The promise of melatonin targets/ receptors as therapeutic targets in multiple therapy areas

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Abdel-Wahab & Abd-Allah	2000	streptozotocin-induced hyperglycaemia	serum	5 mg/kg	mice	[62]
Lagneux et al.	2000	ischemia-reperfusion injury	heart	1-10 mg/kg	rats	[63]
Kaptanoglu et al.	2000	experimental spinal cord injury	spinal tissues	100 mg/kg	rats	[64]
Kaneko et al.	2000	ischemic reperfusion injury	heart	100µM	rats	[65]
Qi et al.	2000	chromium(III)-induced DNA damage		0.51 µM	isolated DNA	[66]
Khaldy et al.	2000	dopamine autoxidation-induced hydroxy radical formation		1-1000 µM	in vitro	[67]
Calvo et al.	2001	α-naphthylisothiocyanate-induced injury	liver	10 mg/kg	rats	[68]
Otsuka et al.	2001	water-immersion restraint stress-induced gastric mucosal lesions	stomach	100 ng/rat icv	rats	[69]
Hara et al.	2001	cisplatin-induced nephrotoxicity	kidney	5 mg/kg	rats	[70]
Salvi et al.	2001	free radicals-induced protein structural damage	cell-free system	up to 1 mM		[71]
Cabeza et al.	2001	ischemia-reperfusion injury	gastrointestinal tissues	5-20 mg/kg	rats	[72]
Othman et al.	2001	indomethacin-induced oxidative stress	gastric and testicular tissues	10 mg/kg	rats	[73]
Montilla et al.	2001	extra-hepatic bile duct ligation oxidative stress	liver	0.5 mg/kg	rats	[74]
Jajte et al.	2001	iron ions and 7 mT 50 Hz magnetic field-indiced damage	lymphocytes	0.5-1.0 mM	rats	[75]
Ryoo et al.	2001	ultraviolet-B induced	dermal fibroblasts	1 nM	human	[76]
Xu et al.	2001	doxorubicin-induced toxicity	heart	90 mg/kg	rats	[77]
Szárszoi et al.	2001	ischemia-reperfusion-induced injury	heart	10-10 000 nmol/L	rats	[78]
Xu & Ashraf	2002	doxorubicin-induced myocyte injury	heart	1 mM	rats	[79]
Arslan et al.	2002	bleomycin-induced fibrosis	lung	10 mg/kg	rats	[80]
Hsu et al.	2002	phosphine-induced lipid and DNA oxidation	brain	1 mM	rats	[81]
Bonilla et al.	2002	extension of life span and stress resistance	whole body	100 µg/L	flies	[82]
Parmar et al.	2002	copper-mediated free radical damage		5 mM	liver homogenates	[83]
Gupta et al.	2002	acute ischemic stroke	brain	80 mg/kg	rats	[84]
Bilici et al.	2002	ethanol-induced gastric mucosal damage	stomach	10 mg/kg	rats	[85]
Görgün et al.	2002	Streptozotocin-induced plasma thiobarbituric acid-reactive substances blockade	plasma	150 µg/kg (x56)	rats	[86]
Tomás-Zapico et al.	2002	delta-aminolevulinic acid-induced oxidative damage	Harderian gland	500 µg/kg	hamsters	[87]
Leaden et al.	2002	lipid peroxidation of long chain polyunsaturated fatty acids	liver	10 mg/kg	rats	[88]
Srivastava et al.	2002	posttraumatic seizures	brain	50 mg/kg	rats	[89]
Abdel-Wahab et al.	2002	dibromoacetonitrile-induced oxidative stress	stomach	10 mg/kg	mice	[90]
Martin et al.	2002	oxidative stress	astrocytes	10nM - 1mM	rats	[91]
Rao et al.	2002	STZ-induced hyperglycemia	plasma	6 mg/kg	rats	[92]
Perotti et al.	2002	delta-aminolevulinic acid phototherapy-induced damages		8 mM	LM2 cell line	[93]
Kocic et al.	2002	diabetes-induced oxidative stress	mesangial cells	1 to 100 µM	rats	[94]
Jaworek et al.	2003	ischemia/reperfusion-induced acute pancreatitis	gut	10-50 mg/kg	rats	[95]
Mayo et al.	2003	metal-catalyzed reaction-induced oxidative protein damage	cell-free system	50 µM to 100 mM	in vitro	[96]
Jahovic et al.	2003	methotrexate-induced oxidative injury	liver & kidneys	10 mg/kg	rats	[97]
Sener et al.	2003	ischemia/reperfusion-induced oxidative injury	liver	10 mg/kg	rats	[98]
Chen et al.	2003	myocardial infarction	heart	150 µg/kg	mice	[99]
Mayo et al.	2003	peroxyl radical-induced oxidative damage	catalase	250 µM	in vitro	[100]
Bonnefont-Rousselot et al.	2003	peroxyl radical-induced oxidative damage	LDL	250 µM	in vitro	[101]
Requintina & Oxenkrug	2003	lipopolysaccharide-induced toxicity	several organs	5 mg/kg	mice	[102]

Cabeza et al.	2003	ischemia-reperfusion-induced lesions	stomach	20 mg/kg	rats	[103]
Erol et al.	2004	gamma radiation-induced damages	brain	100 mg/kg (x5)	rats	[104]
Guajardo et al.	2003	ascorbate-Fe2+ dependent lipid peroxidation	retina (in vitro)	10 mM	bovine	[105]
Yan et al.	2002	transcatheter arterial chemoembolization-induced liver damage	liver	20 mg	humans	[106]
Sperling et al.	2003	iodoacetate-induced neurotoxicity	neuronal cells	1 mM	rats	[107]
Ciuffi et al.	2003	ultraviolet exposure	corneal cells	10 µM	rabbits	[108]
Sahin et al.	2003	heat stress-related depression	whole birds	40 mg/kg diet	quails	[109]
Basile et al.	2004	pathogenesis of sepsis	liver	1 - 10 µM	rat hepatocytes	[110]
Gitto et al.	2004	post-surgical distress	neonates	10 mg/kg (x10)	humans	[111]
Kilic et al.	2004	mild focal ischemia-induced neuronal death	mice	4 mg/kg (x2)	mice	[112]
Gupta et al.	2004	enhances phenytoin and carbamazepine antiseizure effect	drug metabolism	100 to 300 mg/kg	mice	[113]
Leja-Szpak et al.	2004	acute pancreatitis	pancreas	up to 250 mg/kg of precursor	mice	[114]
Liang et al.	2004	oxidative stress-induced macular degeneration	retinal pigment epithelial cells	0.1-200 µM	humans	[115]
Sahin et al.	2004	heat-induced performance inhibition	whole animals	40 mg/kg diet	quails	[116]
Görgün et al.	2004	streptozotocin-induced glutathione depletion	plasma	150 μg/kg (x42)	rats	[117]
Othman et al.	2004	heavy metals-induced severe haematopoietic disorders	blood and bone marrow	30 mg/kg	rats	[118]
Sener et al.	2004	ifosfamide-induced Fanconi syndrome	kidney and bladder tissues	10 mg/kg	rats	[119]
Jou et al.	2004	oxidative stress-induced apoptosis	astrocytes	100 µM	rats	[120]
Yildirim et al.	2004	cyclophosphamide-induced hemorrhagic cystitis	bladder	5 mg/kg (x2)	rats	[121]
Siu et al.	2004	nitric oxide-induced eye toxicity	retina	5 mg/kg	rats	[122]
Feng et al.	2004	beta-amyloid-induced neurotoxicity	brain	10 mg/kg	mice	[123]
Feng et al.	2004	progressive memory deficits	brain	5 - 20 mg/kg	rats	[124]
Ogeturk et al.	2005	CCl4-induced toxicity	kidney	25 mg/kg	rats	[125]
Padillo et al.	2004	experimental cholestasis-induced cell death	liver	500 µg/kg	rats	[126]
Kilic et al.	2004	focal cerebral ischemia	brain	4 mg/kg	mice	[127]

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