The promise of melatonin targets/ receptors as therapeutic targets in multiple therapy areas



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systemic lipopolysaccharide-induced injury

brain

20 mg/kg

rats

[262]

Shokrzadeh et al.

2014

cyclophosphamide-induced DNA damage

bone marrow cells

2.5 to 20 mg/kg

mice

[263]

Tare et al.

2014

intrauterine growth restriction

heart and blood vessels

0.25 to 2 mg/h

sheep

[264]

Zayachkivska et al.

2014

gastroesophageal reflux disease

esophage

20 mg/kg

rats

[265]

Kashani et al.

2014

multiple sclerosis-induced mitochondrial injury

neurons

5 mg/kg

mice

[266]

de Souza et al.

2014

ischemia/reperfusion

kidneys

50 mg/kg

rats

[267]

Tain et al.

2014

maternal fructose intake-induced programmed hypertension

kidneys

0.01% …

rats

[268]

Sehajpal et al.

2014

acute kidney injury

kidneys

4 to 10 mg/kg

rats

[269]

Yu et al.

2014

ischemia/reperfusion injury

heart

10 mg/kg (x7)

rats

[270]

Wu et al.

2014

dexamethasone induced programmed hypertension




0.01%

rats

[271]

Song et al.

2014

reperfusion-induced injury

brain endothelial cells

1 to 100 nM

murine cells

[272]

Chen et al.

2014

cyclophosphamide-induced acute interstitial cystitis

bladder

20 to 50 mg/kg

rats

[273]

Alp et al.

2014

procarbazine induced toxicity

testis

10 mg/kg

rats

[274]

Guo et al.

2014

cadmium-induced toxicity

HepG2

500 nM

human cells

[275]

Chen et al.

2014

inflammatory response-induced edema

brain

150 mg/kg

rats

[253]

Yang et al.

2015

ischemic-stroke induced mitochondrial dysfunction

brain

10 mg/kg

mice

[276]

Mihandoost et al.

2014

lethal-whole-body gamma radiation

whole body

100 mg/kg

rats

[277]

Yang et al.

2014

intestinal ischemia-reperfusion-induced injury

lung

5 to 25 mg/kg

rats

[276]

Liu et al.

2014

ischemia-reperfusion induced damage

heart

2.5 to 10 mg/kg

rats

[278]

Abdel Moneim et al.

2014

Egyptian cobra crude venom-induced oxidative damage

differenet organs

10 mg/kg

rats

[279]

Tan et al.

2014

acid treatment-induced esophageal enhanced permeability

Het-1A cells

10 µM

human cells

[280]

Trivedi et al.

2015

colitis-associated carcinogenesis

colon

1 mg/kg (x 42 and 126)

mice

[281]
































































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