Solid dosage forms
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- FILM COATING
- QUALITY CONTROL/QUALITY STANDARDS OF TABLETS
| COATING OF TABLETS
There are 2 types of coating Sugar coating Film coating SUGAR COATING Sugar coating is used to mask unpleasant taste and/or odour. To protect the ingredient from invitro degradation as a result of exposure to moisture, O2 and light i.e. to protect the ing from env factors To separate incompatible ingredients by forming one of the ingredients in the tablet core while including the others in the tablet coat. To improve the appearance of the tablet i.e. making the tablet more elegant for the patient FILM COATING Film coating is divided into two: Enteric coating Non-enteric coating In film coating, polymer solutions are spread on the tablets to form a thin film or coat round the tablets. ADVANTAGES OF FILM COATING Enteric coating can be used to control the site of release of drug Enteric coating can be used to protect the drug from the acid PH of the stomach e.g. erythromycin Enteric coating can protect the stomach from irritant of drugs e.g. aspirin causes irritation of the GIT and can be prevented by enteric coating. Unlike sugar coating,in film coating,a polymer or plasticizer is added in the coating .The plasticizer makes the coating flexible or elastic preventing it from splitting.Others added to the coating material include:propylene glycol. Unlike sugar coating,film coating is simpler,quicker,time saving.Not much skill is required. Film coating enhances the invitro stability of the drug against hydrolysis,oxidation and photolysis. FIlm coating solution contain materials which could be for enteric or non-enteric coating.U need a polymer,plasticizer QUALITY CONTROL/QUALITY STANDARDS OF TABLETS They are essentialy; To ensure that the patient receive the required amount of the active ingredient in the tablet To exclude any batch-to-batch variation or within batch variation in order to ensure the exact drug content of the tablet. Download 37.21 Kb. Share with your friends:
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