Zahodne et al.23 2012
|
Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson’s disease
|
Cross-sectional study
|
Convenience sample of 181 individuals followed at centre for movement disorders
|
35 individuals taking SSRI, 25 taking non-SSRI.
|
Patients on SSRI more likely to be apathetic (chi-squared=8.916; p=0.005)
|
Popovic et al.24 2015
|
Cognitive tolerability following.. treatment.. with SSRI antidepressants (including apathy)
|
Cross-sectional study: 67 treated with SSRI assessed for cognitive symptoms
|
67 patients treated at outpatient clinic, with SSRI for at least 6 months
|
Several self-rating scales including MGH cognitive and physical functioning questionnaire
|
Most frequent cognitive complaints were inattentiveness, forgetfulness, mental slowing, apathy (6% with moderate to severe and 10% with mild
P value 0.953impairment)
|
-Attempted to separate anxiety and depression groups to account for confounding symptoms. However depressive symptoms not adjusted for
- As in other cross-sectional studies, causality impossible to conclude
- not a significant result with a p-value of 0.953
|
