sponsored T32 Training Grant T32AA013528 Award period: 07/2003-06/2005 ▪Parker B. Francis Fellowship in Pulmonary Research: Award period: 07/2006-06/2009 Directory: documents documents -> Concept stage documents -> Concept stage documents -> The great global switch-off documents -> Nonprofit grant application documents -> The Truth about the Rwandan Genocide documents -> Annual InStructional unit plan documents -> Chaos equipment included Download 26.73 Kb. Share with your friends:
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