The promise of melatonin targets/ receptors as therapeutic targets in multiple therapy areas

186. Diez ER, Prados LV, Carrion A, Ponce ZA, Miatello RM: A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts. J Pineal Res, 2009, 46:155-160.

187. Ling ZQ, Tian Q, Wang L, Fu ZQ, Wang XC, Wang Q, Wang JZ: Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin. J Alzheimers Dis, 2009, 16:287-300.

188. Bertuglia S, Reiter RJ: Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. J Pineal Res, 2009, 46:307-313.

189. Sokullu O, Sanioglu S, Kurc E, Sargin M, Deniz H, Tartan Z, Aka SA, Bilgen F: Does the circadian rhythm of melatonin affect ischemia-reperfusion injury after coronary artery bypass grafting? Heart Surg Forum, 2009, 12:E95-E99.

190. Assayed ME, Abd El-Aty AM: Protection of rat chromosomes by melatonin against gamma radiation-induced damage. Mutat Res, 2009, 677:14-20.

191. Huang JY, Hong YT, Chuang JI: Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J Neurochem, 2009, 109:1400-1412.

192. Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ, Wang L, Zhang C, Lin X, Zhang G, Arendash GW: Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res, 2009, 47:82-96.

193. Simko F, Pechanova O, Pelouch V, Krajcirovicova K, Mullerova M, Bednarova K, Adamcova M, Paulis L: Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. J Hypertens Suppl, 2009, 27:S5-10.

194. Hibaoui Y, Roulet E, Ruegg UT: Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cells. J Pineal Res, 2009, 47:238-252.

195. Tapias V, Cannon JR, Greenamyre JT: Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J Neurosci Res, 2010, 88:420-427.

196. Daglioglu E, Serdar DM, Kilinc K, Erdogan D, Take G, Ergungor F, Okay O, Biyikli Z: Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study. Cent Eur Neurosurg, 2009, 70:109-114.

197. Sirajudeen M, Gopi K, Tyagi JS, Moudgal RP, Mohan J, Singh R: Protective effects of melatonin in reduction of oxidative damage and immunosuppression induced by aflatoxin B1-contaminated diets in young chicks. Environ Toxicol, 2011, 26:153-160.

198. Saxena G, Bharti S, Kamat PK, Sharma S, Nath C: Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats. Pharmacol Biochem Behav, 2010, 94:397-403.

199. Sonmez MF, Narin F, Balcioglu E: Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta. Basic Clin Pharmacol Toxicol, 2009, 105:410-415.

200. Jou MJ, Peng TI, Hsu LF, Jou SB, Reiter RJ, Yang CM, Chiao CC, Lin YF, Chen CC: Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes. J Pineal Res, 2010, 48:20-38.

201. Hoppe JB, Frozza RL, Horn AP, Comiran RA, Bernardi A, Campos MM, Battastini AM, Salbego C: Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation. J Pineal Res, 2010, 48:230-238.

202. Guo Y, Wang J, Wang Z, Yang Y, Wang X, Duan Q: Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement. J Huazhong Univ Sci Technolog Med Sci, 2010, 30:1-7.

203. Mukherjee D, Roy SG, Bandyopadhyay A, Chattopadhyay A, Basu A, Mitra E, Ghosh AK, Reiter RJ, Bandyopadhyay D: Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms. J Pineal Res, 2010, 48:251-262.

204. Rao MV, Purohit A, Patel T: Melatonin protection on mercury-exerted brain toxicity in the rat. Drug Chem Toxicol, 2010, 33:209-216.

205. Lekic T, Hartman R, Rojas H, Manaenko A, Chen W, Ayer R, Tang J, Zhang JH: Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. J Neurotrauma, 2010, 27:627-637.

206. Oliveira LG, Kuehn CC, Santos CD, Toldo MP, do Prado JCJ: Enhanced protection by melatonin and meloxicam combination in experimental infection by Trypanosoma cruzi. Parasite Immunol, 2010, 32:245-251.

207. Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, Friedlander RM: The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity. J Neurosci, 2011, 31:14496-14507.

208. Tripathi DN, Jena GB: Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat. J Pineal Res, 2010, 48:324-331.

209. Dominguez-Rebolledo AE, Fernandez-Santos MR, Bisbal A, Ros-Santaella JL, Ramon M, Carmona M, Martinez-Pastor F, Garde JJ: Improving the effect of incubation and oxidative stress on thawed spermatozoa from red deer by using different antioxidant treatments. Reprod Fertil Dev, 2010, 22:856-870.

210. Ganguly K, Sharma AV, Reiter RJ, Swarnakar S: Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metaloproteinase-2. J Pineal Res, 2010, 49:130-140.

211. Aranda M, Albendea CD, Lostale F, Lopez-Pingarron L, Fuentes-Broto L, Martinez-Ballarin E, Reiter RJ, Perez-Castejon MC, Garcia JJ: In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline. J Pineal Res, 2010, 49:78-85.

212. Romero A, Egea J, Garcia AG, Lopez MG: Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. J Pineal Res, 2010, 49:141-148.

213. Aydemir S, Ozdemir I, Kart A: Role of exogenous melatonin on adriamycin-induced changes in the rat heart. Eur Rev Med Pharmacol Sci, 2010, 14:435-441.

214. Patel V, Upaganlawar A, Zalawadia R, Balaraman R: Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation. Eur J Pharmacol, 2010, 644:160-168.

215. Pant HH, Rao MV: Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures. Ecotoxicol Environ Saf, 2010, 73:1333-1337.

216. Ozturk M, Ozler M, Kurt YG, Ozturk B, Uysal B, Ersoz N, Yasar M, Demirbas S, Kurt B, Acikel C, Oztas Y, Arpaci F, Topal T, Ozet A, Ataergin S, Kuzhan O, Oter S, Korkmaz A: Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity. J Pineal Res, 2011, 50:89-96.

217. Negi G, Kumar A, Sharma SS: Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-kappaB and Nrf2 cascades. J Pineal Res, 2011, 50:124-131.

218. Zhao Y, Qi LW, Wang WM, Saxena PK, Liu CZ: Melatonin improves the survival of cryopreserved callus of Rhodiola crenulata. J Pineal Res, 2011, 50:83-88.

219. Jaworek J, Zwirska-Korczala K, Szklarczyk J, Nawrot-Porabka K, Leja-Szpak A, Jaworek AK, Tomaszewska R: Pinealectomy aggravates acute pancreatitis in the rat. Pharmacol Rep, 2010, 62:864-873.

220. Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH: Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells. J Pineal Res, 2011, 50:281-291.

221. Ionov M, Burchell V, Klajnert B, Bryszewska M, Abramov AY: Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity. Neuroscience, 2011, 180:229-237.

222. Jou MJ: Melatonin preserves the transient mitochondrial permeability transition for protection during mitochondrial Ca(2+) stress in astrocyte. J Pineal Res, 2011, 50:427-435.

223. Espino J, Bejarano I, Paredes SD, Barriga C, Rodriguez AB, Pariente JA: Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. J Pineal Res, 2011, 51:195-206.

224. Dayoub JC, Ortiz F, Lopez LC, Venegas C, Del Pino-Zumaquero A, Roda O, Sanchez-Montesinos I, Acuna-Castroviejo D, Escames G: Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide. J Pineal Res, 2011, 51:324-330.

225. Anjum S, Rahman S, Kaur M, Ahmad F, Rashid H, Ansari RA, Raisuddin S: Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse. Food Chem Toxicol, 2011, 49:2849-2854.

226. Zhou H, Chen J, Lu X, Shen C, Zeng J, Chen L, Pei Z: Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells. J Pineal Res, 2012, 52:120-127.

227. Singh P, Singh N, Palit G: Analysing the role of COX-2 in acute oesophagitis and in melatonin-exerted protection against experimental reflux oesophagitis in rats. J Pharm Pharmacol, 2011, 63:1572-1580.

228. Ono K, Mochizuki H, Ikeda T, Nihira T, Takasaki J, Teplow DB, Yamada M: Effect of melatonin on alpha-synuclein self-assembly and cytotoxicity. Neurobiol Aging, 2012, 33:2172-2185.

229. Shirazi A, Mihandoost E, Mohseni M, Ghazi-Khansari M, Rabie MS: Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood. Phys Med, 2013, 29:65-74.

230. Fu Y, Tang M, Fan Y, Zou H, Sun X, Xu X: Anti-apoptotic effects of melatonin in retinal pigment epithelial cells. Front Biosci (Landmark Ed), 2012, 17:1461-1468.

231. Celinski K, Konturek PC, Konturek SJ, Slomka M, Cichoz-Lach H, Brzozowski T, Bielanski W: Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans. J Physiol Pharmacol, 2011, 62:521-526.

232. Sonmez MF, Narin F, Akkus D, Turkmen AB: Melatonin and vitamin C ameliorate alcohol-induced oxidative stress and eNOS expression in rat kidney. Ren Fail, 2012, 34:480-486.

233. Kunak ZI, Macit E, Yaren H, Yaman H, Cakir E, Aydin I, Turker T, Kurt YG, Ozcan A, Uysal B, Isbilir S, Akgul EO, Cayci T, Korkmaz A, Kenar L: Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity. J Surg Res, 2012, 175:e17-e23.

234. Arguelles S, Munoz MF, Cano M, Machado A, Ayala A: In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis. J Pineal Res, 2012, 53:1-10.

235. Cheshchevik VT, Lapshina EA, Dremza IK, Zabrodskaya SV, Reiter RJ, Prokopchik NI, Zavodnik IB: Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: protection by melatonin and cranberry flavonoids. Toxicol Appl Pharmacol, 2012, 261:271-279.

236. Qin W, Lu W, Li H, Yuan X, Li B, Zhang Q, Xiu R: Melatonin inhibits IL1beta-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kappaB activation. J Endocrinol, 2012, 214:145-153.

237. Ganguly K, Swarnakar S: Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatonin. Biochimie, 2012, 94:2687-2698.

238. Mukherjee D, Ghosh AK, Bandyopadhyay A, Basu A, Datta S, Pattari SK, Reiter RJ, Bandyopadhyay D: Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats. J Pineal Res, 2012, 53:166-179.

239. Bekyarova G, Apostolova M, Kotzev I: Melatonin protection against burn-induced hepatic injury by down-regulation of nuclear factor kappa B activation. Int J Immunopathol Pharmacol, 2012, 25:591-596.

240. Yip HK, Chang YC, Wallace CG, Chang LT, Tsai TH, Chen YL, Chang HW, Leu S, Zhen YY, Tsai CY, Yeh KH, Sun CK, Yen CH: Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury. J Pineal Res, 2013, 54:207-221.

241. Ali SA, Aly HF, Faddah LM, Zaidi ZF: Dietary supplementation of some antioxidants against hypoxia. World J Gastroenterol, 2012, 18:6379-6386.

242. Kireev R, Bitoun S, Cuesta S, Tejerina A, Ibarrola C, Moreno E, Vara E, Tresguerres JA: Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. Eur J Pharmacol, 2013, 701:185-193.

243. Canonico B, Luchetti F, Ambrogini P, Arcangeletti M, Betti M, Cesarini E, Lattanzi D, Ciuffoli S, Palma F, Cuppini R, Papa S: Pharmacological doses of melatonin induce alterations in mitochondrial mass and potential, bcl-2 levels and K+ currents in UVB-exposed U937 cells. Cell Biol Int, 2013, 37:213-226.

244. Espino J, Rodriguez AB, Pariente JA: The inhibition of TNF-alpha-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction. J Pineal Res, 2013, 54:442-452.

245. Yawno T, Castillo-Melendez M, Jenkin G, Wallace EM, Walker DW, Miller SL: Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia. Dev Neurosci, 2012, 34:543-551.

246. Ferreira SG, Peliciari-Garcia RA, Takahashi-Hyodo SA, Rodrigues AC, Amaral FG, Berra CM, Bordin S, Curi R, Cipolla-Neto J: Effects of melatonin on DNA damage induced by cyclophosphamide in rats. Braz J Med Biol Res, 2013, 46:278-286.

247. Konturek PC, Brzozowska I, Targosz A, Pawlik M, Kania J, Hess T, Kwiecien S, Konturek SJ, Reiter RJ, Brzozowski T: Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis. J Pineal Res, 2013, 55:46-57.

248. Bai J, Dong L, Song Z, Ge H, Cai X, Wang G, Liu P: The role of melatonin as an antioxidant in human lens epithelial cells. Free Radic Res, 2013, 47:635-642.

249. Zasada K, Karbownik-Lewinska M: Comparison of potential protective effects of melatonin and propylthiouracil against lipid peroxidation caused by nitrobenzene in the thyroid gland. Toxicol Ind Health, 2013,

250. Lee JY, Kim JH, Lee DC: Urine melatonin levels are inversely associated with sarcopenia in postmenopausal women. Menopause, 2014, 21:39-44.

251. Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, Wang N, Liang Z, Li Y, Chen W, Yi D, Yu S: JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. J Pineal Res, 2013, 55:275-286.

252. Sayyed HG, Jaumdally RJ, Idriss NK, El Sers DA, Blann A: The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat. Dig Dis Sci, 2013, 58:3156-3164.

253. Chen J, Chen G, Li J, Qian C, Mo H, Gu C, Yan F, Yan W, Wang L: Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines. J Pineal Res, 2014, 57:340-347.

254. Karamian A, Shokrzadeh M, Ahmadi A: The potential chemoprotective effects of melatonin against genotoxicity induced by diazinon in human peripheral blood lymphocytes. Toxicol Ind Health, 2013,

255. Drury PP, Davidson JO, Bennet L, Booth LC, Tan S, Fraser M, van den Heuij LG, Gunn AJ: Partial neural protection with prophylactic low-dose melatonin after asphyxia in preterm fetal sheep. J Cereb Blood Flow Metab, 2014, 34:126-135.

256. Macit E, Yaren H, Aydin I, Kunak ZI, Yaman H, Onguru O, Uysal B, Korkmaz A, Turel S, Kenar L: The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats. Environ Toxicol Pharmacol, 2013, 36:1283-1290.

257. Hrenak J, Arendasova K, Rajkovicova R, Aziriova S, Repova K, Krajcirovicova K, Celec P, Kamodyova N, Barta A, Adamcova M, Paulis L, Simko F: Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats. Physiol Res, 2013, 62 Suppl 1:S181-S189.

258. Parada E, Buendia I, Leon R, Negredo P, Romero A, Cuadrado A, Lopez MG, Egea J: Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. J Pineal Res, 2014, 56:204-212.

259. Pinato L, da SC-M, Franco DG, Campos LM, Cecon E, Fernandes PA, Bittencourt JC, Markus RP: Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis. Brain Struct Funct, 2015, 220:827-840.

260. Katkar GD, Sundaram MS, Hemshekhar M, Sharma DR, Santhosh MS, Sunitha K, Rangappa KS, Girish KS, Kemparaju K: Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. J Pineal Res, 2014, 56:295-312.

261. San-Miguel B, Crespo I, Vallejo D, Alvarez M, Prieto J, Gonzalez-Gallego J, Tunon MJ: Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus. J Pineal Res, 2014, 56:313-321.

262. Wong CS, Jow GM, Kaizaki A, Fan LW, Tien LT: Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats. Neuroscience, 2014, 267:147-156.

263. Shokrzadeh M, Naghshvar F, Ahmadi A, Chabra A, Jeivad F: The potential ameliorative effects of melatonin against cyclophosphamide-induced DNA damage in murine bone marrow cells. Eur Rev Med Pharmacol Sci, 2014, 18:605-611.

264. Tare M, Parkington HC, Wallace EM, Sutherland AE, Lim R, Yawno T, Coleman HA, Jenkin G, Miller SL: Maternal melatonin administration mitigates coronary stiffness and endothelial dysfunction, and improves heart resilience to insult in growth restricted lambs. J Physiol, 2014, 592:2695-2709.

265. Zayachkivska O, Pshyk-Titko I, Hrycevych N, Savytska M: New insight into oseophageal injury and protection in physiologically relevant animal models. J Physiol Pharmacol, 2014, 65:295-307.

266. Kashani IR, Rajabi Z, Akbari M, Hassanzadeh G, Mohseni A, Eramsadati MK, Rafiee K, Beyer C, Kipp M, Zendedel A: Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis. Exp Brain Res, 2014, 232:2835-2846.

267. de Souza AV, Golim MA, Deffune E, Domingues MA, de Carvalho LR, Vianna IG, Castiglia YM, Vianna PT: Evaluation of renal protection from high doses of melatonin in an experimental model of renal ischemia and reperfusion in hyperglycemic rats. Transplant Proc, 2014, 46:1591-1593.

268. Tain YL, Leu S, Wu KL, Lee WC, Chan JY: Melatonin prevents maternal fructose intake-induced programmed hypertension in the offspring: roles of nitric oxide and arachidonic acid metabolites. J Pineal Res, 2014, 57:80-89.

269. Sehajpal J, Kaur T, Bhatti R, Singh AP: Role of progesterone in melatonin-mediated protection against acute kidney injury. J Surg Res, 2014, 191:441-447.

270. Yu L, Sun Y, Cheng L, Jin Z, Yang Y, Zhai M, Pei H, Wang X, Zhang H, Meng Q, Zhang Y, Yu S, Duan W: Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1. J Pineal Res, 2014, 57:228-238.

271. Wu TH, Kuo HC, Lin IC, Chien SJ, Huang LT, Tain YL: Melatonin prevents neonatal dexamethasone induced programmed hypertension: histone deacetylase inhibition. J Steroid Biochem Mol Biol, 2014, 144 Pt B:253-259.

272. Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE: The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. Oxid Med Cell Longev, 2014, 2014:639531-

273. Chen YT, Chiang HJ, Chen CH, Sung PH, Lee FY, Tsai TH, Chang CL, Chen HH, Sun CK, Leu S, Chang HW, Yang CC, Yip HK: Melatonin treatment further improves adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in rat. J Pineal Res, 2014, 57:248-261.

274. Alp BF, Kesik V, Malkoc E, Yigit N, Saldir M, Babacan O, Akgul EO, Poyrazoglu Y, Korkmazer N, Gulgun M, Erdem O: The effect of melatonin on procarbazine induced testicular toxicity on rats. Syst Biol Reprod Med, 2014, 60:323-328.

275. Guo P, Pi H, Xu S, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Li R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z: Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicol Sci, 2014, 142:182-195.

276. Yang Y, Jiang S, Dong Y, Fan C, Zhao L, Yang X, Li J, Di S, Yue L, Liang G, Reiter RJ, Qu Y: Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice. J Pineal Res, 2015, 58:61-70.

277. Mihandoost E, Shirazi A, Mahdavi SR, Aliasgharzadeh A: Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin. ScientificWorldJournal, 2014, 2014:621570-

278. Liu LF, Qin Q, Qian ZH, Shi M, Deng QC, Zhu WP, Zhang H, Tao XM, Liu Y: Protective effects of melatonin on ischemia-reperfusion induced myocardial damage and hemodynamic recovery in rats. Eur Rev Med Pharmacol Sci, 2014, 18:3681-3686.

279. Abdel Moneim AE, Ortiz F, Leonardo-Mendonca RC, Vergano-Villodres R, Guerrero-Martinez JA, Lopez LC, Acuna-Castroviejo D, Escames G: Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats. Acta Trop, 2014, 143C:58-65.

280. Tan J, Wang Y, Xia Y, Zhang N, Sun X, Yu T, Lin L: Melatonin Protects the Esophageal Epithelial Barrier by Suppressing the Transcription, Expression and Activity of Myosin Light Chain Kinase Through ERK1/2 Signal Transduction. Cell Physiol Biochem, 2014, 34:2117-2127.