Michael Jensen position title

1. 
   Personal Statement
   

2. 
   Positions and Honors.
   

1993-1997      Fellow, Pediatric Hematology/Oncology, University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA  (Three year research component- Program in Immunology, FHCRC/Mentor- Dr. Philip D. Greenberg)

1997-2004       Assistant Professor, Pediatrics, COHNMC, Duarte, CA

2002-2010  Program Leader, Cancer Immunotherapeutics Program, City of Hope NCI-designated Comprehensive Cancer Center

2004-2009  Associate Professor, Pediatrics, COHNMC

2004-2010   Associate Chairman, Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute at City of Hope

2010-2010       Professor, Pediatrics, COHNMC

2010-present   Jim & Jan Sinegal Endowed Professor, Pediatrics, University of Washington School of Medicine

2010-present   Joint Member, Program in Immunology, Fred Hutchinson Cancer Research Center

2011-Present Associate Head, Program in Immunology and Vaccine Research, UW/FHCRC NCI-designated Comprehensive Cancer Center

2011-Present Director, Center for Childhood Cancer Research, Seattle Children’s Research Institute
Other Experience and Professional Memberships

1997-Present  Member, American Society for Gene and Cell Therapy

2003-Present  Member, Society for Pediatric Research

2005-2010       External Cancer Center Advisory Board, Fred Hutchinson Cancer Research Center

2006-Present  Scientific Advisory Board, Brain Tumor Society

2007-Present CTN SOSS Cell and Gene Therapy Committee

2009-Present  External Advisory Board,  European Union Framework Programme Six Integrated Project

2009-Present  Scientific Advisory Board, Forbeck Foundation

3. 
   Selected peer-reviewed publications (selected from 54 peer reviewed publications)
   

1. 
   Cooper, L.N., Topp, M.S., Serrano, L.M., Gonzalez, S., Chang, W.C., Naranjo, A., Wright, C., Popplewell, L., Raubitschek, A., Forman, S.J., Jensen, M.C.:  T-cell clones can be rendered specific for CD19:  toward the selective augmentation of the graft-versus-B-lineage leukemia effect.  Blood 2003;101(4):1637-44.
   
2. 
   Chen, Y.C., Jensen, M.C.^†, Smolke, C.D.^†:  Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci USA 2010;107(19):8531-8536. PMCID: PMC2889348 (^†M.C.J. and C.D.S. designated equal contributors to work as senior authors).
   
3. 
   Wang, X., Berger, C., Wong, C.W., Forman, S.J., Riddell, S.R., Jensen, M.C.:  Engraftment of human central memory-derived effector CD8⁺ T cells in immunodeficient mice.  Blood 2011;117(6):1888-98. PMCID: PMC3056638
   
4. 
   Wang, X., Chang, C.W., Colcher, D., Sherman, M, Ostberg, J.R., Riddell, S.R., Jensen, M.C.: A transgene encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood 2011; 118(5):1255-63. PMCID: PMC3152493
   
5. 
   Terakura, S., Yamamoto, T.N., Gardner, R.A., Turtle, C.J., Jensen, M.C., Riddell, S.R.: Generation of CD19-chimeric antigen receptor modified CD8⁺ T cells derived from virus-specific central memory cells. Blood 2011;119(1):72-82. PMCID: PMC3251238
   

1. 
   Jensen, M., Tan, G., Forman, S., Wu, A.M., and Raubitschek, A.:  CD20 is a molecular target for scFvFc:z receptor re-directed T cells:  implications for cellular immunotherapy of CD20⁺ malignancy.  Biology of Blood and Marrow Transplantation, 4:75-83, 1998.
   
2. 
   Jensen, M. C., Clarke, P., Tan, G., Wright, C., Chung-Chang, W., Clark, T.N. , Zhang, F., Slovak, M.L., Wu, A.M., Forman, S.J., and Raubitschek, A.:  Human T Lymphocyte genetic modification with naked DNA. Mol Therapy, 1(1):49-55, 2000.
   
3. 
   Jensen, M.C., Cooper, L.J.N., Wu, A.M., Forman, S.J., and Raubitschek, A.:  Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-Cell malignancy.  Cytotherapy, 5(2):131-138, 2003.
   
4. 
   Wang, J., Press, O.W., Lindgren, C.G., Greenberg, P., Riddell, S., Qian, X., Laugen, C., Raubitschek, A., Forman, S.J., and Jensen, M.C.:  Cellular immunotherapy for follicular lymphoma using genetically modified CD20-specific CD8⁺ cytotoxic T lymphocytes.  Molecular Therapy, 9(4) 577-86, 2004.
   
5. 
   Cooper, L.J., Al-Kadhimi, Z., DiGiusto, D., Kalos, M., Colcher, D., Raubitschek, A., Forman, S.J., and Jensen, M.C.:  Development and application of CD19-specific T cells for adoptive immunotherapy of B cell malignancies.  Blood Cells, Molecules, & Diseases. 33(1):83-89, 2004.
   
6. 
   Cooper, L.J.N., Topp, M.S., Pinzon, C, Jensen, M.C., Riddell, S.R., and Greenberg P.D.:  Enhanced transgene expression in quiescent and activated human CD8⁺ T cells.  Human Gene Therapy. 15(7):648-58, 2004.
   
7. 
   Cooper, L.J.N., Al-Kadhimi, Z., Serrano, L.M., Pfeiffer, T., Olivares, S., Castro, A., Chang, W.-C., Gonzalez, S., Smith, D., Forman, S.J., and Jensen, M.C.:  Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTL's by co-transfer of T cells modified to present influenza MP1.  Blood, 105(4):1622-31, 2005.
   
8. 
   Serrano, L.M., Pfeiffer, T., Olivares, S. Numbenjapon, T., Bennitt, J., Kim, D., Smith, D., McNamara, G., Al-Kadhimi, Z., Rosenthal, J., Forman, S.J. Jensen, M.C. and Cooper, L.J.:  Differentiation of naïve cord blood T cells into CD19-specific cytolytic effectors for post-transplant adoptive immunotherapy.  Blood; 107(7):2643-52, 2006. PMCID: PMC1895371
   
9. 
   Kowolik, C.M., Topp, M.S., Gonzalez, S., Pfeiffer, T., Olivares, S., Gonzalez, N., Smith, D.D., Forman, S., Jensen, M.C., and Cooper, L.J.:  CD28 constimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.  Cancer Research, 66(22):10995-1004, 2006.
   
10. 
    Park, J.R., DiGiusto, D.L., Slovak, M., Wright, C., Naranjo, A., Wagner, J., Meechoovet, H.B., Bautista, C., Chang, W.C., Ostberg, J.R., and Jensen, M.C.:  Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma.  Molecular Ther, 15(4):825-33, 2007.
    
11. 
    Wang, J., Jensen, M., Lin, Y., Sui, X., Chen, E., Lindgren, C.G., Till, B., Raubitschek, A., Forman, S.J., Qian, X., James, S., Greenberg, P., Riddell, S., Press, O.W.:  Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains.  Hu Gene Ther. 18(8):712-25, 2007.
    
12. 
    Chang, L., Chang, W.C., McNamara, G., Aguilar, B., Ostberg, J.R., and Jensen, M.C.: Transgene Enforced Costimulation of CD4⁺ T cells leads to Enhanced and Sustained Anti-Tumor Effector Functioning. Cytother., 2007;9:771-84.
    
13. 
    Berger, C., Jensen, M.C., Lansdorp, P.M., Gough, M., Elliott, C., Riddell, S.R.:  Adoptive transfer of effector CD8 T cells derived from central memory cells establishes persistent T cell memory in primates.  J. Clin. Investigation, 2008;118(1):294-305. PMCID: PMC2104476
    
14. 
    Jensen, M.C., Popplewell, L., Cooper, L.J., DiGiusto, D., Kalos, M., Ostberg, J.R., Forman, S.J.: Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol. Of Blood & Marrow Transplantation, 2010:16(9):1245-56. PMCID: in progress.
    
15. 
    Till, B.G., Jensen, M.C., Wang J., Qian, X., Gopal, A.K., Maloney, D.G., Lindgren C.G., Lin, Y., Pagel, J.M., Budde, L.E., Raubitschek, A., Forman, S.J., Greenberg, P.D., Riddell, S.R., Press, O.W.; CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood, 2012: in press.