Start Date 27/11/2008
Molecular Farming: Plants as a Production Platform for High Value Proteins MONITORING
PROGRESS REPORT Reporting Period: from 1 April 2011 to 31 March 2012
This Report is presented to the relevant Domain Committee.
It contains three parts:
I. Management Reportprepared by the COST Office/Grant Holder
II. Scientific Report prepared by the Chair of the Management Committee of the Action
III. Previous versions of the Scientific Report; i.e., part II of past reporting periods The report is a “cumulative” report, i.e. it is updated annually and covers the entire period of the Action.
Confidentiality: the documents will be made available to the public via the COST Action web page except for chapter II.D.Self evaluation.
Based on the monitoring results, the COST Office will decide on the following year’s budget allocation.
Executive summary (max.250 words):
The objective for the Action is to co-ordinate European efforts in plant Molecular Farming (MF) to ensure rapid generation, development and commercialization of products that will sustain the industry. The scientific program is pursued through three topics: WG1 Strategic development of MF, WG2 Production systems and process development, WG3 Target molecules – assessment of (clinical) need and production feasibility. The outcome of the Action will be a sustainable European plant MF community with clear frameworks for regulatory, bio-safety and IP issues. Eventually a European Committee of MF will be established in order to influence European policy and to guarantee continuity of the activities in the fast developing field of recombinant proteins. The Road Map of MF demonstrated promising future trends, verified the availability of a rich toolbox and showed a clear orientation towards products and production systems. The work carried out under WP1 was divided into four focus groups: Regulatory framework, Public perception/stakeholder interactions, Developing country aspects and IP licensing. The outcome will take the form of Position, Information and Vision papers and Strategic Documents. Plant MF can be only successful when it meets industrial requirements with respect to cost of goods as well as product yield, quality and homogeneity. The success of specific plant production platforms is tightly interlinked with the features of specific protein products and the activities of WG2 and WG3 are performed in close cooperation. To facilitate this Molecular farming Protein Expression database has been formulated and is now fully operational.
Molecular farming: plants as a production platform for high value proteins
Dr Kirsi-Marja OKSMAN-CALDENTEY
Dr Ioanna STAVRIDOU
Ms Anja VAN DER SNICKT
+32 2 533 38 46
Start of Action:
Entry into force:
End of Action:
CSO approval date:
Proof-of-principle for Molecular Farming (MF) has been established over the last 15 years through sustained efforts of a growing number of European research groups. This work has been supported by the strategic decision of the EU to fund several initiatives through FPs 4-6 resulting in an impressive volume of generated knowledge. The aim of the Action is to leverage fruits of earlier EU, national and industrial investments in Molecular Farming to reach the next level, i.e. to move from R&D to applications, to develop product-oriented platforms, to enable new classes of products, to lower the costs and ultimately to commercialize the products. This Action will create new opportunities for European agriculture, horticulture and related technology sectors as the plants dedicated to Molecular Farming constitute new high-value crops. The Action brings the key players together and will increase European momentum, capacity and infrastructure. It will also expand activities to countries that have not thus far been able to participate, including developing countries. The concrete outcome will be a sustainable European Molecular Farming community with a clear vision, and links and input into scientific, regulatory, biosafety, intellectual property (IP), dissemination and public engagement activities.
Keywords: Plant-made recombinant proteins, Scale-up and downstream processing, Contained growth or in-field production, Path to commercialization, Intellectual Property Rights, regulatory framework and biosafety