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Course Code: PHP1305
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Course Title: Pharmaceutical Analysis Laboratory-II
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Credits = 2
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L
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T
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P
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Semester: IV
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Total contact hours: 60
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0
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0
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4
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List of Prerequisite Courses
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Analysis Laboratory –I
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List of Courses where this course will be prerequisite
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Pharmaceutics, Pharmacology, and Pharmacognosy, PharmaceuticalAnalysis-II, PharmaceuticalAnalysis-III
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Description of relevance of this course in the B. Pharm. Program
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To train the students with respect to Spectroscopic method and other physical methods of analysis
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Sr. No.
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Course Contents (Topics and subtopics)
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Reqd. hours
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1
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Atomic absorption spectroscopy (Alkali earth metal determinations), DSC,TGA Demonstration
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4
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2
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NMR, Mass Spectroscopy, GCMS Demonstration
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4
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3
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NMR, Mass Spectroscopy problem solving from recorded spectra
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4
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4
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Absorption spectroscopy (UV, Visible);
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12
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5
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Fluorescence spectroscopy (Quinine salt), Quenching phenomenon.
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8
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6
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Chromatography (PC, CC, TLC) application to reaction monitoring, purity assessment of drugs, separation of the mixtures.
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8
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7
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Medicaments in formulations: Liquid oral, tablet, injectable,aerosol, capsule, ointment, eye drops, suppositories, lozenges, etc. (one each);
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4
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8
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Multi component analysisfordrugsincombination. eg: Using simultaneous equation method, using iso absorption point method, Using solvent extraction method, Using colorimetric and UV methods.
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8
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9
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Refractometry
Calibration of Abbe’s Refractometer, Estimation of refractive index of natural oils and laboratory solvents, determination of the percentageof glycerin in the unknown by calibration curve.
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4
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10
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Polarimetry
Instrument information, Optical rotation of dextrose solution, determination of specific optical rotation of ethambutol,
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4
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List of Text Books/ Reference Books
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Indian Pharmacopoeia
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United States pharmacopoeia
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British pharmacopoeia
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Course Outcomes (students will be able to…..)
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1
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Prepare sample for analysis form bulk
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2
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Decide proper mobile phase and separate / resolve the mixture of compounds
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3
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Analyse the drugs in single and multicomponent formulations using various techniques such as UV, IR, NMR, Mass
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4
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Apply the techniques like Refractometry and Polarimetry to known and unknown pharmaceutical samples
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5
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Apply all above the concept to an unknown sample
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Course Code:IPP1102
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Course Title: Computer Laboratory
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Credits = 2
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L
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T
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P
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Semester: IV
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Total contact hours: 60
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0
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0
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4
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List of Prerequisite Courses
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Nil
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List of Courses where this course will be prerequisite
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Nil
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Description of relevance of this course in the B. Pharmacy
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To train the students with respect to use of computer and various applied softawares related to pharmaceutical sciences and technology
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Sr. No.
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Course Contents (Topics and subtopics)
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Reqd. hours
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1
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MS office Excel: Statistical analysis and data treatment
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8
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2
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Graph pad prism, statistica: Statistical analysis and data treatment
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10
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3
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MS office Power point: Basics and advances
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8
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4
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Basics of Matlab, Chemsketch, Chemdraw
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10
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5
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Basics AOT, Epidog, X-pharmacology, QSPR, Kinetica
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10
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6
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Introduction to softwares used for scientific referencing
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4
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8
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C/C++ programming: Basics, arrays, loops, if-else, switch case, functions, pointers, classes; Solving set of linear equations (dissolution etc.)
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10
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Course Outcomes (students will be able to…..)
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1
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Hands on training on use of computer and various softwares
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2
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Application of software knowledge in regular course work
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THIRD YEAR B.PHARM SEMESTER V
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Course Code: PHT1408
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Course Title: Pharmaceutical and Medicinal Chemistry –II
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Credits = 3
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L
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T
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P
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Semester: V
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Total contact hours: 45
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2
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1
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0
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List of Prerequisite Courses
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Pharmaceutical and Medicinal Chemistry I
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List of Courses where this course will be prerequisite
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Pharmaceutical and Medicinal Chemistry III, Pharmaceutical and Medicinal Chemistry IV, Pharmaceutical and Medicinal Chemistry V
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Description of relevance of this course in the B. Pharm. Program
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To train the students with respect to basics of anti-infective, anti-cancer and anti-viral drugs
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Course Contents (Topics and subtopics)
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Reqd. hours
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Chemotherapeuticagents:
Studyofthefollowingclassesofdrugswithrespectto theirclassification,chemicalnomenclature, structure including stereochemistry, generic names, chemistry, physicochemical properties, SAR, metabolism,molecularmechanismofactionandsynthesisandintroductiontorationaldevelopment, if any.
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1
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Antibacterial agents –
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Antibiotics: beta-lactam antibiotics including-penicillin, cephalosporins, carbapenems, monobactams; Tetracyclincs and glycylcyclins.
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5
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Other antibiotics: Marcolides and ketolides, Aminoglcosides, Miscellaneous includingchloramphenicol, vancomycin, bacitracin etc.
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5
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Synthetic antibacterials: Sulfonamides and DHFR inhibitors, Quinolones, Oxazolidinediones and other miscellaneous agents.
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5
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2
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Anitparasitic agents-
a) Antiamoebics, b) Antimalarials, c)Anthelmintics
d) Miscellaneous including drugs versusTrypanosomiasis, leishmaniasis, scabies, filaria etc
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4
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3
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Antifungalagents-
a) Azoles,
b) Polyene antibiotics and Miscellaneous including Allyl amines, Tolnaftate, griseofulvinetc.
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3
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4
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Antimycobacterialagents-
a) Antitubercular agents
b) Antileprotic agents
Drugs versus MAC
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3
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5
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Anticancer agents –
a) DNA alkylating agent
b) Nitrosoureas
Procarbazines, Triazines and misc. Organoplatinumagents
c) Antibiotics
d) Antimetabolites including DNA polymerase inhibitors, Pyrimidine and purine antagonists and misc. agents.
e) Mitosis inhibitors and other misc. anticancer agents.
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5
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6
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Antiviral agents –
a) General aspects
b) Agents interfering with nucleic acid replication including those with modification with bases sugars and phosphate.
c) Amantidine and its analogs, interferon and its inductors.
Nuraminidase inhibitors
d) Antiretroviral drugs including NRTI, NNRTI and protease inhibitors.
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5
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Studyofthefollowingclassesofdrugswithrespecttotheirclassification,chemicalnomenclature, structure including stereochemistry, generic names, chemistry, physicochemical properties, SAR, metabolism,molecularmechanismofactionandsynthesisandintroductiontorationaldevelopment, if any.
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7
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Non Steroidal Anti-inflammatory Agents: Antipyretic analgesics, Salicylates, Aryl alkanoic acids, N-aryl anthranillic acids, Oxicams, Selective COX-2 inhibitors
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5
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8
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Antihistaminic agents: H1antagonists- Classical antagonists & Non-sedative H1antagonists
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2
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9
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Antiulcer agents: H2 antagonists, Proton Pump inhibitors etc
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3
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List of Text Books/ Reference Books
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1
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Foye, William O. Foye's principles of medicinal chemistry. Edited by Thomas L. Lemke, and David A. Williams, 6thedition, Lippincott Williams & Wilkins, 2008.
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2
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Wilson, Charles Owens, and Ole Gisvold, Textbook Of Medicinal And Pharmaceutical Chemistry, 11thedition, Lippincott Williams & Wilkins, Philadelphia, 2004
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3
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Donald J. Abraham, David P. Rotella, Burger's Medicinal Chemistry, Drug Discovery and Development, 7th edition, 8 Volume Set, John Wiley & Sons-New Jersey,2010
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4
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Remington, Joseph Price. Remington: The science and practice of pharmacy. Edited by David B. Troy, and Paul Beringer. Vol. 1. Lippincott Williams & Wilkins, 2006.
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5
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Iyer R. P, Degani M. S., Synthesis Of Drugs: A Synthon Approach, 2nd edition, Vol-1, Sevak Publications Pvt. Ltd., 2008
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6
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Axel Kleemann and Jürgen Engel, Pharmaceutical Substances: Synthesis, Patents, Applications (N-Z) Kleemann 4th edition, Thieme, 2011
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7
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Lednicer, Daniel. The organic chemistry of drug synthesis. Vol. 7. John Wiley & Sons, 2007.
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8
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R. B. Silverman & Holladay, The Organic Chemistry of Drug Design And Drug Action. 3rd edition, Elsevier Publication, 2014
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Course Outcomes (students will be able to…..)
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1
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To classify and understand structures and write IUPAC names of structures (includes 3D structures)
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2
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Understand drug mechanism at molecular level
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3
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Understand and apply the concepts of SAR
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4
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Predict synthetic routes for some of the drugs studied for above class.
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