Garlandee5 typical al.32 2001
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Amotivational syndrome associated with SSRI in children
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Case report
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5 cases of apathy and lack of motivation described in a child and 4 adolescents. Symptoms dose related and reversible with cessation/reduction. Subtlety of symptoms, lack of insight in patients, delayed onset and disabling effects were noted by authors
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Reinblattet al.33 2006
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SSRI induced apathy: A Pediatric Case series
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Case series
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2 pediatric cases, a 9-year-old child and a 16-year-old adolescent, of apathy identified from a study of fluvoxamine in pediatric anxiety disorders. Similar to previous reports, there was a lack of insight, delayed onset, dose dependency with reversibility with SSRI dose reduction and discontinuation
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Padala et al.34 2012
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Reversal of SSRI-associated apathy syndrome by discontinuation of therapy
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Case series
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In 6 cases patients reported loss of motivation of new onset and associated with commencing the use of a SSRI, with symptoms monitored by the Apathy Evaluation Scale, which all improved significantly when SSRI discontinued.
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Sato et al.35 2011
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Sertraline induced apathy
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Case report
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Apathy symptoms reported “felt like nothing mattered” “emotions flat” one month after treatment with good improvement in panic symptoms. After gradual decrease, apathy symptoms disappeared without recurrent panic attacks
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Kodela et al.36 2010
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Antidepressant induced apathy responsive to dose reduction
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Case report
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48-year-old man with diagnosis of personality change due to a medical condition. Depressive symptoms, impulse control and irritability improved significantly but he became apathetic. Responded positively to dose reduction.
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RCT: Randomized Control Trials
SSRI: Selective Serotonin Reuptake Inhibitor
SNRI: Serotonin Norepinephrine Reuptake Inhibitor
AES-C Apathy Evaluation Scale-Clinician version
fMRI: functional Magentic Resonance Imaging
GDS: Geriatric Depression Scale
HAMD: Hamilton Depression Rating Scale
CPFQ: Cognitive and Physical Functioning Questionnaire
SHAPS: Snaith-Hamilton Pleasure Scale
TCA: Tricyclic Antidepressant
HRSD: Hamilton Rating Scale for Depression
MGH: Massachusetts General Hospital
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