Solid dosage forms
METHODS OF MANUFACTURING TABLETS
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- DRY GRANULATION ADVANTAGES
- WET GRANULATION METHOD This is the most widely used method ADVANTAGES
- DISADVANTAGES
| METHODS OF MANUFACTURING TABLETS
There are 3 methods of producing tablets Direct compression Dry granulation Wet granulation DIRECT COMPRESSION: This involves mixing the drugs and all the additives and compressing them into tablets. The advantages include: The method is very quick Simple and Economical. Heat is not employed,no addition of liquids.This method is suitable for water and heat-sensitive drugs. There is high dissolution rate The disadvantages include: 1.It is only limited to low-dose drugs 2.Segregation is likely to occur when the active drug have a different particle size from the other ingredients. PROPERTIES OF A GOOD DIRECT COMPRESSION EXIPIENT 1. It should have good flow properties 2. It should have good compressibility Common direct compression exipients are: microcrystalline cellulose, spray dry lactose, hydrolysed starch, dicalciumphosphate. E.g. of drugs that can be directly compressed are: Aspirins. DRY GRANULATION ADVANTAGES It is suitable for water and heat sensitive drugs Avoids the problem of separation of exipients that have different particle sizes or densities It ia suitable for fine powders DISADVANTAGES Since it involves double lubrication and compression,the tables may be hard which may lead to long disintegration time hence long/slow dissolution rate. Some ingredients may loose their compressibility and properties when required to be compressed twice. WET GRANULATION METHOD This is the most widely used method ADVANTAGES It can be used for exipients with different particle sizes and densities that cannot be compressed by the method of direct compression. If the drug is water sensitive,alcohol is used as granulating fluid therefore suitable for drugs that are water sensitive DISADVANTAGES It is time consuming and has several steps to be followed It is not suitable for heat sensitive drugs There may be variation in the sizes of the granules. Download 37.21 Kb. Share with your friends:
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