These include cases such as vitamin K deficiency, severe liver diseases ie cirrhosis and disseminated intravascular coagulation associated with infections, obstetric complications such as septic abortion, HDNB, snake envenormation and malignancies. They also include overdose of anticoagulants such as warfarin
Laboratory tests to Investigate Haemostatic mechanism
1). Total blood count/platelet count
Normal range 150-400×109/L
Platelet count is usually reduced in haemostatic disorders.
2). Peripheral blood film (PBF) examination. Characterized by lower platelet distribution and appearance of giant platelets.
1). Bleeding time- It tests for platelets and platelet function. It is performed by either Ivy’s method (range 2-7 minutes) or by Dukes method.
Always prolonged in bleeding disorders.
2). Activated partial thromboplastin time (APTT)
It assesses the integrity of the intrinsic pathway of coagulation cascade.
An INR test measures the time for your blood to clot. It is also known as prothrombin time, or PT. It is used to monitor blood-thinning medicines, which are also known as anticoagulants. The INR, or international normalized ratio, can also be used to check if you have a blood clotting problem.