University System of Georgia Format for New Program Proposal



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University System of Georgia
Format for New Program Proposal

(Submit three copies)

Institution _Georgia State University____Date__May 19, 2008__________

School/Division_College of Arts and Sciences____Department_Neuroscience Institute__

Name of Proposed Program_M.S./Ph.D. in Neuroscience___________

Degree __M.S./Ph.D.___Major ____ Neuroscience _____ CIP Code__30.2401__

Starting Date _August 2009____

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Table of Contents:


APPENDICES 36

APPENDIX I 37

APPENDIX II 46

APPENDIX IIIB 55

APPENDIX IV 64

1.Gamble, K.L., Novak, C.M., Paul, K.N., and Albers, H.E. Tetrodotoxin blocks the circadian effects of NMDA during the day but not at night. NeuroReport, 14:641-644, 2003. 65

2.Paul, K.N., Fukuhara, C.,Tosini, G., Albers, H.E. Transduction of light in the suprachiasmatic nucleus: evidence for two different neurochemical cascades regulating the levels of Per1 mRNA and pineal melatonin. Neuroscience, 119:137-144, 2003. 65

3.Caldwell, H.K., Albers, H.E. Short-photoperiod exposure reduces vasopressin (V1a) receptor binding but not arginine-vasopressin-induced flank making in male Syrian hamsters. Journal of Neuroendocrinology, 15:971-977, 2003. 65

4.Novak CM, Albers HE. Novel phase-shifting effects of GABAA receptor activation in the suprachiasmatic nucleus of a diurnal rodent. Am J Physiol Regul Integr Comp Physiol, 285:R820-R825, 2004. 65

5.Caldwell, H.K., Albers, H.E. Photoperiodic regulation of vasopressin receptor binding in female Syrian hamsters. Brain Research, 1002:136-141, 2004. 65

7.Novak CM, Albers HE. Circadian phase alteration by GABA and light differs in diurnal and nocturnal rodents during the day. Behav Neurosci, 118:498-504, 2004. 65

8.Gamble KL, Novak CM, Albers HE. Neuropeptide Y and N-methyl-D-aspartic acid interact within the suprachiasmatic nuclei to alter circadian phase. Neuroscience, 126:559-565, 2004. 65

10.Caldwell, HK, Albers HE. Effect of photoperiod on vasopressin-induced aggression in Syrian hamsters. Horm Behav, 46:444-9, 2004. 65

11.Gamble KL, Ehlen JC, Albers HE. Circadian control during the day and night: Role of neuropeptide Y Y5 receptors in the suprachiasmatic nucleus. Brain Research Bulletin, 65:513-9, 2005. 65

12.Cooper MA, Karom M, Huhman KL, Albers HE. Repeated agonistic encounters in hamsters modulate AVP V1a receptor binding. Horm Behav, 48(5):545-54, 2005 65

13.Paul KN, Fukuhara C, Karom M, Tosini G, Albers HE. AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN. Molecular Brain Research, 2005. 65

14.Ehlen JC, Albers HE, Breyer ED. MEKC-LIF of gamma-amino butyric acid in microdialysate: systematic optimization of the separation conditions by factorial analysis. Journal of Neuroscience Methods, 147(1):36-47, 2005. 65

15.Albers HE, Dean A, Karom MC, Smith D, Huhman KL. Role of V1a vasopressin receptors in the control of aggression in Syrian hamsters. Brain Research Bulletin, 1073-1074:425-30, 2006. 65

16.Gamble KL, Paul KN, Karom MC, Tosini G, Albers HE. Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur J Neurosci, 23(9): 2488-94, 2006. 65

17.Ehlen JC, Novak CM, Karom MC, Gamble KL, Paul KN, Albers HE. GABAA receptor activation suppresses Period 1 mRNA and Period 2 mRNA in the suprachiasmatic nucleus during the mid-subjective day. Eur J Neurosci, 23(12): 3328-36, 2006. 66

18.Powell KR, Albers HE. Center for Behavioral Neuroscience: a prototype multi-institutional collaborative research center. J Biomed Discov Collab, 2006. 66

19.Schulz KM, Menard TA, Smith DA, Albers HE, Sisk CL. Testicular hormone exposure during adolescence organizes flank-marking behavior and vasopressin receptor binding in the lateral septum. Horm Behav, 50(3): 477-83, 2006. 66

20.Haak LL, Albers HE, Mintz EM. Modulation of photic response by the metabotropic glumate receptor agonist t-ACPD. Brain Research Bulletin, 71(1-3): 97-100, 2006 66

21.Novak CM, Ehlen JC, Paul KN, Fukuhara C, Albers HE. Light and GABA(A) receptor activation alter period mRNA levels in the SCN of diurnal Nile grass rats. European Journal of Neuroscience, 24(10): 2843-52, 2006 66

22.Novak CM, Ehlen JC, Albers HE. Photic and nonphotic inputs to the diurnal circadian clock. Biological Rhythms Research, In Press. 66

23.Demas, GE, Cooper, MA, Albers, HE, Soma, KK. Novel mechanisms underlying neuroendocrine regulation of aggression: A synthesis of rodent, avian and primate studies. Handbook of Neurochemistry and Molecular Neurobiology, In Press. 66

24.Caldwell HK, Smith DA, Albers HE. Photoperiodic mechanisms controlling scent marking: interactions of vasopressin and gonadal steroids. Eur J Neurosci, 2008 66

25.Ehlen JC, Novak CM, Karom MC, Gamble KL, Albers HE. Interactions of GABA A receptor activation and light on period mRNA expression in the suprachiasmatic nucleus. J Biol Rhythms, 23(1): 16-25, 2008. 66

26.Wang LM, Schroeder A, Loh D, Smith D, Lin K, Han JH, Michel S, Hummer DL, Ehlen JC, Albers HE, Colwell CS. Role for the NR2B Subunit of the NMDA Receptor in Mediating Light Input to the Circadian System. Eur J Neurosci, In Press. 66

APPENDIX V 228



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  1. Program Description and Objectives:

The program description, written in a one or two page abstract, is a summary of the proposed program. It should be in a format suitable for presentation to the Board of Regents and should include the following: the objectives of the program; the needs the program would meet; an explanation of how the program is to be delivered at the undergraduate and/or graduate levels; and information related to costs, curriculum, faculty, facilities, desegregation impact, and enrollment. Indicate the degree inscription which will be placed on the student's degree upon his/her completion of this program of study. In the program description, it must be clear that the proposed program is central to the institution's mission and a high priority within the institution's strategic plan.

This proposal describes a plan for establishing a multidisciplinary, multi-departmental, M.S./Ph.D. program in Neuroscience (offering a M.S. and Ph.D. in Neuroscience) that will enhance the behavioral and life sciences training and research efforts of Georgia State University (GSU). The program will respond to requests from students and to a need for highly trained specialists in the areas of Neurobiology and Behavioral Neuroscience. The M.S./Ph.D. program in Neuroscience will provide students with the training necessary for careers in the rapidly expanding biotechnology and pharmaceutical industries as well as for academic careers in several related disciplines. Recent studies, as well as our own survey (appended), clearly indicate that prospective students in the neurosciences prefer to earn advanced degrees specifically in Neuroscience rather than in traditional biological or behavioral science programs. The M.S./Ph.D.program in Neuroscience will therefore enhance the ability of GSU to compete for top graduate students nationally and internationally.


The proposed M.S./Ph.D. program in Neuroscience has its origins in the neuroscience-related concentrations within the Ph.D. programs in the Biology and Psychology departments at GSU. However, the proposed M.S./Ph.D. program in Neuroscience will be administered by the new Neuroscience Institute, an interdisciplinary unit within the College of Arts and Sciences at GSU. Instruction of students in the proposed program would be provided by faculty with primary (core) appointments (n=14) in the Neuroscience Institute (most with previous appointments in the departments of Biology and Psychology) as well as by faculty associated (n=41) or affiliated (n=12) with this institute. While the majority of these faculty originate from Biology and Psychology, additional faculty and students in other departments are working in neuroscience-related areas, including theory of mind studies in Philosophy, robotics and neural modeling in Computer Science, Computer Information Systems, Math & Statistics, and Physics & Astronomy, neuromics in Computer Science, neurogenic communication disorders in Educational Psychology and Special Education, and drug development and imaging strategies in Chemistry.
Both the diversity and depth of the neuroscience research community at GSU will define the curriculum of the M.S./Ph.D. in Neuroscience. Specifically, all students will be required to complete three Core courses that cover the full range of neuroscience research, one course in Statistics and an Introduction to Graduate Studies course. All other coursework will be chosen from electives so that each student, in consultation with their advisor, can customize their curriculum to their particular research interests. Topics and Concepts classes and journal clubs will bring together students whose research areas are complementary
We expect that the M.S./Ph.D. Program in Neuroscience would require only minimal administrative resources at its inception; otherwise it is cost-neutral. Our proposed degree program will not require an alteration of the institutional mission because the newly-formed Neuroscience Institute will administer the Neuroscience doctoral program. The proposed M.S./Ph.D. program in Neuroscience does not call for course delivery formats that are new or different for Georgia State University. We anticipate that each tenure-track faculty with a primary appointment in the Neuroscience Institute will have at least one doctoral student in the program and most will have two or more students. When combined with doctoral students mentored by neuroscience-related faculty in other departments, we estimate a total of 65 students enrolled at any one time. For a 5-year program, we expect to graduate approximately 14 Ph.D.s in Neuroscience per year and award a similar number of M.S. degrees annually.
The establishment of a M.S./Ph.D. program in Neuroscience will support the overarching goal of GSU to become one of the nation's premier research universities located in an urban setting. In particular, the strategic plan for GSU calls for increasing interdepartmental or multidisciplinary research in areas of excellence. The strength and interdisciplinary nature of the neuroscience community at GSU was recognized by the establishment and heavy investment by the Provost in the Brains and Behavior Program, one of three multi-disciplinary research foci that built on GSU’s strongest and most successful research programs. To date, this has developed into a vibrant association of faculty and students spanning multiple departments in the natural sciences, mathematics, social sciences, and humanities. Similarly, GSU is the lead institution of the Center for Behavioral Neuroscience (CBN), a NSF-funded consortium of more than 100 researchers at seven Atlanta institutions who examine the neural mechanisms underlying complex social behaviors. Establishment of a M.S./Ph.D. in Neuroscience within the newly-formed Neuroscience Institute would formally unite the faculty and students participating in neuroscience research and align with the University’s larger strategy of training students in cross-disciplinary subjects. The proposed M.S./Ph.D. in Neuroscience at GSU would be unique in that this program would be the only M.S./Ph.D.. in Neuroscience administered by an Institute and unaffiliated with a medical college within the University System of Georgia and, indeed, the Southeast region. This program would also increase our ability to supply, as we currently do, a majority of minority neuroscience-trained Ph.D.s nationally.

  1. Justification and need for the program

    1. Indicate the societal need for graduates prepared by this program. Describe the process used to reach these conclusions, the basis for estimating this need, and those factors that were considered in documenting the program need.

The Neurosciences

The neurosciences are a set of disciplines that have a common interest in understanding the structure and function of the nervous systems of animals, including humans. The neurosciences embrace the traditional fields of neurophysiology, neuroanatomy, and neurology, and the newer fields of neuroethology, neuroeconomics, neurophilosophy, neuropsychology, behavioral, cognitive, computational, and developmental neuroscience, dynamical systems, and neuromics. Neuroscience is informed by and informs psychology, psychiatry, pharmacology, biophysics, computer science, robotics, education, and speech/language pathology. The neurosciences are a growing field; one measure of the growth is the membership of the Society for Neuroscience, which has increased from 500 to over 37,000 since its beginning in 1969. The Association of Neuroscience Departments and Programs (ANDP) (http://www.andp.org/) lists over 130 programs in Neuroscience.


A M.S./Ph.D. degree in Neuroscience will benefit the University, the System, and the state in many ways, including the following:
NEUROSCIENCE IS Interdisciplinary, A KEY to TODAY’S SCIENCE

The interdisciplinary nature of Neuroscience research is fundamental and thereby unites faculty across various disciplines as perhaps no other life science initiative can, as witnessed by the Brains & Behavior Area of Focus incorporation of 9 different departments from 3 different colleges. Neuroscience encompasses several fields of biological and behavioral research and is typically subdivided into the following disciplines: Molecular and Cellular Neuroscience, Systems and Integrative Neuroscience, Behavioral Neuroscience, Cognitive Neuroscience, Computational Neuroscience, and Clinical Neuroscience. Allied areas include biophysics of membranes, biochemistry of neurotransmitters and signal transduction pathways, robotics, brain/computer interfaces, learning/educational research, psychotropic drug design, social behavior, marketing strategy, philosophy of mind, and others.


NEUROSCIENCE IS THE LAST MAJOR FRONTIER IN MEDICINE.

The major medical problems facing the population in the foreseeable future are brain problems. The killer diseases of previous generations, such as polio, heart disease, cancer, and even diabetes, are increasingly preventable or treatable, but diseases or injuries of the brain currently have few solutions. Topics related to these diseases include:

Arthritis

Deafness


Age-and diabetes related blindness, e.g. macular degeneration, glaucoma

Parkinson’s Disease

Alzheimer’s Disease

Diffuse Lewy Body Syndrome

Other Dementias

Drug abuse

Social pathology (e.g. various anti-social personality disorders)

Spinal cord regeneration

Traumatic brain injury

Stroke


Epilepsy

Childhood developmental disorders

Chronic pain

Obesity-induced diabetes, hypertension, joint pain, and congestive heart failure

Mental health/affective disorders (e.g. autism, schizophrenia, bipolar disorder, depression)

Neurological ramifications of disease states

Robotics, sensory and motor prostheses

Terrorism- neurotoxins, neuroimmunology


NEUROSCIENCE PROMOTES RESOURCE DEVELOPMENT

GSU has important resources for supporting students in the emerging field of neuromics. We have the first Center for Neuromics (http://biology.gsu.edu/neuromics) in the nation, which promotes research aimed at understanding the complex interactions of neurons in the brain. Through seed funding from the Brains & Behavior Initative, we have started a collaborative project between biologists and computer scientists to build NeuronBank, a knowledge base of neuronal circuitry, which has now received NIH funding. The Center for Neuromics sponsors seminars and provides student travel and research awards.


Some of our faculty are involved with the Allen Brain Project: (www.brainatlas.org). This is a program for developing cutting-edge bioinformatics-type tools to catalog brain areas, nerve cells and their interconnections, and the genes involved in setting up and maintaining brain function. This information will be of great use in basic research to understand the workings of the brain, in drug development for neurological diseases, in neurosurgical innovations and gene therapy. These endeavors are expected to produce translational research that would lead to patentable innovations.


    1. Indicate the student demand for the program in the region served by the institution. What evidence exists of this demand?

CURRENT NEUROSCIENCE STUDENTS AT GSU SUPPORT THE FORMATION OF A M.S./Ph.D.PROGRAM IN NEUROSCIENCE.

We have conducted a survey of students currently connected with the Brains & Behavior and Center for Behavioral Neuroscience Programs. Most are currently working on a degree in Biology or Psychology; a few are from the other departments involved in the Brains & Behavior Area of Focus. The response was overwhelmingly positive. Out of 51 respondents, 31 agree or strongly agree that they would have applied to such a program, and only 10 said they would not, with the rest neutral. Only 8 out of 51 disagreed with the statement “I would prefer to earn my degree in Neuroscience”

Please see Appendix I for details.
A M.S./Ph.D. PROGRAM IN NEUROSCIENCE AT GSU WILL ENHANCE VISIBILITY OF OUR EXISTING PROGRAMS IN NEUROSCIENCE

Students interested in Neuroscience want to have a M.S./Ph.D. in Neuroscience to reflect their specialized knowledge and training. The annual number of applications for graduate training in the neural sciences has almost tripled during the past 19 years and is now ~65 per program, while the number of matriculates has doubled and is now ~8 students per program. Nonetheless, the academic quality of incoming graduate students has remained high, as suggested by their undergraduate GPA (average = 3.49), their scores on the GRE (average = ~69th percentile), and their research experience.  23% of the incoming students have an undergraduate major in Neuroscience or Behavioral Neuroscience. Other common majors were Biology (23%), Psychology (15%), and Chemistry (6%), and an additional 8% had dual majors including one or more of these disciplines. With a M.S./Ph.D. program in Neuroscience at GSU, this will facilitate our national and international reputation, paying dividends in greater numbers and quality of students as well as better postdoctoral and faculty positions for our Ph.D. graduates. This, in turn, will heighten awareness of Neuroscience at GSU, specifically, and GSU research more generally in the national/international arena. This will lead to even higher quality job applicants for faculty positions in Neuroscience-related Departments.


A M.S./Ph.D. PROGRAM IN NEUROSCIENCE AT GSU WILL FACILITATE ADMINISTRATION OF OUR NEUROSCIENCE DEGREE PROGRAMS

Faculty who would jointly train M.S./Ph.D. students in the proposed Program come from several departments as well as from the Neuroscience Institute. The ANDP 2005 Report finds that more than half of all Neuroscience programs are institution-wide, reflecting the broad-based, interdisciplinary nature of the field. Only 18% are located in Departments of Neuroscience or Neurobiology. In contrast, 64% of the programs link neuroscientists in multiple departments (or in a “Center”, “Division”, or “Institute” of Neuroscience) in a unified, degree-granting program. These numbers are similar to those obtained in the 2000/2001 and 2003 ANDP surveys. On average, there are 51 faculty members per program. In 75% of the programs, the degree awarded to graduate students trained in the neurosciences is a Ph.D. in Neuroscience or in Neurobiology (or in a discipline that had those words in their name). This situation represents a striking reversal from that which occurred 19 years ago, when the majority of such degrees were awarded in other disciplines. The number of applications to graduate training programs in the neurosciences is almost three times the number per program that it was in the 1986 survey. The median number of graduate students in a program is 25. The Ph.D. degrees awarded per year average 3.9 per program and this number has been steadily increasing. The attrition rate is only 4%. 69% accepted postdoctoral positions, 26% were in other neuroscience-related positions, 1% were employed outside the field, and 0% were unemployed. A unified M.S./Ph.D. program under the administration of the Neuroscience Institute would produce a seamless program of study for Neuroscience graduate students across departments.


Neuroscience departments or degree-offering Neuroscience programs may be found in over 130 research universities across the United States. Data generated from surveys conducted by the Association of Neuroscience Departments and Programs (ANDP) in 1986, 1991 and 1998 reveal a growing trend among prospective graduate students to apply to these Neuroscience programs. In its survey of U.S. graduate programs in Neuroscience, the ANDP reports that the number of applications per program has increased 45% from 1991 and 154% from 1986. Additionally, the average number of students enrolled per program has increased steadily.
The ANDP survey also reveals an increasing trend for students to earn advanced degrees specifically in “Neuroscience” rather than in traditional biological or behavioral sciences

    1. Give any additional reasons that make the program desirable (for example, exceptional qualifications of the faculty, special facilities, etc.)

NEUROSCIENCE IS IMPROVING EDUCATION AND MINORITY PARTICIPATION

The Society for Neuroscience has made outreach to K-16 students a fundamental part of its mission, and Atlanta’s Neuroscience community has taken this charge to heart, primarily under the auspices of the NSF-funded Center for Behavioral Neuroscience (CBN) headquartered at GSU. Neuroscience faculty are actively involved in efforts to improve science education at the K-12 level via initiatives coordinated by the CBN. GSU neuroscience educators have established partnerships with the Decatur School System and the DeKalb County School system for a series of programs involving teachers and students, including teacher training workshops, school visits, and a lending library of science education materials made available to classroom teachers. Integrated into these teacher and classroom-oriented activities are summer programs for students, including the ION (Institute on Neuroscience) program for high school students in which the students gain formal mentoring and an opportunity to work in neuroscience labs at GSU and other Atlanta universities and colleges, and Summer Brain Camps, summer science camps for middle school students which both provide science experiences for the students during which GSU science faculty and public school teachers who have completed one of the teacher training workshops work together. GSU neuroscience educators also hold a two-day Neuroscience Expo at the Atlanta Zoo, the first day of which students from a Decatur middle school are exposed to neuroscience-related activities, while on the second day the Expo is open to all children and their parents who visit the Zoo. School-oriented programs are focused on schools with high proportions of underrepresented minorities and disadvantaged students. Summer programs and other student-oriented activities have >80% minority student participation. The Georgia Biomedical Partnership recognized the CBN for its outstanding work in education and community outreach with its 2006 Biomedical Community Award.

Neuroscience faculty members lead the CBN’s undergraduate education initiatives as well. The nationally recognized BRAIN program for undergraduates is held each year, bringing in 22 undergraduates from Atlanta institutions and across the nation for neuroscience research fellowships to gain hands-on research experience at GSU and other Atlanta universities and colleges while attending lectures and seminars on neuroscience topics and professional skills. Historically, >75% of the participants have been women and >60% have been underrepresented minorities. A similar academic year program, CBNuf, is currently being tested, and is targeted specifically at minority undergraduates at Spelman College, Morehouse College, and Clark Atlanta University. Neuroscience faculty have established strong relationships with these Historically Black Colleges and Universities in Atlanta. Career Days and Research Days at Spelman College, Morehouse College, and Clark Atlanta University are attended by neuroscience faculty and CBN staff to provide information about graduate school opportunities, and several students from these institutions have worked in GSU neuroscience labs and/or enrolled in its graduate programs. In recognition of his work with these institutions, CBN Director and GSU neuroscience faculty member Dr. Elliott Albers was named Mentor of the Year by The Center for Biomedical and Behavioral Research at Spelman College in 2006. Improvements in education extend to the professional level as well. There is enhancement of graduate and research programs through the CBN Graduate Scholars Program (providing doctoral students with an interest in behavioral Neuroscience the opportunity to gain a broader breadth of experience by working in a collaborative research environment) and a CBN Post-Doctoral Fellows program.



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