Table 4: Case Reports
Trimble et al.26 1992
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Fluvoxamine induced frontal lobe syndrome
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Case report
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42-year-old man with Obsessive Compulsive Disorder and Tourette’s syndrome, with the apathy subsiding with the reduction of the dose of fluvoxamine
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Bruno et al.27 2015
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Antidepressant induced excessive yawning and indifference
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Case report
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Excessive yawning and a case of emotional numbness in 2 patients on SNRI
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De Berardiset al.28 2013
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Agomelatine reversal of escitalopram induced apathy
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Case Report
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70-year old man with recurrence of major depressive episode on escitalopram 10mg/day for 6 months with improvement then developed prominent loss of drive and motivation lasting 2 months without worsening of depression, obtaining score of 62 on Apathy Evaluation Scale. Agomelatine 25 mg/day added with good improvement and resolution of apathy upon complete switchover to agomelatine.
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