Solid dosage forms
f. TABLETS FOR RECTAL USE(SUPPOSITORIES)
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- Major expipient
- MAJOR EXIPIENTS 1.DILUENTS(fillers or bulking agents)
- TYPES ORGANIC
| f. TABLETS FOR RECTAL USE(SUPPOSITORIES): These are tablets inserted into the rectum. They are usually oval in shape.
TABLET FORMULATIONS The compressed tablet is made up of the drug and other additives known as exipients or adjuvants. The exipients are classified into 2 major groups Major expipient: These are almost always included in the formulation e.g. diluent (filler or bulking agent), binders (binding agents or adhesives), disintegrants (disintegrating agent), lubricant and glidants (lubricating agents) Minor exipient: These are optional depending on what you want to use them for. E.g. colouring agents, flavouring agents, sweetening agents and adsorbents MAJOR EXIPIENTS 1.DILUENTS(fillers or bulking agents): These are inert substances which are added to the drug when the individual dose of the drug is very small and cannot be compressed into tablets. Normally there is a lower limit of a tablet which is 50mg. Therefore, when the active drug is less than 50mg, a diluent is needed to make up the bulk. The diluent is supposed to be an inert material, non-toxic, compatible with the drug and other exipients, should have a good or pleasant taste and odour, should be stable,should have good flow properties, good binding properties, should have good disintegrating properties. TYPES ORGANIC: These include lactose, starch, starch derivatives (spray dry lactose), sucrose, dextrose, mannitol. They come from organic source. INORGANIC: These include CaSO4, CaCO3, NaCl etc. 2. BINDERS: These are substances added to facilitate the adhesiveness of tablet exipients so that they could be made into granules In other words, binders help to bind particles together to form granules. Common examples of binders are: Acacia, tragaccant, gelatin, sucrose, starch, sodium alginate, sodium carboxymethylcellulose and methyl cellulose. These are binders that are soluble in water. Those that are soluble in alcohol are: hydroxymethylcellulose, and polyvinylpyrolidone. Download 37.21 Kb. Share with your friends:
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